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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of ECM2 mRNA | CTD | PMID:30723492 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of ECM2 mRNA | CTD | PMID:17557909 | 2-hydroxypropanoic acid | increases expression | ISO | RGD:1318155 | 6480464 | Lactic Acid results in increased expression of ECM2 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1318155 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ECM2 mRNA | CTD | PMID:28628672 | aflatoxin B1 | affects expression | ISO | RGD:1318155 | 6480464 | Aflatoxin B1 affects the expression of ECM2 protein | CTD | PMID:20106945 | aflatoxin B1 | increases methylation | ISO | RGD:1318155 | 6480464 | Aflatoxin B1 results in increased methylation of ECM2 gene | CTD | PMID:27153756 | aflatoxin B1 | decreases expression | ISO | RGD:1318155 | 6480464 | Aflatoxin B1 results in decreased expression of ECM2 mRNA | CTD | PMID:22100608, PMID:27153756 | antirheumatic drug | increases expression | ISO | RGD:1318155 | 6480464 | Antirheumatic Agents results in increased expression of ECM2 mRNA | CTD | PMID:24449571 | avobenzone | decreases expression | ISO | RGD:1318155 | 6480464 | avobenzone results in decreased expression of ECM2 mRNA | CTD | PMID:31016361 | benzo[a]pyrene | increases expression | ISO | RGD:1552953 | 6480464 | Benzo(a)pyrene results in increased expression of ECM2 mRNA | CTD | PMID:22228805 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1318155 | 6480464 | Diethylhexyl Phthalate results in decreased expression of ECM2 mRNA | CTD | PMID:31163220 | bisphenol A | multiple interactions | ISO | RGD:1318155 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ECM2 mRNA | CTD | PMID:28628672 | bisphenol A | increases expression | ISO | RGD:1552953 | 6480464 | bisphenol A results in increased expression of ECM2 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | RGD:1552953 | 6480464 | bisphenol F results in increased expression of ECM2 mRNA | CTD | PMID:30951980 | carbon nanotube | decreases expression | ISO | RGD:1552953 | 6480464 | Nanotubes, Carbon analog results in decreased expression of ECM2 mRNA, Nanotubes, Carbon results in decreased expression of ECM2 mRNA | CTD | PMID:25554681 | carmustine | increases expression | ISO | RGD:1318155 | 6480464 | Carmustine results in increased expression of ECM2 mRNA | CTD | PMID:15980968 | copper atom | multiple interactions | ISO | RGD:1318155 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of ECM2 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1318155 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of ECM2 mRNA | CTD | PMID:20971185 | cyclosporin A | increases expression | ISO | RGD:1318155 | 6480464 | Cyclosporine results in increased expression of ECM2 mRNA | CTD | PMID:22147139, PMID:27989131 | cyclosporin A | decreases expression | ISO | RGD:1318155 | 6480464 | Cyclosporine results in decreased expression of ECM2 mRNA | CTD | PMID:20106945 | dexamethasone | multiple interactions | ISO | RGD:1318155 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ECM2 mRNA | CTD | PMID:28628672 | dioxygen | multiple interactions | ISO | RGD:1552953 | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ECM2 mRNA | CTD | PMID:30529165 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of ECM2 mRNA | CTD | PMID:21551480 | dopamine | decreases expression | EXP | | 6480464 | Dopamine results in decreased expression of ECM2 mRNA | CTD | PMID:21983523 | doxorubicin | decreases expression | ISO | RGD:1318155 | 6480464 | Doxorubicin results in decreased expression of ECM2 mRNA | CTD | PMID:29803840 | elemental selenium | decreases expression | ISO | RGD:1318155 | 6480464 | Selenium results in decreased expression of ECM2 mRNA | CTD | PMID:19244175 | entinostat | decreases expression | ISO | RGD:1318155 | 6480464 | entinostat results in decreased expression of ECM2 mRNA | CTD | PMID:27188386 | fenoldopam | decreases expression | EXP | | 6480464 | Fenoldopam results in decreased expression of ECM2 mRNA | CTD | PMID:21983523 | formaldehyde | increases expression | ISO | RGD:1318155 | 6480464 | Formaldehyde results in increased expression of ECM2 mRNA | CTD | PMID:23649840, PMID:27664576 | hydroquinone | increases expression | ISO | RGD:1318155 | 6480464 | hydroquinone results in increased expression of