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Gene: KAT8 (lysine acetyltransferase 8) Chlorocebus sabaeus

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Symbol:

KAT8

Name:

lysine acetyltransferase 8

RGD ID:

18561223

Description:

ENCODES a protein that exhibits histone H4K16 acetyltransferase activity (ortholog); histone H4K5 acetyltransferase activity (ortholog); histone H4K8 acetyltransferase activity (ortholog); INVOLVED IN regulation of autophagy (ortholog); PARTICIPATES IN histone modification pathway; p53 signaling pathway; ASSOCIATED WITH branched-chain keto acid dehydrogenase kinase deficiency (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN chromosome (ortholog); mitochondrion (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histone acetyltransferase KAT8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,806,082 - 27,820,832 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	27,805,844 - 27,820,748 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	1,646,095 - 1,660,826 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

branched-chain keto acid dehydrogenase kinase deficiency (ISO)

breast cancer (ISO)

Cardiomegaly (ISO)

clear cell renal cell carcinoma (ISO)

congestive heart failure (ISO)

dilated cardiomyopathy (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

LI-GHORBANI-WEISZ-HUBSHMAN SYNDROME (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin organization (IEA)

dosage compensation by inactivation of X chromosome (IEA)

myeloid cell differentiation (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of epithelial to mesenchymal transition (IEA)

negative regulation of type I interferon production (IEA)

neurogenesis (IEA)

oogenesis (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of skeletal muscle satellite cell differentiation (IEA)

positive regulation of transcription initiation by RNA polymerase II (IEA)

post-embryonic hemopoiesis (IEA)

regulation of autophagy (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of mitochondrial transcription (IEA)

regulation of mRNA processing (IEA)

transcription initiation-coupled chromatin remodeling (IEA)

Cellular Component

chromosome (IEA,ISO)

histone acetyltransferase complex (IEA)

kinetochore (IEA)

mitochondrion (IEA,ISO)

MLL1 complex (IEA)

MSL complex (IEA)

NSL complex (IEA)

NuA4 histone acetyltransferase complex (IEA)

nuclear lumen (IEA)

nuclear matrix (IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

Molecular Function

acetyltransferase activity (IEA)

acyltransferase activity (IEA)

enzyme binding (IEA)

histone acetyltransferase activity (IEA)

histone H2AK5 acetyltransferase activity (IEA)

histone H2AK9 acetyltransferase activity (IEA)

histone H2BK12 acetyltransferase activity (IEA)

histone H2BK5 acetyltransferase activity (IEA)

histone H3K122 acetyltransferase activity (IEA)

histone H3K14 acetyltransferase activity (IEA)

histone H3K18 acetyltransferase activity (IEA)

histone H3K23 acetyltransferase activity (IEA)

histone H3K27 acetyltransferase activity (IEA)

histone H3K36 acetyltransferase activity (IEA)

histone H3K4 acetyltransferase activity (IEA)

histone H3K56 acetyltransferase activity (IEA)

histone H3K9 acetyltransferase activity (IEA)

histone H4 acetyltransferase activity (IEA)

histone H4K12 acetyltransferase activity (IEA)

histone H4K16 acetyltransferase activity (IEA,ISO)

histone H4K5 acetyltransferase activity (IEA,ISO)

histone H4K8 acetyltransferase activity (IEA,ISO)

promoter-specific chromatin binding (IEA)

protein binding (ISO)

protein propionyltransferase activity (IEA)

protein-lysine-acetyltransferase activity (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

transcription coactivator activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

p53 signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

KAT8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,806,082 - 27,820,832 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	27,805,844 - 27,820,748 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	1,646,095 - 1,660,826 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

KAT8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	31,117,664 - 31,131,393 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	31,114,489 - 31,131,393 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	31,128,985 - 31,142,714 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	31,036,488 - 31,050,206 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	31,036,487 - 31,050,206	NCBI
Celera	16	29,155,307 - 29,169,042 (-)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	28,690,132 - 28,703,867 (+)	NCBI		HuRef
CHM1_1	16	32,446,704 - 32,460,437 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	31,505,140 - 31,518,874 (+)	NCBI		T2T-CHM13v2.0

Kat8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	127,511,689 - 127,525,010 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	127,511,688 - 127,525,009 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,912,517 - 127,925,838 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,912,516 - 127,925,837 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	135,056,031 - 135,069,276 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	127,703,665 - 127,716,910 (+)	NCBI		MGSCv36	mm8
Celera	7	127,747,729 - 127,760,951 (+)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.83	NCBI

Kat8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	191,954,827 - 191,967,107 (+)	NCBI		GRCr8
mRatBN7.2	1	182,524,355 - 182,536,638 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	182,515,327 - 182,536,633 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,874,896 - 190,887,176 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	198,060,988 - 198,073,268 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	190,731,410 - 190,743,669 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	199,360,645 - 199,372,925 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	199,360,645 - 199,372,923 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	206,383,425 - 206,395,705 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	187,198,682 - 187,210,962 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	187,348,562 - 187,360,841 (+)	NCBI
Celera	1	180,175,157 - 180,187,444 (+)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

KAT8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	34,322,838 - 34,337,375 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	39,124,227 - 39,138,774 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	23,837,540 - 23,851,376 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	31,486,288 - 31,500,185 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	31,486,098 - 31,500,185 (+)	Ensembl	panpan1.1		panPan2

KAT8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	17,114,528 - 17,125,287 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	17,114,528 - 17,125,203 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	18,689,882 - 18,700,649 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	17,245,427 - 17,256,213 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	17,245,447 - 17,256,189 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	17,045,632 - 17,056,401 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	16,964,664 - 16,975,476 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	17,276,850 - 17,287,643 (-)	NCBI		UU_Cfam_GSD_1.0

Kat8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	125,377,812 - 125,389,760 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	13,474,735 - 13,489,341 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	13,475,676 - 13,487,617 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KAT8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	17,362,267 - 17,373,110 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	17,362,326 - 17,373,110 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	17,499,203 - 17,510,009 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Kat8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	14,157,823 - 14,169,231 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	14,157,905 - 14,169,231 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in KAT8
315 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007990604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000003768 ⟹ ENSCSAP00000002043

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	5	27,805,844 - 27,820,748 (+)	Ensembl

RefSeq Acc Id:

XM_007990604 ⟹ XP_007988795

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	27,806,082 - 27,820,832 (+)	NCBI
Vero_WHO_p1.0	NW_023666068	1,646,095 - 1,660,826 (-)	NCBI

Sequence:

