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Gene: CCNB2 (cyclin B2) Chlorocebus sabaeus

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Symbol:

CCNB2

Name:

cyclin B2

RGD ID:

18723997

Description:

ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase regulator activity (inferred); INVOLVED IN G2/MI transition of meiotic cell cycle (ortholog); in utero embryonic development (ortholog); negative regulation of meiotic cell cycle process involved in oocyte maturation (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); COVID-19 (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

G2/mitotic-specific cyclin-B2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CCNB2 (cyclin B2)	NCBI	Ortholog
Mus musculus (house mouse):	Ccnb2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ccnb2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ccnb2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CCNB2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CCNB2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ccnb2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CCNB2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ccnb2 (cyclin B2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	24,389,654 - 24,408,976 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	24,389,642 - 24,409,346 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	116,914,038 - 116,933,832 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

COVID-19 (ISO)

Experimental Liver Cirrhosis (ISO)

hepatocellular carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

G2/MI transition of meiotic cell cycle (IEA,ISO)

in utero embryonic development (IEA,ISO)

mitotic cell cycle phase transition (IEA)

negative regulation of meiotic cell cycle process involved in oocyte maturation (ISO)

regulation of growth (IEA,ISO)

spindle assembly involved in female meiosis I (IEA,ISO)

T cell homeostasis (IEA,ISO)

thymus development (IEA,ISO)

Cellular Component

centrosome (IEA)

cytoplasm (IEA)

cytosol (IEA)

membrane (IEA)

microtubule cytoskeleton (IEA)

Molecular Function

cyclin-dependent protein serine/threonine kinase regulator activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CCNB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	24,389,654 - 24,408,976 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	24,389,642 - 24,409,346 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	116,914,038 - 116,933,832 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CCNB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	59,105,146 - 59,125,045 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	59,105,126 - 59,125,045 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	59,397,345 - 59,417,244 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	57,184,612 - 57,204,536 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	57,184,611 - 57,204,535	NCBI
Celera	15	36,285,270 - 36,305,194 (+)	NCBI		Celera
Cytogenetic Map	15	q22.2	NCBI
HuRef	15	36,219,537 - 36,239,475 (+)	NCBI		HuRef
CHM1_1	15	59,515,271 - 59,535,219 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	56,907,228 - 56,927,138 (+)	NCBI		T2T-CHM13v2.0

Ccnb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	70,314,971 - 70,328,836 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	70,314,974 - 70,328,829 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	70,407,689 - 70,421,554 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	70,407,692 - 70,421,547 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	70,255,496 - 70,269,361 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	70,206,853 - 70,220,718 (-)	NCBI		MGSCv36	mm8
Celera	9	67,623,704 - 67,637,672 (-)	NCBI		Celera
Cytogenetic Map	9	D	NCBI
cM Map	9	39.53	NCBI

Ccnb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	79,968,459 - 79,981,717 (-)	NCBI		GRCr8
mRatBN7.2	8	71,087,594 - 71,100,794 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	71,087,595 - 71,100,874 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	76,621,984 - 76,635,426 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	74,895,005 - 74,908,447 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	72,732,830 - 72,746,269 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	76,847,972 - 76,861,165 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	76,221,508 - 76,233,944 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	74,892,108 - 74,906,181 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	74,911,162 - 74,925,235 (-)	NCBI
Celera	8	70,627,900 - 70,641,100 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Ccnb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	15,559,022 - 15,581,760 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	15,558,874 - 15,587,456 (-)	NCBI	ChiLan1.0	ChiLan1.0

CCNB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	48,367,902 - 48,390,351 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	52,552,052 - 52,572,806 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	38,075,106 - 38,095,699 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	56,382,391 - 56,402,299 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	56,382,391 - 56,402,299 (+)	Ensembl	panpan1.1		panPan2

CCNB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	24,040,859 - 24,063,084 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	24,040,859 - 24,063,084 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	24,014,627 - 24,036,855 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	24,209,364 - 24,231,601 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	24,209,368 - 24,231,597 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	24,134,552 - 24,156,769 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	24,217,551 - 24,239,776 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	24,361,281 - 24,383,523 (+)	NCBI		UU_Cfam_GSD_1.0

Ccnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	102,368,542 - 102,390,483 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936471	20,216,435 - 20,238,543 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCNB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	112,907,047 - 112,942,235 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	112,907,047 - 112,942,218 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	124,906,568 - 124,942,517 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Ccnb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	12,874,020 - 12,905,932 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	12,875,215 - 12,905,878 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CCNB2
373 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008016425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000010112 ⟹ ENSCSAP00000008212

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	26	24,389,642 - 24,409,346 (-)	Ensembl

RefSeq Acc Id:

XM_008016425 ⟹ XP_008014616

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	24,389,654 - 24,408,976 (-)	NCBI
Vero_WHO_p1.0	NW_023666048	116,914,038 - 116,933,832 (+)	NCBI

