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Gene: N4bp2 (NEDD4 binding protein 2) Heterocephalus glaber

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Symbol:

N4bp2

Name:

NEDD4 binding protein 2

RGD ID:

18929033

Description:

ENCODES a protein that exhibits ATP binding (ortholog); ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity (ortholog); DNA endonuclease activity (ortholog); ASSOCIATED WITH Hyperglycinemia, Lactic Acidosis, and Seizures (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NEDD4-binding protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	N4BP2 (NEDD4 binding protein 2)	NCBI	Ortholog
Mus musculus (house mouse):	N4bp2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	N4bp2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	N4bp2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	N4BP2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	N4BP2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	N4bp2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	N4BP2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	N4BP2 (NEDD4 binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	26,813,526 - 26,874,313 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	26,810,603 - 26,905,017 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
N4bp2	Naked Mole-Rat	Hyperglycinemia, Lactic Acidosis, and Seizures		ISO	N4BP2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: HYPERGLYCINEMIA more ...	ClinVar	PMID:28492532

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
N4bp2	Naked Mole-Rat	cytosol	located_in	ISO	N4bp2 (Mus musculus)	9068941	PMID:11717310	MGI	PMID:11717310
N4bp2	Naked Mole-Rat	nucleus	located_in	IEA	PANTHER:PTN000329842	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
N4bp2	Naked Mole-Rat	ATP binding	enables	ISO	N4BP2 (Homo sapiens)	9068941	PMID:12730195	MGI	PMID:12730195
N4bp2	Naked Mole-Rat	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	enables	ISO	N4BP2 (Homo sapiens)	9068941	PMID:12730195	MGI	PMID:12730195
N4bp2	Naked Mole-Rat	DNA endonuclease activity	enables	ISO	N4BP2 (Homo sapiens)	9068941	PMID:12730195	FlyBase	PMID:12730195
N4bp2	Naked Mole-Rat	endonuclease activity	enables	IEA	PANTHER:PTN000329842	150520179		TreeGrafter	GO_REF:0000118
N4bp2	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:Q9Z2F6	9068941	PMID:12730195	UniProt	PMID:12730195
N4bp2	Naked Mole-Rat	protein binding	enables	ISO	PR:P46935	9068941	PMID:11717310	MGI	PMID:11717310
N4bp2	Naked Mole-Rat	ubiquitin binding	enables	IEA	InterPro:IPR003892	150520179		InterPro	GO_REF:0000002

PMID:21993625	PMID:22301074

N4bp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	26,813,526 - 26,874,313 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	26,810,603 - 26,905,017 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

N4BP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	40,056,850 - 40,190,470 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	40,056,797 - 40,158,252 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	40,058,470 - 40,159,872 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	39,775,242 - 39,833,423 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	40,497,305 - 40,595,932 (+)	NCBI		Celera
Cytogenetic Map	4	p14	NCBI
HuRef	4	39,381,945 - 39,483,119 (+)	NCBI		HuRef
CHM1_1	4	40,057,424 - 40,159,070 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	40,026,953 - 40,157,597 (+)	NCBI		T2T-CHM13v2.0

N4bp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	65,909,462 - 65,987,450 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	65,920,864 - 65,987,451 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	65,760,510 - 65,830,107 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	65,763,521 - 65,830,108 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	66,154,760 - 66,218,023 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	66,042,656 - 66,105,919 (+)	NCBI		MGSCv36	mm8
Celera	5	63,056,171 - 63,121,053 (+)	NCBI		Celera
Cytogenetic Map	5	C3.1	NCBI
cM Map	5	33.8	NCBI

N4bp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	42,696,415 - 42,819,535 (-)	NCBI		GRCr8
mRatBN7.2	14	42,342,690 - 42,479,861 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	42,409,510 - 42,483,960 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	14	43,963,353 - 44,092,844 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	44,038,614 - 44,078,897 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	43,782,882 - 43,908,753 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	45,096,756 - 45,142,700 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	41,560,669 - 41,632,706 (-)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

N4bp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955443	7,301,141 - 7,354,681 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955443	7,295,066 - 7,435,761 (-)	NCBI	ChiLan1.0	ChiLan1.0

N4BP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	40,243,048 - 40,355,355 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	40,428,265 - 40,547,334 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	34,380,215 - 34,482,797 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	40,253,199 - 40,336,040 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	40,253,199 - 40,336,040 (+)	Ensembl	panpan1.1		panPan2

N4BP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	72,323,016 - 72,439,593 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	72,277,190 - 72,439,615 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	74,866,346 - 74,988,131 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	73,084,841 - 73,207,383 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	73,090,114 - 73,207,308 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	72,353,404 - 72,475,357 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	72,503,885 - 72,625,754 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	72,889,208 - 73,011,634 (-)	NCBI		UU_Cfam_GSD_1.0

