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CYTOSOLIC IRON-SULFUR CLUSTER PROTEIN ASSEMBLY PATHWAY (PW:0002636)

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Description

The small inorganic Fe-S cluster (ISC) cofactor acts as an electron carrier in redox and catalytic reactions, and as a sulfur donor and environmental sensor. The ISC proteins can be found in mitochondria, cytoplasm and nucleus and are involved in energy production, tRNA modification and features of protein translation, DNA metabolism and repair. The steps in the assembly of iron-sulfur (Fe-S) clusters (ISC) and delivery to Fe-S proteins are part of the mitochondrial ISC biogenesis and the connec

Pathway Diagram:

Elsevier Inc. Ciao1 Mms19 Fam96b Fam96a nuclear recipients cytosolic recipients mitochondrial iron-sulfur cluster export pathway mitochondrial iron-sulfur cluster protein biogenesis pathway Ndor1 ---> Ciapin1 Ciapin1 ---- Ndor1 Ciapin1 Ndor1 Nubp2 Nubp1 CIA targeting complex Narfl Nubp1 ---- Nubp2 Nubp1 ---> cytosolic recipients Nubp2 ---> nuclear recipients
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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ciao1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 3:114,458,671...114,465,928
Ensembl chr 3:114,458,655...114,467,009
JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 8:66,670,533...66,682,455
Ensembl chr 8:66,670,483...66,682,455
JBrowse link
G Ciao2b cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr19:344,194...346,068
Ensembl chr19:344,203...346,068
JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr10:14,795,888...14,804,953
Ensembl chr10:14,795,961...14,804,950
JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503
JBrowse link
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 1:240,757,279...240,794,291
Ensembl chr 1:240,757,282...240,794,288
JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 3:8,062,629...8,070,873
Ensembl chr 3:8,062,630...8,070,860
JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr10:5,259,328...5,270,848 JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cytosolic iron-sulfur cluster protein assembly pathway
Pathway Annotations Associated with Genes in the cytosolic iron-sulfur cluster protein assembly pathway

References Associated with the cytosolic iron-sulfur cluster protein assembly pathway:

Ontology Path Diagram:

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