Sequence:

show sequence

GCCCAATGGGGCGCAAGCGACGCGGTATTTGAATCCTGGAACAAGGCTACAGCGTCGAAGATCC
CCAGCGCTGCGGGCCCGGAGAGCAGCCCTAACGGCGCCTCGTACGCTAGTGCCCTCCCTTTTCA
GTCCGTGTCCCTCCCTGGGCCGGGCTGGCACTCTTGCTTTCCCCGTCCCTCATGGCGCTGCTCC
GACGCCCGACGGTGTCCAGTGATTTGGAGAATATTGACACAGGATTTAATTCTAAAGTTAAGAG
TCATGTGACTATTAGGCGAACTGTTTTAGAAGAAATTGGAAATAAAGTTACAACCAGAGCAGCA
CAAGTAGCTAAGAAAGCTCAGAACACCAAAGTACCAGTTCAACCCACCAAAACAACAAATGTCA
ACAAACAACTGAAACCTACTGCTTCTGTCAAACCAGTACAGATGGAAATGTTGGCCCCAAAGGG
TCCTTCTCCCACACCTGAGGATGTCTCCATGAAGGAAGAGAATCTCTGCCAAGCTTTTTCTGAT
GCCTTGCTCTGCAAAATCGAGGACATTGATAATGAAGATTGGGAGAACCCTCAGCTCTGCAGTG
ACTACGTTAAGGATATCTATCAGTATCTCAGGCAGCTGGAGGTTTTGCAGTCCATAAACCCACA
TTTCTTAGATGGAAGAGATATAAATGGACGCATGCGTGCCATCCTGGTGGACTGGCTGGTGCAG
GTCCACTCCAAGTTTAGGCTTCTGCAGGAGACTCTGTACATGTGTGTTGCCATTATGGATCGAT
TTTTACAGGTTCAGCCAGTTTCCCGGAAGAAGCTTCAATTAGTTGGGATTACTGCTCTGCTCTT
GGCTTCCAAGTATGAGGAGATGTTTTCTCCAAATATTGAAGACTTTGTTTACATCACAGACAAC
GCTTATACCAGTTCCCAAATCCGAGAAATGGAAACTCTAATTTTGAAAGAATTGAAATTTGAGT
TGGGTCGACCATTGCCACTACACTTCTTAAGGCGAGCATCAAAAGCCGGGGAAGTTGATGTTGA
ACAGCACACTTTAGCCAAATATTTGATGGAGCTGACTCTCATCGACTATGATATGGTGCATTAT
CATCCTTCTAAAGTAGCAGCAGCTGCTTCCTGTTTGTCTCAGAAGCTTCTAGGACAAGGAAAAT
GGAACTTAAAGCAGCAGTATTACACAGGATACACAGAGAATGAAGTTTTGGAAGTCATGCAGCA
CATGGCCAAGAATGTGGTGAAAGTAAACGAAAACTTAACTAAATTCATCGCCATCAAGAATAAG
TATGCAAGCAGCAAACTCCTGAAGATCAGCACGATCCCTCAGCTGAACTCAAAAGCCGTCAAAG
ATCTTGCCTCCCCACTGATGGGAAGGTCCTAGGCTGCCATCGCCCCTGGGGATGTGTGCTTCAT
TGTACCCTTTTTCTTACTGGTTTAGAACTCTTGATTTTGTACATAGTCCTCTGGTCTATCTTAT
GAAACCTCTTCTCAGACCAATTTTCTAAATATATATTGAGGAAAAATAAAGCGATTGGTTTTTC
TTAAGGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008014616	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008212
	ENSCSAP00000008212.1

RefSeq Acc Id:	XP_008014616 ⟸ XM_008016425
- UniProtKB:	A0A0D9RHX3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000008212 ⟸ ENSCSAT00000010112

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012024	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010112.1	UniProtKB/TrEMBL
Gene3D-CATH	Cyclin-like	UniProtKB/TrEMBL
InterPro	Cyclin	UniProtKB/TrEMBL
	Cyclin-like	UniProtKB/TrEMBL
	Cyclin-like_sf	UniProtKB/TrEMBL
	Cyclin_A/B-like	UniProtKB/TrEMBL
	Cyclin_C-dom	UniProtKB/TrEMBL
	Cyclin_N	UniProtKB/TrEMBL
	Cyclins_cyclin-box	UniProtKB/TrEMBL
KEGG Report	csab:103245548	UniProtKB/TrEMBL
NCBI Gene	CCNB2	ENTREZGENE
PANTHER	PTHR10177	UniProtKB/TrEMBL
Pfam	Cyclin_C	UniProtKB/TrEMBL
	Cyclin_N	UniProtKB/TrEMBL
PIRSF	Cyclin_A_B_D_E	UniProtKB/TrEMBL
PROSITE	CYCLINS	UniProtKB/TrEMBL
SMART	CYCLIN	UniProtKB/TrEMBL
	Cyclin_C	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47954	UniProtKB/TrEMBL
UniProt	A0A0D9RHX3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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