Rwdd3 (RWD domain containing 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rwdd3 (RWD domain containing 3) Heterocephalus glaber
Analyze
Symbol: Rwdd3
Name: RWD domain containing 3
RGD ID: 18916010
Description: INVOLVED IN negative regulation of NF-kappaB transcription factor activity (ortholog); positive regulation of hypoxia-inducible factor-1alpha signaling pathway (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: RWD domain-containing protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247422,407,512 - 2,458,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247422,407,055 - 2,420,425 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rwdd3Naked Mole-Ratnegative regulation of NF-kappaB transcription factor activity involved_inISORGD:13145579068941 PMID:23469069UniProtPMID:23469069
Rwdd3Naked Mole-Ratpositive regulation of hypoxia-inducible factor-1alpha signaling pathway involved_inIEAPANTHER:PTN000401729150520179 TreeGrafterGO_REF:0000118
Rwdd3Naked Mole-Ratpositive regulation of hypoxia-inducible factor-1alpha signaling pathway acts_upstream_of_or_withinISORGD:16223219068941 PMID:22009797MGIPMID:22009797
Rwdd3Naked Mole-Ratpositive regulation of hypoxia-inducible factor-1alpha signaling pathway involved_inIEAInterPro:IPR038840150520179 InterProGO_REF:0000002
Rwdd3Naked Mole-Ratpositive regulation of protein sumoylation involved_inIEAInterPro:IPR038840150520179 InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rwdd3Naked Mole-Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
Rwdd3Naked Mole-Ratcytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
Rwdd3Naked Mole-Ratnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
Rwdd3Naked Mole-Ratnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Rwdd3Naked Mole-Ratprotein binding enablesISOUniProtKB:P25963|UniProtKB:P63279|UniProtKB:Q166659068941 PMID:23469069UniProtPMID:23469069
Rwdd3Naked Mole-Ratprotein binding enablesISOUniProtKB:P63165|UniProtKB:P632799068941 PMID:17956732IntActPMID:17956732

PMID:21993625   PMID:22301074   PMID:30032202  



Rwdd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247422,407,512 - 2,458,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247422,407,055 - 2,420,425 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RWDD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,234,155 - 95,247,225 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,234,210 - 95,247,225 (+)EnsemblGRCh38hg38GRCh38
GRCh37195,699,711 - 95,712,781 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,472,299 - 95,485,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 34195,411,787 - 95,424,794NCBI
Celera193,954,133 - 93,967,204 (+)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef193,821,651 - 93,834,724 (+)NCBIHuRef
CHM1_1195,814,224 - 95,827,606 (+)NCBICHM1_1
T2T-CHM13v2.0195,082,240 - 95,095,318 (+)NCBIT2T-CHM13v2.0
Rwdd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393120,949,046 - 120,965,427 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3120,949,047 - 120,965,344 (-)EnsemblGRCm39 Ensembl
GRCm383121,155,397 - 121,171,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,155,398 - 121,171,695 (-)EnsemblGRCm38mm10GRCm38
MGSCv373120,858,318 - 120,874,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363121,163,006 - 121,163,717 (-)NCBIMGSCv36mm8
Celera3127,503,418 - 127,519,689 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
Rwdd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82211,918,361 - 211,933,644 (-)NCBIGRCr8
mRatBN7.22209,233,622 - 209,254,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,233,622 - 209,248,853 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2216,874,398 - 216,890,050 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02214,800,350 - 214,815,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02209,641,329 - 209,657,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02224,710,351 - 224,723,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2224,710,348 - 224,723,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02242,756,616 - 242,769,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42217,738,411 - 217,753,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12217,703,915 - 217,704,175 (-)NCBI
Celera2201,668,749 - 201,684,356 (-)NCBICelera
Cytogenetic Map2q42NCBI
Rwdd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955435398,718 - 412,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955435398,707 - 412,476 (+)NCBIChiLan1.0ChiLan1.0
RWDD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21131,774,332 - 131,792,072 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11130,930,176 - 130,944,559 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,895,972 - 97,909,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,622,134 - 96,634,902 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,622,140 - 96,634,894 (+)Ensemblpanpan1.1panPan2
RWDD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,082,061 - 54,094,218 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,079,751 - 54,086,489 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha656,778,401 - 56,791,978 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0654,451,562 - 54,465,141 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl654,453,931 - 54,465,403 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,126,117 - 54,139,693 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,113,046 - 54,126,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0654,565,794 - 54,579,372 (-)NCBIUU_Cfam_GSD_1.0
Rwdd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,916,011 - 104,928,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365374,017,661 - 4,031,981 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365374,019,337 - 4,031,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RWDD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,187,952 - 122,203,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14122,187,949 - 122,203,146 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24133,994,941 - 133,997,650 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RWDD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,004,334 - 38,021,344 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603380,048,896 - 80,063,445 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000009266   ⟹   ENSHGLP00000009167
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247422,407,512 - 2,458,249 (-)Ensembl
RefSeq Acc Id: XM_004841220   ⟹   XP_004841277
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247422,407,055 - 2,420,424 (-)NCBI
RefSeq Acc Id: XM_013070870   ⟹   XP_012926324
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247422,408,116 - 2,420,425 (-)NCBI
RefSeq Acc Id: XM_021255336   ⟹   XP_021110995
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247422,407,055 - 2,420,425 (-)NCBI
Protein RefSeqs XP_004841277 (Get FASTA)   NCBI Sequence Viewer  
  XP_012926324 (Get FASTA)   NCBI Sequence Viewer  
  XP_021110995 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB01245 (Get FASTA)   NCBI Sequence Viewer  
  JAN97295 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021110995   ⟸   XM_021255336
- Peptide Label: isoform X1
- UniProtKB: A0AAX6ST02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004841277   ⟸   XM_004841220
- Peptide Label: isoform X2
- UniProtKB: G5AW34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012926324   ⟸   XM_013070870
- Peptide Label: isoform X3
- UniProtKB: A0AAX6QUR1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000009167   ⟸   ENSHGLT00000009266



1 to 16 of 16 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000006587 Ensembl
Gene3D-CATH 3.10.110.10 UniProtKB/TrEMBL
InterPro RWD-domain UniProtKB/TrEMBL
  RWDD3 UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/TrEMBL
KEGG Report hgl:101697798 UniProtKB/TrEMBL
NCBI Gene Rwdd3 ENTREZGENE
PANTHER PTHR15628 UniProtKB/TrEMBL
  RWD DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam RWD UniProtKB/TrEMBL
PROSITE RWD UniProtKB/TrEMBL
SMART RWD UniProtKB/TrEMBL
Superfamily-SCOP SSF54495 UniProtKB/TrEMBL
UniProt A0AAX6QUR1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6ST02 ENTREZGENE, UniProtKB/TrEMBL
  G5AW34 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows