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Gene: TIAM2 (TIAM Rac1 associated GEF 2) Chlorocebus sabaeus

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Symbol:

TIAM2

Name:

TIAM Rac1 associated GEF 2

RGD ID:

18793345

Description:

ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN intracellular signal transduction (inferred); signal transduction (inferred); small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH chromosome 6q24-q25 deletion syndrome (ortholog); substance-related disorder (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

T cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	82,537,021 - 82,823,525 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	82,688,773 - 82,822,949 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	54,926,150 - 55,198,751 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TIAM2	Green Monkey	chromosome 6q24-q25 deletion syndrome		ISO	TIAM2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 6q24-q25 deletion syndrome	ClinVar	PMID:25741868 and PMID:38177409

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TIAM2	Green Monkey	substance-related disorder		ISO	TIAM2 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:20098672

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TIAM2	Green Monkey	intracellular signal transduction	involved_in	IEA	InterPro:IPR001331	150520179		InterPro	GO_REF:0000002
TIAM2	Green Monkey	signal transduction	involved_in	IEA	InterPro:IPR003116	150520179		InterPro	GO_REF:0000002
TIAM2	Green Monkey	small GTPase-mediated signal transduction	involved_in	IEA	InterPro:IPR043537	150520179		InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TIAM2	Green Monkey	cytoplasm	located_in	IEA	UniProtKB:Q6ZPF3 and ensembl:ENSMUSP00000072020	150520179		Ensembl	GO_REF:0000107
TIAM2	Green Monkey	membrane	located_in	IEA	UniProtKB:Q6ZPF3 and ensembl:ENSMUSP00000072020	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
TIAM2	Green Monkey	GTPase activator activity	enables	IEA	UniProtKB:Q6ZPF3 and ensembl:ENSMUSP00000072020	150520179		Ensembl	GO_REF:0000107
TIAM2	Green Monkey	guanyl-nucleotide exchange factor activity	enables	IEA	InterPro:IPR000219 more ...	150520179		InterPro	GO_REF:0000002
TIAM2	Green Monkey	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB-KW:KW-0344	150520179		UniProt	GO_REF:0000043
TIAM2	Green Monkey	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB:Q6ZPF3 and ensembl:ENSMUSP00000072020	150520179		Ensembl	GO_REF:0000107
TIAM2	Green Monkey	protein binding	enables	ISO	UniProtKB:P15379 more ...	9068941	PMID:19893486	IntAct	PMID:19893486
TIAM2	Green Monkey	protein binding	enables	ISO	UniProtKB:P15154	9068941	PMID:10364228	MGI	PMID:10364228

PMID:22301074	PMID:30032202

TIAM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	82,537,021 - 82,823,525 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	82,688,773 - 82,822,949 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	54,926,150 - 55,198,751 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TIAM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	154,995,315 - 155,257,723 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	154,832,697 - 155,257,723 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	155,316,449 - 155,578,857 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	155,453,115 - 155,620,549 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	155,540,736 - 155,670,437	NCBI
Celera	6	156,145,600 - 156,313,154 (+)	NCBI		Celera
Cytogenetic Map	6	q25.2-q25.3	NCBI
HuRef	6	152,973,625 - 153,141,133 (+)	NCBI		HuRef
CHM1_1	6	155,674,081 - 155,841,472 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	156,197,278 - 156,459,744 (+)	NCBI		T2T-CHM13v2.0

Tiam2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	3,376,675 - 3,569,672 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	3,376,848 - 3,581,619 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	3,326,313 - 3,519,397 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	3,326,573 - 3,531,344 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	3,326,573 - 3,519,397 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	3,353,689 - 3,475,879 (+)	NCBI		MGSCv36	mm8
Celera	17	3,867,789 - 4,054,192 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	1.99	NCBI

Tiam2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	46,323,450 - 46,524,769 (+)	NCBI		GRCr8
mRatBN7.2	1	43,918,179 - 44,119,499 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	43,918,174 - 44,119,493 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	44,232,520 - 44,433,450 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	44,311,513 - 44,433,193 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	45,562,714 - 45,763,294 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	38,479,385 - 38,514,359 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	39,555,701 - 39,754,110 (+)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

