MGRN1 (mahogunin ring finger 1) - Rat Genome Database

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Gene: MGRN1 (mahogunin ring finger 1) Chlorocebus sabaeus
Analyze
Symbol: MGRN1
Name: mahogunin ring finger 1
RGD ID: 18790081
Description: ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of smoothened signaling pathway (ortholog); protein monoubiquitination (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN melanocortin system pathway; ASSOCIATED WITH epilepsy (ortholog); genetic disease (ortholog); hyperglycemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase MGRN1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,310,924 - 4,372,896 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl54,310,970 - 4,375,423 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606826,292,411 - 26,363,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MGRN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,310,924 - 4,372,896 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl54,310,970 - 4,375,423 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606826,292,411 - 26,363,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MGRN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,624,826 - 4,690,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,616,493 - 4,690,974 (+)EnsemblGRCh38hg38GRCh38
GRCh37164,674,827 - 4,740,973 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,614,854 - 4,680,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 34164,614,853 - 4,680,972NCBI
Celera164,883,683 - 4,949,753 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef164,641,815 - 4,707,494 (+)NCBIHuRef
CHM1_1164,674,882 - 4,741,756 (+)NCBICHM1_1
T2T-CHM13v2.0164,654,281 - 4,720,424 (+)NCBIT2T-CHM13v2.0
Mgrn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,703,964 - 4,756,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,704,113 - 4,756,160 (+)EnsemblGRCm39 Ensembl
GRCm38164,886,100 - 4,938,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,886,249 - 4,938,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,886,252 - 4,938,296 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,801,480 - 4,853,524 (+)NCBIMGSCv36mm8
Celera165,517,662 - 5,569,636 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.48NCBI
Mgrn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,142,626 - 11,194,773 (-)NCBIGRCr8
mRatBN7.21010,638,881 - 10,688,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,638,880 - 10,688,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,348,233 - 15,396,588 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,837,050 - 14,885,406 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,506,186 - 10,554,831 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,832,573 - 10,881,999 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,833,519 - 10,881,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,599,503 - 9,648,909 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,756,804 - 10,805,883 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11010,756,804 - 10,805,883 (-)NCBI
Celera109,604,036 - 9,652,494 (-)NCBICelera
Cytogenetic Map10q12NCBI
Mgrn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544212,781,539 - 12,824,222 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544212,780,795 - 12,823,716 (-)NCBIChiLan1.0ChiLan1.0
MGRN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2185,154,386 - 5,219,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1168,944,813 - 9,009,883 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0163,550,352 - 3,615,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1164,740,763 - 4,782,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl164,740,763 - 4,782,638 (+)Ensemblpanpan1.1panPan2
MGRN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1636,716,071 - 36,775,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl636,716,343 - 36,769,417 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,050,260 - 38,103,958 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0636,919,892 - 36,979,309 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl636,918,610 - 36,979,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1636,713,739 - 36,773,816 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,606,581 - 36,666,904 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,009,268 - 37,068,750 (-)NCBIUU_Cfam_GSD_1.0
Mgrn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,801,950 - 106,847,702 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365304,652,464 - 4,693,999 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365304,647,550 - 4,693,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGRN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl337,694,808 - 37,748,067 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1337,694,798 - 37,748,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2338,753,414 - 38,806,811 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mgrn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248242,420,203 - 2,470,627 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248242,419,973 - 2,473,580 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 40
Low 20 20
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000007129   ⟹   ENSCSAP00000005317
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl54,310,970 - 4,368,273 (+)Ensembl
RefSeq Acc Id: ENSCSAT00000007133   ⟹   ENSCSAP00000005322
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl54,310,970 - 4,375,423 (+)Ensembl
RefSeq Acc Id: XM_007984411   ⟹   XP_007982602
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.154,310,925 - 4,371,055 (+)NCBI
Vero_WHO_p1.0NW_02366606826,292,411 - 26,363,922 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984421   ⟹   XP_007982612
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.154,310,926 - 4,372,896 (+)NCBI
Vero_WHO_p1.0NW_02366606826,292,411 - 26,363,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984430   ⟹   XP_007982621
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.154,310,925 - 4,371,055 (+)NCBI
Vero_WHO_p1.0NW_02366606826,292,411 - 26,363,922 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984440   ⟹   XP_007982631
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.154,310,926 - 4,372,896 (+)NCBI
Vero_WHO_p1.0NW_02366606826,292,411 - 26,363,920 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984448   ⟹   XP_007982639
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.154,310,924 - 4,370,821 (+)NCBI
Vero_WHO_p1.0NW_02366606826,294,436 - 26,363,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984457   ⟹   XP_007982648
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.154,310,925 - 4,370,821 (+)NCBI
Vero_WHO_p1.0NW_02366606826,294,436 - 26,363,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984467   ⟹   XP_007982658
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.154,310,925 - 4,370,821 (+)NCBI
Vero_WHO_p1.0NW_02366606826,294,436 - 26,363,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037989893   ⟹   XP_037845821
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606826,294,436 - 26,363,922 (-)NCBI
RefSeq Acc Id: XP_007982639   ⟸   XM_007984448
- Peptide Label: isoform X5
- UniProtKB: A0A0D9R9M8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982602   ⟸   XM_007984411
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R9N3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982621   ⟸   XM_007984430
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R9N3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982648   ⟸   XM_007984457
- Peptide Label: isoform X6
- UniProtKB: A0A0D9R9M8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982658   ⟸   XM_007984467
- Peptide Label: isoform X8
- UniProtKB: A0A0D9R9M8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982612   ⟸   XM_007984421
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R9N3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982631   ⟸   XM_007984440
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R9N3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005317   ⟸   ENSCSAT00000007129
RefSeq Acc Id: ENSCSAP00000005322   ⟸   ENSCSAT00000007133
RefSeq Acc Id: XP_037845821   ⟸   XM_037989893
- Peptide Label: isoform X7
- UniProtKB: A0A0D9R9M8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007129.1 UniProtKB/TrEMBL
  ENSCSAT00000007133.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro MGRN1/RNF157-like UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene MGRN1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MGRN1 UniProtKB/TrEMBL
  PTHR22996 UniProtKB/TrEMBL
Pfam zf-C3HC4_3 UniProtKB/TrEMBL
PROSITE ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A0D9R9M8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0D9R9N3 ENTREZGENE, UniProtKB/TrEMBL