Slc46a1 (solute carrier family 46 member 1) - Rat Genome Database

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Gene: Slc46a1 (solute carrier family 46 member 1) Heterocephalus glaber
Analyze
Symbol: Slc46a1
Name: solute carrier family 46 member 1
RGD ID: 18902698
Description: ENCODES a protein that exhibits folic acid transmembrane transporter activity (ortholog); folic acid:proton symporter activity (ortholog); heme transmembrane transporter activity (ortholog); INVOLVED IN folate import across plasma membrane (ortholog); folate transmembrane transport (ortholog); folic acid transport (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate metabolic pathway; ASSOCIATED WITH anemia (ortholog); chronic kidney disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN basolateral plasma membrane (ortholog); brush border membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Proton-coupled folate transporter
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,000,444 - 1,007,375 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,000,444 - 1,006,984 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc46a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,000,444 - 1,007,375 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,000,444 - 1,006,984 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SLC46A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,394,642 - 28,406,592 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,394,642 - 28,407,197 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,721,661 - 26,733,230 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,745,788 - 23,757,355 (-)NCBINCBI36Build 36hg18NCBI36
Celera1723,583,422 - 23,594,992 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,930,003 - 22,941,574 (-)NCBIHuRef
CHM1_11726,784,574 - 26,796,145 (-)NCBICHM1_1
T2T-CHM13v2.01729,336,494 - 29,348,065 (-)NCBIT2T-CHM13v2.0
Slc46a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,356,527 - 78,362,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,356,523 - 78,362,885 (+)EnsemblGRCm39 Ensembl
GRCm381178,465,701 - 78,471,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,465,697 - 78,472,059 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,279,203 - 78,285,447 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,281,913 - 78,288,125 (+)NCBIMGSCv36mm8
Celera1188,097,777 - 88,104,021 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Slc46a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,859,551 - 63,865,987 (+)NCBIGRCr8
mRatBN7.21063,361,504 - 63,367,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,361,486 - 63,368,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,994,160 - 68,000,596 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,499,487 - 67,505,923 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,969,164 - 62,975,602 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,728,508 - 65,741,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,733,991 - 65,740,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,902,790 - 65,915,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,576,068 - 64,582,504 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,589,690 - 64,596,123 (+)NCBI
Celera1062,338,075 - 62,344,511 (+)NCBICelera
Cytogenetic Map10q25NCBI
Slc46a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,734,967 - 4,745,586 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,735,325 - 4,741,810 (+)NCBIChiLan1.0ChiLan1.0
SLC46A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,052,013 - 36,063,812 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,932,238 - 37,944,182 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,367,674 - 28,379,618 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,870,678 - 28,877,632 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,870,678 - 28,877,632 (+)Ensemblpanpan1.1panPan2
SLC46A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,638,670 - 42,650,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,643,328 - 42,650,188 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,795,562 - 41,807,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,457,810 - 43,469,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,457,858 - 43,469,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,241,834 - 42,252,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,533,057 - 42,544,655 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,610,324 - 42,621,857 (-)NCBIUU_Cfam_GSD_1.0
Slc46a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,671,087 - 41,763,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,549,599 - 4,555,415 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,549,032 - 4,642,870 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC46A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,677,502 - 44,686,250 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,677,499 - 44,686,277 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21833,258 - 42,053 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC46A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,164,661 - 22,173,376 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,166,318 - 22,173,240 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,954,712 - 7,965,674 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000023622   ⟹   ENSHGLP00000023405
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247861,000,444 - 1,007,375 (-)Ensembl
RefSeq Acc Id: XM_004856983   ⟹   XP_004857040
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247861,000,444 - 1,006,984 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004857040 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB13306 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023405
  ENSHGLP00100056809
GenBank Protein JAO00516 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004857040   ⟸   XM_004856983
- UniProtKB: A0A0P6JA16 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000023405   ⟸   ENSHGLT00000023622


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016685 Ensembl, ENTREZGENE
  ENSHGLG00100016381 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000023622 ENTREZGENE
  ENSHGLT00100053207 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
NCBI Gene Slc46a1 ENTREZGENE
PANTHER PROTON-COUPLED FOLATE TRANSPORTER UniProtKB/TrEMBL
  ZGC:174356 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A0P6JA16 ENTREZGENE, UniProtKB/TrEMBL