Fgfr3 (fibroblast growth factor receptor 3) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Fgfr3 (fibroblast growth factor receptor 3) Rattus rattus
Analyze
Symbol: Fgfr3
Name: fibroblast growth factor receptor 3
RGD ID: 626058284
Description: ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); fibroblast growth factor receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); axonogenesis involved in innervation (ortholog); bone development (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH absence epilepsy (ortholog); acanthosis nigricans (ortholog); achondroplasia (ortholog); FOUND IN cell surface (ortholog); cytoplasmic side of plasma membrane (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly
Position:
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11171,102,760 - 71,117,463 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1
JBrowse:




Disease Annotations     Click to see Annotation Detail View
absence epilepsy  (ISO)
acanthosis nigricans  (ISO)
achondroplasia  (ISO)
Achondroplastic Dwarfism  (ISO)
asphyxiating thoracic dystrophy  (ISO)
atrial heart septal defect  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autosomal dominant disease  (ISO)
bladder urothelial carcinoma  (ISO)
brachydactyly  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
camptodactyly-tall stature-scoliosis-hearing loss syndrome  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
cervix carcinoma  (ISO)
choanal atresia  (ISO)
chondrosarcoma  (ISO)
chronic myeloid leukemia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
connective tissue disease  (ISO)
Constipation  (ISO)
craniosynostosis  (ISO)
craniosynostosis 3  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (ISO)
Crouzon syndrome-acanthosis nigricans syndrome  (ISO)
cryptorchidism  (ISO)
Dandy-Walker syndrome  (ISO)
demyelinating disease  (ISO)
Developmental Disabilities  (ISO)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
disease by infectious agent  (ISO)
disease of cellular proliferation  (ISO)
Dwarfism  (ISO)
epidermal nevus  (ISO)
epilepsy  (ISO)
Facial Asymmetry  (ISO)
Failure to Thrive  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
Human papillomavirus infectious disease  (ISO)
hydrocephalus  (ISO)
Hypertelorism  (ISO)
hypochondroplasia  (ISO)
intellectual disability  (ISO)
Knee Osteoarthritis  (ISO)
lacrimoauriculodentodigital syndrome 1  (ISO)
lacrimoauriculodentodigital syndrome 2  (ISO)
LADD syndrome  (ISO)
lung cancer  (ISO)
lung squamous cell carcinoma  (ISO)
Macrocephaly  (ISO)
Merkel cell carcinoma  (ISO)
MICROMELIA  (ISO)
Muenke syndrome  (ISO)
multiple myeloma  (ISO)
Muscle Hypotonia  (ISO)
Nervous System Malformations  (ISO)
neuroblastoma  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
osteochondrodysplasia  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
polyhydramnios  (ISO)
polymicrogyria  (ISO)
Preauricular Tag, Isolated, Autosomal Dominant, 1  (ISO)
Premature Birth  (ISO)
Pulmonary Artery Stenosis  (ISO)
SADDAN  (ISO)
Saethre-Chotzen syndrome  (ISO)
sarcoma  (ISO)
scoliosis  (ISO)
seminoma  (ISO)
sensorineural hearing loss  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
thanatophoric dysplasia  (ISO)
Thanatophoric Dysplasia, Type I  (ISO)
Thanatophoric Dysplasia, Type II  (ISO)
Thyroid Carcinoma, Nonmedullary 1  (ISO)
tongue cancer  (ISO)
tonsil squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus endometrial carcinoma  (ISO)
Ventriculomegaly  (ISO)
West syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (ISO)
axonogenesis involved in innervation  (ISO)
bone development  (ISO)
bone maturation  (ISO)
bone mineralization  (ISO)
bone morphogenesis  (ISO)
bone trabecula morphogenesis  (ISO)
calcium ion homeostasis  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cell-cell signaling  (ISO)
central nervous system myelination  (ISO)
cochlea development  (ISO)
digestive tract morphogenesis  (ISO)
epithelial cell fate commitment  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor apoptotic signaling pathway  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
forebrain development  (ISO)
inner ear development  (ISO)
inner ear receptor cell differentiation  (ISO)
lens fiber cell development  (ISO)
lens morphogenesis in camera-type eye  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of developmental growth  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mitotic nuclear division  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
oligodendrocyte development  (ISO)
p38MAPK cascade  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phospholipase activity  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
post-anal tail morphogenesis  (ISO)
regulation of bone remodeling  (ISO)
regulation of collagen metabolic process  (ISO)
regulation of ossification  (ISO)
regulation of osteoclast differentiation  (ISO)
response to axon injury  (ISO)
response to sodium phosphate  (ISO)
somatic stem cell population maintenance  (ISO)
substantia nigra development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fgfr3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11171,102,760 - 71,117,463 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1
