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Gene: MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1) Chlorocebus sabaeus

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Symbol:

MTHFD1

Name:

methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

RGD ID:

18790905

Description:

ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); formate-tetrahydrofolate ligase activity (inferred); INVOLVED IN methionine metabolic process (ortholog); one-carbon metabolic process (ortholog); response to nitrogen dioxide (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; altered folate mediated one-carbon metabolic pathway; folate cycle metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); cleft palate (ortholog); Combined Immunodeficiency and Megaloblastic Anemia with or without Hyperhomocysteinemia (ortholog); FOUND IN cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-1-tetrahydrofolate synthase, cytoplasmic

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	41,590,655 - 41,663,551 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	41,590,590 - 41,666,952 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	29,766,843 - 29,840,674 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	abdominal aortic aneurysm	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNPs and haplotypes:intron: (rs8003379) (human)	RGD	PMID:18635682 and REF_RGD_ID:329853746
MTHFD1	Green Monkey	cleft lip	no_association	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:1958G>A(human)	RGD	PMID:18261183 and REF_RGD_ID:12910962
MTHFD1	Green Monkey	cleft lip	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:1958G>A(human)	RGD	PMID:25129243 and REF_RGD_ID:12910961
MTHFD1	Green Monkey	cleft palate	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:1958 G>A (rs2236225)(human)	RGD	PMID:18661527 and REF_RGD_ID:12914151
MTHFD1	Green Monkey	developmental cardiac valvular defect	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:p.R653Q(c.1958G>A)(human)	RGD	PMID:18767138 and REF_RGD_ID:12910957
MTHFD1	Green Monkey	Down syndrome		ISO	MTHFD1 (Homo sapiens)	9068941	protein:increased expression:brain:	RGD	PMID:15068241 and REF_RGD_ID:12914150
MTHFD1	Green Monkey	Down syndrome	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:1958 G>A (rs2236225)(human)	RGD	PMID:25671679 and REF_RGD_ID:12910959
MTHFD1	Green Monkey	Down syndrome	no_association	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:1958G>A(human)	RGD	PMID:22339736 and REF_RGD_ID:12910960
MTHFD1	Green Monkey	Fetal Growth Retardation	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP: :401A>G(human)	RGD	PMID:25118499 and REF_RGD_ID:12910958
MTHFD1	Green Monkey	Fetal Growth Retardation		ISO	Mthfd1 (Mus musculus)	9068941		RGD	PMID:22378735 and REF_RGD_ID:12910955
MTHFD1	Green Monkey	Fetal Growth Retardation	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:1958G>A(human)	RGD	PMID:18771981 and REF_RGD_ID:12914148
MTHFD1	Green Monkey	neural tube defect		ISO	MTHFD1 (Homo sapiens)	9068941		RGD	PMID:16315005 and REF_RGD_ID:1600189
MTHFD1	Green Monkey	neural tube defect	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:1958G>A (rs2236225)(human)	RGD	PMID:25524527 and REF_RGD_ID:11086705
MTHFD1	Green Monkey	spina bifida		ISO	MTHFD1 (Homo sapiens)	9068941		RGD	PMID:9611072 and REF_RGD_ID:1600190
MTHFD1	Green Monkey	tetralogy of Fallot	susceptibility	ISO	MTHFD1 (Homo sapiens)	9068941	DNA:SNP:cds:p.R653Q(c.1958G>A)(human)	RGD	PMID:18767138 and REF_RGD_ID:12910957

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	Combined Immunodeficiency and Megaloblastic Anemia with or without Hyperhomocysteinemia		ISO	MTHFD1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia	ClinVar	PMID:11004530 more ...
MTHFD1	Green Monkey	Folate-Sensitive Neural Tube Defects		ISO	MTHFD1 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:11004530 more ...
MTHFD1	Green Monkey	genetic disease		ISO	MTHFD1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:28492532
MTHFD1	Green Monkey	severe combined immunodeficiency		ISO	MTHFD1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Severe combined immunodeficiency disease	ClinVar	PMID:21813566 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	neural tube defect		ISO	MTHFD1 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:12384833 and PMID:16552426
MTHFD1	Green Monkey	placental abruption		ISO	MTHFD1 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:15633187

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	Combined Immunodeficiency and Megaloblastic Anemia with or without Hyperhomocysteinemia		ISO	MTHFD1 (Homo sapiens)	7240710		OMIM
MTHFD1	Green Monkey	Folate-Sensitive Neural Tube Defects		ISO	MTHFD1 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	10-formyltetrahydrofolate biosynthetic process	involved_in	IEA	UniProtKB:P11586 more ...	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	folic acid metabolic process	involved_in	IEA	UniProtKB:P11586 more ...	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	heart development	involved_in	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	methionine biosynthetic process	acts_upstream_of	IEA	UniProtKB:P11586 and ensembl:ENSP00000498336	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	methionine metabolic process	acts_upstream_of	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	methionine metabolic process	involved_in	ISO	Mthfd1 (Mus musculus)	9068941	PMID:23190757	BHF-UCL	PMID:23190757
MTHFD1	Green Monkey	neural tube closure	involved_in	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	neutrophil homeostasis	involved_in	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	one-carbon metabolic process		ISO	Mthfd1 (Rattus norvegicus)	9068941		RGD	PMID:14597174 and REF_RGD_ID:1302361
MTHFD1	Green Monkey	one-carbon metabolic process	involved_in	IEA	UniProtKB-KW:KW-0554	150520179		UniProt	GO_REF:0000043
MTHFD1	Green Monkey	purine nucleotide biosynthetic process	acts_upstream_of	IEA	UniProtKB:P11586 and ensembl:ENSP00000498336	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	purine nucleotide biosynthetic process	involved_in	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	purine ribonucleotide biosynthetic process	acts_upstream_of	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	response to nitrogen dioxide		ISO	Mthfd1 (Rattus norvegicus)	9068941		RGD	PMID:3264158 and REF_RGD_ID:12914153
MTHFD1	Green Monkey	serine family amino acid metabolic process	involved_in	ISO	Mthfd1 (Mus musculus)	9068941	PMID:23190757	BHF-UCL	PMID:23190757
MTHFD1	Green Monkey	somite development	involved_in	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	tetrahydrofolate interconversion	involved_in	IEA	UniProtKB:P11586 more ...	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	tetrahydrofolate interconversion	involved_in	IEA	PANTHER:PTN009228914	150520179		TreeGrafter	GO_REF:0000118
MTHFD1	Green Monkey	tetrahydrofolate interconversion	involved_in	IEA	UniPathway:UPA00193	150520179		UniProt	GO_REF:0000041
MTHFD1	Green Monkey	transsulfuration	involved_in	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	cytosol	located_in	IEA	UniProtKB:P11586 and ensembl:ENSP00000498336	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	cytosol	located_in	IEA	PANTHER:PTN009228914	150520179		TreeGrafter	GO_REF:0000118
MTHFD1	Green Monkey	cytosol	is_active_in	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	ATP binding	enables	IEA	InterPro:IPR000559 and InterPro:IPR020628	150520179		InterPro	GO_REF:0000002
MTHFD1	Green Monkey	catalytic activity	enables	IEA	UniProtKB-KW:KW-0511	150520179		UniProt	GO_REF:0000043
MTHFD1	Green Monkey	catalytic activity	enables	IEA	InterPro:IPR020867	150520179		InterPro	GO_REF:0000002
MTHFD1	Green Monkey	formate-tetrahydrofolate ligase activity	enables	IEA	UniProtKB:P11586 more ...	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	formate-tetrahydrofolate ligase activity	enables	IEA	EC:6.3.4.3	150520179		UniProt	GO_REF:0000003
MTHFD1	Green Monkey	formate-tetrahydrofolate ligase activity	enables	IEA	InterPro:IPR000559	150520179		InterPro	GO_REF:0000002
MTHFD1	Green Monkey	ligase activity	enables	IEA	UniProtKB-KW:KW-0436	150520179		UniProt	GO_REF:0000043
MTHFD1	Green Monkey	methenyltetrahydrofolate cyclohydrolase activity	enables	IEA	UniProtKB:P11586 more ...	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	methenyltetrahydrofolate cyclohydrolase activity	enables	IEA	PANTHER:PTN009228914	150520179		TreeGrafter	GO_REF:0000118
MTHFD1	Green Monkey	methenyltetrahydrofolate cyclohydrolase activity	enables	IEA	EC:3.5.4.9	150520179		UniProt	GO_REF:0000003
MTHFD1	Green Monkey	methylenetetrahydrofolate dehydrogenase (NAD+) activity	enables	IEA	UniProtKB:Q922D8 and ensembl:ENSMUSP00000021443	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	methylenetetrahydrofolate dehydrogenase (NADP+) activity	enables	IEA	UniProtKB:P11586 more ...	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	methylenetetrahydrofolate dehydrogenase (NADP+) activity	enables	IEA	PANTHER:PTN009228914	150520179		TreeGrafter	GO_REF:0000118
MTHFD1	Green Monkey	methylenetetrahydrofolate dehydrogenase (NADP+) activity	enables	IEA	EC:1.5.1.5	150520179		UniProt	GO_REF:0000003
MTHFD1	Green Monkey	methylenetetrahydrofolate dehydrogenase (NADP+) activity	enables	IEA	InterPro:IPR000672 more ...	150520179		InterPro	GO_REF:0000002
MTHFD1	Green Monkey	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	enables	IEA	UniProtKB:P11586 and ensembl:ENSP00000498336	150520179		Ensembl	GO_REF:0000107
MTHFD1	Green Monkey	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	150520179		UniProt	GO_REF:0000043
MTHFD1	Green Monkey	protein binding	enables	ISO	UniProtKB:Q9WMX2	9068941	PMID:24169621	IntAct	PMID:24169621

