Ctbp2 (C-terminal binding protein 2)

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Gene: Ctbp2 (C-terminal binding protein 2) Rattus norvegicus

Analyze

Symbol:

Ctbp2

Name:

C-terminal binding protein 2

RGD ID:

68372

Description:

Predicted to have several functions, including identical protein binding activity; transcription coregulator activity; and transcription factor binding activity. Predicted to be involved in several processes, including cellular response to leukemia inhibitory factor; positive regulation of retinoic acid receptor signaling pathway; and regulation of transcription, DNA-templated. Predicted to localize to several cellular components, including photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; and presynaptic cytosol. Orthologous to human CTBP2 (C-terminal binding protein 2); PARTICIPATES IN chronic myeloid leukemia pathway; Notch signaling pathway; Wnt signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

C-terminal-binding protein 2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTBP2 (C-terminal binding protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ctbp2 (C-terminal binding protein 2)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Ctbp2 (C-terminal binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100983301 (C-terminal-binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTBP2 (C-terminal binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ctbp2 (C-terminal binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTBP2 (C-terminal binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	CTBP2 (C-terminal binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ctbp2 (C-terminal binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CTBP1 (C-terminal binding protein 1)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	CTBP2 (C-terminal binding protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Ctbp2 (C-terminal binding protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Danio rerio (zebrafish):	ctbp2a (C-terminal binding protein 2a)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CtBP	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	ctbp-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	1	205,001,354 - 205,030,565 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	205,001,396 - 205,040,755 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	211,993,864 - 212,023,075 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	192,463,615 - 192,492,935 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	192,613,495 - 192,642,816 (-)	NCBI
Celera	1	185,527,008 - 185,555,539 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neoplasm Invasiveness (ISO)

Neoplastic Cell Transformation (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-hydroxyphenyl retinamide (ISO)

4-methylthio-2-oxobutanoic acid (ISO)

5-fluorouracil (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

asbestos (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (EXP)

bisphenol F (ISO)

bucladesine (ISO)

carbamazepine (ISO)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diclofenac (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

entinostat (ISO)

enzyme inhibitor (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

glyphosate (ISO)

indometacin (ISO)

irinotecan (ISO)

L-methionine (ISO)

menadione (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

nickel atom (ISO)

paracetamol (ISO)

pyruvic acid (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

Tesaglitazar (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

troglitazone (EXP)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (ISO)

maintenance of presynaptic active zone structure (IEA)

negative regulation of transcription, DNA-templated (ISO,ISS)

obsolete oxidation-reduction process (IEA)

positive regulation of chromatin binding (ISO)

positive regulation of retinoic acid receptor signaling pathway (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

synaptic vesicle docking (ISO)

white fat cell differentiation (ISO,ISS)

Cellular Component

GABA-ergic synapse (ISO)

glutamatergic synapse (ISO)

nucleus (ISO,ISS)

photoreceptor ribbon synapse (ISO)

presynaptic active zone cytoplasmic component (ISO)

presynaptic cytosol (ISO)

ribbon synapse (ISO)

synapse (ISO)

transcription repressor complex (ISO,ISS)

Molecular Function

chromatin binding (ISO)

identical protein binding (ISO)

NAD binding (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

protein kinase binding (ISO)

protein-containing complex binding (ISO)

retinoic acid receptor binding (ISO)

RNA polymerase II transcription corepressor binding (IEA,ISO)

structural constituent of presynaptic active zone (ISO)

transcription coactivator activity (ISO)

transcription corepressor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

chronic myeloid leukemia pathway (IEA)

Notch signaling pathway (IEA)

Wnt signaling pathway (IEA)

References

References - curated


1.	GOA data from the GO Consortium
2.	MGD data from the GO Consortium
3.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Pipeline to import KEGG annotations from KEGG into RGD
5.	RGD automated data pipeline
6.	RGD automated import pipeline for gene-chemical interactions
7.	Schmitz F, etal., Neuron 2000 Dec;28(3):857-72.
8.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10567582	PMID:12444977	PMID:16702210	PMID:18483224	PMID:19932743	PMID:20368623	PMID:20439489	PMID:22745816	PMID:22871113	PMID:23138653	PMID:23393140	PMID:23775127
PMID:25447313	PMID:26929012	PMID:31518606

Genomics

Comparative Map Data

Ctbp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	1	205,001,354 - 205,030,565 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	205,001,396 - 205,040,755 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	211,993,864 - 212,023,075 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	192,463,615 - 192,492,935 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	192,613,495 - 192,642,816 (-)	NCBI
Celera	1	185,527,008 - 185,555,539 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

