Gene: KCNH4 (potassium voltage-gated channel subfamily H member 4) Homo sapiens
Symbol: KCNH4
Name: potassium voltage-gated channel subfamily H member 4
Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BEC2; brain-specific eag-like channel 2; ELK channel 1; ELK1; ether-a-go-go K(+) channel family member; ether-a-go-go-like potassium channel 1; Kv12.3; potassium channel, voltage gated eag related subfamily H, member 4; potassium voltage-gated channel, subfamily H (eag-related), member 4; voltage-gated potassium channel subunit Kv12.3
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381742,156,892 - 42,181,278 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,308,910 - 40,333,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,562,439 - 37,586,822 (-)NCBINCBI36hg18NCBI36
Build 341737,562,438 - 37,586,822NCBI
Celera1736,964,227 - 36,987,523 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,074,129 - 36,098,412 (-)NCBIHuRef
CHM1_11740,544,659 - 40,569,024 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNH4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733889
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE