Mpi (mannose phosphate isomerase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mpi (mannose phosphate isomerase) Rattus norvegicus
Analyze
Symbol: Mpi
Name: mannose phosphate isomerase
RGD ID: 3107
Description: Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-D-mannose biosynthetic process from fructose-6-phosphate and mannose to fructose-6-phosphate catabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mannose phosphate isomerase (mapped); mannose-6-phosphate isomerase; MGC94106; Mpi_mapped; phosphohexomutase; phosphomannose isomerase; PMI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,843,802 - 66,852,108 (-)NCBIGRCr8
mRatBN7.2857,947,883 - 57,956,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,947,893 - 57,956,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,480,996 - 63,488,898 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,758,575 - 61,766,476 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,623,116 - 59,631,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,324,176 - 62,332,080 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,324,092 - 62,332,115 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,101,457 - 62,109,361 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,298,820 - 61,306,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera857,414,355 - 57,422,259 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatcarbohydrate metabolic disorder  ISOMPI (Homo sapiens)1600452CDG Ib more ...RGD 
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatBardet-Biedl syndrome  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:28492532
MpiRatBloom syndrome  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
MpiRatBrugada syndrome 8  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: Brugada syndrome 8ClinVarPMID:28492532
MpiRatcolorectal cancer  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
MpiRatcongenital disorder of glycosylation  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylationClinVar 
MpiRatcongenital disorder of glycosylation Ib  ISOMPI (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10484808 more ...
MpiRatgenetic disease  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
MpiRatPAPA syndrome  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: PAPA SYNDROMEClinVarPMID:28492532
MpiRatschizophrenia  ISOMPI (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatcongenital disorder of glycosylation Ib  ISOMPI (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatcongenital disorder of glycosylation Ib  ISOMPI (Homo sapiens)7240710 OMIM 

1 to 20 of 83 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRat(-)-epigallocatechin 3-gallate multiple interactionsISOMPI (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MPI mRNACTDPMID:22079256
MpiRat1,1,1-trichloroethane increases expressionISOMpi (Mus musculus)64804641 more ...CTDPMID:25270620
MpiRat1,2-dimethylhydrazine multiple interactionsISOMpi (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MPI mRNACTDPMID:22206623
MpiRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of MPI mRNACTDPMID:32145629
MpiRat17beta-estradiol increases expressionISOMpi (Mus musculus)6480464Estradiol results in increased expression of MPI mRNACTDPMID:39298647
MpiRat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOMpi (Mus musculus)64804642 more ...CTDPMID:30294300
MpiRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MPI mRNACTDPMID:33387578
MpiRat2-hydroxypropanoic acid decreases expressionISOMPI (Homo sapiens)6480464Lactic Acid results in decreased expression of MPI mRNACTDPMID:30851411
MpiRat3-methylcholanthrene multiple interactionsISOMPI (Homo sapiens)6480464Methylcholanthrene promotes the reaction [AHR protein binds to MPI promoter]CTDPMID:20348232
MpiRat4,4'-sulfonyldiphenol increases expressionISOMpi (Mus musculus)6480464bisphenol S results in increased expression of MPI mRNACTDPMID:39298647
MpiRat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of MPI mRNACTDPMID:36041667
MpiRatacrylamide decreases expressionISOMPI (Homo sapiens)6480464Acrylamide results in decreased expression of MPI mRNACTDPMID:32763439
MpiRatamiodarone increases expressionISOMPI (Homo sapiens)6480464Amiodarone results in increased expression of MPI mRNACTDPMID:19774075
MpiRataristolochic acid A decreases expressionISOMPI (Homo sapiens)6480464aristolochic acid I results in decreased expression of MPI mRNA and aristolochic acid I results in decreased expression of MPI proteinCTDPMID:33212167
MpiRatarsane increases methylationISOMPI (Homo sapiens)6480464Arsenic results in increased methylation of MPI promoterCTDPMID:21291286
MpiRatarsane multiple interactionsISOMPI (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of MPI mRNACTDPMID:39836092
MpiRatarsenic atom increases methylationISOMPI (Homo sapiens)6480464Arsenic results in increased methylation of MPI promoterCTDPMID:21291286
MpiRatarsenic atom multiple interactionsISOMPI (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of MPI mRNACTDPMID:39836092
MpiRatarsenite(3-) multiple interactionsISOMPI (Homo sapiens)6480464arsenite promotes the reaction [G3BP1 protein binds to MPI mRNA]CTDPMID:32406909
MpiRatAzoxymethane multiple interactionsISOMpi (Mus musculus)6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MPI mRNACTDPMID:29950665

1 to 20 of 83 rows

Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatbiological_process  ND 15984073/2007: no relevant rat dataRGD 
MpiRatcarbohydrate metabolic process involved_inIEAInterPro:IPR0012501600115GO_REF:0000002InterProGO_REF:0000002
MpiRatGDP-D-mannose biosynthetic process from fructose-6-phosphate involved_inISOMPI (Homo sapiens)1624291 PMID:9525984RGDPMID:9525984
MpiRatGDP-D-mannose biosynthetic process from fructose-6-phosphate involved_inIEAUniProtKB:P34949 and ensembl:ENSP000003183181600115GO_REF:0000107EnsemblGO_REF:0000107
MpiRatGDP-mannose biosynthetic process involved_inIEAUniPathway:UPA001261600115GO_REF:0000041UniProtGO_REF:0000041
MpiRatGDP-mannose biosynthetic process involved_inIEAUniProtKB:Q924M7 and ensembl:ENSMUSP000000348561600115GO_REF:0000107EnsemblGO_REF:0000107
MpiRatGDP-mannose biosynthetic process involved_inIBAMGI:97075 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
MpiRatGDP-mannose biosynthetic process involved_inIEAInterPro:IPR0163051600115GO_REF:0000002InterProGO_REF:0000002
MpiRatGDP-mannose biosynthetic process involved_inISOMpi (Mus musculus)1624291 PMID:24218558RGDPMID:24218558
MpiRatmannose to fructose-6-phosphate catabolic process involved_inISSUniProtKB:P349491600115GO_REF:0000024UniProtGO_REF:0000024
MpiRatmannose to fructose-6-phosphate catabolic process acts_upstream_of_or_withinISOMpi (Mus musculus)1624291MGI:3628756 PMID:16339137RGDPMID:16339137
MpiRatmannose to fructose-6-phosphate catabolic process acts_upstream_of_or_withinIEAUniProtKB:Q924M7 and ensembl:ENSMUSP000000348561600115GO_REF:0000107EnsemblGO_REF:0000107
MpiRatmannose to fructose-6-phosphate catabolic process involved_inIEAUniProtKB:P34949 and ensembl:ENSP000003183181600115GO_REF:0000107EnsemblGO_REF:0000107
MpiRatmannose to fructose-6-phosphate catabolic process involved_inISOMPI (Homo sapiens)1624291 PMID:8307007 and PMID:9525984RGDPMID:8307007 and PMID:9525984
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
MpiRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
MpiRatcytosol is_active_inISOMpi (Mus musculus)1624291 PMID:12122025RGDPMID:12122025
MpiRatcytosol is_active_inIEAUniProtKB:Q924M7 and ensembl:ENSMUSP000000348561600115GO_REF:0000107EnsemblGO_REF:0000107
MpiRatcytosol is_active_inIBAMGI:97075 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
MpiRatmannose-6-phosphate isomerase activity enablesISOMpi (Mus musculus)1624291MGI:3628756 PMID:12122025 more ...RGDPMID:12122025 more ...
MpiRatmannose-6-phosphate isomerase activity enablesIEAEC:5.3.1.81600115GO_REF:0000003UniProtGO_REF:0000003
MpiRatmannose-6-phosphate isomerase activity enablesIEAUniProtKB:Q924M7 and ensembl:ENSMUSP000000348561600115GO_REF:0000107EnsemblGO_REF:0000107
MpiRatmannose-6-phosphate isomerase activity enablesIEAInterPro:IPR001250 more ...1600115GO_REF:0000002InterProGO_REF:0000002
MpiRatmannose-6-phosphate isomerase activity enablesIEARHEA:123561600115GO_REF:0000116RHEAGO_REF:0000116
MpiRatmannose-6-phosphate isomerase activity enablesIBACGD:CAL0000189115 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
MpiRatmannose-6-phosphate isomerase activity enablesIEAUniProtKB:P34949 and ensembl:ENSP000003183181600115GO_REF:0000107EnsemblGO_REF:0000107
MpiRatmannose-6-phosphate isomerase activity enablesIEAARBA:ARBA000286341600115GO_REF:0000117UniProtGO_REF:0000117
MpiRatmannose-6-phosphate isomerase activity enablesISOMPI (Homo sapiens)1624291 PMID:8307007 and PMID:9525984RGDPMID:8307007 and PMID:9525984
MpiRatmannose-6-phosphate isomerase activity enablesISSUniProtKB:P349491600115GO_REF:0000024UniProtGO_REF:0000024
MpiRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
MpiRatprotein binding enablesISOMPI (Homo sapiens) and UniProtKB:P34949-21624291UniProtKB:O00291 more ...RGDPMID:32814053
MpiRatzinc ion binding enablesIEAInterPro:IPR001250 and InterPro:IPR0464571600115GO_REF:0000002InterProGO_REF:0000002
1 to 14 of 14 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatfructose and mannose metabolic pathway  ISOMPI (Homo sapiens)10402751 SMPDBSMP:00064
MpiRatfructosuria pathway  ISOMPI (Homo sapiens)10402751 SMPDBSMP:00561
MpiRathereditary fructose intolerance syndrome pathway  ISOMPI (Homo sapiens)10402751 SMPDBSMP:00725

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MpiRatamino sugar metabolic pathway  IEA 6907045 KEGGrno:00520
MpiRatfructose and mannose metabolic pathway  IEA 6907045 KEGGrno:00051
MpiRatnucleotide sugar metabolic pathway  IEA 6907045 KEGGrno:00520

1 to 10 of 10 rows
#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. Niehues R, etal., J Clin Invest. 1998 Apr 1;101(7):1414-20.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
1 to 10 of 10 rows
PMID:204065   PMID:1235912   PMID:4693062   PMID:6838491   PMID:7323947   PMID:7444718   PMID:12477932   PMID:15489334   PMID:16339137   PMID:23376485   PMID:23533145   PMID:24218558  



Mpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,843,802 - 66,852,108 (-)NCBIGRCr8
mRatBN7.2857,947,883 - 57,956,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl857,947,893 - 57,956,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,480,996 - 63,488,898 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,758,575 - 61,766,476 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,623,116 - 59,631,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,324,176 - 62,332,080 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,324,092 - 62,332,115 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,101,457 - 62,109,361 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,298,820 - 61,306,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera857,414,355 - 57,422,259 (-)NCBICelera
Cytogenetic Map8q24NCBI
MPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,890,042 - 74,902,219 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,890,005 - 74,902,219 (+)EnsemblGRCh38hg38GRCh38
GRCh371575,182,383 - 75,194,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,969,463 - 72,977,618 (+)NCBINCBI36Build 36hg18NCBI36
Build 341572,969,462 - 72,977,618NCBI
Celera1552,132,413 - 52,140,533 (+)NCBICelera
Cytogenetic Map15q24.1-q24.2NCBI
HuRef1551,979,301 - 51,987,407 (+)NCBIHuRef
CHM1_11575,301,023 - 75,309,170 (+)NCBICHM1_1
T2T-CHM13v2.01572,759,851 - 72,772,100 (+)NCBIT2T-CHM13v2.0
Mpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,448,744 - 57,460,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,451,539 - 57,460,046 (-)EnsemblGRCm39 Ensembl
GRCm38957,544,260 - 57,552,812 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,544,256 - 57,552,763 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,392,075 - 57,400,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,341,789 - 57,350,900 (-)NCBIMGSCv36mm8
Celera954,780,013 - 54,788,501 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.05NCBI
Mpi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,061,079 - 3,067,585 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,061,079 - 3,071,202 (-)NCBIChiLan1.0ChiLan1.0
MPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,117,236 - 64,123,976 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,281,032 - 68,287,680 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,832,088 - 53,841,832 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,449,397 - 73,457,213 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,449,439 - 73,457,205 (+)Ensemblpanpan1.1panPan2
MPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,933,091 - 37,940,945 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,932,186 - 37,940,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,865,054 - 37,872,927 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,137,552 - 38,145,350 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,137,516 - 38,145,369 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,090,271 - 38,098,059 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,136,650 - 38,144,442 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,372,382 - 38,380,172 (+)NCBIUU_Cfam_GSD_1.0
