Sema5a (semaphorin 5A) - Rat Genome Database

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Gene: Sema5a (semaphorin 5A) Heterocephalus glaber
Analyze
Symbol: Sema5a
Name: semaphorin 5A
RGD ID: 18925224
Description: ENCODES a protein that exhibits axon guidance receptor activity (ortholog); chondroitin sulfate proteoglycan binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN axon extension (ortholog); axon guidance (ortholog); axonal fasciculation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Charcot-Marie-Tooth disease (ortholog); intellectual disability (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Semaphorin-5A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247516,436,854 - 6,738,216 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247516,429,814 - 6,913,673 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Sema5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247516,436,854 - 6,738,216 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247516,429,814 - 6,913,673 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SEMA5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3859,035,033 - 9,546,075 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl59,035,033 - 9,546,075 (-)EnsemblGRCh38hg38GRCh38
GRCh3759,035,145 - 9,546,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3659,088,138 - 9,599,233 (-)NCBINCBI36Build 36hg18NCBI36
Build 3459,091,858 - 9,599,158NCBI
Celera59,075,672 - 9,586,506 (-)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef59,020,618 - 9,529,962 (-)NCBIHuRef
CHM1_159,034,070 - 9,546,215 (-)NCBICHM1_1
T2T-CHM13v2.058,974,898 - 9,485,916 (-)NCBIT2T-CHM13v2.0
Sema5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391532,244,959 - 32,696,487 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1532,244,956 - 32,696,487 (+)EnsemblGRCm39 Ensembl
GRCm381532,244,813 - 32,696,341 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1532,244,810 - 32,696,341 (+)EnsemblGRCm38mm10GRCm38
MGSCv371532,174,568 - 32,626,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361532,361,948 - 32,640,922 (+)NCBIMGSCv36mm8
Celera1532,949,262 - 33,396,657 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1513.02NCBI
Sema5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8285,020,724 - 85,451,938 (+)NCBIGRCr8
mRatBN7.2283,309,843 - 83,741,084 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl283,309,843 - 83,741,084 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx290,354,073 - 90,791,652 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0288,475,679 - 88,913,259 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0283,531,943 - 83,969,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0285,377,318 - 85,808,970 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl285,377,318 - 85,808,970 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02105,049,343 - 105,480,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4284,725,092 - 85,158,599 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1284,835,136 - 85,097,066 (+)NCBI
Celera278,800,990 - 79,231,054 (+)NCBICelera
Cytogenetic Map2q23NCBI
Sema5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555046,350,866 - 6,762,104 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555046,343,747 - 6,691,945 (-)NCBIChiLan1.0ChiLan1.0
SEMA5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v249,272,092 - 9,780,658 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan157,425,701 - 7,935,102 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v059,349,473 - 9,852,183 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.159,168,549 - 9,672,779 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl59,168,549 - 9,564,356 (-)Ensemblpanpan1.1panPan2
SEMA5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1344,612,202 - 5,089,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl344,612,142 - 5,082,280 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha349,122,860 - 9,593,613 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0344,522,038 - 4,992,481 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl344,521,503 - 4,998,657 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1344,573,215 - 5,048,444 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0344,553,933 - 5,029,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0344,776,835 - 5,250,400 (+)NCBIUU_Cfam_GSD_1.0
Sema5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213237,599,219 - 238,050,371 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366431,355,070 - 1,637,151 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366431,352,401 - 1,803,553 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEMA5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1672,756,383 - 73,328,981 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11672,796,453 - 73,335,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21678,742,131 - 79,220,468 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SEMA5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.148,598,680 - 9,095,346 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl48,600,959 - 9,095,423 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606419,470,071 - 19,975,962 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000024947   ⟹   ENSHGLP00000024725
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247516,436,854 - 6,738,216 (-)Ensembl
RefSeq Acc Id: XM_004845176   ⟹   XP_004845233
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247516,429,814 - 6,913,673 (-)NCBI
RefSeq Acc Id: XM_021258604   ⟹   XP_021114263
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247516,429,814 - 6,913,673 (-)NCBI
RefSeq Acc Id: XM_021258605   ⟹   XP_021114264
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247516,429,814 - 6,913,673 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004845233 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114263 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114264 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB03176 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000024725
  ENSHGLP00100022938
GenBank Protein JAN97580 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004845233   ⟸   XM_004845176
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021114264   ⟸   XM_021258605
- Peptide Label: isoform X2
- UniProtKB: G5B1L5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114263   ⟸   XM_021258604
- Peptide Label: isoform X1
Ensembl Acc Id: ENSHGLP00000024725   ⟸   ENSHGLT00000024947


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017629 Ensembl, ENTREZGENE
  ENSHGLG00100016871 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000024947 ENTREZGENE
  ENSHGLT00100023178 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  2.20.100.10 UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
InterPro Plexin_repeat UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  Sema5A_sema UniProtKB/TrEMBL
  Semap_dom UniProtKB/TrEMBL
  Semap_dom_sf UniProtKB/TrEMBL
  Semaphorin UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Sema5a ENTREZGENE
PANTHER PTHR11036 UniProtKB/TrEMBL
  SEMAPHORIN-5A UniProtKB/TrEMBL
Pfam PSI UniProtKB/TrEMBL
  Sema UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS TSP1REPEAT UniProtKB/TrEMBL
PROSITE SEMA UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART PSI UniProtKB/TrEMBL
  Sema UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Plexin repeat UniProtKB/TrEMBL
  SSF101912 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt G5B1L5 ENTREZGENE, UniProtKB/TrEMBL