CTBP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	10	124,984,317 - 125,161,170 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	10	124,984,317 - 125,161,039 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	10	126,676,418 - 126,849,624 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	126,666,408 - 126,839,614 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	126,667,390 - 126,706,443	NCBI
Celera	10	120,450,227 - 120,623,304 (-)	NCBI
Cytogenetic Map	10	q26.13	NCBI
HuRef	10	120,363,415 - 120,486,611 (-)	NCBI		HuRef
CHM1_1	10	126,958,181 - 127,131,360 (-)	NCBI		CHM1_1

Ctbp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	132,588,727 - 132,725,908 (-)	NCBI	GRCm39		mm39
GRCm38	7	132,986,998 - 133,124,009 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	132,987,563 - 133,124,354 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	140,178,694 - 140,315,166 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	132,825,913 - 132,961,691 (-)	NCBI			mm8
Celera	7	132,792,998 - 132,952,787 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	76.32	NCBI

Ctbp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955477	2,922,334 - 3,082,406 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955477	2,922,334 - 3,082,088 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100983301
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	125,814,926 - 125,985,395 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	125,814,926 - 125,901,248 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	121,550,194 - 121,722,828 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

CTBP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	28	34,260,856 - 34,415,696 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	28	34,259,912 - 34,415,113 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Ctbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936486	13,173,280 - 13,261,257 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTBP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	134,329,941 - 134,487,755 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	134,329,312 - 134,488,805 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	145,880,742 - 145,990,152 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTBP2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	117,635,124 - 117,806,908 (-)	NCBI

Ctbp2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624737	22,135,046 - 22,166,580 (+)	NCBI

Position Markers

RH130239

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	205,001,635 - 205,001,824	NCBI	Rnor6.0
Rnor_6.0	19	896,204 - 896,389	NCBI	Rnor6.0
Rnor_5.0	19	896,860 - 897,045	UniSTS	Rnor5.0
Rnor_5.0	1	211,994,145 - 211,994,334	UniSTS	Rnor5.0
RGSC_v3.4	19	645,674 - 645,859	UniSTS	RGSC3.4
RGSC_v3.4	1	192,463,896 - 192,464,085	UniSTS	RGSC3.4
Celera	19	683,662 - 683,847	UniSTS
Celera	1	185,527,289 - 185,527,478	UniSTS
Cytogenetic Map	1	q41	UniSTS
Cytogenetic Map	19	p14	UniSTS

RH144529

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	205,026,998 - 205,027,137	NCBI	Rnor6.0
Rnor_5.0	1	212,019,508 - 212,019,647	UniSTS	Rnor5.0
RGSC_v3.4	1	192,489,368 - 192,489,507	UniSTS	RGSC3.4
Celera	1	185,551,972 - 185,552,111	UniSTS
Cytogenetic Map	1	q41	UniSTS
RH 3.4 Map	1	1432.7	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	99983293	216325819	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	175447029	220447029	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	175447029	220447029	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	184419946	215097919	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	184419946	215097919	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	126240667	217054291	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	193220385	238220385	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	156446196	274977688	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	156446196	214277437	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	189514504	234514504	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	161321152	273792054	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	198585664	236763415	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	137787261	236763528	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	99983293	216213510	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	156446196	243311614	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	189514504	214277437	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	197963658	242963658	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	167394665	278228889	Rat
2325725	Eae31	Experimental allergic encephalomyelitis QTL 31			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	193968438	205603226	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	100131562	236763528	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	191825895	279986079	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130779320	219238476	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	197187728	230420772	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	153834077	232297227	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	189170900	234170900	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	189170900	234170900	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	189170900	234170900	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	189170900	234170900	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	189170900	234170900	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	189170900	234170900	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	189170900	234170900	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	189170900	234170900	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	198446729	240017341	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49578693	217054291	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	193968438	261264776	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	195598053	265002735	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	194554354	239554354	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	161321256	273791893	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	196395041	282763074	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	161321256	273791893	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	82788437	239853971	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	201146802	241482368	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	108986301	219232156	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	219232156	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	108986301	238830534	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	108986301	219232156	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	167394665	219232156	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	161784169	219232156	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	192639698	278228889	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	161784169	219232156	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	161784169	219232156	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	161784169	278228889	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	192639698	278228889	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	185390068	230390068	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	161784169	278228889	Rat
1359018	Hrtrt20	Heart rate QTL 20	3.08		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	201358068	221983732	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	196738546	241738546	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	163796316	282763074	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	174905700	264802994	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	174905700	233490237	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	198655722	244992610	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	167394665	238830534	Rat
2312558	Glom17	Glomerulus QTL 17	3.9	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	177235071	208786962	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	201358068	252480016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	169971964	214971964	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	161784422	246226103	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	190282646	235282646	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	188850303	233850303	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	137787261	236763528	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	167027868	212027868	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	175462885	220462885	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	154337847	215828102	Rat
61378	Bp43	Blood pressure QTL 43	22.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	198572999	214277437	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	166577232	211577232	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	197187728	238220385	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	202571665	264802994	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	122614824	262664716	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	144634295	241482368	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	125875758	262433692	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	202571665	264802994	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	35377692	217372257	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	194872362	239872362	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	306
Count of miRNA genes:	149
Interacting mature miRNAs:	192
Transcripts:	ENSRNOT00000023404, ENSRNOT00000023574
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	14	6	11	6	2	2	74	35	41	11	2
Low		9	43	35	8	35	6	9					6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07005890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01008755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01008756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF222712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000023404 ⟹ ENSRNOP00000023404

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	205,001,396 - 205,030,567 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000023574 ⟹ ENSRNOP00000023574

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	205,001,761 - 205,040,755 (-)	Ensembl

RefSeq Acc Id:

NM_053335 ⟹ NP_445787

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	205,001,354 - 205,030,565 (-)	NCBI
Rnor_5.0	1	211,993,864 - 212,023,075 (-)	NCBI
RGSC_v3.4	1	192,463,615 - 192,492,935 (-)	RGD
Celera	1	185,527,008 - 185,555,539 (-)	RGD

Sequence:

show sequence

GAATTCGGCACGAGGAAAGGCCTCCTCCCCACCTCTGCTGTATTGCTTTGCTCTGCCAATGCCG
GTTCCCAGCAGGCACATCAACATTGGCCGTTCTCAGAGCTGGGATGCCGCTGGCTGGTATGAGG
GCCCTTGGGAGAATGCTGGCCCTCCAGGGAGGAGAAGTTCTCTGACTTATGGCCCTGGAGAAGG
GGTCTGGTGTGAGCTGGTAAACCACCGTGCCCAGGACACTGAGTCCTGCCTGTCCCGGGAAGCT
TTTTATAACTCACTGGCATCAAGAAAGGGCTCCGTGCCTGACTTCACCTTCTACGACAGCAGGC
AGGCAGTGATGTCTGGCCGTGGCTCCGTGCTGCCACAAGACTACTATGGCGACCCATCCAGGGG
CACCAGGGTACCCAAGGAGCCTCCCTTCTATCGGGACCCAGGAACCAGCCGGCCGGTGCCCAGC
TACGGAGTGCTGGGCAGCAGAATACCATGGGAGCAGGTACAAGGCCAGTTACCTGCTCTGCAGG
ATGCTGGCCACCTGTACCGGGAATCTGGGAGTAAAACTGTCCTGCATGGGCAGCGGACACACTG
CAGGGCTCCATCTCCTGGGAGGTATGGAAGGGAACAACCTGATTCTAGATTAGGGATAGAGGTA
CCCACCTATTCCCCCAACTCCAGCCAGGTCTACAACGATATCTGCGAAAGACCCGTTGACTCTA
CCCATGCCAGACAGGTGGCCCCAACATGCCTGGTTGTGGACCCCAGCTCGACCGCCCCTACTGA
GAACAGCACGGGGGTGGCCCCAGGTTCCCTGAATAGAGGCTACGGGCCTACCCGAGAAAGCATC
CATTCAAAGCTGGCTTATGAGAATTATGAAGCCGACTTGTCAACATTCCAAGGACCCGGGGGCA
AGAGGACCGTCTACCCTGAGTTTTTGGCCCTGCTGAGGGCAGAGGGTGTGGCAGAGGCTACCCT
GGCAGCCCTGTTACAACAAGGCTTTGACTCCCCAGCTGTCTTGGCCACCCTAGAGGATGCTGAC
ATCAAGTCTGTTGCCCCCAACCTGGGCCAGGCCCGTGTCCTGAGCCGCCTGGTCAGCAGCTGCA
GGACAGAGATGCAGTTTCGGCGACAGGACCGGACAGGCCCTCCACCCCGCCATCGGTCCAGTAG
CTTCAGCCACCGAAGTGAGCTGCTGCCCAATGACACGGCCTCGCTGGGGACCACAGCACTGCAG
TTTCACCCAGCTGGACCTTTGCAGACACCCTCTCCCCGAGGTGGAGATCTAGGTCGCCGCCCCT
CCAGTGCACCTTCCCAGCACCTCCTGGAGACAGCAGCTACTTACTCTGCCCCAGTGGTGGGGTC
CCAGACTCCCCACTTACCCTCCAACTCTGGATATAGCTCTCCTACCCCTTGTGCCCTAACAGCA
CGACTGGCCTCCTCCTACCCTTCACAAGCTGGGGTAGCCTTGACTGCTAACCCAGGCCCCTCTG
TCCCCCTTCACTCAAGTCCCAGAACAGCCTATTCCACCTCCTACACGGTGCCCATGGAACTGCT
TAAGAGGGAACGCAGTGTGACCGCCTCTCCGCTGCCCAGCCCCCATGCCAGCCCCCAGCTTCTG
CGGAAACCTGGAGCAGCCCCCGTGGAGCCGGCTGCCCTGCCACCAGTCAGGCAAAGTCTCCACA
CACCTCATCCGCCATACCAGAAGGTGGCCCGGCGGACAGGGGCTCCCATCATCGTGTCAACCAT
