Myo7a (myosin VIIA) - Rat Genome Database

Name: Myo7a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Myo7a (myosin VIIA) Heterocephalus glaber

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Symbol:

Myo7a

Name:

myosin VIIA

RGD ID:

18927912

Description:

ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); ADP binding (ortholog); INVOLVED IN actin filament-based movement (ortholog); auditory receptor cell stereocilium organization (ortholog); cell projection organization (ortholog); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; ASSOCIATED WITH Auditory Neuropathy (ortholog); autosomal dominant nonsyndromic deafness 11 (ortholog); autosomal dominant nonsyndromic deafness 80 (ortholog); FOUND IN apical plasma membrane (ortholog); cytosol (ortholog); lysosomal membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

unconventional myosin-VIIa

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MYO7A (myosin VIIA)	NCBI	Ortholog
Mus musculus (house mouse):	Myo7a (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Myo7a (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Myo7a (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MYO7A (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MYO7A (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Myo7a (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MYO7A (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MYO7A (myosin VIIA)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624863	205,478 - 283,839 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624863	205,468 - 283,840 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Auditory Neuropathy (ISO)

autosomal dominant nonsyndromic deafness 11 (ISO)

autosomal dominant nonsyndromic deafness 80 (ISO)

autosomal recessive nonsyndromic deafness (ISO)

autosomal recessive nonsyndromic deafness 2 (ISO)

autosomal recessive nonsyndromic deafness 7 (ISO)

Cohen syndrome (ISO)

congenital nystagmus (ISO)

COVID-19 (ISO)

Cutis Verticis Gyrata, Retinitis Pigmentosa, and Sensorineural Deafness (ISO)

Deafness (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

hereditary breast ovarian cancer syndrome (ISO)

intellectual disability (ISO)

Leber congenital amaurosis (ISO)

melanoma (ISO)

Meniere's disease (ISO)

nonsyndromic deafness (ISO)

Nonsyndromic Sensorineural Hearing Loss (ISO)

Pendred syndrome (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

sensorineural hearing loss (ISO)

Usher syndrome (ISO)

Usher syndrome type 1 (ISO)

Usher Syndrome Type 1B (ISO)

Usher syndrome type 2 (ISO)

vestibular disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament-based movement (ISO)

auditory receptor cell stereocilium organization (ISO)

cell projection organization (ISO)

cochlea development (ISO)

equilibrioception (ISO)

inner ear auditory receptor cell differentiation (ISO)

inner ear development (ISO)

inner ear morphogenesis (ISO)

inner ear receptor cell differentiation (ISO)

inner ear receptor cell stereocilium organization (ISO)

intracellular protein transport (ISO)

lysosome organization (ISO)

mechanoreceptor differentiation (ISO)

phagocytosis (ISO)

phagolysosome assembly (ISO)

pigment granule localization (ISO)

pigment granule transport (ISO)

protein localization (ISO)

sensory perception (ISO)

sensory perception of light stimulus (ISO)

sensory perception of sound (ISO)

visual perception (ISO)

Cellular Component

apical plasma membrane (ISO)

cytoplasm (IEA)

cytoskeleton (IEA)

cytosol (ISO)

lysosomal membrane (ISO)

melanosome (ISO)

myosin complex (IEA,ISO)

myosin VII complex (ISO)

photoreceptor connecting cilium (ISO)

photoreceptor inner segment (ISO)

photoreceptor outer segment (ISO)

plasma membrane bounded cell projection (IEA)

stereocilium (ISO)

stereocilium base (ISO)

synapse (ISO)

upper tip-link density (ISO)

Molecular Function

actin binding (IEA,ISO)

actin filament binding (ISO)

ADP binding (ISO)

ATP binding (IEA,ISO)

calmodulin binding (ISO)

cytoskeletal motor activity (IEA,ISO)

identical protein binding (ISO)

microfilament motor activity (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein-containing complex binding (ISO)

spectrin binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

auditory mechanotransduction pathway (ISO)

retinitis pigmentosa pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Myo7a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624863	205,478 - 283,839 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624863	205,468 - 283,840 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

MYO7A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	77,128,246 - 77,215,241 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	77,128,246 - 77,215,241 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	76,839,292 - 76,926,286 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	76,516,964 - 76,603,932 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	76,516,957 - 76,603,931	NCBI
Celera	11	74,146,794 - 74,233,913 (+)	NCBI		Celera
Cytogenetic Map	11	q13.5	NCBI
HuRef	11	73,136,682 - 73,224,253 (+)	NCBI		HuRef
CHM1_1	11	76,722,561 - 76,809,502 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	77,058,823 - 77,147,851 (+)	NCBI		T2T-CHM13v2.0

Myo7a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	97,700,261 - 97,768,730 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	97,700,267 - 97,768,731 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	98,051,054 - 98,119,522 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	98,051,060 - 98,119,524 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	105,199,570 - 105,268,003 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	97,926,593 - 97,992,926 (-)	NCBI		MGSCv36	mm8
Celera	7	98,371,628 - 98,440,211 (-)	NCBI		Celera
Cytogenetic Map	7	E1	NCBI
cM Map	7	53.57	NCBI

Myo7a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	161,755,110 - 161,825,397 (-)	NCBI		GRCr8
mRatBN7.2	1	152,342,611 - 152,414,171 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	152,344,448 - 152,414,157 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	160,331,375 - 160,401,213 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	167,511,561 - 167,581,393 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	160,385,070 - 160,454,912 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	163,001,313 - 163,071,545 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	163,001,875 - 163,071,508 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	169,206,150 - 169,276,706 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	155,292,620 - 155,362,698 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	155,371,025 - 155,441,104 (-)	NCBI
Celera	1	150,435,342 - 150,505,024 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

Myo7a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	14,576,356 - 14,647,500 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	14,576,356 - 14,647,500 (-)	NCBI	ChiLan1.0	ChiLan1.0

MYO7A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	78,045,811 - 78,134,539 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	79,093,985 - 79,182,922 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	72,187,024 - 72,265,931 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	75,834,409 - 75,908,297 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	75,834,185 - 75,907,752 (+)	Ensembl	panpan1.1		panPan2

MYO7A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	21,539,735 - 21,624,063 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	21,539,785 - 21,624,279 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	21,371,283 - 21,451,548 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	21,739,388 - 21,823,670 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	21,739,387 - 21,823,979 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	21,514,983 - 21,599,193 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	21,731,135 - 21,815,380 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	21,654,692 - 21,739,052 (-)	NCBI		UU_Cfam_GSD_1.0

Myo7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	64,150,067 - 64,224,924 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	5,751,779 - 5,824,378 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	5,758,572 - 5,824,526 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYO7A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	11,249,075 - 11,666,296 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	11,251,187 - 11,337,618 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	12,345,556 - 12,430,950 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYO7A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	68,334,781 - 68,423,215 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	68,350,598 - 68,425,625 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	57,352,101 - 57,439,357 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013067417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01093489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000016043 ⟹ ENSHGLP00000015877

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624863	205,478 - 283,839 (+)	Ensembl

Ensembl Acc Id:

ENSHGLT00000016044 ⟹ ENSHGLP00000015878

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624863	218,020 - 283,296 (+)	Ensembl

Ensembl Acc Id:

ENSHGLT00000016045 ⟹ ENSHGLP00000015879

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624863	218,228 - 283,296 (+)	Ensembl

RefSeq Acc Id:

XM_013067417 ⟹ XP_012922871

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624863	205,468 - 283,840 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_012922871	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000015877

RefSeq Acc Id:	XP_012922871 ⟸ XM_013067417
- UniProtKB:	G5AW78 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000015878 ⟸ ENSHGLT00000016044

Ensembl Acc Id:

ENSHGLP00000015877 ⟸ ENSHGLT00000016043

Ensembl Acc Id:

ENSHGLP00000015879 ⟸ ENSHGLT00000016045

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000011345	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000016043	ENTREZGENE
Gene3D-CATH	1.10.10.820	UniProtKB/TrEMBL
	1.20.5.190	UniProtKB/TrEMBL
	1.20.58.530	UniProtKB/TrEMBL
	1.20.80.10	UniProtKB/TrEMBL
	6.20.240.20	UniProtKB/TrEMBL
	Kinesin motor domain	UniProtKB/TrEMBL
	Myosin VI head, motor domain, U50 subdomain	UniProtKB/TrEMBL
	MyTH4 domain	UniProtKB/TrEMBL
	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	Band_41_domain	UniProtKB/TrEMBL
	FERM/acyl-CoA-bd_prot_sf	UniProtKB/TrEMBL
	FERM_2	UniProtKB/TrEMBL
	FERM_central	UniProtKB/TrEMBL
	FERM_domain	UniProtKB/TrEMBL
	IQ_motif_EF-hand-BS	UniProtKB/TrEMBL
	IRS_PTB	UniProtKB/TrEMBL
	Kinesin_motor_dom_sf	UniProtKB/TrEMBL
	Myosin_head_motor_dom	UniProtKB/TrEMBL
	MyoVII_FERM_C1	UniProtKB/TrEMBL
	MyoVII_FERM_C2	UniProtKB/TrEMBL
	MYSc_Myo7	UniProtKB/TrEMBL
	MyTH4_dom	UniProtKB/TrEMBL
	MyTH4_dom_sf	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Ubiquitin-like_domsf	UniProtKB/TrEMBL
	Unconventional_Myosin_ATPase	UniProtKB/TrEMBL
NCBI Gene	Myo7a	ENTREZGENE
PANTHER	MYOSIN VII, XV	UniProtKB/TrEMBL
	MYOSIN VIIA	UniProtKB/TrEMBL
Pfam	FERM_C1_MyoVII	UniProtKB/TrEMBL
	FERM_M	UniProtKB/TrEMBL
	IRS	UniProtKB/TrEMBL
	Myosin_head	UniProtKB/TrEMBL
	MyTH4	UniProtKB/TrEMBL
	PF00612	UniProtKB/TrEMBL
	RA_2	UniProtKB/TrEMBL
PRINTS	MYOSINHEAVY	UniProtKB/TrEMBL
PROSITE	FERM_3	UniProtKB/TrEMBL
	MYOSIN_MOTOR	UniProtKB/TrEMBL
	MYTH4	UniProtKB/TrEMBL
	PS50096	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	B41	UniProtKB/TrEMBL
	MYSc	UniProtKB/TrEMBL
	MyTH4	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00015	UniProtKB/TrEMBL
Superfamily-SCOP	P-loop containing nucleoside triphosphate hydrolases	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	Second domain of FERM	UniProtKB/TrEMBL
	SH3-domain	UniProtKB/TrEMBL
	Ubiquitin-like	UniProtKB/TrEMBL
UniProt	A0AAX6QPB6_HETGA	UniProtKB/TrEMBL
	G5AW78	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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RGD Manual Annotations