Iapp (islet amyloid polypeptide) - Rat Genome Database

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Gene: Iapp (islet amyloid polypeptide) Heterocephalus glaber
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Symbol: Iapp
Name: islet amyloid polypeptide
RGD ID: 18908340
Description: ENCODES a protein that exhibits identical protein binding (ortholog); lipid binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); amylin receptor 1 signaling pathway (ortholog); amylin receptor 2 signaling pathway (ortholog); ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); gastric ulcer (ortholog); type 1 diabetes mellitus (ortholog); FOUND IN extracellular space (ortholog); inclusion body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,584,225 - 17,593,693 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475217,528,214 - 17,594,622 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Iapp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,584,225 - 17,593,693 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475217,528,214 - 17,594,622 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IAPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,354,959 - 21,379,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,354,959 - 21,379,980 (+)EnsemblGRCh38hg38GRCh38
GRCh371221,507,893 - 21,532,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,417,085 - 21,423,683 (+)NCBINCBI36Build 36hg18NCBI36
Build 341221,417,084 - 21,423,683NCBI
Celera1226,681,196 - 26,688,308 (+)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,299,907 - 21,307,017 (+)NCBIHuRef
CHM1_11221,491,270 - 21,498,381 (+)NCBICHM1_1
T2T-CHM13v2.01221,233,632 - 21,258,654 (+)NCBIT2T-CHM13v2.0
Iapp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,244,151 - 142,249,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,244,149 - 142,249,687 (+)EnsemblGRCm39 Ensembl
GRCm386142,298,425 - 142,303,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,298,423 - 142,303,961 (+)EnsemblGRCm38mm10GRCm38
MGSCv376142,246,945 - 142,252,340 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,255,650 - 142,261,039 (+)NCBIMGSCv36mm8
Celera6145,357,925 - 145,363,320 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map673.81NCBI
Iapp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84176,968,097 - 176,975,363 (+)NCBIGRCr8
mRatBN7.24175,237,107 - 175,244,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,237,115 - 175,242,920 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,532,318 - 181,537,233 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,316,585 - 177,321,500 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04175,937,142 - 175,942,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
RH 3.4 Map41043.4RGD
Cytogenetic Map4q44NCBI
Iapp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,835,037 - 16,840,682 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,834,940 - 16,841,071 (-)NCBIChiLan1.0ChiLan1.0
IAPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21075,425,109 - 75,432,306 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11275,421,507 - 75,428,704 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,918,000 - 64,925,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,520,986 - 67,528,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,520,986 - 67,528,103 (-)Ensemblpanpan1.1panPan2
IAPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12726,295,481 - 26,299,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2726,295,481 - 26,299,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2720,156,535 - 20,161,021 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02726,621,265 - 26,625,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2726,621,265 - 26,625,751 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12726,484,470 - 26,488,955 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02726,462,824 - 26,467,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02719,861,411 - 19,865,898 (+)NCBIUU_Cfam_GSD_1.0
Iapp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,540,811 - 87,546,687 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365485,463,828 - 5,469,139 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365485,463,829 - 5,469,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IAPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,046,573 - 52,050,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,046,570 - 52,051,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,323,381 - 55,327,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IAPP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,240,947 - 21,247,409 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,241,514 - 21,247,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,897,267 - 13,904,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000019276   ⟹   ENSHGLP00000019085
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475217,584,225 - 17,593,693 (+)Ensembl
RefSeq Acc Id: XM_004845781   ⟹   XP_004845838
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475217,586,456 - 17,594,622 (+)NCBI
RefSeq Acc Id: XM_021259121   ⟹   XP_021114780
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475217,528,214 - 17,594,622 (+)NCBI
RefSeq Acc Id: XR_002395352
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475217,528,214 - 17,529,387 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004845838 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019085
  ENSHGLP00100000133
GenBank Protein JAN96067 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021114780   ⟸   XM_021259121
- UniProtKB: A0A0P6J1R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845838   ⟸   XM_004845781
- UniProtKB: A0A0P6J1R0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000019085   ⟸   ENSHGLT00000019276


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013677 Ensembl, ENTREZGENE
  ENSHGLG00100000122 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000019276 ENTREZGENE
  ENSHGLT00100000157 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2190 UniProtKB/TrEMBL
InterPro Calcitonin-like UniProtKB/TrEMBL
  Calcitonin/adrenomedullin UniProtKB/TrEMBL
  Calcitonin_peptide-like UniProtKB/TrEMBL
  IAPP UniProtKB/TrEMBL
KEGG Report hgl:101702167 UniProtKB/TrEMBL
NCBI Gene Iapp ENTREZGENE
PANTHER PTHR10505 UniProtKB/TrEMBL
  PTHR10505:SF4 UniProtKB/TrEMBL
Pfam Calc_CGRP_IAPP UniProtKB/TrEMBL
PRINTS ISLETAMYLOID UniProtKB/TrEMBL
SMART CALCITONIN UniProtKB/TrEMBL
UniProt A0A0P6J1R0 ENTREZGENE, UniProtKB/TrEMBL