POLR1A (RNA polymerase I subunit A) - Rat Genome Database

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Gene: POLR1A (RNA polymerase I subunit A) Chlorocebus sabaeus
Analyze
Symbol: POLR1A
Name: RNA polymerase I subunit A
RGD ID: 18662020
Description: ENCODES a protein that exhibits DNA-directed RNA polymerase activity (ortholog); INVOLVED IN rRNA transcription (ortholog); PARTICIPATES IN nucleotide excision repair pathway; RNA polymerase I transcription pathway; ASSOCIATED WITH acrofacial dysostosis Cincinnati type (ortholog); genetic disease (ortholog); hereditary spastic paraplegia 31 (ortholog); FOUND IN RNA polymerase I complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA-directed RNA polymerase I subunit RPA1; polymerase (RNA) I polypeptide A, 194kDa
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,050,526 - 21,127,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,050,799 - 21,125,990 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604591,355,366 - 91,437,424 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1AGreen Monkeyacrofacial dysostosis Cincinnati type  ISOPOLR1A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
POLR1AGreen Monkeygenetic disease  ISOPOLR1A (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24153182 more ...
POLR1AGreen Monkeyhereditary spastic paraplegia 31  ISOPOLR1A (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 31ClinVarPMID:18321925 more ...
POLR1AGreen MonkeyHypomyelinating Leukodystrophy 27  ISOPOLR1A (Homo sapiens)8554872ClinVar Annotator: match by term: Leukodystrophy more ...ClinVarPMID:25741868
POLR1AGreen Monkeyimmunodeficiency 116  ISOPOLR1A (Homo sapiens)8554872ClinVar Annotator: match by term: Cd8 deficiency and familialClinVarPMID:28492532
POLR1AGreen MonkeyNESCAV syndrome  ISOPOLR1A (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and autosomal dominant 9ClinVarPMID:25741868
POLR1AGreen Monkeysalt and pepper syndrome  ISOPOLR1A (Homo sapiens)8554872ClinVar Annotator: match by term: GM3 synthase deficiencyClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1AGreen Monkeyacrofacial dysostosis Cincinnati type  ISOPOLR1A (Homo sapiens)7240710 OMIM 
POLR1AGreen MonkeyHypomyelinating Leukodystrophy 27  ISOPOLR1A (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1AGreen MonkeyDNA-templated transcription involved_inIEAInterPro:IPR000722 more ...150520179 InterProGO_REF:0000002
POLR1AGreen Monkeynegative regulation of protein localization to nucleolus involved_inIEAUniProtKB:O95602 and ensembl:ENSP00000263857150520179 EnsemblGO_REF:0000107
POLR1AGreen MonkeyrRNA transcription  ISOPolr1a (Rattus norvegicus)9068941 RGDPMID:9422795 and REF_RGD_ID:2312782
POLR1AGreen Monkeytranscription by RNA polymerase I involved_inIEAUniProtKB:O95602 and ensembl:ENSP00000263857150520179 EnsemblGO_REF:0000107

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1AGreen Monkeychromatin part_ofIEAUniProtKB:O95602 and ensembl:ENSP00000263857150520179 EnsemblGO_REF:0000107
POLR1AGreen Monkeychromosome located_inIEAUniProtKB:O35134 and ensembl:ENSMUSP00000060858150520179 EnsemblGO_REF:0000107
POLR1AGreen MonkeyDNA-directed RNA polymerase complex part_ofIEAUniProtKB-KW:KW-0240150520179 UniProtGO_REF:0000043
POLR1AGreen Monkeymitochondrion located_inIEAGO:0006390150520179 GOCGO_REF:0000108
POLR1AGreen Monkeynucleus located_inIEAUniProtKB:O35134 and ensembl:ENSMUSP00000060858150520179 EnsemblGO_REF:0000107
POLR1AGreen Monkeynucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
POLR1AGreen MonkeyRNA polymerase I complex part_ofIEAARBA:ARBA00044582150520179 UniProtGO_REF:0000117
POLR1AGreen MonkeyRNA polymerase I complex part_ofIEAUniProtKB:O35134 more ...150520179 EnsemblGO_REF:0000107
POLR1AGreen MonkeyRNA polymerase I complex part_ofIEAPANTHER:PTN000453577150520179 TreeGrafterGO_REF:0000118
POLR1AGreen MonkeyRNA polymerase I complex  ISOPolr1a (Rattus norvegicus)9068941 RGDPMID:9422795 and REF_RGD_ID:2312782
1 to 10 of 10 rows

