TMED4 (transmembrane p24 trafficking protein 4) - Rat Genome Database

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Gene: TMED4 (transmembrane p24 trafficking protein 4) Chlorocebus sabaeus
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Symbol: TMED4
Name: transmembrane p24 trafficking protein 4
RGD ID: 18675404
Description: INVOLVED IN positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); endoplasmic reticulum-Golgi intermediate compartment (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transmembrane emp24 domain-containing protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,095,120 - 14,099,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,095,538 - 14,098,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,431,190 - 8,440,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TMED4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,095,120 - 14,099,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,095,538 - 14,098,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,431,190 - 8,440,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TMED4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,577,894 - 44,582,231 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,576,392 - 44,582,287 (-)EnsemblGRCh38hg38GRCh38
GRCh37744,617,493 - 44,621,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,585,287 - 44,588,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 34744,392,002 - 44,395,067NCBI
Celera744,717,606 - 44,720,671 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,503,138 - 44,506,203 (-)NCBIHuRef
CHM1_1744,623,158 - 44,626,223 (-)NCBICHM1_1
T2T-CHM13v2.0744,737,656 - 44,741,987 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,658,279 - 44,661,344 (-)NCBI
Tmed4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,220,714 - 6,224,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,220,369 - 6,224,870 (-)EnsemblGRCm39 Ensembl
GRCm38116,270,714 - 6,274,837 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,270,369 - 6,274,870 (-)EnsemblGRCm38mm10GRCm38
MGSCv37116,170,717 - 6,174,840 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,170,717 - 6,174,840 (-)NCBIMGSCv36mm8
Celera116,752,660 - 6,756,791 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.94NCBI
Tmed4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,338,980 - 85,343,577 (-)NCBIGRCr8
mRatBN7.21481,125,049 - 81,129,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,125,053 - 81,129,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,525,765 - 85,530,504 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,765,848 - 86,770,587 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,215,174 - 83,219,913 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,390,327 - 86,395,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,390,338 - 86,395,135 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01487,351,512 - 87,356,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,997,282 - 87,001,869 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,016,423 - 87,021,016 (-)NCBI
Celera1480,007,995 - 80,012,582 (-)NCBICelera
Cytogenetic Map14q21NCBI
Tmed4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,500,848 - 7,504,310 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,500,848 - 7,504,310 (+)NCBIChiLan1.0ChiLan1.0
TMED4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,487,406 - 49,494,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,811,961 - 97,819,543 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,289,666 - 45,297,030 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,358,692 - 45,366,036 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,361,693 - 45,366,395 (-)Ensemblpanpan1.1panPan2
TMED4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,355,451 - 2,357,820 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,503,747 - 14,506,117 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,503,778 - 14,516,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,135,234 - 14,137,604 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,115,849 - 14,118,219 (+)NCBIUU_Cfam_GSD_1.0
Tmed4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,265,967 - 100,270,922 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,477,698 - 19,482,706 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,477,698 - 19,482,656 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMED4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,699,470 - 50,702,705 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,698,819 - 50,702,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,602,126 - 55,605,640 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tmed4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,558,717 - 7,562,517 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,549,549 - 7,562,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000013735   ⟹   ENSCSAP00000011725
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2114,095,538 - 14,098,321 (+)Ensembl
RefSeq Acc Id: XM_007981429   ⟹   XP_007979620
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12114,095,490 - 14,099,415 (+)NCBI
Vero_WHO_p1.0NW_0236660628,436,023 - 8,440,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007981430   ⟹   XP_007979621
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12114,095,120 - 14,099,415 (+)NCBI
Vero_WHO_p1.0NW_0236660628,436,023 - 8,440,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037988243   ⟹   XP_037844171
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660628,431,190 - 8,440,025 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007979620 (Get FASTA)   NCBI Sequence Viewer  
  XP_007979621 (Get FASTA)   NCBI Sequence Viewer  
  XP_037844171 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011725
  ENSCSAP00000011725.1
RefSeq Acc Id: XP_007979621   ⟸   XM_007981430
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007979620   ⟸   XM_007981429
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RSY6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000011725   ⟸   ENSCSAT00000013735
RefSeq Acc Id: XP_037844171   ⟸   XM_037988243
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015650 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013735.1 UniProtKB/TrEMBL
InterPro GOLD_dom UniProtKB/TrEMBL
  TMP21-related UniProtKB/TrEMBL
KEGG Report csab:103226132 UniProtKB/TrEMBL
NCBI Gene TMED4 ENTREZGENE
PANTHER PTHR22811 UniProtKB/TrEMBL
  TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam EMP24_GP25L UniProtKB/TrEMBL
PROSITE GOLD UniProtKB/TrEMBL
SMART EMP24_GP25L UniProtKB/TrEMBL
UniProt A0A0D9RSY6 ENTREZGENE, UniProtKB/TrEMBL