FGFR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,793,293 - 1,808,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,793,286 - 1,808,873 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh3741,795,020 - 1,810,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,765,421 - 1,780,396 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3441,762,853 - 1,777,829NCBI
Celera41,707,555 - 1,723,113 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,725,137 - 1,753,471 (+)NCBIHuRef
CHM1_141,792,977 - 1,808,551 (+)NCBICHM1_1
T2T-CHM13v2.041,791,772 - 1,807,344 (+)NCBIT2T-CHM13v2.0
Fgfr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,879,068 - 33,894,412 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,879,018 - 33,894,412 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38533,721,724 - 33,737,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,721,674 - 33,737,068 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37534,064,373 - 34,079,713 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36534,038,581 - 34,053,924 (+)NCBIMGSCv36mm8
Celera531,197,840 - 31,213,180 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Fgfr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,211,800 - 81,227,215 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1481,211,800 - 81,227,209 (-)EnsemblGRCr8
mRatBN7.21476,987,242 - 77,002,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,987,993 - 77,003,341 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1481,439,608 - 81,454,998 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,680,217 - 82,695,599 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,125,523 - 79,140,901 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1481,746,734 - 81,762,145 (-)NCBI
Lyon_Normotensive1480,371,687 - 80,387,092 (-)NCBI
Lyon_Hypertensive1481,894,238 - 81,909,647 (-)NCBI
F344_StmMcwi1480,805,199 - 80,820,550 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,273,070 - 82,287,706 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01482,961,882 - 82,977,113 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41482,683,191 - 82,697,229 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1475,911,344 - 75,925,631 (-)NCBICelera
RGSC_v3.11482,685,581 - 82,699,620 (-)NCBI
Cytogenetic Map14q21NCBI
Fgfr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049555141,030,244 - 1,038,590 (+)NCBIChiLan1.0ChiLan1.0
FGFR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,123,500 - 2,139,072 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,060,383 - 2,075,946 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,933,172 - 1,948,742 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,843,780 - 1,858,635 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,843,774 - 1,861,692 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
FGFR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,309,128 - 62,318,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,303,756 - 62,323,896 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha364,826,871 - 64,841,704 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0362,784,572 - 62,799,405 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,783,114 - 62,800,195 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,278,095 - 62,292,924 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,481,623 - 62,496,456 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,840,834 - 62,855,656 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fgfr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap191,118,163 - 1,133,285 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440528567,890,080 - 67,904,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,591,792 - 21,606,296 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,591,772 - 21,606,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8879,159 - 894,964 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.18879,151 - 894,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28336,714 - 341,509 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12747,967,259 - 47,982,856 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660513,334,868 - 3,350,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12746,958,444 - 46,974,032 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,957,254 - 46,973,392 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Fgfr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475525,633,690 - 25,647,361 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462475525,635,165 - 25,646,932 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl1058,281,206 - 58,294,412 (-)Ensembl


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_032916139   ⟹   XP_032772030
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v11171,102,760 - 71,111,384 (-)NCBI
RefSeq Acc Id: XM_032916140   ⟹   XP_032772031
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v11171,102,760 - 71,111,384 (-)NCBI
RefSeq Acc Id: XM_032916141   ⟹   XP_032772032
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v11171,102,760 - 71,117,463 (-)NCBI
Protein Sequences
Protein RefSeqs XP_032772030 (Get FASTA)   NCBI Sequence Viewer  
  XP_032772031 (Get FASTA)   NCBI Sequence Viewer  
  XP_032772032 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_032772032   ⟸   XM_032916141
- Peptide Label: isoform X3
RefSeq Acc Id: XP_032772030   ⟸   XM_032916139
- Peptide Label: isoform X1
RefSeq Acc Id: XP_032772031   ⟸   XM_032916140
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
NCBI Gene Fgfr3 ENTREZGENE