ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2) - Rat Genome Database

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Gene: ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2) Pan paniscus
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Symbol: ITIH2
Name: inter-alpha-trypsin inhibitor heavy chain 2
RGD ID: 11813294
Description: ENCODES a protein that exhibits hyaluronic acid binding (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN hyaluronan metabolic process (inferred); ASSOCIATED WITH hypoparathyroidism-deafness-renal disease syndrome (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inter-alpha-trypsin inhibitor heavy chain H2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2820,251,216 - 20,300,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11020,256,543 - 20,306,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0107,732,931 - 7,782,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1107,713,517 - 7,762,756 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl107,713,454 - 7,762,756 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ITIH2Bonobohypoparathyroidism-deafness-renal disease syndrome  ISOITIH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypoparathyroidism more ...ClinVarPMID:25741868


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ITIH2Bonobohyaluronan metabolic process involved_inIEAInterPro:IPR010600150520179 InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ITIH2Bonoboextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
ITIH2Bonoboextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ITIH2Bonobohyaluronic acid binding enablesIEAUniProtKB:P19823 and ensembl:ENSP00000351190150520179 EnsemblGO_REF:0000107
ITIH2Bonoboprotein binding enablesISOUniProtKB:P02760-PRO_00000178879068941 PMID:16873769 and PMID:20463016UniProtPMID:16873769 and PMID:20463016
ITIH2Bonoboserine-type endopeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-0722150520179 UniProtGO_REF:0000043
ITIH2Bonoboserine-type endopeptidase inhibitor activity enablesIEAInterPro:IPR010600150520179 InterProGO_REF:0000002

PMID:22301074  



ITIH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2820,251,216 - 20,300,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11020,256,543 - 20,306,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0107,732,931 - 7,782,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1107,713,517 - 7,762,756 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl107,713,454 - 7,762,756 (+)Ensemblpanpan1.1panPan2
ITIH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38107,703,316 - 7,749,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl107,703,316 - 7,749,520 (+)EnsemblGRCh38hg38GRCh38
GRCh37107,745,279 - 7,791,483 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36107,785,242 - 7,831,489 (+)NCBINCBI36Build 36hg18NCBI36
Build 34107,785,342 - 7,831,488NCBI
Celera107,671,050 - 7,717,293 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef107,663,584 - 7,709,831 (+)NCBIHuRef
CHM1_1107,745,665 - 7,791,444 (+)NCBICHM1_1
T2T-CHM13v2.0107,703,948 - 7,750,283 (+)NCBIT2T-CHM13v2.0
Itih2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39210,099,408 - 10,135,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl210,099,404 - 10,136,207 (-)EnsemblGRCm39 Ensembl
GRCm38210,094,591 - 10,130,683 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl210,094,593 - 10,131,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37210,016,218 - 10,052,310 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36210,012,444 - 10,048,517 (-)NCBIMGSCv36mm8
Celera210,033,646 - 10,069,833 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map26.89NCBI
Itih2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81773,285,281 - 73,321,555 (+)NCBIGRCr8
mRatBN7.21768,375,574 - 68,411,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1768,375,567 - 68,411,841 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01772,160,734 - 72,197,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1772,160,735 - 72,195,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01773,846,130 - 73,882,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41779,688,702 - 79,726,869 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1767,862,012 - 67,898,344 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Itih2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542124,150,526 - 24,189,810 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542124,149,081 - 24,189,810 (+)NCBIChiLan1.0ChiLan1.0
ITIH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1228,367,842 - 28,403,610 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl228,367,908 - 28,403,667 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha225,408,695 - 25,444,418 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0228,749,446 - 28,785,349 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl228,749,543 - 28,785,325 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1225,855,861 - 25,891,725 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0226,697,790 - 26,733,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0227,415,891 - 27,451,788 (-)NCBIUU_Cfam_GSD_1.0
Itih2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934430,900,059 - 30,936,820 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364847,065,406 - 7,101,855 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364847,064,836 - 7,101,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1063,635,210 - 63,672,163 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11063,635,206 - 63,672,200 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21069,732,423 - 69,752,000 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITIH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.197,748,818 - 7,794,932 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl97,749,464 - 7,794,933 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605113,144,753 - 13,190,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itih2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247752,667,781 - 2,707,046 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247752,667,840 - 2,706,951 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_003827801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000000642   ⟹   ENSPPAP00000000158
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl107,713,454 - 7,762,756 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000000670   ⟹   ENSPPAP00000000165
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl107,713,741 - 7,762,570 (+)Ensembl
RefSeq Acc Id: XM_003827801   ⟹   XP_003827849
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2820,251,216 - 20,300,738 (+)NCBI
NHGRI_mPanPan11020,256,543 - 20,306,869 (+)NCBI
Mhudiblu_PPA_v0107,732,931 - 7,782,362 (+)NCBI
PanPan1.1107,713,517 - 7,762,756 (+)NCBI
Sequence:
Protein RefSeqs XP_003827849 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000000158.1
  ENSPPAP00000000165.1
RefSeq Acc Id: XP_003827849   ⟸   XM_003827801
- UniProtKB: A0A2R8Z9R9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000000165   ⟸   ENSPPAT00000000670
Ensembl Acc Id: ENSPPAP00000000158   ⟸   ENSPPAT00000000642
VIT   VWFA



1 to 23 of 23 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000000244 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000000642.1 UniProtKB/TrEMBL
  ENSPPAT00000000670.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/TrEMBL
  ITIH UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100969601 UniProtKB/TrEMBL
NCBI Gene ITIH2 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A2R8Z603_PANPA UniProtKB/TrEMBL
  A0A2R8Z9R9 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows