Gene: Np4 (defensin NP-4 precursor) Rattus norvegicus
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Symbol: Np4
Name: defensin NP-4 precursor
Description: ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antifungal humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); FOUND IN azurophil granule (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 4-amino-2,6-dinitrotoluene; ammonium chloride
AGR Description: Predicted to have protein heterodimerization activity and protein homodimerization activity; predicted to be involved in several processes, including antimicrobial humoral response, cellular response to lipopolysaccharide, and defense response to other organism; predicted to localize to the azurophil granule and extracellular space; orthologous to several human genes including DEFA5 (defensin alpha 5).
Merged Description: Predicted to have protein heterodimerization activity and protein homodimerization activity; predicted to be involved in several processes, including antimicrobial humoral response, cellular response to lipopolysaccharide, and defense response to other organism; predicted to localize to the azurophil granule and extracellular space; orthologous to several human genes including DEFA5 (defensin alpha 5); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 4-amino-2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: defensin 3b; neutrophil antibiotic peptide NP-4; neutrophil defensin 4; NP-4; ratNP-4
Orthologs:
Homo sapiens (human) : DEFA4 (defensin alpha 4)  HGNC  Alliance
Mus musculus (house mouse) : Defa31 (defensin, alpha, 31)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : DEFA4 (defensin alpha 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01675,478,548 - 75,481,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01675,079,890 - 75,082,489 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,284,693 - 75,337,014 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11675,284,957 - 75,337,279 (-)NCBI
Celera1668,357,038 - 68,359,592 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
  
More on Np4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727857
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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