ECM2 mRNA | CTD | PMID:31256213 | indometacin | multiple interactions | ISO | RGD:1318155 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ECM2 mRNA | CTD | PMID:28628672 | methylseleninic acid | increases expression | ISO | RGD:1318155 | 6480464 | methylselenic acid results in increased expression of ECM2 mRNA | CTD | PMID:18548127 | nickel atom | decreases expression | ISO | RGD:1318155 | 6480464 | Nickel results in decreased expression of ECM2 mRNA | CTD | PMID:25583101 | ozone | multiple interactions | ISO | RGD:1552953 | 6480464 | [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of ECM2 mRNA | CTD | PMID:25658374 | paracetamol | decreases expression | ISO | RGD:1318155 | 6480464 | Acetaminophen results in decreased expression of ECM2 mRNA | CTD | PMID:29067470 | pirinixic acid | decreases expression | ISO | RGD:1552953 | 6480464 | pirinixic acid results in decreased expression of ECM2 mRNA | CTD | PMID:20813756 | rac-lactic acid | increases expression | ISO | RGD:1318155 | 6480464 | Lactic Acid results in increased expression of ECM2 mRNA | CTD | PMID:30851411 | rotenone | decreases expression | ISO | RGD:1318155 | 6480464 | Rotenone results in decreased expression of ECM2 mRNA | CTD | PMID:29955902 | selenium atom | decreases expression | ISO | RGD:1318155 | 6480464 | Selenium results in decreased expression of ECM2 mRNA | CTD | PMID:19244175 | silicon dioxide | increases expression | ISO | RGD:1318155 | 6480464 | Silicon Dioxide analog results in increased expression of ECM2 mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | RGD:1318155 | 6480464 | sodium arsenite results in decreased expression of ECM2 mRNA | CTD | PMID:29301061 | titanium dioxide | decreases expression | ISO | RGD:1552953 | 6480464 | titanium dioxide results in decreased expression of ECM2 mRNA | CTD | PMID:29264374 | trimellitic anhydride | decreases expression | ISO | RGD:1552953 | 6480464 | trimellitic anhydride results in decreased expression of ECM2 mRNA | CTD | PMID:19042947 | valproic acid | decreases expression | ISO | RGD:1318155 | 6480464 | Valproic Acid results in decreased expression of ECM2 mRNA | CTD | PMID:29154799 | |
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1. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
2. | RGD automated import pipeline for gene-chemical interactions |
PubMed | 18757743 |
Ecm2 (Rattus norvegicus - Norway rat) |
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ECM2 (Homo sapiens - human) |
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Ecm2 (Mus musculus - house mouse) |
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Ecm2 (Chinchilla lanigera - long-tailed chinchilla) |
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ECM2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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ECM2 (Canis lupus familiaris - dog) |
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Ecm2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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ECM2 (Sus scrofa - pig) |
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BF405276 |
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RH141814 |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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High | ||||||||||||||||
Medium | ||||||||||||||||
Low | 8 | 25 | 11 | 6 | 4 | 2 | 3 | 8 | 10 | 15 | 11 | 11 | 3 | 22 | 8 | 8 |
Below cutoff | 9 | 10 | 10 | 9 | 1 | 16 | 10 | 24 | 11 |
RefSeq Transcripts | XM_006222357 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006222358 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006253741 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006253742 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017587707 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017600705 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AABR07072539 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AAHX01090253 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AC111847 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ215770 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | XM_006222357 ⟹ XP_006222419 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
CCCACCCCGCCCAACTCCCGCTGATGTTTTCCACTTTTTCTGTGATTAAAAAAAATTTCCCTTGhide sequence |