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	altered folate cycle metabolic pathway		ISO	MTHFD1 (Homo sapiens)	9068941		RGD	PMID:22108709 and REF_RGD_ID:7242557
MTHFD1	Green Monkey	altered folate mediated one-carbon metabolic pathway		ISO	MTHFD1 (Homo sapiens)	9068941		RGD	PMID:22353665 and REF_RGD_ID:7242562
MTHFD1	Green Monkey	folate cycle metabolic pathway		ISO	MTHFD1 (Homo sapiens)	9068941		RGD	PMID:22108709 and REF_RGD_ID:7242557
MTHFD1	Green Monkey	folate mediated one-carbon metabolic pathway		ISO	Mthfd1 (Rattus norvegicus)	9068941		RGD	PMID:2186031 and REF_RGD_ID:1299513
MTHFD1	Green Monkey	folate mediated one-carbon metabolic pathway		ISO	MTHFD1 (Homo sapiens)	9068941		RGD	PMID:22332074 and REF_RGD_ID:7242561
MTHFD1	Green Monkey	folate metabolic pathway		ISO	Mthfd1 (Rattus norvegicus)	9068941		RGD	PMID:2186031 and REF_RGD_ID:1299513

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MTHFD1	Green Monkey	folate metabolic pathway		ISO	MTHFD1 (Homo sapiens)	9068941		SMPDB	SMP:00053
MTHFD1	Green Monkey	hereditary folate malabsorption pathway		ISO	MTHFD1 (Homo sapiens)	9068941		SMPDB	SMP:00724
MTHFD1	Green Monkey	methotrexate pharmacodynamics pathway		ISO	MTHFD1 (Homo sapiens)	9068941		SMPDB	SMP:00432

PMID:22301074	PMID:30032202

MTHFD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	41,590,655 - 41,663,551 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	41,590,590 - 41,666,952 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	29,766,843 - 29,840,674 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MTHFD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	64,388,353 - 64,460,025 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	64,388,031 - 64,463,457 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	64,855,071 - 64,926,743 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	63,924,846 - 63,996,474 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	63,924,845 - 63,996,474	NCBI
Celera	14	44,912,512 - 44,984,454 (+)	NCBI		Celera
Cytogenetic Map	14	q23.3	NCBI
HuRef	14	45,027,910 - 45,099,523 (+)	NCBI		HuRef
CHM1_1	14	64,794,532 - 64,866,438 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	58,596,072 - 58,667,774 (+)	NCBI		T2T-CHM13v2.0

