Kcnh3 (potassium voltage-gated channel, subfamily H (eag-related), member 3) - Rat Genome Database

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Gene: Kcnh3 (potassium voltage-gated channel, subfamily H (eag-related), member 3) Mus musculus
Analyze
Symbol: Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
RGD ID: 736943
MGI Page MGI
Description: Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to act upstream of or within potassium ion transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; genitourinary system; spinal cord; and submandibular gland. Orthologous to human KCNH3 (potassium voltage-gated channel subfamily H member 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AU019351; C030044P22Rik; Elk; ELK channel 2; Elk2; ether a go-go like; ether-a-go-go-like potassium channel 2; Kv12.2; Melk; Melk2; potassium voltage-gated channel subfamily H member 3; voltage-gated potassium channel subunit Kv12.2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,122,396 - 99,140,699 (+)NCBIGRCm39mm39
GRCm39 Ensembl1599,122,742 - 99,140,698 (+)Ensembl
GRCm381599,224,517 - 99,242,818 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,224,861 - 99,242,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,055,407 - 99,073,248 (+)NCBIGRCm37mm9NCBIm37
MGSCv361599,053,010 - 99,070,851 (+)NCBImm8
Celera15101,380,704 - 101,398,527 (+)NCBICelera
Cytogenetic Map15F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10191308   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16985003   PMID:19623261   PMID:19808681  
PMID:19923296   PMID:20676103   PMID:21267068   PMID:21873635   PMID:24194600   PMID:27224923   PMID:27626380   PMID:28700664  