Molecular Function
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1AGreen Monkeychromatin binding enablesIEAUniProtKB:O95602 and ensembl:ENSP00000263857150520179 EnsemblGO_REF:0000107
POLR1AGreen MonkeyDNA binding enablesIEAInterPro:IPR000722 more ...150520179 InterProGO_REF:0000002
POLR1AGreen MonkeyDNA-directed RNA polymerase activity enablesIEAInterPro:IPR000722 more ...150520179 InterProGO_REF:0000002
POLR1AGreen MonkeyDNA-directed RNA polymerase activity enablesIEAPANTHER:PTN000453577150520179 TreeGrafterGO_REF:0000118
POLR1AGreen MonkeyDNA-directed RNA polymerase activity enablesIEAEC:2.7.7.6150520179 UniProtGO_REF:0000003
POLR1AGreen MonkeyDNA-directed RNA polymerase activity enablesIEAUniProtKB:O95602 and ensembl:ENSP00000263857150520179 EnsemblGO_REF:0000107
POLR1AGreen MonkeyDNA-directed RNA polymerase activity contributes_toISOPolr1a (Rattus norvegicus)9068941 RGDPMID:9422795 and REF_RGD_ID:2312782
POLR1AGreen MonkeyDNA/RNA hybrid binding enablesIEAUniProtKB:O95602 and ensembl:ENSP00000263857150520179 EnsemblGO_REF:0000107
POLR1AGreen Monkeymagnesium ion binding enablesIEAUniProtKB:O95602 and ensembl:ENSP00000263857150520179 EnsemblGO_REF:0000107
POLR1AGreen Monkeynucleotidyltransferase activity enablesIEAUniProtKB-KW:KW-0548150520179 UniProtGO_REF:0000043
POLR1AGreen Monkeyprotein binding enablesISOUniProtKB:Q96FC99068941 PMID:26089203UniProtPMID:26089203
POLR1AGreen Monkeyprotein binding enablesISOPR:P707009068941 PMID:9236775MGIPMID:9236775
POLR1AGreen Monkeyprotein binding enablesISOUniProtKB:O547249068941 PMID:10589839UniProtPMID:10589839
POLR1AGreen Monkeyprotein binding enablesISOPR:P97304 and PR:Q76KJ59068941 PMID:15226435MGIPMID:15226435
POLR1AGreen Monkeyprotein binding enablesISOUniProtKB:P113889068941 PMID:36271492UniProtPMID:36271492
POLR1AGreen Monkeyprotein binding enablesISOUniProtKB:Q6FHY5 and UniProtKB:Q96IM99068941 PMID:32296183IntActPMID:32296183
POLR1AGreen Monkeyprotein binding enablesISOUniProtKB:P15884 and UniProtKB:Q048649068941 PMID:25416956IntActPMID:25416956
POLR1AGreen Monkeyprotein binding enablesISOUniProtKB:Q9H9Y69068941 PMID:16514417 more ...IntActPMID:16514417 more ...
POLR1AGreen Monkeyprotein binding enablesISOUniProtKB:P046269068941 PMID:21555369IntActPMID:21555369
POLR1AGreen Monkeytransferase activity enablesIEAUniProtKB-KW:KW-0808150520179 UniProtGO_REF:0000043
1 to 20 of 21 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1AGreen MonkeyRNA polymerase I transcription pathway   ISOPOLR1A (Homo sapiens)9068941 RGDPMID:21893173 more ...

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1AGreen Monkeynucleotide excision repair pathway   ISOPOLR1A (Homo sapiens)9068941 SMPDBSMP:00478
PMID:22301074   PMID:30032202  



