Gene: Np4 (defensin NP-4 precursor) Rattus norvegicus
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Symbol: Np4
Name: defensin NP-4 precursor
Description: ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antifungal humoral response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); FOUND IN azurophil granule (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 4-amino-2,6-dinitrotoluene; ammonium chloride
AGR Description: Predicted to have protein heterodimerization activity and protein homodimerization activity; predicted to be involved in several processes, including antimicrobial humoral response, cellular response to lipopolysaccharide, and defense response to other organism; predicted to localize to the azurophil granule and extracellular space; orthologous to several human genes including DEFA5 (defensin alpha 5).
Merged Description: Predicted to have protein heterodimerization activity and protein homodimerization activity; predicted to be involved in several processes, including antimicrobial humoral response, cellular response to lipopolysaccharide, and defense response to other organism; predicted to localize to the azurophil granule and extracellular space; orthologous to several human genes including DEFA5 (defensin alpha 5); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 4-amino-2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: defensin 3b; neutrophil antibiotic peptide NP-4; neutrophil defensin 4; NP-4; ratNP-4
Orthologs:
Homo sapiens (human) : DEFA4 (defensin alpha 4)  HGNC  Alliance
Mus musculus (house mouse) : Defa31 (defensin, alpha, 31)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : DEFA4 (defensin alpha 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01675,478,548 - 75,481,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01675,079,890 - 75,082,489 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,284,693 - 75,337,014 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11675,284,957 - 75,337,279 (-)NCBI
Celera1668,357,038 - 68,359,592 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Np4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727857
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.