PRSS8 Human (1->4)-beta-D-glucan multiple interactions ISO Prss8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRSS8 mRNA CTD PMID:36331819 PRSS8 Human 1,1-dichloroethene decreases expression ISO Prss8 (Mus musculus) 6480464 vinylidene chloride results in decreased expression of PRSS8 mRNA CTD PMID:26682919 PRSS8 Human 1,2-dichloroethane decreases expression ISO Prss8 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of PRSS8 mRNA CTD PMID:28960355 PRSS8 Human 1-naphthyl isothiocyanate increases expression ISO Prss8 (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in increased expression of PRSS8 mRNA CTD PMID:30723492 PRSS8 Human 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of PRSS8 mRNA CTD PMID:23019147 and PMID:31614463 PRSS8 Human 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of PRSS8 mRNA CTD PMID:30165855 PRSS8 Human 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO Prss8 (Rattus norvegicus) 6480464 2 more ... CTD PMID:20959002 PRSS8 Human 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Prss8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 PRSS8 Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Prss8 (Rattus norvegicus) 6480464 2 more ... CTD PMID:31826744 PRSS8 Human 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Prss8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 PRSS8 Human 2,3,4,7,8-Pentachlorodibenzofuran decreases expression ISO Prss8 (Rattus norvegicus) 6480464 2 more ... CTD PMID:21724226 PRSS8 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Prss8 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of PRSS8 mRNA CTD PMID:22298810 PRSS8 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PRSS8 mRNA CTD PMID:23152189 PRSS8 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Prss8 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of PRSS8 mRNA CTD PMID:20959002 PRSS8 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Prss8 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of PRSS8 mRNA CTD PMID:21724226 and PMID:32109520 PRSS8 Human 2,3,7,8-Tetrachlorodibenzofuran decreases expression ISO Prss8 (Rattus norvegicus) 6480464 2 more ... CTD PMID:21724226 PRSS8 Human 2,4-dinitrotoluene affects expression ISO Prss8 (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of PRSS8 mRNA CTD PMID:21346803 PRSS8 Human 3,3',5,5'-tetrabromobisphenol A increases expression ISO Prss8 (Rattus norvegicus) 6480464 tetrabromobisphenol A results in increased expression of PRSS8 mRNA CTD PMID:27914987 PRSS8 Human 4,4'-sulfonyldiphenol increases expression ISO Prss8 (Mus musculus) 6480464 bisphenol S results in increased expression of PRSS8 mRNA CTD PMID:30951980 PRSS8 Human 4,4'-sulfonyldiphenol affects methylation ISO Prss8 (Mus musculus) 6480464 bisphenol S affects the methylation of PRSS8 gene CTD PMID:31683443 PRSS8 Human 4-hydroxyphenyl retinamide increases expression ISO Prss8 (Mus musculus) 6480464 Fenretinide results in increased expression of PRSS8 mRNA CTD PMID:28973697 PRSS8 Human acetamide increases expression ISO Prss8 (Rattus norvegicus) 6480464 acetamide results in increased expression of PRSS8 mRNA CTD PMID:31881176 PRSS8 Human acrylamide decreases expression ISO Prss8 (Rattus norvegicus) 6480464 Acrylamide results in decreased expression of PRSS8 mRNA CTD PMID:28959563 PRSS8 Human afimoxifene multiple interactions EXP 6480464 afimoxifene inhibits the reaction [Estrogens results in decreased expression of PRSS8 mRNA] CTD PMID:21233418 PRSS8 Human aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of PRSS8 mRNA CTD PMID:27153756 PRSS8 Human aflatoxin B1 increases expression ISO Prss8 (Rattus norvegicus) 6480464 Aflatoxin B1 results in increased expression of PRSS8 mRNA CTD PMID:25378103 PRSS8 Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of PRSS8 mRNA CTD PMID:21934132 PRSS8 Human alpha-hexachlorocyclohexane increases expression ISO Prss8 (Rattus norvegicus) 6480464 alpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNA CTD PMID:17785943 PRSS8 