Mthfd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	76,301,180 - 76,366,594 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	76,302,072 - 76,366,577 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	76,254,406 - 76,319,820 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	76,255,298 - 76,319,803 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	77,356,219 - 77,420,807 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	77,174,248 - 77,238,643 (+)	NCBI		MGSCv36	mm8
Celera	12	77,346,103 - 77,410,765 (+)	NCBI		Celera
Cytogenetic Map	12	C3	NCBI
cM Map	12	33.52	NCBI

Mthfd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	100,713,510 - 100,781,013 (+)	NCBI		GRCr8
mRatBN7.2	6	94,977,862 - 95,045,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	94,977,862 - 95,045,372 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	95,371,191 - 95,438,507 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	95,669,698 - 95,737,014 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	95,098,499 - 95,165,827 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	99,282,850 - 99,350,367 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	99,282,850 - 99,350,340 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	108,694,405 - 108,761,922 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	98,849,446 - 98,916,936 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	98,852,901 - 98,920,392 (+)	NCBI
Celera	6	93,402,792 - 93,470,182 (+)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

Mthfd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955466	5,420,702 - 5,485,773 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955466	5,422,141 - 5,485,773 (-)	NCBI	ChiLan1.0	ChiLan1.0

MTHFD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	65,499,740 - 65,571,719 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	64,716,255 - 64,788,232 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	44,969,573 - 45,041,296 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	63,223,484 - 63,293,881 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	63,223,484 - 63,293,881 (+)	Ensembl	panpan1.1		panPan2

MTHFD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	38,831,672 - 38,889,607 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	38,831,860 - 38,889,453 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	38,523,089 - 38,581,005 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	39,053,525 - 39,110,717 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	39,053,695 - 39,110,711 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	38,674,867 - 38,732,782 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	38,746,016 - 38,804,174 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	39,107,099 - 39,164,254 (+)	NCBI		UU_Cfam_GSD_1.0

Mthfd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	66,022,476 - 66,090,639 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	8,100,912 - 8,171,800 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	8,100,977 - 8,170,244 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MTHFD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	88,471,414 - 88,537,387 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	88,471,317 - 88,533,690 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	94,832,549 - 94,894,977 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Mthfd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	36,560,486 - 36,620,026 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	36,560,486 - 36,620,043 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in MTHFD1
1249 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20


RefSeq Transcripts	XM_007986954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007986955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011903 ⟹ ENSCSAP00000009961

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	24	41,590,590 - 41,666,952 (+)	Ensembl

RefSeq Acc Id:

XM_007986954 ⟹ XP_007985145

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	24	41,590,655 - 41,663,551 (+)	NCBI
Vero_WHO_p1.0	NW_023666053	29,766,843 - 29,840,674 (+)	NCBI

Sequence:

