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Gene: CIAO3 (cytosolic iron-sulfur assembly component 3) Chlorocebus sabaeus

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Symbol:

CIAO3

Name:

cytosolic iron-sulfur assembly component 3

RGD ID:

18589140

Description:

INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); iron-sulfur cluster assembly (ortholog); PARTICIPATES IN cytosolic iron-sulfur cluster protein assembly pathway; ASSOCIATED WITH epilepsy (ortholog); hereditary hemorrhagic telangiectasia (ortholog); High Myopia (ortholog); FOUND IN cytosolic [4Fe-4S] assembly targeting complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytosolic Fe-S cluster assembly factor NARFL; NARFL; nuclear prelamin A recognition factor like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	649,457 - 661,085 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	650,100 - 660,518 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	30,475,095 - 30,486,224 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

hereditary hemorrhagic telangiectasia (ISO)

High Myopia (ISO)

idiopathic generalized epilepsy (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

tuberous sclerosis 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

hematopoietic progenitor cell differentiation (IEA,ISO)

intracellular oxygen homeostasis (IEA)

iron-sulfur cluster assembly (IEA,ISO)

regulation of gene expression (IEA)

response to hypoxia (IEA)

Cellular Component

cytosolic [4Fe-4S] assembly targeting complex (IEA)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cytosolic iron-sulfur cluster protein assembly pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CIAO3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	649,457 - 661,085 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	650,100 - 660,518 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	30,475,095 - 30,486,224 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CIAO3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	729,765 - 740,997 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	729,760 - 741,329 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	779,765 - 790,997 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	719,768 - 730,998 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	979,932 - 991,162 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	701,355 - 713,420 (-)	NCBI		HuRef
CHM1_1	16	779,737 - 790,967 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	733,939 - 745,171 (-)	NCBI		T2T-CHM13v2.0

Ciao3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	25,992,750 - 26,002,306 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	25,992,750 - 26,002,306 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	25,773,776 - 25,783,332 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	25,773,776 - 25,783,332 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,910,721 - 25,920,277 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	25,501,400 - 25,510,932 (+)	NCBI		MGSCv36	mm8
Celera	17	26,306,378 - 26,316,138 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.88	NCBI

Ciao3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,300,403 - 15,309,467 (+)	NCBI		GRCr8
mRatBN7.2	10	14,795,888 - 14,804,953 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,795,961 - 14,804,950 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,535,018 - 19,543,954 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,023,897 - 19,032,831 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,524,003 - 14,532,951 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	15,143,732 - 15,152,706 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	15,143,713 - 15,153,396 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,956,675 - 14,965,649 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,041,376 - 15,050,350 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,041,375 - 15,050,349 (+)	NCBI
Celera	10	14,464,975 - 14,473,945 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Ciao3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	16,465,178 - 16,475,110 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	16,465,759 - 16,475,110 (+)	NCBI	ChiLan1.0	ChiLan1.0

CIAO3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	970,394 - 981,690 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	4,754,231 - 4,765,546 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	742,818 - 754,087 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	742,818 - 754,087 (-)	Ensembl	panpan1.1		panPan2

CIAO3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,846,782 - 39,853,952 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	39,846,856 - 39,853,956 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	41,111,447 - 41,118,616 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,189,920 - 40,197,089 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	40,189,928 - 40,198,067 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	39,878,530 - 39,885,699 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,838,744 - 39,845,912 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,317,618 - 40,324,787 (+)	NCBI		UU_Cfam_GSD_1.0

Ciao3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	112,179,668 - 112,189,069 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	277,518 - 286,932 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	277,525 - 286,929 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CIAO3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	41,042,702 - 41,050,012 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	41,042,672 - 41,050,013 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,427,901 - 41,435,243 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Ciao3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	1,538,546 - 1,553,415 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	1,538,561 - 1,553,409 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CIAO3
314 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007980653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000010239 ⟹ ENSCSAP00000008336