N4bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	38,651,322 - 38,726,191 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	7,592,442 - 7,646,821 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	7,576,188 - 7,648,140 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

N4BP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	31,219,397 - 31,287,990 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	31,216,942 - 31,287,993 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	32,865,820 - 32,955,396 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

N4BP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	10,147,274 - 10,249,824 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	10,151,301 - 10,249,772 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	56,520,517 - 56,617,505 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_021262425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021262436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01042523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01042524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01042525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01042526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01042527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01042528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01042529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01042530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH173192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000013610 ⟹ ENSHGLP00000013470

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624761	26,813,526 - 26,874,313 (-)	Ensembl

RefSeq Acc Id:

XM_021262425 ⟹ XP_021118084

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,905,017 (-)	NCBI

RefSeq Acc Id:

XM_021262427 ⟹ XP_021118086

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,904,563 (-)	NCBI

RefSeq Acc Id:

XM_021262428 ⟹ XP_021118087

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,905,017 (-)	NCBI

RefSeq Acc Id:

XM_021262429 ⟹ XP_021118088

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,905,017 (-)	NCBI

RefSeq Acc Id:

XM_021262430 ⟹ XP_021118089

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,905,017 (-)	NCBI

RefSeq Acc Id:

XM_021262431 ⟹ XP_021118090

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,904,563 (-)	NCBI

RefSeq Acc Id:

XM_021262433 ⟹ XP_021118092

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,904,110 (-)	NCBI

RefSeq Acc Id:

XM_021262434 ⟹ XP_021118093

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,874,022 (-)	NCBI

RefSeq Acc Id:

XM_021262435 ⟹ XP_021118094

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,870,524 (-)	NCBI

RefSeq Acc Id:

XM_021262436 ⟹ XP_021118095

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624761	26,810,603 - 26,869,805 (-)	NCBI


Protein RefSeqs	XP_021118084	(Get FASTA)	NCBI Sequence Viewer
	XP_021118086	(Get FASTA)	NCBI Sequence Viewer
	XP_021118087	(Get FASTA)	NCBI Sequence Viewer
	XP_021118088	(Get FASTA)	NCBI Sequence Viewer
	XP_021118089	(Get FASTA)	NCBI Sequence Viewer
	XP_021118090	(Get FASTA)	NCBI Sequence Viewer
	XP_021118092	(Get FASTA)	NCBI Sequence Viewer
	XP_021118093	(Get FASTA)	NCBI Sequence Viewer
	XP_021118094	(Get FASTA)	NCBI Sequence Viewer
	XP_021118095	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHB16203	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000013470

RefSeq Acc Id:	XP_021118089 ⟸ XM_021262430
- Peptide Label:	isoform X2
- UniProtKB:	A0AAX6TE54 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021118084 ⟸ XM_021262425
- Peptide Label:	isoform X1
- UniProtKB:	G5C3U2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021118088 ⟸ XM_021262429
- Peptide Label:	isoform X1
- UniProtKB:	G5C3U2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021118087 ⟸ XM_021262428
- Peptide Label:	isoform X1
- UniProtKB:	G5C3U2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021118090 ⟸ XM_021262431
- Peptide Label:	isoform X2
- UniProtKB:	A0AAX6TE54 (UniProtKB/TrEMBL)

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000009629	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000013610	ENTREZGENE
Gene3D-CATH	3.30.1370.110	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/TrEMBL
InterPro	CUE	UniProtKB/TrEMBL
	DUF1771	UniProtKB/TrEMBL
	Endo/PolyKinase_Domain-Protein	UniProtKB/TrEMBL
	N4BP2_CUE	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Smr_dom	UniProtKB/TrEMBL
	Smr_dom_sf	UniProtKB/TrEMBL
	UBA-like_sf	UniProtKB/TrEMBL
NCBI Gene	N4bp2	ENTREZGENE
PANTHER	NEDD4-BINDING PROTEIN 2	UniProtKB/TrEMBL
	NEDD4-BINDING PROTEIN 2	UniProtKB/TrEMBL
Pfam	AAA_33	UniProtKB/TrEMBL
	DUF1771	UniProtKB/TrEMBL
	Smr	UniProtKB/TrEMBL
PROSITE	CUE	UniProtKB/TrEMBL
	SMR	UniProtKB/TrEMBL
SMART	DUF1771	UniProtKB/TrEMBL
	SMR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF160443	UniProtKB/TrEMBL
	SSF46934	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0AAX6TE54	ENTREZGENE, UniProtKB/TrEMBL
	G5C3U2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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