N4BP2 (NEDD4 binding protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: N4BP2 (NEDD4 binding protein 2) Sus scrofa
Analyze
Symbol: N4BP2
Name: NEDD4 binding protein 2
RGD ID: 13985566
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity (inferred); DNA endonuclease activity (inferred); INVOLVED IN DNA metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); Hyperglycinemia, Lactic Acidosis, and Seizures (ortholog); FOUND IN cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NEDD4-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl831,219,397 - 31,287,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1831,216,942 - 31,287,993 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2832,865,820 - 32,955,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
N4BP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl831,219,397 - 31,287,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1831,216,942 - 31,287,993 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2832,865,820 - 32,955,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
N4BP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38440,056,850 - 40,190,470 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl440,056,797 - 40,158,252 (+)EnsemblGRCh38hg38GRCh38
GRCh37440,058,470 - 40,159,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36439,775,242 - 39,833,423 (+)NCBINCBI36Build 36hg18NCBI36
Celera440,497,305 - 40,595,932 (+)NCBICelera
Cytogenetic Map4p14NCBI
HuRef439,381,945 - 39,483,119 (+)NCBIHuRef
CHM1_1440,057,424 - 40,159,070 (+)NCBICHM1_1
T2T-CHM13v2.0440,026,953 - 40,157,597 (+)NCBIT2T-CHM13v2.0
N4bp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39565,909,462 - 65,987,450 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl565,920,864 - 65,987,451 (+)EnsemblGRCm39 Ensembl
GRCm38565,760,510 - 65,830,107 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl565,763,521 - 65,830,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37566,154,760 - 66,218,023 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,042,656 - 66,105,919 (+)NCBIMGSCv36mm8
Celera563,056,171 - 63,121,053 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map533.8NCBI
N4bp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81442,696,415 - 42,819,535 (-)NCBIGRCr8
mRatBN7.21442,342,690 - 42,479,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1442,409,510 - 42,483,960 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01443,963,353 - 44,092,844 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1444,038,614 - 44,078,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01443,782,882 - 43,908,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41445,096,756 - 45,142,700 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1441,560,669 - 41,632,706 (-)NCBICelera
Cytogenetic Map14p11NCBI
N4bp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554437,301,141 - 7,354,681 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554437,295,066 - 7,435,761 (-)NCBIChiLan1.0ChiLan1.0
N4BP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2340,243,048 - 40,355,355 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1440,428,265 - 40,547,334 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0434,380,215 - 34,482,797 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1440,253,199 - 40,336,040 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl440,253,199 - 40,336,040 (+)Ensemblpanpan1.1panPan2
N4BP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1372,323,016 - 72,439,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl372,277,190 - 72,439,615 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha374,866,346 - 74,988,131 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0373,084,841 - 73,207,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl373,090,114 - 73,207,308 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1372,353,404 - 72,475,357 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0372,503,885 - 72,625,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0372,889,208 - 73,011,634 (-)NCBIUU_Cfam_GSD_1.0
N4bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528538,651,322 - 38,726,191 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364827,592,442 - 7,646,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364827,576,188 - 7,648,140 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
N4BP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12710,147,274 - 10,249,824 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2710,151,301 - 10,249,772 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604756,520,517 - 56,617,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
N4bp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476126,813,526 - 26,874,313 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476126,810,603 - 26,905,017 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in N4BP2
1829 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 5 17 1 3 3
Low 1 2 2 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009619   ⟹   ENSSSCP00000009371
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl831,219,397 - 31,287,990 (+)Ensembl
RefSeq Acc Id: XM_021101117   ⟹   XP_020956776
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1831,216,942 - 31,287,993 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020956776   ⟸   XM_021101117
- UniProtKB: A0A4X1UYU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009371   ⟸   ENSSSCT00000009619
Protein Domains
CUE   Smr


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015033424 UniProtKB/TrEMBL
  ENSSSCG00025066593 UniProtKB/TrEMBL
  ENSSSCG00035045865 UniProtKB/TrEMBL
  ENSSSCG00045026834 UniProtKB/TrEMBL
  ENSSSCG00055017797 UniProtKB/TrEMBL
  ENSSSCG00070020668 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009619 ENTREZGENE
  ENSSSCT00000009619.5 UniProtKB/TrEMBL
  ENSSSCT00015044292.1 UniProtKB/TrEMBL
  ENSSSCT00015044438.1 UniProtKB/TrEMBL
  ENSSSCT00025091461.1 UniProtKB/TrEMBL
  ENSSSCT00025091803.1 UniProtKB/TrEMBL
  ENSSSCT00025092132.1 UniProtKB/TrEMBL
  ENSSSCT00025092371.1 UniProtKB/TrEMBL
  ENSSSCT00035060974.1 UniProtKB/TrEMBL
  ENSSSCT00035060979.1 UniProtKB/TrEMBL
  ENSSSCT00035060992.1 UniProtKB/TrEMBL
  ENSSSCT00035060998.1 UniProtKB/TrEMBL
  ENSSSCT00045045698.1 UniProtKB/TrEMBL
  ENSSSCT00045045889.1 UniProtKB/TrEMBL
  ENSSSCT00055034879.1 UniProtKB/TrEMBL
  ENSSSCT00055035065.1 UniProtKB/TrEMBL
  ENSSSCT00055035220.1 UniProtKB/TrEMBL
  ENSSSCT00055035395.1 UniProtKB/TrEMBL
  ENSSSCT00070041098.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.110 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro CUE UniProtKB/TrEMBL
  DUF1771 UniProtKB/TrEMBL
  N4BP2_CUE UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Smr_dom UniProtKB/TrEMBL
  Smr_dom_sf UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
NCBI Gene N4BP2 ENTREZGENE
PANTHER NEDD4-BINDING PROTEIN 2 UniProtKB/TrEMBL
  NEDD4-BINDING PROTEIN 2 UniProtKB/TrEMBL
Pfam AAA_33 UniProtKB/TrEMBL
  DUF1771 UniProtKB/TrEMBL
  Smr UniProtKB/TrEMBL
PROSITE CUE UniProtKB/TrEMBL
  SMR UniProtKB/TrEMBL
SMART DUF1771 UniProtKB/TrEMBL
  SMR UniProtKB/TrEMBL
Superfamily-SCOP SSF160443 UniProtKB/TrEMBL
  SSF46934 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A4X1UYU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T3F9_PIG UniProtKB/TrEMBL
  A0A8D0T3X6_PIG UniProtKB/TrEMBL
  A0A8D0U142_PIG UniProtKB/TrEMBL
  A0A8D0U151_PIG UniProtKB/TrEMBL
  A0A8D0ZZS0_PIG UniProtKB/TrEMBL
  A0A8D1A4J5_PIG UniProtKB/TrEMBL
  A0A8D1I9N7_PIG UniProtKB/TrEMBL
  A0A8D1IDM9_PIG UniProtKB/TrEMBL
  A0A8D1QYF8_PIG UniProtKB/TrEMBL
  A0A8D1R1Q1_PIG UniProtKB/TrEMBL
  A0A8D1U542_PIG UniProtKB/TrEMBL
  A0A8D1U587_PIG UniProtKB/TrEMBL
  F1S4H4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90554 ENTREZGENE