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	5	650,100 - 660,518 (-)	Ensembl

RefSeq Acc Id:

XM_007980653 ⟹ XP_007978844

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	649,457 - 661,085 (-)	NCBI
Vero_WHO_p1.0	NW_023666068	30,475,095 - 30,486,224 (+)	NCBI

Sequence:

show sequence

AAAAAAAAAAAGCGAATCGGTCCGCAGAGTCCTGTTTCAGGGTCTCCCAGGGGTATGGACTTTT
CCAGACTGATCTCCAAGATAACAGAAAAGGGTGCTGGAGGCCCTGGGAGCGGCTCCCCAGGAAG
GTGAGGCCTGCCCCCATCCCTGCTTTCTTCCCTGCCTGAATTCCCCAACACTAGCTGAGCGCCT
TCTGCCTGCCACGCGAGTTCCGGGTTCTTGGGTTGCATCCGGGAACACCTGGTCCGCAGGTACT
CAGCGGATAACGAAGTGGACGGAGCCAAGATCCCCTCCGCTTTCTTGTGAAGGCGGAGAGACTC
CGGGGCCGGAGCTGCGGCGCTGGCCCGGCCGCCCCCTGCAACCCAACCCGGGGCCGGGGACGCG
CGGGAGGCGGAGGAAAGGGTCGGTCCCGGGTTCCCGCGGGGTGGGCGGGGAGCAGCAGCGCCCG
GGTTCGTCAGCAGAGGGCGCCGGTCGCGGGGCGAGGTGCGCGGTGCGCATGCACCTTGGAGGCG
CTTTCCGGCAGCGTGGCGGAACCACCCCTTCGTTTCACGCCGTTGGGCGACATCTCCGCGCGGC
GGCAGTGCGGCCGTCATGGCGTCGCCCTTCAGTGGGGCGCTGCAGCTGACGGACCTGGATGACT
TCATCGGGCCGTCTCAGGAATGCATCAAGCCTGTCAAAGTGGAAAAAAGACCGGGAAGTGGCGT
GGCCAAGATTCGCATAGAAGATGATGGGAGCTACTTCCAAGTTAACCAAGACGGCGGGACCCGG
AGGCTGGAGAAGGCCAAGGTCTCCCTAAATGACTGCCTGGCGTGCAGCGGCTGCATCACCTCTG
CAGAGACCGTGCTTATCACCCAGCAGAGCCACGAAGAGCTGAAGAAGGTTCTAGATGCTAACAA
AATGGTGGCGCCCAGTCAGCAGAGGCTGGTTGTAGTTTCAGTCTCGCCACAGTCTAGAGCATCG
CTGGCTGCACGGTTTCAGCTGAATCCTACAGACACTGCCAGGAAATTAACCTCATTCTTTAAAA
AAATAGGGGTGCACTTTGTCTTCGACACCGCCTTCTCAAGGCACTTCAGCCTCCTGGAGAGCCA
GCGAGAGTTTGTGCGGCGATTCCGAGGACAGGCCGACTGCAGACAGGCCCTGCCCCTGCTGGCC
TCCGCCTGCCCAGGCTGGATCTGCTATGCCGAGAAGACCCACGGCAGCTTCATCCTCCCCCACA
TCAGCACCGCCCGGTCCCCGCAGCAGGTCATGGGCTCCCTGGTCAAGGACTTCTTCGCCCAGCA
GCAGCGCTTGACTCCTGACAAGATCTACCACGTCACGGTGATGCCCTGCTACGACAAAAAGCTG
GAAGCCTCTAGACCCGACTTTTTCAACCAGGAGCACCAGACGCGGGACGTGGACTGTGTCCTCA
CAACAGGAGAAGTTTTCAGGTTGCTGGAGGAAGAGGACGTCTCCCTCCCCGACCTGGAACCAGC
GCCTCTGGACAGCCTGTGCAGCGGTGCCTCTGCAGAGGAGCCCACCAGCCATCGGGGAGGGGGC
TCGGGGGGCTACCTGGAGCACGTGTTCCGGCACGCAGCCCGAGAGCTCTTTGGAATCCACGTGG
CTGAGGTTACCTACAAACCCCTGAGGAACAAGGACTTCCAGGAGGTGACCCTGGAGAAGGAGGG
CCAGGTGCTGCTGCACTTCGCGATGGTGTACGGCTTCCGCAACATCCAGAACCTGGTGCAGAGG
