TPR (translocated promoter region, nuclear basket protein) - Rat Genome Database

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Gene: TPR (translocated promoter region, nuclear basket protein) Chlorocebus sabaeus
Analyze
Symbol: TPR
Name: translocated promoter region, nuclear basket protein
RGD ID: 18716991
Description: ENCODES a protein that exhibits protein-membrane adaptor activity (ortholog); INVOLVED IN cellular response to interferon-alpha (ortholog); nuclear matrix organization (ortholog); nuclear pore complex assembly (ortholog); ASSOCIATED WITH Autosomal Recessive Intellectual Developmental Disorder 79 (ortholog); camptodactyly-arthropathy-coxa vara-pericarditis syndrome (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN kinetochore (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nucleoprotein TPR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12543,056,605 - 43,120,570 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2543,056,886 - 43,123,474 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605544,245,730 - 44,312,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TPRGreen MonkeyAutosomal Recessive Intellectual Developmental Disorder 79  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual developmental disorder and autosomal recessive 79ClinVarPMID:34494102
TPRGreen Monkeycamptodactyly-arthropathy-coxa vara-pericarditis syndrome  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Camptodactyly-arthropathy-coxa vara-pericarditis syndromeClinVarPMID:25741868 and PMID:29397575
TPRGreen Monkeygastrointestinal stromal tumor  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
TPRGreen Monkeygenetic disease  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
TPRGreen Monkeyintellectual disability  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
TPRGreen Monkeyparathyroid carcinoma  ISOTPR (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TPRGreen MonkeyThyroid Neoplasms  ISOTPR (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23811263
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TPRGreen MonkeyAutosomal Recessive Intellectual Developmental Disorder 79  ISOTPR (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 36 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TPRGreen Monkeycellular response to heat involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeycellular response to interferon-alpha involved_inISOTpr (Mus musculus)9068941 PMID:12513910UniProtPMID:12513910
TPRGreen Monkeymitotic spindle assembly checkpoint signaling involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen MonkeymRNA export from nucleus involved_inIEAPANTHER:PTN000431192150520179 TreeGrafterGO_REF:0000118
TPRGreen MonkeymRNA export from nucleus in response to heat stress involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynegative regulation of RNA export from nucleus involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynegative regulation of translational initiation involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynuclear matrix organization NOT|involved_inISOTPR (Homo sapiens)9068941 PMID:11952838UniProtPMID:11952838
TPRGreen Monkeynuclear pore complex assembly NOT|involved_inISOTpr (Rattus norvegicus)9068941PMID:11839768UniProtPMID:11839768 and REF_RGD_ID:8553300
TPRGreen Monkeynuclear pore complex assembly NOT|involved_inISOTPR (Homo sapiens)9068941 PMID:12802065UniProtPMID:12802065
TPRGreen Monkeynuclear pore organization NOT|involved_inISOTPR (Homo sapiens)9068941 PMID:11952838UniProtPMID:11952838
TPRGreen Monkeynuclear pore organization involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeypositive regulation of heterochromatin formation involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeypositive regulation of intracellular protein transport involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeypositive regulation of mitotic cell cycle spindle assembly checkpoint involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeypositive regulation of protein export from nucleus involved_inISOTpr (Rattus norvegicus)9068941PMID:11839768UniProtPMID:11839768 and REF_RGD_ID:8553300
TPRGreen Monkeypositive regulation of protein import into nucleus involved_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeyprotein export from nucleus NOT|involved_inISOTPR (Homo sapiens)9068941 PMID:11952838UniProtPMID:11952838
TPRGreen Monkeyprotein export from nucleus  ISOTpr (Rattus norvegicus)9068941 RGDPMID:11839768 and REF_RGD_ID:8553300
1 to 20 of 36 rows

Cellular Component
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TPRGreen Monkeycytoplasm located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeycytoplasmic dynein complex part_ofIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeykinetochore NOT|located_inISOTPR (Homo sapiens)9068941 PMID:19273613UniProtPMID:19273613
TPRGreen Monkeykinetochore located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeymitotic spindle located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynuclear envelope located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynuclear inclusion body located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynuclear membrane located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynuclear periphery located_inIEAARBA:ARBA00029208150520179 UniProtGO_REF:0000117
TPRGreen Monkeynuclear periphery located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynuclear pore part_ofIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynuclear pore part_ofIEAPANTHER:PTN000431192150520179 TreeGrafterGO_REF:0000118
TPRGreen Monkeynuclear pore part_ofIEAARBA:ARBA00026270150520179 UniProtGO_REF:0000117
TPRGreen Monkeynuclear pore nuclear basket part_ofIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynucleus located_inIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeynucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
TPRGreen Monkeynucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
1 to 17 of 17 rows

