ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2) - Rat Genome Database

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Gene: ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2) Chlorocebus sabaeus
Analyze
Symbol: ITIH2
Name: inter-alpha-trypsin inhibitor heavy chain 2
RGD ID: 18713252
Description: ENCODES a protein that exhibits hyaluronic acid binding (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN hyaluronan metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); hypoparathyroidism-deafness-renal disease syndrome (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inter-alpha-trypsin inhibitor heavy chain H2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.197,748,818 - 7,794,932 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl97,749,464 - 7,794,933 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605113,144,753 - 13,190,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ITIH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.197,748,818 - 7,794,932 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl97,749,464 - 7,794,933 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605113,144,753 - 13,190,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ITIH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38107,703,316 - 7,749,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl107,703,316 - 7,749,520 (+)EnsemblGRCh38hg38GRCh38
GRCh37107,745,279 - 7,791,483 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36107,785,242 - 7,831,489 (+)NCBINCBI36Build 36hg18NCBI36
Build 34107,785,342 - 7,831,488NCBI
Celera107,671,050 - 7,717,293 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef107,663,584 - 7,709,831 (+)NCBIHuRef
CHM1_1107,745,665 - 7,791,444 (+)NCBICHM1_1
T2T-CHM13v2.0107,703,948 - 7,750,283 (+)NCBIT2T-CHM13v2.0
Itih2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39210,099,408 - 10,135,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl210,099,404 - 10,136,207 (-)EnsemblGRCm39 Ensembl
GRCm38210,094,591 - 10,130,683 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl210,094,593 - 10,131,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37210,016,218 - 10,052,310 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36210,012,444 - 10,048,517 (-)NCBIMGSCv36mm8
Celera210,033,646 - 10,069,833 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map26.89NCBI
Itih2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81773,285,281 - 73,321,555 (+)NCBIGRCr8
mRatBN7.21768,375,574 - 68,411,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1768,375,567 - 68,411,841 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01772,160,734 - 72,197,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1772,160,735 - 72,195,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01773,846,130 - 73,882,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41779,688,702 - 79,726,869 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1767,862,012 - 67,898,344 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Itih2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542124,150,526 - 24,189,810 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542124,149,081 - 24,189,810 (+)NCBIChiLan1.0ChiLan1.0
ITIH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2820,251,216 - 20,300,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11020,256,543 - 20,306,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0107,732,931 - 7,782,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1107,713,517 - 7,762,756 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl107,713,454 - 7,762,756 (+)Ensemblpanpan1.1panPan2
ITIH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1228,367,842 - 28,403,610 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl228,367,908 - 28,403,667 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha225,408,695 - 25,444,418 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0228,749,446 - 28,785,349 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl228,749,543 - 28,785,325 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1225,855,861 - 25,891,725 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0226,697,790 - 26,733,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0227,415,891 - 27,451,788 (-)NCBIUU_Cfam_GSD_1.0
Itih2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934430,900,059 - 30,936,820 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364847,065,406 - 7,101,855 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364847,064,836 - 7,101,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1063,635,210 - 63,672,163 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11063,635,206 - 63,672,200 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21069,732,423 - 69,752,000 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Itih2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247752,667,781 - 2,707,046 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247752,667,840 - 2,706,951 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 23 15 43
Below cutoff 13 3 17

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008002219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000011564   ⟹   ENSCSAP00000009631
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl97,749,464 - 7,794,933 (+)Ensembl
RefSeq Acc Id: XM_008002219   ⟹   XP_008000410
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.197,748,818 - 7,794,932 (+)NCBI
Vero_WHO_p1.0NW_02366605113,144,753 - 13,190,763 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008000410 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009631.1
Reference Protein Sequences
RefSeq Acc Id: XP_008000410   ⟸   XM_008002219
- UniProtKB: A0A0D9RLZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009631   ⟸   ENSCSAT00000011564


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013467 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011564.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103237854 UniProtKB/TrEMBL
NCBI Gene ITIH2 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A0D9RLZ2 ENTREZGENE, UniProtKB/TrEMBL