Tiam2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	6,939,563 - 7,067,507 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	6,942,702 - 7,147,145 (-)	NCBI	ChiLan1.0	ChiLan1.0

TIAM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	175,016,172 - 175,281,087 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	172,907,831 - 173,172,685 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	152,809,716 - 153,074,427 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	158,774,096 - 159,038,777 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	158,902,783 - 159,038,777 (+)	Ensembl	panpan1.1		panPan2

TIAM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	44,897,699 - 45,001,094 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	44,870,103 - 45,002,684 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	45,707,011 - 45,838,149 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	45,062,854 - 45,184,503 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	45,053,768 - 45,184,501 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	44,920,794 - 45,051,675 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	44,792,357 - 44,923,421 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	45,357,659 - 45,479,661 (+)	NCBI		UU_Cfam_GSD_1.0

Tiam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	140,110,602 - 140,212,560 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	7,362,598 - 7,465,076 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	7,336,078 - 7,464,553 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TIAM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	11,648,508 - 11,759,348 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	11,648,506 - 11,897,869 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	13,622,596 - 13,664,877 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tiam2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624785	3,086,449 - 3,192,680 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624785	3,085,876 - 3,303,006 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in TIAM2
7950 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20


RefSeq Transcripts	XM_008007663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008007664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038001128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038001129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038001130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038001131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038001132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011358 ⟹ ENSCSAP00000009432

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	13	82,688,773 - 82,822,949 (+)	Ensembl

RefSeq Acc Id:

XM_038001128 ⟹ XP_037857056

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666040	54,926,194 - 55,198,751 (+)	NCBI

RefSeq Acc Id:

XM_038001129 ⟹ XP_037857057

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666040	55,014,996 - 55,198,445 (+)	NCBI

RefSeq Acc Id:

XM_038001130 ⟹ XP_037857058

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666040	55,044,718 - 55,198,445 (+)	NCBI

RefSeq Acc Id:

XM_038001131 ⟹ XP_037857059

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666040	55,156,053 - 55,198,751 (+)	NCBI

RefSeq Acc Id:

XM_038001132 ⟹ XP_037857060

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666040	54,926,150 - 55,198,751 (+)	NCBI


Protein RefSeqs	XP_037857056	(Get FASTA)	NCBI Sequence Viewer
	XP_037857057	(Get FASTA)	NCBI Sequence Viewer
	XP_037857058	(Get FASTA)	NCBI Sequence Viewer
	XP_037857059	(Get FASTA)	NCBI Sequence Viewer
	XP_037857060	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009432.1

Ensembl Acc Id:

ENSCSAP00000009432 ⟸ ENSCSAT00000011358

RefSeq Acc Id:	XP_037857060 ⟸ XM_038001132
- Peptide Label:	isoform X3
- UniProtKB:	A0A0D9RLE3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037857056 ⟸ XM_038001128
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RLE3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037857057 ⟸ XM_038001129
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RLE3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037857058 ⟸ XM_038001130
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RLE3 (UniProtKB/TrEMBL)

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013369	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011358.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.900.10	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
	6.10.140.680	UniProtKB/TrEMBL
InterPro	DBL_dom_sf	UniProtKB/TrEMBL
	DH-domain	UniProtKB/TrEMBL
	GDS_CDC24_CS	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	PH_Tiam1/2	UniProtKB/TrEMBL
	RBD_dom	UniProtKB/TrEMBL
	Tiam1/Tiam2/Sif	UniProtKB/TrEMBL
	TIAM1_CC-Ex	UniProtKB/TrEMBL
NCBI Gene	TIAM2	ENTREZGENE
PANTHER	PTHR46001	UniProtKB/TrEMBL
	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2	UniProtKB/TrEMBL
Pfam	PDZ	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	PH_Tiam1	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	Tiam_CC_Ex	UniProtKB/TrEMBL
PROSITE	DH_1	UniProtKB/TrEMBL
	DH_2	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
SMART	PDZ	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF48065	UniProtKB/TrEMBL
	SSF50156	UniProtKB/TrEMBL
UniProt	A0A0D9RLE3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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