Human ammonium chloride affects expression ISO Prss8 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of PRSS8 mRNA CTD PMID:16483693 PRSS8 Human Aroclor 1254 increases expression ISO Prss8 (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of PRSS8 mRNA CTD PMID:23650126 PRSS8 Human arsane affects methylation EXP 6480464 Arsenic affects the methylation of PRSS8 gene CTD PMID:25304211 PRSS8 Human arsenic atom affects methylation EXP 6480464 Arsenic affects the methylation of PRSS8 gene CTD PMID:25304211 PRSS8 Human benzo[a]pyrene decreases methylation EXP 6480464 Benzo(a)pyrene results in decreased methylation of PRSS8 exon CTD PMID:27901495 PRSS8 Human benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of PRSS8 promoter CTD PMID:27901495 PRSS8 Human benzo[b]fluoranthene increases expression ISO Prss8 (Mus musculus) 6480464 benzo(b)fluoranthene results in increased expression of PRSS8 mRNA CTD PMID:26377693 PRSS8 Human beta-naphthoflavone multiple interactions ISO Prss8 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PRSS8 mRNA CTD PMID:18164116 PRSS8 Human bisphenol A affects expression ISO Prss8 (Rattus norvegicus) 6480464 bisphenol A affects the expression of PRSS8 mRNA CTD PMID:25181051 PRSS8 Human bisphenol A decreases expression ISO Prss8 (Mus musculus) 6480464 bisphenol A results in decreased expression of PRSS8 mRNA CTD PMID:35479511 PRSS8 Human bisphenol A increases expression ISO Prss8 (Mus musculus) 6480464 bisphenol A results in increased expression of PRSS8 mRNA CTD PMID:30951980 more ... PRSS8 Human bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PRSS8 mRNA CTD PMID:30903817 PRSS8 Human bisphenol F increases expression ISO Prss8 (Mus musculus) 6480464 bisphenol F results in increased expression of PRSS8 mRNA CTD PMID:30951980 PRSS8 Human bisphenol F decreases expression ISO Prss8 (Mus musculus) 6480464 bisphenol F results in decreased expression of PRSS8 mRNA CTD PMID:38685157 PRSS8 Human cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of PRSS8 mRNA CTD PMID:24376830 PRSS8 Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of PRSS8 mRNA CTD PMID:38568856 PRSS8 Human carbon nanotube decreases expression ISO Prss8 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 and PMID:25620056 PRSS8 Human choline multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS8 mRNA CTD PMID:20938992 and PMID:33549593 PRSS8 Human copper atom multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA CTD PMID:24690739 PRSS8 Human copper(0) multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA CTD PMID:24690739 PRSS8 Human copper(II) chloride decreases expression EXP 6480464 cupric chloride results in decreased expression of PRSS8 mRNA CTD PMID:38568856 PRSS8 Human copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of PRSS8 mRNA CTD PMID:19549813 PRSS8 Human coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of PRSS8 mRNA CTD PMID:19167446 PRSS8 Human coumestrol decreases expression EXP 6480464 Coumestrol results in decreased expression of PRSS8 mRNA CTD PMID:19167446 PRSS8 Human cyanocob(III)alamin multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA CTD PMID:33549593 PRSS8 Human cyclosporin A affects expression EXP 6480464 Cyclosporine affects the expression of PRSS8 mRNA CTD PMID:25562108 PRSS8 Human DDE decreases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of PRSS8 mRNA CTD PMID:38568856 PRSS8 Human decabromodiphenyl ether increases expression ISO Prss8 (Rattus norvegicus) 6480464 decabromobiphenyl ether results in increased expression of PRSS8 mRNA CTD PMID:23914054 PRSS8 Human diethyl maleate decreases expression ISO Prss8 (Rattus norvegicus) 6480464 diethyl maleate results in decreased expression of PRSS8 mRNA CTD PMID:21161181 PRSS8 Human disulfiram multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA CTD PMID:24690739 PRSS8 Human diuron decreases expression ISO Prss8 (Rattus norvegicus) 6480464 Diuron results in decreased expression of PRSS8 mRNA CTD PMID:21551480 PRSS8 