Mpi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,996,823 - 116,006,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,844,815 - 33,854,366 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,845,003 - 33,854,263 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,657,662 - 58,666,929 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,657,960 - 58,666,803 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,346,388 - 63,355,230 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q21-pterNCBI
MPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,574,135 - 8,582,575 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl268,573,219 - 8,582,515 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048133,066,376 - 133,074,976 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462489487,355 - 93,965 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462489484,508 - 96,598 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Mpi
39 total Variants

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000025783
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 60 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat

1 to 10 of 60 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000025783   ⟹   ENSRNOP00000025783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,947,905 - 57,956,150 (-)Ensembl
Rnor_6.0 Ensembl862,324,092 - 62,332,115 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106855   ⟹   ENSRNOP00000096180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,947,901 - 57,956,148 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113263   ⟹   ENSRNOP00000093777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl857,947,893 - 57,956,121 (-)Ensembl
RefSeq Acc Id: NM_001004081   ⟹   NP_001004081
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,844,112 - 66,852,016 (-)NCBI
mRatBN7.2857,948,209 - 57,956,113 (-)NCBI
Rnor_6.0862,324,176 - 62,332,080 (-)NCBI
Rnor_5.0862,101,457 - 62,109,361 (-)NCBI
RGSC_v3.4861,298,820 - 61,306,727 (-)RGD
Celera857,414,355 - 57,422,259 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081085   ⟹   XP_038937013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,843,802 - 66,851,971 (-)NCBI
mRatBN7.2857,947,893 - 57,956,071 (-)NCBI
RefSeq Acc Id: XM_039081087   ⟹   XP_038937015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,843,802 - 66,852,108 (-)NCBI
mRatBN7.2857,947,883 - 57,956,205 (-)NCBI
RefSeq Acc Id: XM_063265119   ⟹   XP_063121189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,843,802 - 66,852,108 (-)NCBI
RefSeq Acc Id: XM_063265120   ⟹   XP_063121190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,845,927 - 66,852,108 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_001004081 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937013 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937015 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121189 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121190 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79111 (Get FASTA)   NCBI Sequence Viewer  
  EDL95633 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025783
  ENSRNOP00000025783.4
  ENSRNOP00000093777
GenBank Protein Q68FX1 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_001004081   ⟸   NM_001004081
- UniProtKB: Q68FX1 (UniProtKB/Swiss-Prot),   A0A8I6ARZ5 (UniProtKB/TrEMBL),   A6J4W0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025783   ⟸   ENSRNOT00000025783
RefSeq Acc Id: XP_038937015   ⟸   XM_039081087
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937013   ⟸   XM_039081085
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARZ5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096180   ⟸   ENSRNOT00000106855
Phosphomannose isomerase type I C-terminal   Phosphomannose isomerase type I catalytic   Phosphomannose isomerase type I helical insertion

