Eif2d (eukaryotic translation initiation factor 2D) - Rat Genome Database

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Gene: Eif2d (eukaryotic translation initiation factor 2D) Heterocephalus glaber
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Symbol: Eif2d
Name: eukaryotic translation initiation factor 2D
RGD ID: 18925405
Description: ENCODES a protein that exhibits RNA binding (inferred); translation initiation factor activity (inferred); INVOLVED IN IRES-dependent viral translational initiation (ortholog); ribosome disassembly (ortholog); ASSOCIATED WITH autistic disorder (ortholog); familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytosol (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,818,585 - 4,836,280 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,818,652 - 4,834,898 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nuclear body  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Eif2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,818,585 - 4,836,280 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,818,652 - 4,834,898 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EIF2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,569,146 - 206,612,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,571,292 - 206,612,465 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,764,974 - 206,785,818 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,831,597 - 204,852,527 (-)NCBINCBI36Build 36hg18NCBI36
Build 341203,153,371 - 203,174,299NCBI
Celera1180,016,423 - 180,037,351 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,463,289 - 177,484,217 (-)NCBIHuRef
CHM1_11208,037,181 - 208,058,090 (-)NCBICHM1_1
T2T-CHM13v2.01205,827,369 - 205,876,640 (-)NCBIT2T-CHM13v2.0
Eif2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,080,903 - 131,115,396 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,080,918 - 131,115,395 (+)EnsemblGRCm39 Ensembl
GRCm381131,153,172 - 131,187,659 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,153,181 - 131,187,658 (+)EnsemblGRCm38mm10GRCm38
MGSCv371133,049,784 - 133,070,048 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,980,782 - 132,999,780 (+)NCBIMGSCv36mm8
Celera1133,775,887 - 133,795,744 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.9NCBI
Eif2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,168,161 - 45,189,362 (+)NCBIGRCr8
mRatBN7.21342,615,901 - 42,637,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,615,911 - 42,639,719 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,222,598 - 45,241,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,510,729 - 46,529,694 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,774,845 - 43,793,785 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,935,138 - 47,958,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,935,163 - 47,954,090 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,011,077 - 53,033,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,099,725 - 44,118,652 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1342,961,793 - 42,980,721 (+)NCBICelera
Cytogenetic Map13q13NCBI
Eif2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,163,632 - 42,181,337 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,163,508 - 42,181,482 (-)NCBIChiLan1.0ChiLan1.0
EIF2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,762,926 - 42,784,684 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,728,446 - 42,750,211 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,193,709 - 182,214,981 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,473,496 - 186,494,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,473,496 - 186,494,896 (-)Ensemblpanpan1.1panPan2
EIF2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,851,972 - 2,871,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,851,978 - 2,871,518 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,944,091 - 2,963,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,849,269 - 2,868,948 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,846,143 - 2,868,902 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,842,501 - 2,862,019 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0383,235,478 - 3,255,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,436,042 - 3,455,816 (-)NCBIUU_Cfam_GSD_1.0
Eif2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,725,272 - 68,745,708 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,965,504 - 5,986,064 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,965,496 - 5,985,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,240,588 - 67,261,223 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,240,586 - 67,261,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,593,837 - 73,614,045 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,752,852 - 22,773,566 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,752,926 - 22,773,568 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,451,194 - 23,471,916 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000012002   ⟹   ENSHGLP00000011873
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248074,818,585 - 4,834,814 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000012003   ⟹   ENSHGLP00000011874
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248074,818,800 - 4,836,280 (+)Ensembl
RefSeq Acc Id: XM_004862062   ⟹   XP_004862119
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248074,818,652 - 4,834,898 (+)NCBI
RefSeq Acc Id: XM_021242235   ⟹   XP_021097894
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248074,818,652 - 4,834,601 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004862119 (Get FASTA)   NCBI Sequence Viewer  
  XP_021097894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011873
RefSeq Acc Id: XP_004862119   ⟸   XM_004862062
- Peptide Label: isoform X1
- UniProtKB: G5BP24 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021097894   ⟸   XM_021242235
- Peptide Label: isoform X2
- UniProtKB: G5BP24 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011873   ⟸   ENSHGLT00000012002
Ensembl Acc Id: ENSHGLP00000011874   ⟸   ENSHGLT00000012003


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008498 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000012002 ENTREZGENE
Gene3D-CATH 3.10.400.20 UniProtKB/TrEMBL
  SUI1-like domain UniProtKB/TrEMBL
InterPro EIF2D UniProtKB/TrEMBL
  eIF2D_N UniProtKB/TrEMBL
  eIF2D_SUI1 UniProtKB/TrEMBL
  Pre-PUA UniProtKB/TrEMBL
  PUA UniProtKB/TrEMBL
  PUA-like_sf UniProtKB/TrEMBL
  PUA_eIF2d-like UniProtKB/TrEMBL
  SUI1 UniProtKB/TrEMBL
  SUI1_dom_sf UniProtKB/TrEMBL
  SWIB_MDM2_dom_sf UniProtKB/TrEMBL
  SWIB_MDM2_domain UniProtKB/TrEMBL
NCBI Gene Eif2d ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2D UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 2D UniProtKB/TrEMBL
Pfam Pre-PUA UniProtKB/TrEMBL
  SUI1 UniProtKB/TrEMBL
PROSITE PUA UniProtKB/TrEMBL
  SUI1 UniProtKB/TrEMBL
  SWIB_MDM2 UniProtKB/TrEMBL
SMART PUA UniProtKB/TrEMBL
Superfamily-SCOP eIF1-like UniProtKB/TrEMBL
  PUA domain-like UniProtKB/TrEMBL
  SWIB/MDM2 domain UniProtKB/TrEMBL
UniProt G5BP24 ENTREZGENE, UniProtKB/TrEMBL