Tiam2 (TIAM Rac1 associated GEF 2) - Rat Genome Database

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Gene: Tiam2 (TIAM Rac1 associated GEF 2) Ictidomys tridecemlineatus
Analyze
Symbol: Tiam2
Name: TIAM Rac1 associated GEF 2
RGD ID: 12441308
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); GTPase regulator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN positive regulation of axonogenesis (inferred); small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH chromosome 6q24-q25 deletion syndrome (ortholog); genetic disease (ortholog); substance-related disorder (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); synapse (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T cell lymphoma invasion and metastasis 2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946140,110,602 - 140,212,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364897,362,598 - 7,465,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364897,336,078 - 7,464,553 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
membrane  (IEA)
synapse  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tiam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946140,110,602 - 140,212,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364897,362,598 - 7,465,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364897,336,078 - 7,464,553 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIAM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386154,995,315 - 155,257,723 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6154,832,697 - 155,257,723 (+)EnsemblGRCh38hg38GRCh38
GRCh376155,316,449 - 155,578,857 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366155,453,115 - 155,620,549 (+)NCBINCBI36Build 36hg18NCBI36
Build 346155,540,736 - 155,670,437NCBI
Celera6156,145,600 - 156,313,154 (+)NCBICelera
Cytogenetic Map6q25.2-q25.3NCBI
HuRef6152,973,625 - 153,141,133 (+)NCBIHuRef
CHM1_16155,674,081 - 155,841,472 (+)NCBICHM1_1
T2T-CHM13v2.06156,197,278 - 156,459,744 (+)NCBIT2T-CHM13v2.0
Tiam2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39173,376,675 - 3,569,672 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl173,376,848 - 3,581,619 (+)EnsemblGRCm39 Ensembl
GRCm38173,326,313 - 3,519,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl173,326,573 - 3,531,344 (+)EnsemblGRCm38mm10GRCm38
MGSCv37173,326,573 - 3,519,397 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36173,353,689 - 3,475,879 (+)NCBIMGSCv36mm8
Celera173,867,789 - 4,054,192 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map171.99NCBI
Tiam2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,323,450 - 46,524,769 (+)NCBIGRCr8
mRatBN7.2143,918,179 - 44,119,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl143,918,174 - 44,119,493 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0144,232,520 - 44,433,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl144,311,513 - 44,433,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,562,714 - 45,763,294 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4138,479,385 - 38,514,359 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera139,555,701 - 39,754,110 (+)NCBICelera
Cytogenetic Map1q11NCBI
Tiam2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554396,939,563 - 7,067,507 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554396,942,702 - 7,147,145 (-)NCBIChiLan1.0ChiLan1.0
TIAM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25175,016,172 - 175,281,087 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16172,907,831 - 173,172,685 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06152,809,716 - 153,074,427 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16158,774,096 - 159,038,777 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6158,902,783 - 159,038,777 (+)Ensemblpanpan1.1panPan2
TIAM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1144,897,699 - 45,001,094 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl144,870,103 - 45,002,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,707,011 - 45,838,149 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0145,062,854 - 45,184,503 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl145,053,768 - 45,184,501 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1144,920,794 - 45,051,675 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0144,792,357 - 44,923,421 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0145,357,659 - 45,479,661 (+)NCBIUU_Cfam_GSD_1.0
TIAM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl111,648,508 - 11,759,348 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1111,648,506 - 11,897,869 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2113,622,596 - 13,664,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIAM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11382,537,021 - 82,823,525 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1382,688,773 - 82,822,949 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604054,926,150 - 55,198,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tiam2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247853,086,449 - 3,192,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247853,085,876 - 3,303,006 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000000785   ⟹   ENSSTOP00000000705
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364897,362,598 - 7,464,037 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000036836   ⟹   ENSSTOP00000030919
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364897,436,660 - 7,465,076 (+)Ensembl
RefSeq Acc Id: XM_040282072   ⟹   XP_040138006
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946140,110,602 - 140,212,560 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040138006 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000705.3
  ENSSTOP00000030919.1
GenBank Protein KAG3290484 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040138006   ⟸   XM_040282072
- UniProtKB: I3LXC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000030919   ⟸   ENSSTOT00000036836
RefSeq Acc Id: ENSSTOP00000000705   ⟸   ENSSTOT00000000785
Protein Domains
DH   PDZ   RBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000784 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000785.3 UniProtKB/TrEMBL
  ENSSTOT00000036836.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  6.10.140.680 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  Tiam1/Tiam2/Sif UniProtKB/TrEMBL
  TIAM1_CC-Ex UniProtKB/TrEMBL
NCBI Gene Tiam2 ENTREZGENE
PANTHER PTHR46001 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  Tiam_CC_Ex UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A287DBL1_ICTTR UniProtKB/TrEMBL
  I3LXC2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-10 Tiam2  TIAM Rac1 associated GEF 2  Tiam2  T cell lymphoma invasion and metastasis 2  Symbol and/or name change 5135510 APPROVED
2017-12-19 Tiam2  T cell lymphoma invasion and metastasis 2    T-cell lymphoma invasion and metastasis 2  Symbol and/or name change 5135510 APPROVED