Grk4 (G protein-coupled receptor kinase 4) - Rat Genome Database

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Gene: Grk4 (G protein-coupled receptor kinase 4) Mus musculus
Analyze
Symbol: Grk4
Name: G protein-coupled receptor kinase 4
RGD ID: 62150
MGI Page MGI
Description: Predicted to enable rhodopsin kinase activity. Predicted to be involved in G protein-coupled receptor internalization. Predicted to be located in several cellular components, including cytosol; dendrite; and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A830025H08Rik; G protein-coupled receptor kinase 2, groucho gene related; g protein-coupled receptor kinase 2, groucho gene related (drosophila); g protein-coupled receptor kinase GRK4; Gpr; Gprk2l; Gprk4; GRK
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,817,641 - 34,912,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,817,723 - 34,912,649 (+)EnsemblGRCm39 Ensembl
GRCm38534,660,250 - 34,755,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,660,379 - 34,755,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv37535,003,028 - 35,097,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,977,810 - 35,072,160 (+)NCBIMGSCv36mm8
Celera532,133,988 - 32,229,425 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA)
cytoplasm  (IBA)
cytosol  (IEA,ISO)
dendrite  (ISO)
neuronal cell body  (ISO)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Mouse models for the Wolf-Hirschhorn deletion syndrome. Naf D, etal., Hum Mol Genet 2001 Jan 15;10(2):91-8.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. Speirs HJ, etal., J Hypertens. 2004 May;22(5):931-6.
14. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
Additional References at PubMed
PMID:7919654   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15994203   PMID:16141072   PMID:16141073   PMID:19556343   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:24952961   PMID:26250109   PMID:27045027   PMID:28189851   PMID:32940654   PMID:35661789   PMID:36552750   PMID:36669643   PMID:37622333   PMID:37641972  


Genomics

Comparative Map Data
Grk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,817,641 - 34,912,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,817,723 - 34,912,649 (+)EnsemblGRCm39 Ensembl
GRCm38534,660,250 - 34,755,305 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,660,379 - 34,755,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv37535,003,028 - 35,097,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,977,810 - 35,072,160 (+)NCBIMGSCv36mm8
Celera532,133,988 - 32,229,425 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.91NCBI
GRK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,963,571 - 3,040,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,963,571 - 3,040,760 (+)EnsemblGRCh38hg38GRCh38
GRCh3742,965,298 - 3,042,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,935,141 - 3,012,272 (+)NCBINCBI36Build 36hg18NCBI36
Celera42,876,244 - 2,953,687 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,903,673 - 2,980,923 (+)NCBIHuRef
CHM1_142,963,374 - 3,040,591 (+)NCBICHM1_1
T2T-CHM13v2.042,962,247 - 3,039,448 (+)NCBIT2T-CHM13v2.0
Grk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,230,699 - 80,305,292 (-)NCBIGRCr8
mRatBN7.21475,998,554 - 76,080,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,006,218 - 76,080,693 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,458,931 - 80,533,471 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,699,586 - 81,774,124 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,144,821 - 78,219,352 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,261,708 - 81,339,516 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,265,672 - 81,339,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,953,108 - 82,026,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,648,003 - 81,722,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,650,393 - 81,724,871 (-)NCBI
Celera1474,930,817 - 75,005,219 (-)NCBICelera
Cytogenetic Map14q21NCBI
Grk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,837,141 - 1,895,785 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,837,141 - 1,895,785 (+)NCBIChiLan1.0ChiLan1.0
GRK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,299,377 - 3,374,945 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,235,633 - 3,310,914 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,106,064 - 3,181,270 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,007,989 - 3,083,215 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,008,126 - 3,083,094 (+)Ensemblpanpan1.1panPan2
GRK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,233,066 - 61,331,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,079,904 - 61,330,290 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,816,745 - 63,913,652 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,708,736 - 61,805,626 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,708,837 - 61,805,819 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,200,173 - 61,297,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,404,752 - 61,501,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,764,513 - 61,861,425 (-)NCBIUU_Cfam_GSD_1.0
GRK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,738,333 - 1,792,374 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,737,960 - 1,792,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,370,315 - 1,444,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,691,936 - 45,765,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660512,054,185 - 2,131,243 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,742,073 - 24,830,314 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,741,985 - 24,789,972 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:888
Count of miRNA genes:569
Interacting mature miRNAs:683
Transcripts:ENSMUST00000001112, ENSMUST00000074651, ENSMUST00000134217, ENSMUST00000148588, ENSMUST00000153323
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse

