Isx (intestine specific homeobox) - Rat Genome Database
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Gene: Isx (intestine specific homeobox) Mus musculus
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Symbol: Isx
Name: intestine specific homeobox
RGD ID: 1623943
MGI Page MGI
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of intestinal absorption; regulation of transcription by RNA polymerase II; and regulation of vitamin A metabolic process. Predicted to localize to nuclear chromatin. Is expressed in genitourinary system; midgut; and thymus. Orthologous to human ISX (intestine specific homeobox); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9130012O13Rik; intestine-specific homeobox; pancreas-intestine homeodomain transcription factor; Pix-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,599,802 - 75,620,134 (+)NCBIGRCm39mm39
GRCm38874,873,174 - 74,893,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl874,873,173 - 74,893,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,397,073 - 77,417,405 (+)NCBIGRCm37mm9NCBIm37
MGSCv36877,768,789 - 77,789,578 (+)NCBImm8
Celera879,169,160 - 79,189,471 (+)NCBICelera
Cytogenetic Map8C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15618518   PMID:16141072   PMID:16141073   PMID:16971476   PMID:18093975   PMID:18287559  
PMID:20059953   PMID:20932939   PMID:21267068   PMID:21873635   PMID:23393141   PMID:24005908   PMID:24952961   PMID:25701869   PMID:29073082   PMID:29463648   PMID:29882710  


Genomics

Comparative Map Data
Isx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,599,802 - 75,620,134 (+)NCBIGRCm39mm39
GRCm38874,873,174 - 74,893,506 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl874,873,173 - 74,893,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,397,073 - 77,417,405 (+)NCBIGRCm37mm9NCBIm37
MGSCv36877,768,789 - 77,789,578 (+)NCBImm8
Celera879,169,160 - 79,189,471 (+)NCBICelera
Cytogenetic Map8C1NCBI
ISX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2235,066,136 - 35,087,387 (+)EnsemblGRCh38hg38GRCh38
GRCh382235,066,158 - 35,087,387 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372235,462,130 - 35,483,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,792,130 - 33,813,380 (+)NCBINCBI36hg18NCBI36
Celera2219,264,831 - 19,286,082 (+)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2218,424,658 - 18,445,908 (+)NCBIHuRef
CHM1_12235,420,992 - 35,442,242 (+)NCBICHM1_1
Isx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01914,198,899 - 14,219,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,198,899 - 14,218,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,312,031 - 25,333,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1913,089,232 - 13,110,157 (+)NCBICelera
Cytogenetic Map19p11NCBI
Isx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540542,979,063 - 43,015,561 (+)NCBIChiLan1.0ChiLan1.0
ISX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12233,917,642 - 33,938,908 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2233,917,642 - 33,938,908 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02216,071,117 - 16,095,029 (+)NCBIMhudiblu_PPA_v0panPan3
ISX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1028,993,795 - 29,011,640 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11028,993,515 - 29,011,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Isx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364925,245,211 - 5,265,419 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.259,957,450 - 9,975,312 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11917,827,274 - 17,850,296 (+)NCBI
ChlSab1.1 Ensembl1917,828,177 - 17,852,069 (+)Ensembl
Isx
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624750460,058 - 483,303 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:442
Count of miRNA genes:289
Interacting mature miRNAs:323
Transcripts:ENSMUST00000034034, ENSMUST00000174427
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034034   ⟹   ENSMUSP00000034034
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl874,873,173 - 74,893,506 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174427   ⟹   ENSMUSP00000134368
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl874,873,540 - 74,893,147 (+)Ensembl
RefSeq Acc Id: NM_001294278   ⟹   NP_001281207
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39875,599,802 - 75,620,134 (+)NCBI
GRCm38874,873,174 - 74,893,506 (+)NCBI
Celera879,169,160 - 79,189,471 (+)NCBI
Sequence:
RefSeq Acc Id: NM_027837   ⟹   NP_082113
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39875,599,802 - 75,620,134 (+)NCBI
GRCm38874,873,174 - 74,893,506 (+)NCBI
MGSCv37877,397,073 - 77,417,405 (+)RGD
Celera879,169,160 - 79,189,471 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082113   ⟸   NM_027837
- Peptide Label: isoform 2
- UniProtKB: A1A546 (UniProtKB/Swiss-Prot),   B1Q2M1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001281207   ⟸   NM_001294278
- Peptide Label: isoform 1
- UniProtKB: A1A546 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034034   ⟸   ENSMUST00000034034
RefSeq Acc Id: ENSMUSP00000134368   ⟸   ENSMUST00000174427

Promoters
RGD ID:8667523
Promoter ID:EPDNEW_M11779
Type:initiation region
Name:Isx_1
Description:Mus musculus intestine specific homeobox , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38874,873,205 - 74,873,265EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918847 AgrOrtholog
Ensembl Genes ENSMUSG00000031621 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034034 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134368 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034034 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000174427 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71597 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1918847 ENTREZGENE
NCBI Gene 71597 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Isx PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.158735 ENTREZGENE
UniProt A1A546 ENTREZGENE
  B1Q2M1 ENTREZGENE, UniProtKB/TrEMBL
  ISX_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A1A545 UniProtKB/Swiss-Prot
  Q9D2Z0 UniProtKB/Swiss-Prot