RefSeq Acc Id: | XM_006222358 ⟹ XP_006222420 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
CCCCACCCCGCCCAACTCCCGCTGATGTTTTCCACTTTTTCTGTGATTAAAAAAAATTTCCCTThide sequence |
RefSeq Acc Id: | XM_006253741 ⟹ XP_006253803 | ||||||||||||||
RefSeq Status: | |||||||||||||||
Type: | CODING | ||||||||||||||
Position: |
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Sequence: |
CCCACCCCGCCCAACTCCCGCTGATGTTTTCCACTTTTTCTGTGATTAAAAAAAATTTCCCTTGhide sequence |
RefSeq Acc Id: | XM_006253742 ⟹ XP_006253804 | ||||||||||||||
RefSeq Status: | |||||||||||||||
Type: | CODING | ||||||||||||||
Position: |
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Sequence: |
CCCCACCCCGCCCAACTCCCGCTGATGTTTTCCACTTTTTCTGTGATTAAAAAAAATTTCCCTThide sequence |
RefSeq Acc Id: | XM_017587707 ⟹ XP_017443196 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
GAGACAGCGTGGAACCATGAGGCCAGTTACTGCAGCAGGACAACAGTATGGTGGTTCATGGGAThide sequence |
RefSeq Acc Id: | XM_017600705 ⟹ XP_017456194 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
CAGAGAACCTCCTGAGTGCTGGGATCAAAGGTGTGCGCCACCACTACCCAGCTGTATATTAACThide sequence |
Protein RefSeqs | XP_006222419 | (Get FASTA) | NCBI Sequence Viewer |
XP_006222420 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006253803 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006253804 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017443196 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017456194 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | XP_006222420 ⟸ XM_006222358 |
- Peptide Label: | isoform X2 |
- Sequence: |
MKQAVWFCLLLLILLTVFQTDCEPSPRRQRRRMHQRLRKSSSLYPRADRWLEVQQTTAAPDAGLhide sequence |
RefSeq Acc Id: | XP_006222419 ⟸ XM_006222357 |
- Peptide Label: | isoform X1 |
- Sequence: |
MKQAVWFCLLLLILLTVFQTDCEPSPRRQRRRMHQRLRKSSSLYPRADRWLEVQQTTAAPDAGLhide sequence |
RefSeq Acc Id: | XP_006253804 ⟸ XM_006253742 |
- Peptide Label: | isoform X2 |
- Sequence: |
MKQAVWFCLLLLILLTVFQTDCEPSPRRQRRRMHQRLRKSSSLYPRADRWLEVQQTTAAPDAGLhide sequence |
RefSeq Acc Id: | XP_006253803 ⟸ XM_006253741 |
- Peptide Label: | isoform X1 |
- UniProtKB: | D3ZS41 (UniProtKB/TrEMBL) |
- Sequence: |
MKQAVWFCLLLLILLTVFQTDCEPSPRRQRRRMHQRLRKSSSLYPRADRWLEVQQTTAAPDAGLhide sequence |
RefSeq Acc Id: | XP_017443196 ⟸ XM_017587707 |
- Peptide Label: | isoform X1 |
- Sequence: |
MKQAVWFCLLLLILLTVFQTDCEPSPRRQRRRMHQRLRKSSSLYPRADRWLEVQQTTAAPDAGLhide sequence |
RefSeq Acc Id: | XP_017456194 ⟸ XM_017600705 |
- Peptide Label: | isoform X1 |
- UniProtKB: | D3ZS41 (UniProtKB/TrEMBL) |
- Sequence: |
MKQAVWFCLLLLILLTVFQTDCEPSPRRQRRRMHQRLRKSSSLYPRADRWLEVQQTTAAPDAGLhide sequence |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2320282 | AgrOrtholog |
Ensembl Genes | ENSRNOG00000031716 | ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000051031 | ENTREZGENE, UniProtKB/TrEMBL |
ENSRNOP00000076346 | ENTREZGENE, UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000043852 | ENTREZGENE, UniProtKB/TrEMBL |
ENSRNOT00000093743 | ENTREZGENE, UniProtKB/TrEMBL | |
Gene3D-CATH | 3.80.10.10 | UniProtKB/TrEMBL |
InterPro | L_dom-like | UniProtKB/TrEMBL |
Leu-rich_rpt | UniProtKB/TrEMBL | |
Leu-rich_rpt_typical-subtyp | UniProtKB/TrEMBL | |
VWF_C | UniProtKB/TrEMBL | |
NCBI Gene | 100361383 | ENTREZGENE |
Pfam | LRR_8 | UniProtKB/TrEMBL |
VWC | UniProtKB/TrEMBL | |
PhenoGen | Ecm2 | PhenoGen |
PROSITE | LRR | UniProtKB/TrEMBL |
VWFC_1 | UniProtKB/TrEMBL | |
VWFC_2 | UniProtKB/TrEMBL | |
SMART | LRR_TYP | UniProtKB/TrEMBL |
VWC | UniProtKB/TrEMBL | |
UniGene | Rn.106785 | ENTREZGENE |
UniProt | D3ZS41 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-03-22 | Ecm2 | extracellular matrix protein 2 | Ecm2 | extracellular matrix protein 2, female organ and adipocyte specific | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2014-07-23 | Ecm2 | extracellular matrix protein 2, female organ and adipocyte specific | LOC100361383 | extracellular matrix protein 2-like | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2010-05-05 | LOC100361383 | extracellular matrix protein 2-like | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
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More on Ecm2 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
RGD Object Information | |
RGD ID: | 2320282 |
Created: | 2010-05-05 |
Species: | Rattus norvegicus |
Last Modified: | 2019-11-27 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.