Human dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 PRSS8 Human elemental selenium increases expression EXP 6480464 Selenium results in increased expression of PRSS8 mRNA CTD PMID:19244175 PRSS8 Human endosulfan decreases expression ISO Prss8 (Rattus norvegicus) 6480464 Endosulfan results in decreased expression of PRSS8 mRNA CTD PMID:29391264 PRSS8 Human entinostat increases expression EXP 6480464 entinostat results in increased expression of PRSS8 mRNA CTD PMID:26272509 PRSS8 Human entinostat multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA CTD PMID:27188386 PRSS8 Human epoxiconazole decreases expression ISO Prss8 (Mus musculus) 6480464 epoxiconazole results in decreased expression of PRSS8 mRNA CTD PMID:35436446 PRSS8 Human ethanol multiple interactions ISO Prss8 (Rattus norvegicus) 6480464 [Fish Oils co-treated with Ethanol] results in increased expression of PRSS8 mRNA CTD PMID:17347304 PRSS8 Human flavonoids increases expression ISO Prss8 (Rattus norvegicus) 6480464 Flavonoids results in increased expression of PRSS8 mRNA CTD PMID:18035473 PRSS8 Human folic acid multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS8 mRNA CTD PMID:20938992 and PMID:33549593 PRSS8 Human folpet decreases expression ISO Prss8 (Mus musculus) 6480464 folpet results in decreased expression of PRSS8 mRNA CTD PMID:31558096 PRSS8 Human genistein multiple interactions EXP 6480464 ESR2 promotes the reaction [Genistein results in decreased expression of PRSS8 protein] CTD PMID:20884965 PRSS8 Human genistein decreases expression EXP 6480464 Genistein results in decreased expression of PRSS8 protein CTD PMID:20884965 PRSS8 Human glycine betaine multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA CTD PMID:33549593 PRSS8 Human inulin multiple interactions ISO Prss8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of PRSS8 mRNA CTD PMID:36331819 PRSS8 Human isotretinoin decreases expression EXP 6480464 Isotretinoin results in decreased expression of PRSS8 mRNA CTD PMID:20436886 PRSS8 Human L-methionine multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS8 mRNA CTD PMID:20938992 and PMID:33549593 PRSS8 Human lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of PRSS8 mRNA CTD PMID:38568856 PRSS8 Human mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of PRSS8 mRNA CTD PMID:26272509 PRSS8 Human mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA CTD PMID:27188386 PRSS8 Human Muraglitazar decreases expression ISO Prss8 (Rattus norvegicus) 6480464 muraglitazar results in decreased expression of PRSS8 mRNA CTD PMID:21515302 PRSS8 Human N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PRSS8 mRNA CTD PMID:24810058 PRSS8 Human N-methyl-4-phenylpyridinium decreases expression ISO Prss8 (Rattus norvegicus) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of PRSS8 mRNA CTD PMID:28801915 PRSS8 Human N-nitrosodiethylamine multiple interactions ISO Prss8 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PRSS8 mRNA CTD PMID:18164116 PRSS8 Human N-nitrosodiethylamine increases expression ISO Prss8 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of PRSS8 mRNA CTD PMID:24535843 PRSS8 Human nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of PRSS8 mRNA CTD PMID:24768652 PRSS8 Human nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of PRSS8 mRNA CTD PMID:18651567 PRSS8 Human panobinostat multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA CTD PMID:27188386 PRSS8 Human panobinostat increases expression EXP 6480464 panobinostat results in increased expression of PRSS8 mRNA CTD PMID:26272509 PRSS8 Human PCB138 multiple interactions ISO Prss8 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 PRSS8 Human perfluorooctane-1-sulfonic acid multiple interactions ISO Prss8 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRSS8 mRNA more ... CTD PMID:36331819 PRSS8 Human perfluorooctanoic acid decreases expression ISO Prss8 (Rattus norvegicus) 6480464 perfluorooctanoic acid results in decreased expression of PRSS8 