show sequence

CTGGAATTGGGGCCGGGTACCAGAGTCCTTTCCAGCTTAGTCTTCGGCCGGGTTTCCCGCCGAATGCAAAGGCGCACCGTGGACTGGCTCTTTCTTTCCGCCACTCATATCCGCCAGCCATTCATCAC
CGATTTTCTTCATCTTCCCCTCCCTCTTCCGTCCCTCAGGCCCCGACCCTTTAGCTCTCAGCTGGTTAAGGGACGCCAGGCCTTCCGGGCTGCGCATGCGCTGCCGCGTCTGCCAAGAAGCGGGCAGG
GGCGCAGGCGCAGTAGTGTGATCCCCTGGCCAGTCCCTAAGCACGTGGTTTGGGCTGTCCTGCTTGGCTGCGGAGGGACTGGAACCTCGATATTGGTGGTGTCCATCGTGGGCAGCGGACTAATAAAG
GCTATGGCGCCAGCAGAAATCCTGAACGGGAAGGAGATCTCCGCGCAAATAAGGGCGAGACTGAAAAATCAAGTCACTCAGTTGAAGGAGGAAGTACCTGGTTTCATACCAGGCCTGGCAATATTACA
GATTGGCAACAGAGATGATTCCAATCTTTATATAAAAGTGAAGCTGAAGGCTGCTGAGGAGATTGGGATCAAAGCCACTCACATTAAGTTACCAAGAACAACCACAGAATCTGAGGTGATCAAGTACA
TTACATCTTTGAATGAAGACTCTACTATACACGGGTTCTTAGTGCAGCTACCTTTTGATTCAGAGAATTCCATTAACACTGAAGAAGTGATCAATGCTATTGCACCCGAGAAGGATGTGGATGGATTG
ACCAGCATCAGTGCTGGGAAACTTGCTAGAGGTGACCTCAATGACTGTTTCATTCCTTGTACGCCTAAGGGATGCTTGGAACTCATCAAAGAGACAGGGCTGCCGATTGCCGGAAGGCATGCTGTGGT
GGTCGGGCGCAGTAAAATTGTCGGGGCCCCGATGCATGACTTGCTTCTGTGGAACAATGCCACAGTGACCACCTGCCACTCCAAGACTGCCAATCTGAATGAGGAGGTAAATAAAGGTGACATCCTGG
TGGTTGCAACTGGTCAGCCTGAAATGGTTAAAGGGGAGTGGATCAAACCTGGGGCAATAGTCATCGACTGTGGAATCAATTACGTCCCAGATGATAAAACAAATGGGAGAAAAGTTGTGGGTGATGTG
GCATACGACGAGGCCAAAGAGAGGGCGAGCTTCATCACTCCTGTTCCTGGCGGCGTAGGGCCCATGACGGTTGCAATGCTCATGCAGAGCACAGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAA
GCCAGGAAAGTGGATGATTGAGTACAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATTGATATATCACGATCTTGTAAACTGAAGCCCATTGGTAAGCTGGCTCGAGAAATTGGTCTGCTGT
CTGAAGAAGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACTAGAGCGCCTGAGGCACCGGCCTGATGGGAAATACGTGGTGGTGACTGGAATAACTCCAACACCGCTGGGAGAA
GGGAAAAGCACAACTACAATTGGGCTAGTGCAAGCCCTTGGTGCCCATCTCTACCAGAACGTCTTTGCATGTGTGCGACAGCCGTCTCAGGGTCCTACCTTTGGAATAAAAGGTGGCGCTGCAGGAGG
AGGTTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTCCATCTCACAGGTGACATCCATGCCATCACTGCAGCTAATAACCTCGTTGCTGCGGCCATTGATGCTCGGATATTTCATGAACTGACCC
AGACAGACAAGGCTCTCTTTAATCGTTTGGTGCCATCAGTAAATGGAGTGAGAAAGTTCTCTGATATCCAAATCCGAAGGTTAAAGAGACTAGGCATTGAAAAGACTGACCCTACCACACTGACAGAT
GAAGAGATAAACAGATTTGCAAGATTGGACATTGATCCAGAAACCATAACTTGGCAAAGAGTGTTGGATACTAATGATAGATTCCTGAGGAAGATCACGATTGGACAGGCTCCAACGGAGAAGGGTCA
CGCACGGACGGCCCAGTTTGATATCTCTGTGGCCAGTGAAATTATGGCTGTGCTGGCTCTCACCACTTCTCTAGAAGACATGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGGG
AGCCCGTCAGTGCCGAAGATCTGGGGGTGAGTGGTGCGTTGACAGTGCTTATGAAGGACGCAATCAAGCCCAATCTCATGCAGACATTGGAGGGCACTCCAGTGTTTGTCCATGCTGGTCCGTTTGCC
AACATCGCACACGGCAATTCCTCCATCCTTGCAGACCGGATCGCACTGAAGCTTGTTGGACCAGAAGGGTTTGTAGTGACGGAAGCGGGATTTGGAGCAGACATTGGAATGGAAAAGTTTTTTAACAT
CAAATGCCGGTATTCCGGCCTCCGCCCTCACGTGGTGGTGCTTGTTGCCACTGTCAGAGCTCTCAAGATGCACGGGGGCGGCCCCACGGTCACTGCTGGACTGCCTCTTCCCAAGGCTTACATAGAGG
AGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAACAAATTGAAAATGCCAGAATGTTTGGAATTCCAGTAGTAGTGGCCGTGAATGCATTCAAGACAGACACAGAGGCTGAGCTGGAC
CTCATCAGCCACCTTTCCAGAGAACATGGGGCTTTTGATGCCGTGAAGTGCACTCACTGGGCAGAAGGGGGCAAGGGTGCCTTAGCCCTGGCTCAGGCCGTCCAGAGAGCAGCACAAGCACCCAGCAG
CTTCCAGCTCCTTTATGACCTCAAGCTCCCAGTCGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGATGACATTGAATTACTCCCCGAAGCTCAACACAAAGCTGAAGTCTACACAA
AGCAGGGCTTTGGGAATCTCCCCATCTGCATGGCTAAAACACACTTGTCTTTGTCTCACAACCCAGAGCAAAAAGGTGTCCCTACAGGTTTCGTTCTGCCCATTCGTGACATCCGTGCCAGCGTCGGG
GCTGGTTTTCTGTACCCCTTAGTAGGAACGATGAGCACAATGCCTGGACTCCCCACCCGGCCCTGTTTTTATGATATTGATTTGGACCCTGAAACAGAACAGGTGAATGGATTATTCTAAACAGATCC
TCATCCATCTTCAAGAAGCTACTTTGAAAGTCTGGCCAGTGTCTATTCAGGCCCACTGGGAGTTAGGAAGTATAAGGAAGCCAAGAGAAGTCAGCCCCTGCCCAGAAACTAATAGTAGGAGTTTCCCC
GGAAGTCATTTTCAGCCTTAATTCTCATCATGTATAAATTAACTTAAATCATGCACATGTCTATTTACTTTAGTGACGTTCCACAGAATAAAAGGAAATAATTTTGCCATC