Name Modeler Protein Id AA Range Protein Structure
AF-Q68FX1-F1-model_v2 AlphaFold Q68FX1 1-423 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696014
Promoter ID:EPDNEW_R6538
Type:multiple initiation site
Name:Mpi_1
Description:mannose phosphate isomerase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,332,094 - 62,332,154EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30306 BioCyc
BioCyc Pathway PWY-3861 [mannitol degradation II] BioCyc
  PWY-5659 [GDP-mannose biosynthesis] BioCyc
  PWY3O-1743 [D-mannose degradation II] BioCyc
BioCyc Pathway Image PWY-3861 BioCyc
  PWY-5659 BioCyc
  PWY3O-1743 BioCyc
Ensembl Genes ENSRNOG00000018898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025783 ENTREZGENE
  ENSRNOT00000025783.6 UniProtKB/Swiss-Prot
  ENSRNOT00000113263 ENTREZGENE
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
  Phosphomannose Isomerase, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7125738 IMAGE-MGC_LOAD
InterPro Man6P_Isoase-1 UniProtKB/Swiss-Prot
  Mannose-6-P_Isomerase UniProtKB/Swiss-Prot
  Pmannose_isomerase-type1_CS UniProtKB/Swiss-Prot
  PMI_typeI_C UniProtKB/Swiss-Prot
  PMI_typeI_cat UniProtKB/Swiss-Prot
  PMI_typeI_hel UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
  RmlC_Cupin_sf UniProtKB/Swiss-Prot
KEGG Report rno:300741 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94106 IMAGE-MGC_LOAD
NCBI Gene Mpi ENTREZGENE
PANTHER MANNOSE-6-PHOSPHATE ISOMERASE UniProtKB/Swiss-Prot
  PTHR10309 UniProtKB/Swiss-Prot
Pfam PMI_typeI UniProtKB/Swiss-Prot
  PMI_typeI_cat UniProtKB/Swiss-Prot
  PMI_typeI_hel UniProtKB/Swiss-Prot
PhenoGen Mpi PhenoGen
PIRSF Mannose-6-phosphate_isomerase UniProtKB/Swiss-Prot
PRINTS MAN6PISMRASE UniProtKB/Swiss-Prot
PROSITE PMI_I_1 UniProtKB/Swiss-Prot
  PMI_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018898 RatGTEx
Superfamily-SCOP SSF51182 UniProtKB/Swiss-Prot
UniProt A0A8I6AKP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARZ5 ENTREZGENE, UniProtKB/TrEMBL
  A6J4W0 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-05 Mpi  mannose phosphate isomerase  Mpi  mannose phosphate isomerase (mapped)  Name changed 629549 APPROVED
2007-03-08 Mpi    Mpi_mapped  mannose phosphate isomerase (mapped)  Symbol updated 1299863 PROVISIONAL
2007-03-08 Mpi_mapped  mannose phosphate isomerase (mapped)  Mpi_retired  mannose phosphate isomerase (mapped)  Data merged from RGD:1593264 737654 PROVISIONAL
2007-03-08 Mpi_retired    Mpi  mannose phosphate isomerase (mapped)  Symbol updated 1299863 PROVISIONAL
2006-11-20 Mpi  mannose phosphate isomerase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Mpi_mapped  mannose phosphate isomerase (mapped)  Mpi  mannose phosphate isomerase  Symbol and Name updated 1556543 APPROVED
2002-11-06 Mpi  mannose phosphate isomerase    Mannose phosphate isomerase  Name updated 625702 APPROVED
2002-06-10 Mpi  Mannose phosphate isomerase      Symbol and Name status set to approved 70586 APPROVED