Genomics

Comparative Map Data
Kcnh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,122,396 - 99,140,699 (+)NCBIGRCm39mm39
GRCm39 Ensembl1599,122,742 - 99,140,698 (+)Ensembl
GRCm381599,224,517 - 99,242,818 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,224,861 - 99,242,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,055,407 - 99,073,248 (+)NCBIGRCm37mm9NCBIm37
MGSCv361599,053,010 - 99,070,851 (+)NCBImm8
Celera15101,380,704 - 101,398,527 (+)NCBICelera
Cytogenetic Map15F1NCBI
KCNH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,539,030 - 49,558,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1249,539,030 - 49,558,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371249,932,813 - 49,952,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,219,207 - 48,238,344 (+)NCBINCBI36hg18NCBI36
Build 341248,219,206 - 48,238,344NCBI
Celera1248,727,399 - 48,746,536 (+)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1246,963,792 - 46,982,929 (+)NCBIHuRef
CHM1_11249,899,177 - 49,918,314 (+)NCBICHM1_1
T2T-CHM13v2.01249,501,276 - 49,520,593 (+)NCBI
Kcnh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,365,593 - 130,383,859 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7130,366,011 - 130,383,855 (+)Ensembl
Rnor_6.07140,788,987 - 140,910,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,788,987 - 140,910,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,293,665 - 115,414,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,984,618 - 138,002,553 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17138,061,054 - 138,078,990 (+)NCBI
Celera7126,849,591 - 126,866,683 (+)NCBICelera
Cytogenetic Map7q36NCBI
Kcnh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547163,130 - 180,792 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547163,130 - 180,792 (+)NCBIChiLan1.0ChiLan1.0
KCNH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11240,083,642 - 40,102,585 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,083,642 - 40,102,579 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01239,192,912 - 39,212,472 (-)NCBIMhudiblu_PPA_v0panPan3
KCNH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,085,474 - 5,102,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,085,835 - 5,100,974 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,156,843 - 41,173,389 (+)NCBI
ROS_Cfam_1.0275,134,286 - 5,150,806 (-)NCBI
ROS_Cfam_1.0 Ensembl275,134,297 - 5,151,278 (-)Ensembl
UMICH_Zoey_3.1275,100,122 - 5,116,413 (-)NCBI
UNSW_CanFamBas_1.0275,089,681 - 5,106,235 (-)NCBI
UU_Cfam_GSD_1.02741,550,557 - 41,567,110 (+)NCBI
Kcnh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,887,078 - 65,906,383 (-)NCBI
SpeTri2.0NW_0049365127,259,685 - 7,277,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,495,157 - 15,517,022 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,494,649 - 15,517,024 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,782,453 - 45,801,529 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,784,292 - 45,801,173 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037200,323,943 - 200,343,228 (-)NCBIVero_WHO_p1.0
Kcnh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,683,333 - 2,701,166 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248162,683,345 - 2,701,203 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH126595  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,242,823 - 99,243,049UniSTSGRCm38
GRCm384144,588,717 - 144,588,943UniSTSGRCm38
MGSCv374144,178,620 - 144,178,846UniSTSGRCm37
MGSCv371599,073,254 - 99,073,480UniSTSGRCm37
Celera15101,398,533 - 101,398,759UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map4E1UniSTS
Whitehead/MRC_RH15974.98UniSTS
RH136487  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381599,242,447 - 99,242,670UniSTSGRCm38
MGSCv371599,072,878 - 99,073,101UniSTSGRCm37
Celera15101,398,157 - 101,398,380UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map15F1UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:181
Interacting mature miRNAs:198
Transcripts:ENSMUST00000041415
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041415   ⟹   ENSMUSP00000040548
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,122,742 - 99,140,698 (+)Ensembl
GRCm38.p6 Ensembl1599,224,861 - 99,242,817 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228983
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,125,700 - 99,126,701 (+)Ensembl
GRCm38.p6 Ensembl1599,227,819 - 99,228,820 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230552
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,136,151 - 99,140,677 (+)Ensembl
GRCm38.p6 Ensembl1599,238,270 - 99,242,796 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230973
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1599,135,786 - 99,136,117 (+)Ensembl
GRCm38.p6 Ensembl1599,237,905 - 99,238,236 (+)Ensembl
RefSeq Acc Id: NM_010601   ⟹   NP_034731
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,122,473 - 99,140,698 (+)NCBI
GRCm381599,224,592 - 99,242,817 (+)NCBI
MGSCv371599,055,407 - 99,073,248 (+)RGD
Celera15101,380,704 - 101,398,527 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520483   ⟹   XP_006520546
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,122,396 - 99,140,699 (+)NCBI
GRCm381599,224,517 - 99,242,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006520484   ⟹   XP_006520547
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,123,954 - 99,140,699 (+)NCBI
GRCm381599,225,934 - 99,242,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248343   ⟹   XP_030104203
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,123,954 - 99,140,699 (+)NCBI
GRCm381599,225,934 - 99,242,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248344   ⟹   XP_030104204
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,123,694 - 99,140,699 (+)NCBI
GRCm381599,225,659 - 99,242,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159170   ⟹   XP_036015063
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,122,399 - 99,140,699 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159171   ⟹   XP_036015064
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391599,122,401 - 99,140,699 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034731   ⟸   NM_010601
- UniProtKB: Q9WVJ0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006520546   ⟸   XM_006520483
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006520547   ⟸   XM_006520484
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030104204   ⟸   XM_030248344
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030104203   ⟸   XM_030248343
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000040548   ⟸   ENSMUST00000041415
RefSeq Acc Id: XP_036015063   ⟸   XM_036159170
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036015064   ⟸   XM_036159171
- Peptide Label: isoform X3
Protein Domains
PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVJ0-F1-model_v2 AlphaFold Q9WVJ0 1-1095 view protein structure

Promoters
RGD ID:8684972
Promoter ID:EPDNEW_M20517
Type:single initiation site
Name:Kcnh3_1
Description:Mus musculus potassium voltage-gated channel, subfamily H (eag-related),member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381599,238,152 - 99,238,212EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341723 AgrOrtholog
Ensembl Genes ENSMUSG00000037579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000040548 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000041415 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot
  K_chnl_volt-dep_ELK UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-assoc_C UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report mmu:16512 UniProtKB/Swiss-Prot
MGD MGI:1341723 ENTREZGENE
NCBI Gene 16512 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  PAS_9 UniProtKB/Swiss-Prot
PhenoGen Kcnh3 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot
  ELKCHANNEL UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
SMART cNMP UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
TIGRFAMs sensory_box UniProtKB/Swiss-Prot
UniProt KCNH3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RU85 UniProtKB/Swiss-Prot
  E9QMZ8 UniProtKB/Swiss-Prot
  Q6U1M1 UniProtKB/Swiss-Prot