SLC46A1 (solute carrier family 46 member 1) - Rat Genome Database

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Gene: SLC46A1 (solute carrier family 46 member 1) Canis lupus familiaris
Analyze
Symbol: SLC46A1
Name: solute carrier family 46 member 1
RGD ID: 12159922
Description: ENCODES a protein that exhibits heme transmembrane transporter activity (ortholog); INVOLVED IN folate import across plasma membrane (inferred); folate transmembrane transport (inferred); folic acid transport (inferred); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate metabolic pathway; ASSOCIATED WITH anemia (ortholog); chronic kidney disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN basolateral plasma membrane (ortholog); brush border membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proton-coupled folate transporter
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,638,670 - 42,650,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,643,328 - 42,650,188 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,795,562 - 41,807,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,457,810 - 43,469,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,457,858 - 43,469,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,241,834 - 42,252,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,533,057 - 42,544,655 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,610,324 - 42,621,857 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC46A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,638,670 - 42,650,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,643,328 - 42,650,188 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,795,562 - 41,807,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,457,810 - 43,469,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,457,858 - 43,469,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,241,834 - 42,252,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,533,057 - 42,544,655 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,610,324 - 42,621,857 (-)NCBIUU_Cfam_GSD_1.0
SLC46A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,394,642 - 28,406,592 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,394,642 - 28,407,197 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,721,661 - 26,733,230 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,745,788 - 23,757,355 (-)NCBINCBI36Build 36hg18NCBI36
Celera1723,583,422 - 23,594,992 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,930,003 - 22,941,574 (-)NCBIHuRef
CHM1_11726,784,574 - 26,796,145 (-)NCBICHM1_1
T2T-CHM13v2.01729,336,494 - 29,348,065 (-)NCBIT2T-CHM13v2.0
Slc46a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,356,527 - 78,362,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,356,523 - 78,362,885 (+)EnsemblGRCm39 Ensembl
GRCm381178,465,701 - 78,471,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,465,697 - 78,472,059 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,279,203 - 78,285,447 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,281,913 - 78,288,125 (+)NCBIMGSCv36mm8
Celera1188,097,777 - 88,104,021 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Slc46a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,859,551 - 63,865,987 (+)NCBIGRCr8
mRatBN7.21063,361,504 - 63,367,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,361,486 - 63,368,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,994,160 - 68,000,596 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,499,487 - 67,505,923 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,969,164 - 62,975,602 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,728,508 - 65,741,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,733,991 - 65,740,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,902,790 - 65,915,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,576,068 - 64,582,504 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,589,690 - 64,596,123 (+)NCBI
Celera1062,338,075 - 62,344,511 (+)NCBICelera
Cytogenetic Map10q25NCBI
Slc46a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,734,967 - 4,745,586 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,735,325 - 4,741,810 (+)NCBIChiLan1.0ChiLan1.0
SLC46A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,052,013 - 36,063,812 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,932,238 - 37,944,182 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,367,674 - 28,379,618 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,870,678 - 28,877,632 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,870,678 - 28,877,632 (+)Ensemblpanpan1.1panPan2
Slc46a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,671,087 - 41,763,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,549,599 - 4,555,415 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,549,032 - 4,642,870 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC46A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,677,502 - 44,686,250 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,677,499 - 44,686,277 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21833,258 - 42,053 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC46A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,164,661 - 22,173,376 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,166,318 - 22,173,240 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,954,712 - 7,965,674 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc46a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,000,444 - 1,007,375 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,000,444 - 1,006,984 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC46A1
153 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 20 6 1 6 6 7 8 2
Low 2 5 2 5 6 5 8 2 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000029653   ⟹   ENSCAFP00000027559
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,643,328 - 42,650,188 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076827   ⟹   ENSCAFP00000053705
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,643,328 - 42,650,188 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013033   ⟹   ENSCAFP00845010154
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,457,858 - 43,469,603 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013067   ⟹   ENSCAFP00845010174
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,457,858 - 43,469,603 (-)Ensembl
RefSeq Acc Id: XM_003435306   ⟹   XP_003435354
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,638,670 - 42,650,241 (-)NCBI
Dog10K_Boxer_Tasha941,795,562 - 41,807,087 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038486394   ⟹   XP_038342322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1942,241,834 - 42,252,876 (-)NCBI
RefSeq Acc Id: XM_038548232   ⟹   XP_038404160
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0942,610,324 - 42,621,857 (-)NCBI
RefSeq Acc Id: XM_038612198   ⟹   XP_038468126
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0942,533,057 - 42,544,655 (-)NCBI
RefSeq Acc Id: XM_038677455   ⟹   XP_038533383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0943,457,810 - 43,469,341 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003435354   ⟸   XM_003435306
- UniProtKB: A0A8C0Z2T9 (UniProtKB/TrEMBL),   A0A8C0KG29 (UniProtKB/TrEMBL),   A0A8I3N1L5 (UniProtKB/TrEMBL),   A0A8C0TAH1 (UniProtKB/TrEMBL),   A0A8I3N5N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000027559   ⟸   ENSCAFT00000029653
RefSeq Acc Id: ENSCAFP00000053705   ⟸   ENSCAFT00000076827
RefSeq Acc Id: XP_038342322   ⟸   XM_038486394
RefSeq Acc Id: XP_038468126   ⟸   XM_038612198
RefSeq Acc Id: XP_038533383   ⟸   XM_038677455
- UniProtKB: A0A8C0Z2T9 (UniProtKB/TrEMBL),   A0A8C0KG29 (UniProtKB/TrEMBL),   A0A8I3N1L5 (UniProtKB/TrEMBL),   A0A8C0TAH1 (UniProtKB/TrEMBL),   A0A8I3N5N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404160   ⟸   XM_038548232
- UniProtKB: A0A8C0KG29 (UniProtKB/TrEMBL),   A0A8C0TAH1 (UniProtKB/TrEMBL),   A0A8C0Z2T9 (UniProtKB/TrEMBL),   A0A8I3N1L5 (UniProtKB/TrEMBL),   A0A8I3N5N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845010154   ⟸   ENSCAFT00845013033
RefSeq Acc Id: ENSCAFP00845010174   ⟸   ENSCAFT00845013067

Promoters
RGD ID:13684673
Promoter ID:EPDNEW_C2741
Type:multiple initiation site
Name:SLC46A1_1
Description:solute carrier family 46 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,650,237 - 42,650,297EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018682 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013583 UniProtKB/TrEMBL
  ENSCAFG00040020297 UniProtKB/TrEMBL
  ENSCAFG00845007379 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029653.5 UniProtKB/TrEMBL
  ENSCAFT00030025212.1 UniProtKB/TrEMBL
  ENSCAFT00030025269.1 UniProtKB/TrEMBL
  ENSCAFT00040037581.1 UniProtKB/TrEMBL
  ENSCAFT00040037617.1 UniProtKB/TrEMBL
  ENSCAFT00845013033 ENTREZGENE
  ENSCAFT00845013033.1 UniProtKB/TrEMBL
  ENSCAFT00845013067.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
KEGG Report cfa:491166 UniProtKB/TrEMBL
NCBI Gene SLC46A1 ENTREZGENE
PANTHER PROTON-COUPLED FOLATE TRANSPORTER UniProtKB/TrEMBL
  ZGC:174356 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PROSITE SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A8C0KG29 ENTREZGENE
  A0A8C0TAH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z2T9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N1L5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N5N9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46426 ENTREZGENE