ARHGEF15 (Rho guanine nucleotide exchange factor 15) - Rat Genome Database

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Pathways
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Gene: ARHGEF15 (Rho guanine nucleotide exchange factor 15) Chlorocebus sabaeus
Analyze
Symbol: ARHGEF15
Name: Rho guanine nucleotide exchange factor 15
RGD ID: 18700670
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN positive regulation of stress fiber assembly (ortholog); retina vasculature morphogenesis in camera-type eye (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); Diamond-Blackfan anemia (ortholog); dyskeratosis congenita (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); postsynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,674,190 - 7,687,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,674,577 - 7,687,834 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,712,012 - 13,724,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
dendrite  (IEA)
glutamatergic synapse  (IEA,ISO)
postsynapse  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARHGEF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,674,190 - 7,687,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,674,577 - 7,687,834 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,712,012 - 13,724,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ARHGEF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,310,241 - 8,322,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,310,241 - 8,322,514 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,213,559 - 8,225,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,154,315 - 8,166,554 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,154,314 - 8,166,553NCBI
Celera178,244,326 - 8,256,604 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,108,796 - 8,121,074 (+)NCBIHuRef
CHM1_1178,222,461 - 8,234,738 (+)NCBICHM1_1
T2T-CHM13v2.0178,216,478 - 8,228,747 (+)NCBIT2T-CHM13v2.0
Arhgef15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,819,726 - 68,847,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,833,981 - 68,848,306 (-)EnsemblGRCm39 Ensembl
GRCm381168,928,900 - 68,956,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,943,155 - 68,957,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,756,656 - 68,770,360 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,759,349 - 68,773,053 (-)NCBIMGSCv36mm8
Celera1175,885,590 - 75,899,659 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.21NCBI
Arhgef15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,149,372 - 54,162,128 (-)NCBIGRCr8
mRatBN7.21053,650,521 - 53,663,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,650,553 - 53,663,913 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,311,746 - 58,324,031 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,800,344 - 57,812,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,309,305 - 53,321,725 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,532,097 - 55,545,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,532,077 - 55,544,429 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,274,558 - 55,288,124 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,703,919 - 55,716,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,719,072 - 55,729,109 (-)NCBI
Celera1052,816,914 - 52,829,189 (-)NCBICelera
Cytogenetic Map10q24NCBI
Arhgef15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,587,873 - 8,602,747 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,590,217 - 8,603,778 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,430,225 - 65,448,985 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,239,706 - 70,258,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,336,764 - 43,349,787 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,070,223 - 48,082,499 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,070,223 - 48,082,499 (-)Ensemblpanpan1.1panPan2
ARHGEF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,096,108 - 33,110,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,098,159 - 33,121,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,232,023 - 33,246,695 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0533,199,015 - 33,213,954 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,199,053 - 33,213,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,165,967 - 33,180,883 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,121,691 - 33,136,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,301,486 - 33,316,166 (+)NCBIUU_Cfam_GSD_1.0
Arhgef15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560248,057,476 - 48,071,035 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,534,717 - 1,543,448 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,531,694 - 1,545,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,495,453 - 53,506,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,495,409 - 53,506,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,970,955 - 55,981,937 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Arhgef15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,892,422 - 10,901,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,872,793 - 10,902,948 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 13 42
Below cutoff 5 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008545   ⟹   ENSCSAP00000006690
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl167,674,577 - 7,687,834 (+)Ensembl
RefSeq Acc Id: XM_008010286   ⟹   XP_008008477
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1167,674,190 - 7,687,129 (+)NCBI
Vero_WHO_p1.0NW_02366605913,712,012 - 13,724,580 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008010287   ⟹   XP_008008478
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1167,674,709 - 7,687,129 (+)NCBI
Vero_WHO_p1.0NW_02366605913,712,012 - 13,724,014 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005236716
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605913,712,012 - 13,724,581 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008008477 (Get FASTA)   NCBI Sequence Viewer  
  XP_008008478 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006690
  ENSCSAP00000006690.1
Reference Protein Sequences
RefSeq Acc Id: XP_008008477   ⟸   XM_008010286
- UniProtKB: A0A0D9RDK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008008478   ⟸   XM_008010287
- UniProtKB: A0A0D9RDK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000006690   ⟸   ENSCSAT00000008545


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010464 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008545.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Ephexin-like UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_ephexin UniProtKB/TrEMBL
KEGG Report csab:103242355 UniProtKB/TrEMBL
NCBI Gene ARHGEF15 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 15 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
UniProt A0A0D9RDK1 ENTREZGENE, UniProtKB/TrEMBL