FLT4 (fms related receptor tyrosine kinase 4) - Rat Genome Database

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Gene: FLT4 (fms related receptor tyrosine kinase 4) Chlorocebus sabaeus
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Symbol: FLT4
Name: fms related receptor tyrosine kinase 4
RGD ID: 18750401
Description: ENCODES a protein that exhibits growth factor binding (ortholog); vascular endothelial growth factor receptor activity (ortholog); INVOLVED IN lung alveolus development (ortholog); lymph vessel development (ortholog); peptidyl-tyrosine phosphorylation (ortholog); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway; altered vascular endothelial growth factor signaling pathway involving the main players; axitinib pharmacodynamics pathway; ASSOCIATED WITH clear cell renal cell carcinoma (ortholog); colon carcinoma (ortholog); colorectal cancer (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fms related tyrosine kinase 4; vascular endothelial growth factor receptor 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12382,328,257 - 82,373,785 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2382,328,258 - 82,357,044 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607513,749,531 - 13,795,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
blood vessel morphogenesis  (IEA)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to vascular endothelial growth factor stimulus  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
hepatocyte growth factor receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
lung alveolus development  (IEA,ISO)
lymph vessel development  (IEA,ISO)
lymphangiogenesis  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
negative regulation of apoptotic process  (IEA)
peptidyl-tyrosine phosphorylation  (ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
protein autophosphorylation  (ISO)
regulation of blood vessel remodeling  (IEA)
regulation of cell population proliferation  (IEA)
regulation of MAPK cascade  (IEA)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
respiratory system process  (IEA,ISO)
sprouting angiogenesis  (IEA)
vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)
vasculature development  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FLT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12382,328,257 - 82,373,785 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2382,328,258 - 82,357,044 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607513,749,531 - 13,795,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FLT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385180,601,506 - 180,650,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5180,601,506 - 180,649,624 (-)EnsemblGRCh38hg38GRCh38
GRCh375180,028,506 - 180,076,600 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,961,112 - 180,009,206 (-)NCBINCBI36Build 36hg18NCBI36
Build 345179,962,147 - 180,009,171NCBI
Celera5175,651,089 - 175,699,841 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5174,752,484 - 174,782,989 (-)NCBIHuRef
CHM1_15179,460,942 - 179,509,118 (-)NCBICHM1_1
T2T-CHM13v2.05181,157,398 - 181,206,988 (-)NCBIT2T-CHM13v2.0
Flt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,500,506 - 49,543,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,500,090 - 49,543,566 (+)EnsemblGRCm39 Ensembl
GRCm381149,609,679 - 49,652,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,609,263 - 49,652,739 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,423,181 - 49,466,241 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361149,453,150 - 49,495,652 (+)NCBIMGSCv36mm8
Celera1154,171,357 - 54,214,402 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.69NCBI
Flt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81034,414,834 - 34,455,878 (+)NCBIGRCr8
mRatBN7.21033,913,725 - 33,954,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,913,608 - 33,954,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,589,263 - 38,630,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,127,669 - 7,168,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01033,582,919 - 33,624,021 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,078,782 - 35,120,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,078,726 - 35,121,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,850,707 - 34,892,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,071,002 - 35,112,006 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,072,050 - 35,113,055NCBI
Celera1033,270,535 - 33,311,432 (+)NCBICelera
Cytogenetic Map10q21NCBI
Flt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408107,056 - 140,056 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540898,995 - 137,922 (+)NCBIChiLan1.0ChiLan1.0
FLT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24175,624,976 - 175,674,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15173,789,056 - 173,838,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05175,804,728 - 175,852,703 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15183,114,166 - 183,148,518 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5183,115,856 - 183,149,006 (-)Ensemblpanpan1.1panPan2
FLT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,145,643 - 1,184,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,145,585 - 1,185,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,205,492 - 1,245,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,114,649 - 1,154,193 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,114,656 - 1,154,194 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,067,618 - 1,107,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,165,705 - 1,205,208 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,405,676 - 1,445,228 (+)NCBIUU_Cfam_GSD_1.0
Flt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,026,753 - 119,071,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739236,510 - 281,729 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739240,572 - 281,925 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,076,080 - 78,115,126 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,076,008 - 78,115,137 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,479,951 - 79,504,057 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Flt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473343,204,651 - 43,238,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473343,203,311 - 43,238,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FLT4
1348 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000006121   ⟹   ENSCSAP00000004321
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2382,328,258 - 82,357,044 (-)Ensembl
RefSeq Acc Id: XM_008015555   ⟹   XP_008013746
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12382,328,257 - 82,373,785 (-)NCBI
Vero_WHO_p1.0NW_02366607513,749,531 - 13,795,003 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015557   ⟹   XP_008013748
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12382,329,047 - 82,373,782 (-)NCBI
Vero_WHO_p1.0NW_02366607513,750,349 - 13,795,003 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015559   ⟹   XP_008013750
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12382,334,263 - 82,373,782 (-)NCBI
Vero_WHO_p1.0NW_02366607513,755,490 - 13,795,003 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037992783   ⟹   XP_037848711
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607513,755,013 - 13,795,003 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008013746 (Get FASTA)   NCBI Sequence Viewer  
  XP_008013748 (Get FASTA)   NCBI Sequence Viewer  
  XP_008013750 (Get FASTA)   NCBI Sequence Viewer  
  XP_037848711 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004321.1
RefSeq Acc Id: XP_008013746   ⟸   XM_008015555
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R6T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008013748   ⟸   XM_008015557
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R6T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008013750   ⟸   XM_008015559
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R6T2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000004321   ⟸   ENSCSAT00000006121
RefSeq Acc Id: XP_037848711   ⟸   XM_037992783
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R6T2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008130 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006121.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/TrEMBL
  VEGFR1-3_5th UniProtKB/TrEMBL
  VEGFR1-3_N_Ig-like UniProtKB/TrEMBL
NCBI Gene FLT4 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
  VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  VEGFR-1-like_5th UniProtKB/TrEMBL
  VEGFR-1-like_Ig-like UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/TrEMBL
  VEGFR1-3_N_Ig-like UniProtKB/TrEMBL
PIRSF TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/TrEMBL
  VEGFRECEPTR3 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9R6T2 ENTREZGENE, UniProtKB/TrEMBL