mRNA CTD PMID:28511854 PRSS8 Human phenobarbital multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA and NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PRSS8 mRNA] CTD PMID:19482888 and PMID:33549593 PRSS8 Human phenobarbital affects expression ISO Prss8 (Mus musculus) 6480464 Phenobarbital affects the expression of PRSS8 mRNA CTD PMID:19136022 and PMID:23091169 PRSS8 Human phenobarbital increases expression ISO Prss8 (Mus musculus) 6480464 Phenobarbital results in increased expression of PRSS8 mRNA CTD PMID:19270015 more ... PRSS8 Human phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of PRSS8 mRNA CTD PMID:26272509 PRSS8 Human phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA CTD PMID:27188386 PRSS8 Human pirinixic acid affects expression ISO Prss8 (Mus musculus) 6480464 pirinixic acid affects the expression of PRSS8 mRNA CTD PMID:19136022 and PMID:23811191 PRSS8 Human propiconazole increases expression ISO Prss8 (Mus musculus) 6480464 propiconazole results in increased expression of PRSS8 mRNA CTD PMID:21278054 PRSS8 Human resveratrol multiple interactions EXP 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of PRSS8 mRNA CTD PMID:19167446 PRSS8 Human SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 PRSS8 Human selenium atom increases expression EXP 6480464 Selenium results in increased expression of PRSS8 mRNA CTD PMID:19244175 PRSS8 Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of PRSS8 mRNA CTD PMID:12634122 and PMID:38568856 PRSS8 Human sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of PRSS8 mRNA CTD PMID:38568856 PRSS8 Human sodium dodecyl sulfate increases expression EXP 6480464 Sodium Dodecyl Sulfate results in increased expression of PRSS8 mRNA CTD PMID:31734321 PRSS8 Human sunitinib decreases expression EXP 6480464 Sunitinib results in decreased expression of PRSS8 mRNA CTD PMID:31533062 PRSS8 Human tamoxifen decreases expression ISO Prss8 (Mus musculus) 6480464 Tamoxifen results in decreased expression of PRSS8 mRNA CTD PMID:25123088 PRSS8 Human Tesaglitazar decreases expression ISO Prss8 (Rattus norvegicus) 6480464 tesaglitazar results in decreased expression of PRSS8 mRNA CTD PMID:21515302 PRSS8 Human tetrachloromethane decreases expression ISO Prss8 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of PRSS8 mRNA CTD PMID:31919559 PRSS8 Human thioacetamide increases expression ISO Prss8 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of PRSS8 mRNA CTD PMID:23411599 PRSS8 Human trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of PRSS8 mRNA CTD PMID:24935251 and PMID:26272509 PRSS8 Human trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA CTD PMID:27188386 PRSS8 Human Triptolide decreases expression ISO Prss8 (Mus musculus) 6480464 triptolide results in decreased expression of PRSS8 mRNA CTD PMID:32835833 PRSS8 Human triptonide increases expression ISO Prss8 (Mus musculus) 6480464 triptonide results in increased expression of PRSS8 mRNA CTD PMID:33045310 PRSS8 Human urethane decreases expression EXP 6480464 Urethane results in decreased expression of PRSS8 mRNA CTD PMID:28818685 PRSS8 Human valproic acid affects expression ISO Prss8 (Mus musculus) 6480464 Valproic Acid affects the expression of PRSS8 mRNA CTD PMID:17292431 PRSS8 Human valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA CTD PMID:27188386 PRSS8 Human valproic acid increases methylation EXP 6480464 Valproic Acid results in increased methylation of PRSS8 gene CTD PMID:29154799 PRSS8 Human valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of PRSS8 mRNA CTD PMID:23179753 more ... PRSS8 Human vinclozolin decreases methylation ISO Prss8 (Rattus norvegicus) 6480464 vinclozolin results in decreased methylation of PRSS8 gene CTD PMID:31079544 PRSS8 Human zinc atom multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA CTD PMID:33549593 PRSS8 Human zinc(0) multiple interactions ISO Prss8 (Mus musculus) 6480464 [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA CTD PMID:33549593