show sequence

GCTGCGTGGCGTCCGACTCTGGCGTCACTTCCCCTCCCGCGATGGCGGCACAGGGAGCTGCTGC
GGCGGTTGCAGCGGCGACTTCAGGGGTCGCGGGGGAGGGCGAGCCAGGGCCCGGGGAGAATGCG
GCCGCCGAGGGGACCGCCCCATCCCCGGGCCGCGTCTCTCCGCCGACCCCGGCGCGCGGCGAGC
CGGAAGTCACGGTGGAGATCGGAGAAACGTACCTGTGCCGGCGGCCGGATAGCACCTGGCATTC
TGCTGAAGTGATCCAGTCTCGAGTGAACGACCAGGAGGGCCGAGAGGAATTCTATGTACACTAT
GTGGGCTTTAACCGGCGGCTGGATGAGTGGGTAGACAAGAACCGGCTGGCGCTGACCAAGACAG
TGAAGGATGCTGTGCAGAAGAACTCAGAGAAGTACCTGAGCGAGCTCGCAGAGCAGCCTGAGCG
CAAGATCACTCGCAACCAAAAGCGCAAGCATGATGAGATCAACCATGTGCAGAAGACTTATGCA
GAGATGGACCCCACCACAGCGGCCTTGGAGAAGGAGCACGAGGCGATCACCAAGGTGAAGTATG
TGGACAAGATCCATATCGGGAACTATGAAATTGACGCCTGGTATTTCTCACCGTTCCCCGAAGA
TTATGGGAAACAGCCCAAGCTCTGGCTCTGCGAGTACTGCCTCAAGTACATGAAATACGAGAAG
AGCTACCGCTTCCACTTGGGTCAGTGCCAGTGGCGGCAGCCCCCCGGGAAAGAGATCTACCGCA
AGAGCAACATCTCTGTCTACGAAGTTGATGGCAAAGACCATAAGATTTACTGTCAGAACCTGTG
TCTGCTGGCCAAGCTTTTCCTGGACCATAAGACACTGTACTTTGACGTGGAGCCGTTCGTTTTT
TACATCCTAACTGAGGTGGACCGGCAGGGGGCCCACATTGTCGGCTACTTCTCCAAGGAGAAGG
AGTCCCCCGATGGAAACAACGTGGCCTGCATCCTGACCCTGCCCCCCTACCAACGCCGTGGCTA
CGGGAAGTTCCTCATCGCTTTCAGCTATGAGCTCTCCAAGCTGGAAAGCACGGTCGGCTCCCCT
GAGAAGCCCCTGTCTGACCTGGGCAAGCTCAGCTACCGCAGCTACTGGTCCTGGGTGCTGCTGG
AGATCCTGCGGGACTTCCGGGGCACACTGTCCATCAAGGACCTCAGCCAGATGACCAGCATCAC
CCAGAATGACATCATCAGTACCCTGCAGTCCCTCAATATGGTCAAGTACTGGAAGGGCCAGCAC
GTGATCTGTGTCACACCCAAGCTGGTGGAGGAGCACCTCAAAAGTGCCCAGTATAAGAAACCAC
CCATCACAGTGGACTCCGTCTGCCTCAAGTGGGCACCCCCCAAGCACAAGCAAGTCAAGCTCTC
CAAGAAGTGAGCGGCCTGGCCCCCAGCCTGTAAATATGTATAGACCTGTTTTGTCCTTTTTTTT
AATAAAGTCAGTTTTGCTGGTGGCCCTGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007988795	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000002043
	ENSCSAP00000002043.1

RefSeq Acc Id:	XP_007988795 ⟸ XM_007990604
- UniProtKB:	A0A0D9R0A4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000002043 ⟸ ENSCSAT00000003768

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005731	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003768.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	2.30.30.140	UniProtKB/TrEMBL
	3.40.630.30	UniProtKB/TrEMBL
	N-acetyl transferase-like	UniProtKB/TrEMBL
InterPro	Acyl_CoA_acyltransferase	UniProtKB/TrEMBL
	Chromo-like_dom_sf	UniProtKB/TrEMBL
	Chromo/chromo_shadow_dom	UniProtKB/TrEMBL
	HAT_MYST-type	UniProtKB/TrEMBL
	MYST_HAT	UniProtKB/TrEMBL
	Tudor-knot	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	Zf-MYST	UniProtKB/TrEMBL
KEGG Report	csab:103231303	UniProtKB/TrEMBL
NCBI Gene	KAT8	ENTREZGENE
PANTHER	HISTONE ACETYLTRANSFERASE	UniProtKB/TrEMBL
	PTHR10615:SF82	UniProtKB/TrEMBL
Pfam	MOZ_SAS	UniProtKB/TrEMBL
	Tudor-knot	UniProtKB/TrEMBL
	zf-MYST	UniProtKB/TrEMBL
PROSITE	MYST_HAT	UniProtKB/TrEMBL
SMART	CHROMO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54160	UniProtKB/TrEMBL
	SSF55729	UniProtKB/TrEMBL
UniProt	A0A0D9R0A4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)