GCTAACACCAGAACCAAGTATCCGCCCCCAGATCATGAACGGCCCCCTGCACCCCCGCCCCCTA
GTGGCACTGCTGGATGGCAGAGACTGCACTGTGGAAATGCCCATCCTGAAGGACCTGGCCACTG
TGGCCTTCTGTGATGCACAGTCCACTCAGGAAATCCATGAGAAGGTATTGAATGAGGCTGTGGG
CGCCATGATGTACCACACCATCACTCTCACCCGGGAAGACCTGGAGAAGTTCAAGGCCCTGAGA
GTGATTGTTCGAATCGGTAGTGGCTACGACAATGTGGACATCAAGGCTGCTGGCGAACTCGGAA
TCGCCGTGTGCAACATCCCATCTGCTGCAGTGGAGGAGACAGCAGATTCGACAGTCTGCCATAT
CCTCAATCTGTATCGGCGGAACACATGGCTGTACCAGGCCCTACGAGAAGGCACGCGGGTACAA
AGCGTGGAACAGATCCGTGAGGTCGCCTCAGGAGCTGCTCGGATCCGAGGGGAAACACTGGGCC
TCATTGGCTTTGGTCGCACTGGGCAGGCAGTTGCTGTTCGAGCCAAGGCCTTTGGATTCAGCGT
CATATTTTATGACCCCTACTTACAGGATGGGATAGAGCGGTCTCTGGGCGTGCAAAGGGTCTAC
ACCCTGCAGGACTTGTTATATCAGAGCGACTGTGTCTCCTTGCACTGCAATCTGAATGAACACA
ACCACCACCTCATCAATGACTTCACCATCAAGCAGATGAGGCAAGGAGCATTCCTTGTGAATGC
AGCCCGAGGTGGCCTGGTGGATGAGAAAGCCTTAGCTCAGGCCCTCAAAGAGGGCAGGATACGA
GGCGCTGCTCTGGATGTGCATGAGTCTGAGCCCTTCAGCTTTGCTCAGGGCCCATTGAAGGATG
CTCCAAATCTCATCTGCACACCACACACAGCCTGGTACAGCGAACAAGCATCACTAGAGATGAG
GGAAGCAGCTGCCACGGAGATCCGCCGAGCAATCACAGGTCGCATTCCAGAAAGCTTACGAAAC
TGTGTCAACAAAGAATTCTTTGTTACTTCAACTCCTTGGTCAGTCATTGACCAGCAAGCAATTC
ATCCTGAGCTCAATGGTGCCACATACAGGTATCCACCAGGCATTGTAGGTGTGGCTCCAGGAGG
GCTTCCTCCAGCTATGGAAGGGATCATCCCTGGAGGCATCCCTGTGACTCACAACCTCCCCACT
GTGGCACACCCTTCCCAAGCTCCCTCCCCAAACCAGCCCACAAAACACGGGGACAATCGAGAGC
ACCCCAACGAGCAATAGCAGAGAATACGTGAAGGTAATCATTCAGATAAACTTGGGACCAAGAG
ACAGTAGAAAACGGATGAATTTGATGGTCTTTTAAACTGATCCTGGACATCACTGATACTGCAG
TGTGAAAGCTACAAAAGCTAGAAAACAAGATGGTATCTGCTTCCAGAAGTGTGGAAAGACTAGG
ACGTGATTATTAACGACCAACTTCTGTTATTGTGTGTTAAGTTTTTCATCTGTGCATCAAATCA
CAAAGAATAGAGCTTTTCCTTTATCAATCAATCCCCTGGGCACAGCAGGTCCTGCGCAGCTTGT
TGTAGAATGTTGCATCAAGAGCTCCGAATATCAATAAAAAAAATTGAGAGGAAATCCCCATCAA
GGCTAGTCCCTTTGGTCTTCAGGGGCTGGTGCCTCCTTTGCTGATAGGAAGATTAAAAATAAGA
CAAGATGGGGAGGACATTGTTTGCTGGTGTAGACATCTCCGCGCACAGGATTGAAGAGGTAAAA
GCTCCTGTACAGAAGGTTTCACATCTGAGCAGCAAAGTCGGTTGTGAGTTCAGTAAAACCCTCT
GATGACACAAAACAAAAACAACAAACAAACAAAAAAAAAAAAAAAAAACTCGAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_445787	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG45952	(Get FASTA)	NCBI Sequence Viewer
	EDM11743	(Get FASTA)	NCBI Sequence Viewer
	EDM11744	(Get FASTA)	NCBI Sequence Viewer
	EDM11745	(Get FASTA)	NCBI Sequence Viewer
	EDM11746	(Get FASTA)	NCBI Sequence Viewer
	Q9EQH5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_445787 ⟸ NM_053335

