Symbol:
Np4
Name:
defensin NP-4 precursor
RGD ID:
727857
Description:
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including T cell chemotaxis; cellular response to lipopolysaccharide; and defense response to other organism. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in azurophil granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA5 (defensin alpha 5); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
defensin 3b; defensin alpha 4; neutrophil antibiotic peptide NP-4; neutrophil defensin 4; NP-4; ratNP-4
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DEFA4 (defensin alpha 4)
HGNC
EggNOG, Ensembl, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Defa31 (defensin, alpha, 31)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DEFA4 (defensin alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
DEFA4 (defensin alpha 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
DEFA5 (defensin alpha 5)
HGNC
Ensembl, Inparanoid, OrthoDB, Panther, PhylomeDB
Homo sapiens (human):
DEFA6 (defensin alpha 6)
HGNC
Ensembl, Panther, PhylomeDB, Treefam
Homo sapiens (human):
DEFA3 (defensin alpha 3)
HGNC
Ensembl, Panther, PhylomeDB, Treefam
Homo sapiens (human):
DEFA1B (defensin alpha 1B)
HGNC
Ensembl, PhylomeDB, Treefam
Homo sapiens (human):
DEFA1 (defensin alpha 1)
HGNC
Ensembl, Panther, Treefam
Alliance orthologs 3
Homo sapiens (human):
DEFA3 (defensin alpha 3)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER)
Homo sapiens (human):
DEFA5 (defensin alpha 5)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Homo sapiens (human):
DEFA1 (defensin alpha 1)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER)
Homo sapiens (human):
DEFA4 (defensin alpha 4)
Alliance
DIOPT (Ensembl Compara|HGNC|OMA|OrthoFinder|PANTHER)
Homo sapiens (human):
DEFA1B (defensin alpha 1B)
Alliance
DIOPT (Ensembl Compara|OrthoInspector|PANTHER)
Latest Assembly:
mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 16 70,494,607 - 70,497,261 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 16 70,342,529 - 70,497,202 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 16 75,771,469 - 75,774,026 (-) NCBI Rnor_SHR UTH_Rnor_SHRSP_BbbUtx_1.0 16 79,217,054 - 79,219,596 (-) NCBI Rnor_SHRSP UTH_Rnor_WKY_Bbb_1.0 16 74,466,481 - 74,469,025 (-) NCBI Rnor_WKY Rnor_6.0 16 75,478,548 - 75,481,146 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 75,414,786 - 75,481,115 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 16 75,079,890 - 75,082,489 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 75,284,693 - 75,337,014 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 16 75,284,957 - 75,337,279 (-) NCBI Celera 16 68,357,038 - 68,359,592 (-) NCBI Celera Cytogenetic Map 16 q12.5 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
1,2-dichloroethane decreases expression ISO RGD:1622406 6480464 ethylene dichloride results in decreased expression of DEFA4 mRNA CTD PMID:28960355 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NP4 mRNA CTD PMID:32741896 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NP4 mRNA CTD PMID:32741896 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of NP4 mRNA CTD PMID:33387578 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of NP4 mRNA CTD PMID:21346803 all-trans-retinoic acid multiple interactions ISO RGD:1353794 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of DEFA4 mRNA CTD PMID:15894607 all-trans-retinoic acid increases expression ISO RGD:1353794 6480464 Tretinoin results in increased expression of DEFA4 mRNA CTD PMID:15894607 more ... ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NP4 mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of NP4 mRNA CTD PMID:30779732 arsenous acid multiple interactions ISO RGD:1353794 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of DEFA4 mRNA CTD PMID:15894607 arsenous acid increases expression ISO RGD:1353794 6480464 Arsenic Trioxide results in increased expression of DEFA4 mRNA CTD PMID:15070760 , PMID:15761015 benzo[a]pyrene increases methylation ISO RGD:1353794 6480464 Benzo(a)pyrene results in increased methylation of DEFA4 5' UTR CTD PMID:27901495 bisphenol A decreases expression ISO RGD:1622406 6480464 bisphenol A results in decreased expression of DEFA4 mRNA CTD PMID:26063408 CGP 52608 multiple interactions ISO RGD:1353794 6480464 CGP 52608 promotes the reaction [RORA protein binds to DEFA4 gene] CTD PMID:28238834 ciguatoxin CTX1B affects expression ISO RGD:1622406 6480464 Ciguatoxins affects the expression of DEFA4 mRNA CTD PMID:18353800 DDT increases methylation EXP 6480464 DDT results in increased methylation of NP4 gene CTD PMID:31682807 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of NP4 mRNA CTD PMID:23640034 diarsenic trioxide increases expression ISO RGD:1353794 6480464 Arsenic Trioxide results in increased expression of DEFA4 mRNA CTD PMID:15070760 , PMID:15761015 diarsenic trioxide multiple interactions ISO RGD:1353794 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of DEFA4 mRNA CTD PMID:15894607 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of NP4 mRNA CTD PMID:21266533 genistein increases expression ISO RGD:1622406 6480464 Genistein results in increased expression of DEFA4 mRNA CTD PMID:32186404 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of NP4 mRNA CTD PMID:31378766 nitrofen increases expression EXP 6480464 nitrofen results in increased expression of NP4 mRNA CTD PMID:33484710 testosterone multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NP4 mRNA CTD PMID:32741896 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of NP4 mRNA CTD PMID:33387578 valproic acid increases methylation ISO RGD:1353794 6480464 Valproic Acid results in increased methylation of DEFA4 gene CTD PMID:29154799