IAPP (islet amyloid polypeptide) - Rat Genome Database
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Gene: IAPP (islet amyloid polypeptide) Sus scrofa
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Symbol: IAPP
Name: islet amyloid polypeptide
RGD ID: 14240913
Description: ENCODES a protein that exhibits hormone activity (inferred); identical protein binding (inferred); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); amylin receptor signaling pathway (ortholog); amyloid fibril formation (ortholog); ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); gastric ulcer (ortholog); type 1 diabetes mellitus (ortholog); FOUND IN extracellular space (ortholog); inclusion body (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: Amylin
Orthologs:
Homo sapiens (human) : IAPP (islet amyloid polypeptide)  HGNC  Alliance
Mus musculus (house mouse) : Iapp (islet amyloid polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Iapp (islet amyloid polypeptide)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iapp (islet amyloid polypeptide)
Pan paniscus (bonobo/pygmy chimpanzee) : IAPP (islet amyloid polypeptide)
Canis lupus familiaris (dog) : IAPP (islet amyloid polypeptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iapp (islet amyloid polypeptide)
Chlorocebus sabaeus (African green monkey) : IAPP (islet amyloid polypeptide)
Heterocephalus glaber (naked mole-rat) : Iapp (islet amyloid polypeptide)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,046,573 - 52,050,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,046,570 - 52,051,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,323,381 - 55,327,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:20160085   PMID:21130765  


Genomics

Comparative Map Data
IAPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,046,573 - 52,050,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,046,570 - 52,051,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,323,381 - 55,327,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IAPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1221,354,959 - 21,379,980 (+)EnsemblGRCh38hg38GRCh38
GRCh381221,354,959 - 21,379,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371221,525,802 - 21,532,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,417,085 - 21,423,683 (+)NCBINCBI36hg18NCBI36
Build 341221,417,084 - 21,423,683NCBI
Celera1226,681,196 - 26,688,308 (+)NCBI
Cytogenetic Map12p12.1NCBI
HuRef1221,299,907 - 21,307,017 (+)NCBIHuRef
CHM1_11221,491,270 - 21,498,381 (+)NCBICHM1_1
Iapp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,244,151 - 142,249,546 (+)NCBI
GRCm386142,298,425 - 142,303,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,298,423 - 142,303,961 (+)EnsemblGRCm38mm10GRCm38
MGSCv376142,246,945 - 142,252,340 (+)NCBIGRCm37mm9NCBIm37
MGSCv366142,255,650 - 142,261,039 (+)NCBImm8
Celera6145,357,925 - 145,363,320 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map673.81NCBI
Iapp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
Cytogenetic Map4q44NCBI
RH 3.4 Map41043.4RGD
Iapp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,835,037 - 16,840,682 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,834,940 - 16,841,071 (-)NCBIChiLan1.0ChiLan1.0
IAPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11267,520,986 - 67,528,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,520,986 - 67,528,103 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01264,918,000 - 64,925,191 (-)NCBIMhudiblu_PPA_v0panPan3
IAPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2726,295,481 - 26,299,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12726,295,481 - 26,299,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Iapp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365485,463,829 - 5,469,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IAPP
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1121,241,514 - 21,247,207 (+)Ensembl
ChlSab1.11121,240,947 - 21,247,409 (+)NCBI
Iapp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475217,528,214 - 17,594,622 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system reproductive system respiratory system
High
Medium 10 1
Low 1 11 1
Below cutoff 4 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000059687   ⟹   ENSSSCP00000046960
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl552,046,573 - 52,050,446 (-)Ensembl
RefSeq Acc Id: XM_003126437   ⟹   XP_003126485
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1552,046,570 - 52,050,494 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002344089
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1552,046,570 - 52,051,475 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003126485 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB05919 (Get FASTA)   NCBI Sequence Viewer  
  ADD13605 (Get FASTA)   NCBI Sequence Viewer  
  Q29119 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003126485   ⟸   XM_003126437
- UniProtKB: A0A287ASB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000046960   ⟸   ENSSSCT00000059687
Protein Domains
CALCITONIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000582 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070023727 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000046960 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070039929 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000059687 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070047323 UniProtKB/TrEMBL
InterPro Calcitonin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcitonin_peptide-like UniProtKB/TrEMBL
  Pro-islet_amyloid_polypep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100520838 UniProtKB/TrEMBL
NCBI Gene IAPP ENTREZGENE
PANTHER PTHR10505 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10505:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ISLETAMYLOID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CALCITONIN UniProtKB/TrEMBL
UniGene Ssc.8324 ENTREZGENE
UniProt A0A287ASB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VGM3_PIG UniProtKB/TrEMBL
  D3Y4D2_PIG UniProtKB/TrEMBL
  IAPP_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:89015 ENTREZGENE