- UniProtKB:

Q9EQH5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPVPSRHINIGRSQSWDAAGWYEGPWENAGPPGRRSSLTYGPGEGVWCELVNHRAQDTESCLSR
EAFYNSLASRKGSVPDFTFYDSRQAVMSGRGSVLPQDYYGDPSRGTRVPKEPPFYRDPGTSRPV
PSYGVLGSRIPWEQVQGQLPALQDAGHLYRESGSKTVLHGQRTHCRAPSPGRYGREQPDSRLGI
EVPTYSPNSSQVYNDICERPVDSTHARQVAPTCLVVDPSSTAPTENSTGVAPGSLNRGYGPTRE
SIHSKLAYENYEADLSTFQGPGGKRTVYPEFLALLRAEGVAEATLAALLQQGFDSPAVLATLED
ADIKSVAPNLGQARVLSRLVSSCRTEMQFRRQDRTGPPPRHRSSSFSHRSELLPNDTASLGTTA
LQFHPAGPLQTPSPRGGDLGRRPSSAPSQHLLETAATYSAPVVGSQTPHLPSNSGYSSPTPCAL
TARLASSYPSQAGVALTANPGPSVPLHSSPRTAYSTSYTVPMELLKRERSVTASPLPSPHASPQ
LLRKPGAAPVEPAALPPVRQSLHTPHPPYQKVARRTGAPIIVSTMLTPEPSIRPQIMNGPLHPR
PLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKA
LRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTR
VQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQR
VYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGR
IRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESL
RNCVNKEFFVTSTPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNL
PTVAHPSQAPSPNQPTKHGDNREHPNEQ

hide sequence

RefSeq Acc Id:

ENSRNOP00000023574 ⟸ ENSRNOT00000023574

RefSeq Acc Id:

ENSRNOP00000023404 ⟸ ENSRNOT00000023404

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68372	AgrOrtholog
Ensembl Genes	ENSRNOG00000017326	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000023404	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000023574	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023404	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000023574	UniProtKB/Swiss-Prot
InterPro	CtBP	UniProtKB/Swiss-Prot
	D-isomer_2_OHA_DH_cat_dom	UniProtKB/Swiss-Prot
	D-isomer_DH_CS	UniProtKB/Swiss-Prot
	D-isomer_DH_NAD-bd	UniProtKB/Swiss-Prot
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:81717	UniProtKB/Swiss-Prot
NCBI Gene	81717	ENTREZGENE
Pfam	2-Hacid_dh	UniProtKB/Swiss-Prot
	2-Hacid_dh_C	UniProtKB/Swiss-Prot
PhenoGen	Ctbp2	PhenoGen
PROSITE	D_2_HYDROXYACID_DH_3	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot
TIGR	TC204483
UniGene	Rn.138124	ENTREZGENE
UniProt	CTBP2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Ctbp2	C-terminal binding protein 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains an A domain specific for ribbons, and a B domain identical with CtBP2, a transcriptional repressor that in turn is related to 2-hydroxyacid dehydrogenases	68229

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)