Markers in Region
Gprk2l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38534,710,594 - 34,711,000UniSTSGRCm38
MGSCv37535,053,243 - 35,053,649UniSTSGRCm37
Celera532,184,322 - 32,184,728UniSTS
Cytogenetic Map5B2UniSTS
cM Map520.0UniSTS
px-31d4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B2UniSTS
Cytogenetic MapXC1UniSTS
Cytogenetic Map8C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map4C3UniSTS
cM Map520.0UniSTS
cM Map439.4UniSTS
px-38e3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D1UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map18D3UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map17B3UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map16B5UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map7F2UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic MapYA1UniSTS
Cytogenetic Map11A3.2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map10A1UniSTS
cM Map1060.0UniSTS
cM Map1106.6UniSTS
cM Map1936.5UniSTS
cM Map520.0UniSTS
cM Map1340.0UniSTS
px-56c9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map16C3.1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic Map11A3.2UniSTS
Cytogenetic Map11B1.2UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapYA1UniSTS
cM Map520.0UniSTS
cM Map621.0UniSTS
cM Map1238.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001080743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC151669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF040745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY719486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000001112   ⟹   ENSMUSP00000001112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,817,723 - 34,912,647 (+)Ensembl
GRCm38.p6 Ensembl534,660,379 - 34,755,303 (+)Ensembl
Ensembl Acc Id: ENSMUST00000074651   ⟹   ENSMUSP00000074223
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,817,723 - 34,858,426 (+)Ensembl
GRCm38.p6 Ensembl534,660,379 - 34,701,082 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134217
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,901,787 - 34,912,649 (+)Ensembl
GRCm38.p6 Ensembl534,744,443 - 34,755,305 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148588   ⟹   ENSMUSP00000122826
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,818,319 - 34,832,059 (+)Ensembl
GRCm38.p6 Ensembl534,660,975 - 34,674,715 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153323
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,867,477 - 34,902,681 (+)Ensembl
GRCm38.p6 Ensembl534,710,133 - 34,745,337 (+)Ensembl
RefSeq Acc Id: NM_001080743   ⟹   NP_001074212
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,723 - 34,858,432 (+)NCBI
GRCm38534,660,379 - 34,701,088 (+)NCBI
MGSCv37535,003,028 - 35,097,952 (+)RGD
Celera532,133,988 - 32,229,425 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_019497   ⟹   NP_062370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,723 - 34,912,647 (+)NCBI
GRCm38534,660,379 - 34,755,303 (+)NCBI
MGSCv37535,003,028 - 35,097,952 (+)RGD
Celera532,133,988 - 32,229,425 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503742   ⟹   XP_006503805
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,651 - 34,902,040 (+)NCBI
GRCm38534,660,250 - 34,744,715 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017320670   ⟹   XP_017176159
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,652 - 34,912,649 (+)NCBI
GRCm38534,660,250 - 34,755,305 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017320671   ⟹   XP_017176160
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,653 - 34,912,649 (+)NCBI
GRCm38534,660,250 - 34,755,305 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254135   ⟹   XP_030109995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,826,457 - 34,912,649 (+)NCBI
GRCm38534,669,113 - 34,755,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254136   ⟹   XP_030109996
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,654 - 34,912,649 (+)NCBI
GRCm38534,660,250 - 34,755,305 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254137   ⟹   XP_030109997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,826,473 - 34,912,649 (+)NCBI
GRCm38534,669,133 - 34,755,305 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254138   ⟹   XP_030109998
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,857,854 - 34,912,649 (+)NCBI
GRCm38534,700,510 - 34,755,305 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164796   ⟹   XP_036020689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,653 - 34,911,026 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164797   ⟹   XP_036020690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,810 - 34,912,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164798   ⟹   XP_036020691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,641 - 34,912,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164799   ⟹   XP_036020692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,826,532 - 34,912,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164800   ⟹   XP_036020693
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,651 - 34,905,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164801   ⟹   XP_036020694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,655 - 34,912,649 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003955583
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,651 - 34,905,611 (+)NCBI
GRCm38534,660,250 - 34,748,267 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003955585
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,817,651 - 34,912,649 (+)NCBI
GRCm38534,660,250 - 34,755,305 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062370   ⟸   NM_019497
- Peptide Label: isoform 1
- UniProtKB: Q3V151 (UniProtKB/Swiss-Prot),   O70291 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001074212   ⟸   NM_001080743
- Peptide Label: isoform 2
- UniProtKB: Q8BP13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503805   ⟸   XM_006503742
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017176159   ⟸   XM_017320670
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017176160   ⟸   XM_017320671
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_030109996   ⟸   XM_030254136
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030109995   ⟸   XM_030254135
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030109997   ⟸   XM_030254137
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030109998   ⟸   XM_030254138
- Peptide Label: isoform X6
Ensembl Acc Id: ENSMUSP00000074223   ⟸   ENSMUST00000074651
Ensembl Acc Id: ENSMUSP00000001112   ⟸   ENSMUST00000001112
Ensembl Acc Id: ENSMUSP00000122826   ⟸   ENSMUST00000148588
RefSeq Acc Id: XP_036020691   ⟸   XM_036164798
- Peptide Label: isoform X6
RefSeq Acc Id: XP_036020693   ⟸   XM_036164800
- Peptide Label: isoform X7
RefSeq Acc Id: XP_036020689   ⟸   XM_036164796
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036020694   ⟸   XM_036164801
- Peptide Label: isoform X6
RefSeq Acc Id: XP_036020690   ⟸   XM_036164797
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036020692   ⟸   XM_036164799
- Peptide Label: isoform X6
Protein Domains
AGC-kinase C-terminal   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70291-F1-model_v2 AlphaFold O70291 1-574 view protein structure

Promoters
RGD ID:6886484
Promoter ID:EPDNEW_M6693
Type:initiation region
Name:Grk4_1
Description:Mus musculus G protein-coupled receptor kinase 4 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38534,660,379 - 34,660,439EPDNEW
RGD ID:6837955
Promoter ID:MM_KWN:41979
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000114320,   NM_001080743,   NM_019497,   OTTMUST00000055964,   OTTMUST00000056035
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36535,001,911 - 35,003,322 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95801 AgrOrtholog
Ensembl Genes ENSMUSG00000052783 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001112 ENTREZGENE
  ENSMUST00000001112.14 UniProtKB/Swiss-Prot
  ENSMUST00000074651 ENTREZGENE
  ENSMUST00000074651.11 UniProtKB/TrEMBL
  ENSMUST00000148588.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  GPCR_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:14772 UniProtKB/Swiss-Prot
MGD MGI:95801 ENTREZGENE
NCBI Gene 14772 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR KINASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grk4 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
UniProt F7BEP0_MOUSE UniProtKB/TrEMBL
  GRK4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V151 ENTREZGENE
  Q8BP13 ENTREZGENE, UniProtKB/TrEMBL
  Q9D203_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3V151 UniProtKB/Swiss-Prot