Molecular Function
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TPRGreen Monkeychromatin binding enablesIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeydynein complex binding enablesIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeyheat shock protein binding enablesIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeymitogen-activated protein kinase binding enablesIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen MonkeymRNA binding enablesIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeyprotein binding enablesISOUniProtKB:P0DOV29068941 PMID:12513910UniProtPMID:12513910
TPRGreen Monkeyprotein binding enablesISOUniProtKB:Q9Y6D99068941 PMID:24581499IntActPMID:24581499
TPRGreen Monkeyprotein binding enablesISOUniProtKB:P27361 and UniProtKB:P284829068941 PMID:18794356UniProtPMID:18794356
TPRGreen Monkeyprotein binding enablesISOUniProtKB:Q13257 and UniProtKB:Q9Y6D99068941 PMID:18981471UniProtPMID:18981471
TPRGreen Monkeyprotein binding enablesISOUniProtKB:P49790 more ...9068941 PMID:20133940UniProtPMID:20133940
TPRGreen Monkeyprotein binding enablesISOUniProtKB:P33981 more ...9068941 PMID:19273613UniProtPMID:19273613
TPRGreen Monkeyprotein binding enablesISOUniProtKB:P284829068941 PMID:22253824UniProtPMID:22253824
TPRGreen Monkeyprotein binding enablesISOUniProtKB:P49790 and UniProtKB:Q9UKX79068941 PMID:12802065UniProtPMID:12802065
TPRGreen Monkeyprotein binding enablesISOUniProtKB:P428589068941 PMID:15654337UniProtPMID:15654337
TPRGreen Monkeyprotein binding enablesISOUniProtKB:Q133309068941 PMID:24970816UniProtPMID:24970816
TPRGreen Monkeyprotein binding enablesISOUniProtKB:Q9H2G29068941 PMID:26094769UniProtPMID:26094769
TPRGreen Monkeyprotein binding enablesISOUniProtKB:Q006139068941 PMID:17897941UniProtPMID:17897941
TPRGreen Monkeyprotein homodimerization activity enablesIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
TPRGreen Monkeyprotein-membrane adaptor activity NOT|enablesISOTPR (Homo sapiens)9068941 PMID:12802065UniProtPMID:12802065
TPRGreen Monkeystructural constituent of nuclear pore enablesIEAUniProtKB:P12270 and ensembl:ENSP00000356448150520179 EnsemblGO_REF:0000107
1 to 20 of 22 rows

PMID:22301074   PMID:30032202  



TPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12543,056,605 - 43,120,570 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2543,056,886 - 43,123,474 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605544,245,730 - 44,312,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,311,652 - 186,375,253 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,311,652 - 186,375,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,280,784 - 186,344,385 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,547,407 - 184,611,080 (-)NCBINCBI36Build 36hg18NCBI36
Build 341183,014,615 - 183,076,114NCBI
Celera1159,391,490 - 159,455,165 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,515,355 - 157,578,976 (-)NCBIHuRef
CHM1_11187,702,490 - 187,766,196 (-)NCBICHM1_1
T2T-CHM13v2.01185,666,310 - 185,729,984 (-)NCBIT2T-CHM13v2.0
Tpr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,268,544 - 150,325,686 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,268,589 - 150,325,686 (+)EnsemblGRCm39 Ensembl
GRCm381150,392,802 - 150,449,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,392,838 - 150,449,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv371152,239,968 - 152,297,065 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361152,155,071 - 152,212,147 (+)NCBIMGSCv36mm8
Celera1152,832,018 - 152,889,087 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Tpr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,974,419 - 65,037,604 (+)NCBIGRCr8
mRatBN7.21362,424,312 - 62,487,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,424,312 - 62,487,496 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1365,070,740 - 65,133,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,341,843 - 66,405,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,603,135 - 63,666,355 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,611,685 - 67,672,833 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,611,708 - 67,672,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,576,506 - 72,637,654 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,688,585 - 64,753,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,702,435 - 64,767,635 (+)NCBI
Celera1362,384,785 - 62,447,122 (+)NCBICelera
Cytogenetic Map13q21NCBI
Tpr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540624,742,525 - 24,805,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540624,742,525 - 24,805,989 (-)NCBIChiLan1.0ChiLan1.0
TPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2163,343,613 - 63,405,202 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1163,025,048 - 63,086,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,842,037 - 161,903,567 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,993,726 - 166,055,223 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,993,726 - 166,055,223 (-)Ensemblpanpan1.1panPan2
TPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,376,951 - 19,442,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,376,975 - 19,442,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha718,898,638 - 18,964,055 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,112,960 - 19,178,509 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,112,979 - 19,179,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,019,776 - 19,085,277 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,129,102 - 19,194,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,259,646 - 19,325,389 (-)NCBIUU_Cfam_GSD_1.0
Tpr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934486,203,944 - 86,264,933 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364814,050,794 - 4,111,682 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364814,050,693 - 4,111,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,481,684 - 127,540,398 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,481,678 - 127,540,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29139,933,094 - 139,992,501 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Tpr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248147,249,278 - 7,306,235 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248147,249,379 - 7,306,239 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in TPR
1026 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20


RefSeq Transcripts XM_007989156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000011383   ⟹   ENSCSAP00000009457
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2543,056,886 - 43,123,474 (+)Ensembl
RefSeq Acc Id: XM_007989156   ⟹   XP_007987347
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12543,056,605 - 43,120,570 (+)NCBI
Vero_WHO_p1.0NW_02366605544,245,730 - 44,312,643 (+)NCBI
Sequence:
Protein RefSeqs XP_007987347 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009457
  ENSCSAP00000009457.1
RefSeq Acc Id: XP_007987347   ⟸   XM_007989156
- UniProtKB: A0A0D9RLG8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000009457   ⟸   ENSCSAT00000011383



1 to 9 of 9 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000013292 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011383.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
InterPro TPR/MLP1 UniProtKB/TrEMBL
NCBI Gene TPR ENTREZGENE
PANTHER NUCLEOPROTEIN TPR UniProtKB/TrEMBL
  NUCLEOPROTEIN TPR-RELATED UniProtKB/TrEMBL
Pfam TPR_MLP1_2 UniProtKB/TrEMBL
UniProt A0A0D9RLG8 ENTREZGENE, UniProtKB/TrEMBL
1 to 9 of 9 rows