hide sequence


Protein RefSeqs	XP_007985145	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009961
	ENSCSAP00000009961.1

RefSeq Acc Id:	XP_007985145 ⟸ XM_007986954
- UniProtKB:	A0A0D9RMX2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000009961 ⟸ ENSCSAT00000011903

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013809	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011903.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.770	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	Formyltetrahydrofolate synthetase, domain 3	UniProtKB/TrEMBL
	Leucine Dehydrogenase, chain A, domain 1	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	Aminiacid_DH-like_N_sf	UniProtKB/TrEMBL
	Formate_THF_ligase	UniProtKB/TrEMBL
	Formate_THF_ligase_CS	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	THF_DH/CycHdrlase	UniProtKB/TrEMBL
	THF_DH/CycHdrlase_cat_dom	UniProtKB/TrEMBL
	THF_DH/CycHdrlase_CS	UniProtKB/TrEMBL
	THF_DH/CycHdrlase_NAD-bd_dom	UniProtKB/TrEMBL
KEGG Report	csab:103229163	UniProtKB/TrEMBL
NCBI Gene	MTHFD1	ENTREZGENE
PANTHER	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC	UniProtKB/TrEMBL
	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED	UniProtKB/TrEMBL
Pfam	FTHFS	UniProtKB/TrEMBL
	THF_DHG_CYH	UniProtKB/TrEMBL
	THF_DHG_CYH_C	UniProtKB/TrEMBL
PRINTS	THFDHDRGNASE	UniProtKB/TrEMBL
PROSITE	FTHFS_1	UniProtKB/TrEMBL
	FTHFS_2	UniProtKB/TrEMBL
	THF_DHG_CYH_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
	SSF53223	UniProtKB/TrEMBL
UniProt	A0A0D9RMX2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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