POLR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,050,526 - 21,127,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,050,799 - 21,125,990 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604591,355,366 - 91,437,424 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
POLR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38286,020,216 - 86,105,886 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl286,020,216 - 86,106,155 (-)EnsemblGRCh38hg38GRCh38
GRCh37286,247,339 - 86,333,009 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36286,106,962 - 86,186,789 (-)NCBINCBI36Build 36hg18NCBI36
Build 34286,166,037 - 86,244,626NCBI
Celera286,081,632 - 86,161,424 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef286,150,981 - 86,230,775 (-)NCBIHuRef
CHM1_1286,182,963 - 86,262,735 (-)NCBICHM1_1
T2T-CHM13v2.0286,022,315 - 86,107,956 (-)NCBIT2T-CHM13v2.0
Polr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39671,886,037 - 71,956,419 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl671,886,037 - 71,961,919 (+)EnsemblGRCm39 Ensembl
GRCm38671,909,053 - 71,979,435 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,909,053 - 71,984,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv37671,859,047 - 71,929,354 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36671,838,582 - 71,908,869 (+)NCBIMGSCv36mm8
Celera673,992,680 - 74,063,054 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.21NCBI
Polr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84105,508,305 - 105,572,272 (+)NCBIGRCr8
mRatBN7.24103,950,051 - 104,014,022 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4103,950,051 - 104,014,020 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,329,917 - 109,393,831 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,105,033 - 105,168,947 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04103,719,955 - 103,783,923 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0499,822,964 - 99,903,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl499,823,252 - 99,887,132 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04164,601,148 - 164,665,022 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,187,426 - 105,251,385 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,431,906 - 105,495,866 (+)NCBI
Celera493,106,344 - 93,170,325 (+)NCBICelera
Cytogenetic Map4q32NCBI
Polr1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,508,037 - 1,593,108 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,507,935 - 1,595,068 (+)NCBIChiLan1.0ChiLan1.0
POLR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,277,726 - 40,365,224 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,280,716 - 40,361,804 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A86,070,160 - 86,157,606 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,618,880 - 87,705,352 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,622,466 - 87,705,357 (-)Ensemblpanpan1.1panPan2
POLR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11738,990,379 - 39,070,910 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,000,778 - 39,070,356 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1738,675,191 - 38,756,338 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01739,722,717 - 39,805,020 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1739,733,845 - 39,805,015 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11738,891,244 - 38,972,175 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01738,927,011 - 39,009,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,313,308 - 39,394,902 (+)NCBIUU_Cfam_GSD_1.0
Polr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,467,900 - 79,527,456 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,331,073 - 1,389,856 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,331,016 - 1,390,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl358,667,971 - 58,750,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1358,670,377 - 58,750,441 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2361,529,882 - 61,609,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Polr1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,138,476 - 17,215,124 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,138,352 - 17,216,039 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in POLR1A
2050 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20


RefSeq Transcripts XM_007969992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000014344   ⟹   ENSCSAP00000012320
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1421,050,799 - 21,125,990 (+)Ensembl
RefSeq Acc Id: XM_007969992   ⟹   XP_007968183
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11421,050,526 - 21,127,010 (+)NCBI
Vero_WHO_p1.0NW_02366604591,355,366 - 91,437,424 (-)NCBI
Sequence:
Protein RefSeqs XP_007968183 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012320.1
RefSeq Acc Id: XP_007968183   ⟸   XM_007969992
- UniProtKB: A0A0D9RUN1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000012320   ⟸   ENSCSAT00000014344



1 to 34 of 34 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000016251 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014344.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.30 UniProtKB/TrEMBL
  1.10.274.100 UniProtKB/TrEMBL
  1.10.357.120 UniProtKB/TrEMBL
  2.40.40.20 UniProtKB/TrEMBL
  3.30.70.2850 UniProtKB/TrEMBL
  4.10.860.120 UniProtKB/TrEMBL
  6.10.250.2940 UniProtKB/TrEMBL
  RNA polymerase ii UniProtKB/TrEMBL
InterPro DNA-dir_RNA_pol1_lsu_C UniProtKB/TrEMBL
  DNA-dir_RNA_pol1_lsu_N UniProtKB/TrEMBL
  DNA-dir_RpoC_beta_prime UniProtKB/TrEMBL
  RNA_pol_asu UniProtKB/TrEMBL
  RNA_pol_N UniProtKB/TrEMBL
  RNA_pol_Rpb1_1 UniProtKB/TrEMBL
  RNA_pol_Rpb1_3 UniProtKB/TrEMBL
  RNA_pol_Rpb1_3_sf UniProtKB/TrEMBL
  RNA_pol_Rpb1_4 UniProtKB/TrEMBL
  RNA_pol_Rpb1_5 UniProtKB/TrEMBL
  RNA_pol_Rpb1_clamp_domain UniProtKB/TrEMBL
  Rpb1_funnel_sf UniProtKB/TrEMBL
KEGG Report csab:103219930 UniProtKB/TrEMBL
NCBI Gene POLR1A ENTREZGENE
PANTHER PTHR19376 UniProtKB/TrEMBL
  PTHR19376:SF11 UniProtKB/TrEMBL
Pfam RNA_pol_Rpb1_1 UniProtKB/TrEMBL
  RNA_pol_Rpb1_2 UniProtKB/TrEMBL
  RNA_pol_Rpb1_3 UniProtKB/TrEMBL
  RNA_pol_Rpb1_4 UniProtKB/TrEMBL
  RNA_pol_Rpb1_5 UniProtKB/TrEMBL
SMART RPOLA_N UniProtKB/TrEMBL
Superfamily-SCOP beta and beta-prime subunits of DNA dependent RNA-polymerase UniProtKB/TrEMBL
UniProt A0A0D9RUN1 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows