TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1) - Rat Genome Database

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Gene: TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1) Chlorocebus sabaeus
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Symbol: TIAL1
Name: TIA1 cytotoxic granule associated RNA binding protein like 1
RGD ID: 18563876
Description: ENCODES a protein that exhibits mRNA 3'-UTR AU-rich region binding (ortholog); INVOLVED IN germ cell development (ortholog); positive regulation of stem cell proliferation (ortholog); stem cell division (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Disease Progression (ortholog); Experimental Liver Cirrhosis (ortholog); malignant astrocytoma (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nucleolysin TIAR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19112,355,900 - 112,379,531 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9112,358,101 - 112,379,671 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604873,628,854 - 73,652,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TIAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19112,355,900 - 112,379,531 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9112,358,101 - 112,379,671 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604873,628,854 - 73,652,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TIAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,573,465 - 119,596,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,571,802 - 119,597,029 (-)EnsemblGRCh38hg38GRCh38
GRCh3710121,332,977 - 121,356,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610121,322,967 - 121,346,531 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410121,324,903 - 121,343,015NCBI
Celera10115,063,941 - 115,087,519 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,962,544 - 114,986,092 (-)NCBIHuRef
CHM1_110121,617,558 - 121,641,117 (-)NCBICHM1_1
T2T-CHM13v2.010120,471,044 - 120,494,540 (-)NCBIT2T-CHM13v2.0
Tial1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397128,041,496 - 128,063,450 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7128,041,501 - 128,063,441 (-)EnsemblGRCm39 Ensembl
GRCm387128,439,772 - 128,461,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,439,777 - 128,461,717 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,583,291 - 135,605,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367128,233,450 - 128,252,437 (-)NCBIMGSCv36mm8
Celera7128,278,008 - 128,299,764 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.2NCBI
Tial1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,438,794 - 192,475,520 (-)NCBIGRCr8
mRatBN7.21183,008,358 - 183,045,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,009,253 - 183,031,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,361,276 - 191,381,864 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,547,363 - 198,567,951 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01191,217,117 - 191,237,695 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,844,854 - 199,865,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,844,859 - 199,865,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,892,006 - 206,913,468 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,687,606 - 187,706,035 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1180,656,068 - 180,676,817 (-)NCBICelera
Cytogenetic Map1q37NCBI
Tial1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955551370,792 - 395,836 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955551370,792 - 395,836 (-)NCBIChiLan1.0ChiLan1.0
TIAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28131,432,182 - 131,453,375 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110131,433,733 - 131,458,680 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010116,142,127 - 116,165,631 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,561,977 - 119,585,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,561,786 - 119,585,157 (-)Ensemblpanpan1.1panPan2
TIAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,729,246 - 29,750,703 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,731,950 - 29,750,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,871,505 - 29,892,642 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02830,260,194 - 30,281,358 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2830,259,529 - 30,281,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,814,092 - 29,835,256 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,834,767 - 29,855,900 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02830,028,947 - 30,050,087 (-)NCBIUU_Cfam_GSD_1.0
Tial1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,613,431 - 16,636,073 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,924,738 - 8,947,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,925,819 - 8,947,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,441,211 - 129,467,112 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114129,441,209 - 129,467,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,967,450 - 140,991,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Tial1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473727,236,533 - 27,259,464 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000002764   ⟹   ENSCSAP00000001062
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl9112,358,101 - 112,379,671 (-)Ensembl
RefSeq Acc Id: XM_007964251   ⟹   XP_007962442
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.19112,355,904 - 112,379,531 (-)NCBI
Vero_WHO_p1.0NW_02366604873,628,856 - 73,652,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007964252   ⟹   XP_007962443
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.19112,355,904 - 112,379,531 (-)NCBI
Vero_WHO_p1.0NW_02366604873,629,680 - 73,652,611 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007964253   ⟹   XP_007962444
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.19112,355,900 - 112,375,980 (-)NCBI
Vero_WHO_p1.0NW_02366604873,628,856 - 73,648,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007964254   ⟹   XP_007962445
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.19112,355,900 - 112,378,972 (-)NCBI
Vero_WHO_p1.0NW_02366604873,629,680 - 73,652,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038009612   ⟹   XP_037865540
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604873,629,680 - 73,652,213 (-)NCBI
RefSeq Acc Id: XM_038009613   ⟹   XP_037865541
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604873,629,711 - 73,652,278 (-)NCBI
RefSeq Acc Id: XM_038009614   ⟹   XP_037865542
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604873,629,680 - 73,652,213 (-)NCBI
RefSeq Acc Id: XM_038009615   ⟹   XP_037865543
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604873,629,680 - 73,652,213 (-)NCBI
RefSeq Acc Id: XR_005244238
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604873,628,854 - 73,652,611 (-)NCBI
RefSeq Acc Id: XR_005244239
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604873,628,854 - 73,652,611 (-)NCBI
RefSeq Acc Id: XP_007962445   ⟸   XM_007964254
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007962444   ⟸   XM_007964253
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007962443   ⟸   XM_007964252
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QXH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007962442   ⟸   XM_007964251
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCSAP00000001062   ⟸   ENSCSAT00000002764
RefSeq Acc Id: XP_037865542   ⟸   XM_038009614
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037865543   ⟸   XM_038009615
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037865540   ⟸   XM_038009612
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037865541   ⟸   XM_038009613
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004734 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002764.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/TrEMBL
  TIAR_RRM1 UniProtKB/TrEMBL
  TIAR_RRM2 UniProtKB/TrEMBL
  TIAR_RRM3 UniProtKB/TrEMBL
NCBI Gene TIAL1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A0D9QXH3 ENTREZGENE, UniProtKB/TrEMBL