RGD Reference Report - New ether-a-go-go K(+) channel family members localized in human telencephalon. - Rat Genome Database

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New ether-a-go-go K(+) channel family members localized in human telencephalon.

Authors: Miyake, A  Mochizuki, S  Yokoi, H  Kohda, M  Furuichi, K 
Citation: Miyake A, etal., J Biol Chem 1999 Aug 27;274(35):25018-25.
RGD ID: 70783
Pubmed: PMID:10455180   (View Abstract at PubMed)

A cDNA encoding a novel voltage-gated K(+) channel protein was isolated from human brain. This protein, termed BEC1, is 46% identical to rat elk in the ether-a-go-go K(+) channel family. The BEC1 gene maps to the 12q13 region of the human genome. Northern blot analysis indicates that BEC1 is exclusively expressed in human brain, where the expression is concentrated in the telencephalic areas such as the cerebral cortex, amygdala, hippocampus, and striatum. By in situ hybridization, BEC1 is detected in the CA1-CA3 pyramidal cell layers and the dentate gyrus granule cell layers of the hippocampus. Specific signals are also found in neocortical neurons. Transfection of mammalian L929 and Chinese hamster ovary cells with BEC1 cDNA induces a voltage-gated outward current with a fast inactivation component. This current is insensitive to tetraethylammonium and quinidine. Additionally, a second related gene BEC2 was isolated from human brain. BEC2 is also brain-specific, located in the neocortex and the striatum, and functional as a channel gene. Phylogenetic analysis indicates that BEC1 and BEC2 constitute a subfamily, together with elk, in the ether-a-go-go family. The two genes may be involved in cellular excitability of restricted neurons in the human central nervous system.

Objects referenced in this article
Gene KCNH3 potassium voltage-gated channel subfamily H member 3 Homo sapiens
Gene KCNH4 potassium voltage-gated channel subfamily H member 4 Homo sapiens
Gene Kcnh3 potassium voltage-gated channel subfamily H member 3 Rattus norvegicus
Gene Kcnh4 potassium voltage-gated channel subfamily H member 4 Rattus norvegicus

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