CTCAAACGCGGGCGCTGCCCCTACCACTACGTGGAGGTCATGGCCTGCCCCTCAGGCTGCCTGA
ACGGCGGGGGCCAGCTGCAGGCCCCAGACAGGCCCAGCAGGGAGCTCCTCCAGCACGTGGAGAG
GCTGTACGGCATGGTCCGGGCTGAGGTGCCCGAGGATGCGCCTGGGGTTCAGGAGCTGTACACA
CACTGGCTGCAGGGCACGGACTCGGAGTGTGCAGGCCGCTTGCTGCATACACAGTACCACGCCG
TGGAGAAGGCCAGCACTGGCCTGGGCATCCGGTGGTAGGGGCTGCAGGACCAGGACTCCCAGGA
GGCCATGCGTGTGCGTGACAGCGGAACCACATGCCCCAAGACCCCAGGGCTCCTCCAAAAACTG
TGAGTGAGCTGCAGGGTGTGCTGGGACCCAAGCAGGAGCTGGGACTGGCCAGGACCCGCGGCTG
CCCCGTCACCTCCAGTTGGGTGCCTCTGGGTTCCCCGCTGGCTCTGCGCAGGTGGGGTGGCCCA
GGCAGTAGAAGGTCCCTGAGGTCCCACGGCCTGTTCGTTGGCCCTGGGCCGAGGCCCACAGGTG
CTGCCCTTGCTGTTGCTAGTCGGGCACCCAAGTGCTTGAGGGGCTTCAGCCTGTCTTGGGGTTG
CCTGAGGAAGAGCAAGACGGGTTCCCACCCCTGACTTCTGTAGGCTTCCCCTGAAGCTCTGTGC
AGAAGGTGGGAGACAGAGCTGGACCTGCAGGGGTGGTCCCACCACAACCCTGTGTGTGGACCCT
GGCAAGAGGGGGTGCTGGGCCCCTGGAAAGCAGGGGTTACTGTTACGAGGCTGTGGTCCAAGGC
AAGCCAAGTACGAAGTGGCAGCCATCACTAGCTGTGTCATCCCCCAGCCTGGTCCCCACCAGGC
CTGTCTCCCAGCGTTTGTCTAATAAAGGCATCCCCTCAACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007978844	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008336.1

RefSeq Acc Id:	XP_007978844 ⟸ XM_007980653
- UniProtKB:	A0A0D9RI97 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000008336 ⟸ ENSCSAT00000010239

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012192	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010239.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1780	UniProtKB/TrEMBL
	Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3	UniProtKB/TrEMBL
InterPro	Cytosolic_Fe-S_CAF	UniProtKB/TrEMBL
	Fe_hydrogenase	UniProtKB/TrEMBL
	Fe_hydrogenase_lsu_C	UniProtKB/TrEMBL
	Fe_hydrogenase_ssu	UniProtKB/TrEMBL
NCBI Gene	CIAO3	ENTREZGENE
PANTHER	NITRATE, FORMATE, IRON DEHYDROGENASE	UniProtKB/TrEMBL
Pfam	Fe_hyd_lg_C	UniProtKB/TrEMBL
	Fe_hyd_SSU	UniProtKB/TrEMBL
SMART	Fe_hyd_SSU	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53920	UniProtKB/TrEMBL
UniProt	A0A0D9RI97	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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