Sigmar1 (sigma non-opioid intracellular receptor 1) - Rat Genome Database

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Gene: Sigmar1 (sigma non-opioid intracellular receptor 1) Heterocephalus glaber
Analyze
Symbol: Sigmar1
Name: sigma non-opioid intracellular receptor 1
RGD ID: 18918137
Description: ENCODES a protein that exhibits G protein-coupled opioid receptor activity (ortholog); identical protein binding (ortholog); signaling receptor activity (ortholog); INVOLVED IN nervous system development (ortholog); protein homotrimerization (ortholog); regulation of neuron apoptotic process (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); amnestic disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog); postsynaptic density (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Sigma 1-type opioid receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,032,517 - 39,035,176 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473639,023,641 - 39,035,180 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sigmar1Naked Mole-Ratpost-traumatic stress disorder treatmentISOSigmar1 (Rattus norvegicus)9068941 RGDPMID:28791385 and REF_RGD_ID:401940159
1 to 11 of 11 rows
Object Symbol
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Reference
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Source
Original Reference(s)
Sigmar1Naked Mole-Ratacromesomelic dysplasia, Maroteaux type  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Acromesomelic dysplasia 1 and Maroteaux typeClinVarPMID:28492532
Sigmar1Naked Mole-Ratamyotrophic lateral sclerosis type 16  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Amyotrophic lateral sclerosis type 16ClinVarPMID:21842496 more ...
Sigmar1Naked Mole-Ratanauxetic dysplasia  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Anauxetic dysplasiaClinVarPMID:28492532
Sigmar1Naked Mole-Ratautosomal recessive distal hereditary motor neuronopathy 2  ISOSIGMAR1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
Sigmar1Naked Mole-Ratdistal arthrogryposis type 1A  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Arthrogryposis more ...ClinVarPMID:28492532
Sigmar1Naked Mole-Ratfrontotemporal dementia and/or amyotrophic lateral sclerosis 6  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Frontotemporal dementia and/or amyotrophic lateral sclerosis 6ClinVarPMID:28492532
Sigmar1Naked Mole-Ratgalactosemia  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseClinVarPMID:28492532
Sigmar1Naked Mole-Ratgenetic disease  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:21842496 more ...
Sigmar1Naked Mole-Rathyperphosphatasia with impaired intellectual development syndrome 2  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 6ClinVarPMID:22683086 more ...
Sigmar1Naked Mole-Ratparaplegia  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:23332916 more ...
Sigmar1Naked Mole-Ratprimary ciliary dyskinesia  ISOSIGMAR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
1 to 11 of 11 rows
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sigmar1Naked Mole-Ratamnestic disorder  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:12028363
Sigmar1Naked Mole-Ratamyotrophic lateral sclerosis  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24885036
Sigmar1Naked Mole-RatCocaine-Related Disorders  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12736327 and PMID:16132061
Sigmar1Naked Mole-RatExperimental Autoimmune Encephalomyelitis  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30661753
Sigmar1Naked Mole-RatFrontotemporal Lobar Degeneration  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24885036
Sigmar1Naked Mole-Rathuman immunodeficiency virus infectious disease  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16204638
Sigmar1Naked Mole-Ratlearning disability  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:15451042
Sigmar1Naked Mole-RatMemory Disorders  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:15451042
Sigmar1Naked Mole-RatPrenatal Exposure Delayed Effects  ISOSIGMAR1 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:15451042
1 to 9 of 9 rows
Object Symbol
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Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sigmar1Naked Mole-Ratamyotrophic lateral sclerosis type 16  ISOSIGMAR1 (Homo sapiens)7240710 OMIM 
Sigmar1Naked Mole-Ratautosomal recessive distal hereditary motor neuronopathy 2  ISOSIGMAR1 (Homo sapiens)7240710 OMIM 


Biological Process

  

Cellular Component
1 to 19 of 19 rows

  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
Sigmar1Naked Mole-Ratcytoplasmic vesicle located_inIEAUniRule:UR001553755150520179 UniProtGO_REF:0000104
Sigmar1Naked Mole-Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-0968150520179 UniProtGO_REF:0000043
Sigmar1Naked Mole-Ratendoplasmic reticulum located_inIEAPANTHER:PTN000792371150520179 TreeGrafterGO_REF:0000118
Sigmar1Naked Mole-Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
Sigmar1Naked Mole-Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
Sigmar1Naked Mole-Ratendoplasmic reticulum membrane located_inIEAUniRule:UR001553755150520179 UniProtGO_REF:0000104
Sigmar1Naked Mole-Ratglutamatergic synapse is_active_inISOSigmar1 (Rattus norvegicus)9068941PMID:20018732SynGOPMID:20018732 and REF_RGD_ID:405650297
Sigmar1Naked Mole-Ratmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
Sigmar1Naked Mole-Ratmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
Sigmar1Naked Mole-Ratmembrane located_inIEAUniRule:UR001553755150520179 UniProtGO_REF:0000104
Sigmar1Naked Mole-Ratnuclear envelope located_inIEAUniProtKB-SubCell:SL-0178150520179 UniProtGO_REF:0000044
Sigmar1Naked Mole-Ratnuclear inner membrane located_inIEAUniProtKB-SubCell:SL-0179150520179 UniProtGO_REF:0000044
Sigmar1Naked Mole-Ratnuclear inner membrane located_inIEAUniRule:UR001553755150520179 UniProtGO_REF:0000104
Sigmar1Naked Mole-Ratnuclear outer membrane located_inIEAUniProtKB-SubCell:SL-0183150520179 UniProtGO_REF:0000044
Sigmar1Naked Mole-Ratnuclear outer membrane located_inIEAUniRule:UR001553755150520179 UniProtGO_REF:0000104
Sigmar1Naked Mole-Ratnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
Sigmar1Naked Mole-Ratpostsynapse is_active_inISOSigmar1 (Mus musculus)9068941 PMID:20167253SynGOPMID:20167253
Sigmar1Naked Mole-Ratpostsynaptic density located_inISOSIGMAR1 (Homo sapiens)9068941 PMID:23314020UniProtPMID:23314020
Sigmar1Naked Mole-Ratpostsynaptic density located_inISOSigmar1 (Mus musculus)9068941 PMID:20167253UniProtPMID:20167253
1 to 19 of 19 rows

PMID:21993625   PMID:30032202  



Sigmar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,032,517 - 39,035,176 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473639,023,641 - 39,035,180 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SIGMAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,634,722 - 34,637,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,634,722 - 34,637,844 (-)EnsemblGRCh38hg38GRCh38
GRCh37934,634,719 - 34,637,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,624,719 - 34,627,768 (-)NCBINCBI36Build 36hg18NCBI36
Build 34934,624,719 - 34,627,768NCBI
Celera934,566,222 - 34,569,271 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,589,001 - 34,592,050 (-)NCBIHuRef
CHM1_1934,634,494 - 34,637,538 (-)NCBICHM1_1
T2T-CHM13v2.0934,653,268 - 34,656,333 (-)NCBIT2T-CHM13v2.0
Sigmar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,738,493 - 41,741,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,738,493 - 41,756,157 (-)EnsemblGRCm39 Ensembl
GRCm38441,738,493 - 41,741,359 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,738,493 - 41,756,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv37441,685,369 - 41,688,186 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,927,007 - 41,929,824 (-)NCBIMGSCv36mm8
Celera441,399,281 - 41,402,095 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.05NCBI
Sigmar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,700,021 - 61,702,799 (-)NCBIGRCr8
mRatBN7.2556,904,155 - 56,907,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,904,159 - 56,907,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,883,693 - 58,886,471 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,702,523 - 60,705,301 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,688,434 - 60,691,212 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,121,824 - 58,124,687 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,121,786 - 58,124,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,645,887 - 62,648,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,162,537 - 59,165,315 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,162,715 - 59,165,489 (-)NCBI
Celera555,498,271 - 55,501,049 (-)NCBICelera
Cytogenetic Map5q22NCBI
Sigmar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,493,896 - 1,496,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,493,896 - 1,496,377 (+)NCBIChiLan1.0ChiLan1.0
SIGMAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,963,584 - 89,968,985 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,971,824 - 89,974,927 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,471,362 - 34,474,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,280,777 - 35,283,672 (-)NCBIpanpan1.1PanPan1.1panPan2
SIGMAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,310,672 - 51,313,426 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,311,085 - 51,313,400 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,939,025 - 49,941,785 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01152,251,407 - 52,254,167 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,251,413 - 52,311,364 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,914,114 - 50,916,874 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,782,279 - 50,785,039 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,547,030 - 51,549,790 (-)NCBIUU_Cfam_GSD_1.0
Sigmar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,170,303 - 166,173,309 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,715,769 - 2,721,085 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,717,885 - 2,720,874 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIGMAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,160,822 - 32,164,718 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,160,767 - 32,163,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,303,067 - 36,305,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3

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Ensembl Acc Id: ENSHGLT00000011830   ⟹   ENSHGLP00000011702
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473639,032,517 - 39,035,176 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000011831   ⟹   ENSHGLP00000011703
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473639,033,333 - 39,035,072 (-)Ensembl
RefSeq Acc Id: XM_004838438   ⟹   XP_004838495
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473639,033,127 - 39,035,170 (-)NCBI
RefSeq Acc Id: XM_004838439   ⟹   XP_004838496
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473639,023,641 - 39,035,180 (-)NCBI
Protein RefSeqs XP_004838495 (Get FASTA)   NCBI Sequence Viewer  
  XP_004838496 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02674 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011702
GenBank Protein JAN96693 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004838496   ⟸   XM_004838439
- Peptide Label: isoform X1
- UniProtKB: A0AAX6NWF8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004838495   ⟸   XM_004838438
- Peptide Label: isoform X2
- UniProtKB: G5B063 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011702   ⟸   ENSHGLT00000011830
Ensembl Acc Id: ENSHGLP00000011703   ⟸   ENSHGLT00000011831



1 to 10 of 10 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000008389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000011830 ENTREZGENE, UniProtKB/TrEMBL
InterPro ERG2_sigma1_rcpt-like UniProtKB/TrEMBL
KEGG Report hgl:101707150 UniProtKB/TrEMBL
NCBI Gene Sigmar1 ENTREZGENE
PANTHER PTHR10868 UniProtKB/TrEMBL
  SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 UniProtKB/TrEMBL
Pfam ERG2_Sigma1R UniProtKB/TrEMBL
UniProt A0AAX6NWF8 ENTREZGENE, UniProtKB/TrEMBL
  G5B063 ENTREZGENE, UniProtKB/TrEMBL
1 to 10 of 10 rows