Isx (intestine specific homeobox) - Rat Genome Database

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Gene: Isx (intestine specific homeobox) Heterocephalus glaber
Analyze
Symbol: Isx
Name: intestine specific homeobox
RGD ID: 18912563
Description: ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of intestinal absorption (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: intestine-specific homeobox
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750468,316 - 482,716 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750460,058 - 483,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Isx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750468,316 - 482,716 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750460,058 - 483,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ISX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,066,158 - 35,087,387 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,066,136 - 35,087,387 (+)EnsemblGRCh38hg38GRCh38
GRCh372235,462,151 - 35,483,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,792,130 - 33,813,380 (+)NCBINCBI36Build 36hg18NCBI36
Celera2219,264,831 - 19,286,082 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,424,658 - 18,445,908 (+)NCBIHuRef
CHM1_12235,420,993 - 35,442,242 (+)NCBICHM1_1
T2T-CHM13v2.02235,524,914 - 35,546,195 (+)NCBIT2T-CHM13v2.0
Isx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,599,326 - 75,620,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl875,599,801 - 75,620,134 (+)EnsemblGRCm39 Ensembl
GRCm38874,873,174 - 74,893,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl874,873,173 - 74,893,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,397,073 - 77,417,405 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36877,768,789 - 77,789,578 (+)NCBIMGSCv36mm8
Celera879,169,160 - 79,189,471 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.54NCBI
Isx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,222,834 - 13,245,506 (+)NCBIGRCr8
mRatBN7.21913,217,637 - 13,239,754 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,218,552 - 13,239,760 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,192,658 - 13,214,362 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01913,957,905 - 13,979,607 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,239,598 - 13,260,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,198,899 - 14,219,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,198,899 - 14,218,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,312,031 - 25,333,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1913,089,232 - 13,110,157 (+)NCBICelera
Cytogenetic Map19p11NCBI
Isx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540542,979,063 - 43,015,561 (+)NCBIChiLan1.0ChiLan1.0
ISX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,004,839 - 45,026,076 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12247,701,590 - 47,722,834 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,071,117 - 16,095,029 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12233,917,642 - 33,938,908 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2233,917,642 - 33,938,908 (+)Ensemblpanpan1.1panPan2
ISX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,993,515 - 29,011,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,993,795 - 29,011,640 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,929,188 - 28,948,497 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,779,524 - 29,798,838 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,779,924 - 29,797,781 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,503,201 - 29,522,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,811,951 - 29,831,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,991,729 - 30,011,036 (-)NCBIUU_Cfam_GSD_1.0
Isx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,234,407 - 12,250,365 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364925,245,211 - 5,265,419 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364925,245,211 - 5,265,419 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.259,957,450 - 9,975,312 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11917,827,274 - 17,850,296 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1917,828,177 - 17,852,069 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045108,100,487 - 108,122,703 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004845064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01030291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000021587   ⟹   ENSHGLP00000021378
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624750468,316 - 482,716 (-)Ensembl
RefSeq Acc Id: XM_004845064   ⟹   XP_004845121
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624750460,058 - 483,303 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004845121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021378
Reference Protein Sequences
RefSeq Acc Id: XP_004845121   ⟸   XM_004845064
- UniProtKB: G5BPE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000021378   ⟸   ENSHGLT00000021587


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015276 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021587 ENTREZGENE
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
NCBI Gene Isx ENTREZGENE
PANTHER HOMEOBOX PROTEIN ARISTALESS UniProtKB/TrEMBL
  INTESTINE-SPECIFIC HOMEOBOX UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain-like UniProtKB/TrEMBL
UniProt G5BPE7 ENTREZGENE, UniProtKB/TrEMBL