Tial1 (Tia1 cytotoxic granule-associated RNA binding protein-like 1) - Rat Genome Database

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Gene: Tial1 (Tia1 cytotoxic granule-associated RNA binding protein-like 1) Rattus norvegicus
Analyze
Symbol: Tial1
Name: Tia1 cytotoxic granule-associated RNA binding protein-like 1
RGD ID: 1595845
Description: Predicted to enable mRNA 3'-UTR AU-rich region binding activity; mRNA base-pairing translational repressor activity; and protein-RNA adaptor activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of hippo signaling; and positive regulation of miRNA-mediated gene silencing. Predicted to act upstream of or within germ cell development; positive regulation of stem cell proliferation; and stem cell division. Located in cytoplasmic stress granule and nucleus. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC109552; nucleolysin TIAR; RNA binding protein TIAR (TIA-1 related); Tial 1 cytotoxic granule-associated RNA- binding protein-like 1; Tial1 cytotoxic granule-associated RNA binding protein-like 1; Tial1 cytotoxic granule-associated RNA binding protein-like 1 (mapped); Tial1_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,008,358 - 183,045,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,009,253 - 183,031,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,361,276 - 191,381,864 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01198,547,363 - 198,567,951 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01191,217,117 - 191,237,695 (-)NCBIRnor_WKY
Rnor_6.01199,844,854 - 199,865,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,844,859 - 199,865,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,892,006 - 206,913,468 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,687,606 - 187,706,035 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1180,656,068 - 180,676,817 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. Cok SJ, etal., J Biol Chem. 2003 Sep 19;278(38):36157-62. Epub 2003 Jul 9.
2. Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. Jin K, etal., J Neurosci Res 2000 Mar 15;59(6):767-74.
3. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Kornblihtt AR, etal., Nat Rev Mol Cell Biol. 2013 Mar;14(3):153-65. doi: 10.1038/nrm3525. Epub 2013 Feb 6.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. Zhu H, etal., Mol Cell Biol 2003 Sep;23(17):5959-71.
8. Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Zou T, etal., Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C102-11. doi: 10.1152/ajpcell.00009.2012. Epub 2012 May 2.
Additional References at PubMed
PMID:1300485   PMID:9482885   PMID:10921895   PMID:12477932   PMID:16278295   PMID:17488725   PMID:19825938   PMID:19861488   PMID:22658674   PMID:22681889   PMID:23376485  


Genomics

Comparative Map Data
Tial1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,008,358 - 183,045,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,009,253 - 183,031,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,361,276 - 191,381,864 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01198,547,363 - 198,567,951 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01191,217,117 - 191,237,695 (-)NCBIRnor_WKY
Rnor_6.01199,844,854 - 199,865,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,844,859 - 199,865,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,892,006 - 206,913,468 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,687,606 - 187,706,035 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1180,656,068 - 180,676,817 (-)NCBICelera
Cytogenetic Map1q37NCBI
TIAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,573,465 - 119,596,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10119,571,802 - 119,597,029 (-)EnsemblGRCh38hg38GRCh38
GRCh3710121,332,977 - 121,356,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610121,322,967 - 121,346,531 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410121,324,903 - 121,343,015NCBI
Celera10115,063,941 - 115,087,519 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,962,544 - 114,986,092 (-)NCBIHuRef
CHM1_110121,617,558 - 121,641,117 (-)NCBICHM1_1
T2T-CHM13v2.010120,471,044 - 120,494,540 (-)NCBIT2T-CHM13v2.0
Tial1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397128,041,496 - 128,063,450 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7128,041,501 - 128,063,441 (-)EnsemblGRCm39 Ensembl
GRCm387128,439,772 - 128,461,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,439,777 - 128,461,717 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,583,291 - 135,605,027 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367128,233,450 - 128,252,437 (-)NCBIMGSCv36mm8
Celera7128,278,008 - 128,299,764 (-)NCBICelera
Cytogenetic Map7F3NCBI
Tial1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955551370,792 - 395,836 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955551370,792 - 395,836 (-)NCBIChiLan1.0ChiLan1.0
TIAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110119,561,977 - 119,585,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,561,786 - 119,585,157 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010116,142,127 - 116,165,631 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TIAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,729,246 - 29,750,703 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,731,950 - 29,750,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,871,505 - 29,892,642 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02830,260,194 - 30,281,358 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2830,259,529 - 30,281,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,814,092 - 29,835,256 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,834,767 - 29,855,900 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02830,028,947 - 30,050,087 (-)NCBIUU_Cfam_GSD_1.0
Tial1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,613,431 - 16,636,073 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364868,925,819 - 8,947,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,441,211 - 129,467,112 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114129,441,209 - 129,467,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,967,450 - 140,991,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19112,355,900 - 112,379,531 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9112,358,101 - 112,379,671 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604873,628,854 - 73,652,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tial1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473727,236,533 - 27,259,464 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tial1
195 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:98
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000027463
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383635Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383635Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat

Markers in Region
RH128409  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1180,656,272 - 180,656,464UniSTS
Cytogenetic Map1q36UniSTS
RH144407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21183,011,202 - 183,011,487 (+)MAPPERmRatBN7.2
Rnor_6.01199,845,253 - 199,845,537NCBIRnor6.0
Rnor_5.01206,892,405 - 206,892,689UniSTSRnor5.0
RGSC_v3.41187,687,670 - 187,687,954UniSTSRGSC3.4
Celera1180,656,465 - 180,656,749UniSTS
RH 3.4 Map11417.01UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC091409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000027463   ⟹   ENSRNOP00000027463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,011,073 - 183,031,637 (-)Ensembl
Rnor_6.0 Ensembl1199,844,859 - 199,865,548 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099693   ⟹   ENSRNOP00000079395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,011,005 - 183,031,637 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102400   ⟹   ENSRNOP00000091228
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,009,253 - 183,031,406 (-)Ensembl
RefSeq Acc Id: NM_001013193   ⟹   NP_001013211
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,010,806 - 183,031,397 (-)NCBI
Rnor_6.01199,844,854 - 199,865,548 (-)NCBI
Rnor_5.01206,892,006 - 206,913,468 (-)NCBI
RGSC_v3.41187,687,606 - 187,706,035 (-)RGD
Celera1180,656,068 - 180,676,817 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230310   ⟹   XP_006230372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,008,358 - 183,031,691 (-)NCBI
Rnor_6.01199,845,079 - 199,865,840 (-)NCBI
Rnor_5.01206,892,006 - 206,913,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230312   ⟹   XP_006230374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,012,387 - 183,031,727 (-)NCBI
Rnor_6.01199,846,484 - 199,865,843 (-)NCBI
Rnor_5.01206,892,006 - 206,913,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230313   ⟹   XP_006230375
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,012,386 - 183,031,727 (-)NCBI
Rnor_6.01199,846,484 - 199,865,843 (-)NCBI
Rnor_5.01206,892,006 - 206,913,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589418   ⟹   XP_017444907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,008,358 - 183,031,177 (-)NCBI
Rnor_6.01199,845,079 - 199,865,328 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083031   ⟹   XP_038938959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,008,358 - 183,031,226 (-)NCBI
RefSeq Acc Id: XM_039083032   ⟹   XP_038938960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,008,358 - 183,031,223 (-)NCBI
RefSeq Acc Id: XM_039083035   ⟹   XP_038938963
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,008,358 - 183,045,092 (-)NCBI
RefSeq Acc Id: XM_039083050   ⟹   XP_038938978
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,008,358 - 183,031,686 (-)NCBI
RefSeq Acc Id: XR_005488851
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,010,806 - 183,031,705 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001013211   ⟸   NM_001013193
- UniProtKB: Q5BJN3 (UniProtKB/TrEMBL),   F1LQ36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230372   ⟸   XM_006230310
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006230374   ⟸   XM_006230312
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006230375   ⟸   XM_006230313
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017444907   ⟸   XM_017589418
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000027463   ⟸   ENSRNOT00000027463
RefSeq Acc Id: XP_038938963   ⟸   XM_039083035
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938978   ⟸   XM_039083050
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038938959   ⟸   XM_039083031
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938960   ⟸   XM_039083032
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000091228   ⟸   ENSRNOT00000102400
RefSeq Acc Id: ENSRNOP00000079395   ⟸   ENSRNOT00000099693
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJN3-F1-model_v2 AlphaFold Q5BJN3 1-392 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690459
Promoter ID:EPDNEW_R984
Type:initiation region
Name:Tial1_1
Description:Tia1 cytotoxic granule-associated RNA binding protein-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,865,537 - 199,865,597EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595845 AgrOrtholog
BioCyc Gene G2FUF-57296 BioCyc
Ensembl Genes ENSRNOG00000020271 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027463 ENTREZGENE
  ENSRNOP00000027463.5 UniProtKB/TrEMBL
  ENSRNOP00000079395.1 UniProtKB/TrEMBL
  ENSRNOP00000091228 ENTREZGENE
  ENSRNOP00000091228.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027463 ENTREZGENE
  ENSRNOT00000027463.6 UniProtKB/TrEMBL
  ENSRNOT00000099693.1 UniProtKB/TrEMBL
  ENSRNOT00000102400 ENTREZGENE
  ENSRNOT00000102400.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325481 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/TrEMBL
  TIAR_RRM1 UniProtKB/TrEMBL
  TIAR_RRM2 UniProtKB/TrEMBL
  TIAR_RRM3 UniProtKB/TrEMBL
KEGG Report rno:361655 UniProtKB/TrEMBL
MGC_CLONE MGC:109552 IMAGE-MGC_LOAD
NCBI Gene 361655 ENTREZGENE
Pfam RRM_1 UniProtKB/TrEMBL
PhenoGen Tial1 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8I5ZND7_RAT UniProtKB/TrEMBL
  A0A8I6GIU6_RAT UniProtKB/TrEMBL
  F1LQ36 ENTREZGENE
  Q5BJN3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LQ36 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Tial1  Tia1 cytotoxic granule-associated RNA binding protein-like 1  Tial1  Tial1 cytotoxic granule-associated RNA binding protein-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   Tial1 cytotoxic granule-associated RNA binding protein-like 1  Tial1  Tial1 cytotoxic granule-associated RNA binding protein-like 1 (mapped)  Name updated 737654 APPROVED
2007-04-12 Tial1  Tial1 cytotoxic granule-associated RNA binding protein-like 1 (mapped)  Tial1_mapped  Tial1 cytotoxic granule-associated RNA binding protein-like 1 (mapped)  Data Merged 737654 APPROVED
2006-11-20 Tial1  Tial1 cytotoxic granule-associated RNA binding protein-like 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Tial1_mapped  Tial1 cytotoxic granule-associated RNA binding protein-like 1 (mapped)  Tial1  Tial1 cytotoxic granule-associated RNA binding protein-like 1  Symbol and Name updated 1556543 APPROVED
2003-04-09 Tial1  Tial1 cytotoxic granule-associated RNA binding protein-like 1    Tial 1 cytotoxic granule-associated RNA- binding protein-like 1  Name updated 629478 APPROVED
2001-10-24 Tial1  Tial 1 cytotoxic granule-associated RNA- binding protein-like 1      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED