YARS1 (tyrosyl-tRNA synthetase 1) - Rat Genome Database

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Gene: YARS1 (tyrosyl-tRNA synthetase 1) Chlorocebus sabaeus
Analyze
Symbol: YARS1
Name: tyrosyl-tRNA synthetase 1
RGD ID: 18559668
Description: ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); ligase activity (inferred); INVOLVED IN response to starvation (inferred); translation (inferred); tRNA aminoacylation for protein translation (inferred); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine--tRNA ligase, cytoplasmic; YARS
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,050,717 - 100,096,719 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,052,535 - 100,095,980 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,595,637 - 16,639,571 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YARS1Green MonkeyAgenesis of Corpus Callosum  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Corpus callosum and agenesis ofClinVarPMID:29232904
YARS1Green MonkeyCharcot-Marie-Tooth disease  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth diseaseClinVarPMID:14606043 more ...
YARS1Green MonkeyCharcot-Marie-Tooth disease dominant intermediate C  ISOYARS1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:14606043 more ...
YARS1Green MonkeyCharcot-Marie-Tooth disease intermediate type  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth and IntermediateClinVarPMID:26467025 and PMID:28492532
YARS1Green MonkeyDevelopmental Disabilities  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:27633801 and PMID:33490854
YARS1Green Monkeygenetic disease  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:16429158 more ...
YARS1Green MonkeyInfantile-Onset Multisystem Neurologic, Endocrine, and Pancreatic Disease  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurologic more ...ClinVarPMID:25741868
YARS1Green MonkeyInfantile-Onset Multisystem Neurologic, Endocrine, and Pancreatic Disease 2  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurologic more ...ClinVarPMID:14606043 more ...
YARS1Green Monkeymetachromatic leukodystrophy  ISOYARS1 (Homo sapiens)8554872ClinVar Annotator: match by term: Metachromatic leukodystrophyClinVarPMID:25741868
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YARS1Green MonkeyCharcot-Marie-Tooth disease dominant intermediate C  ISOYARS1 (Homo sapiens)7240710 OMIM 
YARS1Green MonkeyInfantile-Onset Multisystem Neurologic, Endocrine, and Pancreatic Disease 2  ISOYARS1 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YARS1Green Monkeyresponse to starvation involved_inIEAUniProtKB:P54577 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107
YARS1Green Monkeytranslation involved_inIEAUniProtKB-KW:KW-0648150520179 UniProtGO_REF:0000043
YARS1Green MonkeytRNA aminoacylation for protein translation involved_inIEAInterPro:IPR002305150520179 InterProGO_REF:0000002
YARS1Green Monkeytyrosyl-tRNA aminoacylation involved_inIEAInterPro:IPR002307150520179 InterProGO_REF:0000002
YARS1Green Monkeytyrosyl-tRNA aminoacylation involved_inIEAUniProtKB:P54577 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YARS1Green Monkeycytoplasm is_active_inIEAUniProtKB:P54577 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107
YARS1Green Monkeycytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
YARS1Green Monkeycytosol located_inIEAUniProtKB:A0A0S2Z4R1 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107
YARS1Green Monkeycytosol is_active_inIEAUniProtKB:P54577 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107
YARS1Green Monkeynuclear body located_inIEAUniProtKB:A0A0S2Z4R1 more ...150520179 EnsemblGO_REF:0000107
YARS1Green Monkeynucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
YARS1Green Monkeynucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
YARS1Green Monkeynucleus is_active_inIEAUniProtKB:P54577 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107

Molecular Function
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YARS1Green Monkeyaminoacyl-tRNA ligase activity enablesIEAUniProtKB-KW:KW-0030150520179 UniProtGO_REF:0000043
YARS1Green Monkeyaminoacyl-tRNA ligase activity enablesIEAInterPro:IPR002305150520179 InterProGO_REF:0000002
YARS1Green MonkeyATP binding enablesIEAInterPro:IPR002305 and InterPro:IPR002307150520179 InterProGO_REF:0000002
YARS1Green MonkeyATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
YARS1Green Monkeyligase activity enablesIEAUniProtKB-KW:KW-0436150520179 UniProtGO_REF:0000043
YARS1Green Monkeynucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
YARS1Green Monkeynucleotide binding enablesIEAInterPro:IPR002305 and InterPro:IPR002307150520179 InterProGO_REF:0000002
YARS1Green Monkeyprotein binding enablesISOUniProtKB:P098749068941 PMID:25533949IntActPMID:25533949
YARS1Green Monkeyprotein binding enablesISOUniProtKB:P19712-PRO_00000380509068941 PMID:24965446AgBasePMID:24965446
YARS1Green Monkeyprotein binding enablesISOUniProtKB:O75925 more ...9068941 PMID:32814053IntActPMID:32814053
YARS1Green MonkeyRNA binding enablesIEAUniRule:UR000414443150520179 UniProtGO_REF:0000104
YARS1Green MonkeyRNA binding enablesIEAUniProtKB-KW:KW-0694150520179 UniProtGO_REF:0000043
YARS1Green Monkeysmall molecule binding enablesIEAUniProtKB:P54577 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107
YARS1Green MonkeytRNA binding enablesIEAUniRule:UR000414443150520179 UniProtGO_REF:0000104
YARS1Green MonkeytRNA binding enablesIEAUniProtKB-KW:KW-0820150520179 UniProtGO_REF:0000043
YARS1Green MonkeytRNA binding enablesIEAInterPro:IPR002547150520179 InterProGO_REF:0000002
YARS1Green Monkeytyrosine-tRNA ligase activity enablesIEAUniProtKB:P54577 and ensembl:ENSP00000362576150520179 EnsemblGO_REF:0000107
YARS1Green Monkeytyrosine-tRNA ligase activity enablesIEAPANTHER:PTN000236318150520179 TreeGrafterGO_REF:0000118
YARS1Green Monkeytyrosine-tRNA ligase activity enablesIEARHEA:10220150520179 RHEAGO_REF:0000116
YARS1Green Monkeytyrosine-tRNA ligase activity enablesIEAInterPro:IPR002307150520179 InterProGO_REF:0000002
1 to 20 of 21 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YARS1Green Monkeyphenylketonuria pathway  ISOYARS1 (Homo sapiens)9068941 SMPDBSMP:00206
YARS1Green Monkeytyrosinemia type II pathway  ISOYARS1 (Homo sapiens)9068941 SMPDBSMP:00369
YARS1Green Monkeytyrosinemia type III pathway  ISOYARS1 (Homo sapiens)9068941 SMPDBSMP:00370
PMID:22301074   PMID:30032202  



YARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,050,717 - 100,096,719 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,052,535 - 100,095,980 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,595,637 - 16,639,571 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
YARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,775,239 - 32,817,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,775,237 - 32,818,031 (-)EnsemblGRCh38hg38GRCh38
GRCh37133,240,840 - 33,282,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,013,427 - 33,056,220 (-)NCBINCBI36Build 36hg18NCBI36
Build 34132,909,932 - 32,952,726NCBI
Celera131,509,662 - 31,552,283 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,356,139 - 31,399,200 (-)NCBIHuRef
CHM1_1133,356,247 - 33,399,028 (-)NCBICHM1_1
T2T-CHM13v2.0132,635,023 - 32,677,140 (-)NCBIT2T-CHM13v2.0
Yars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,083,595 - 129,113,033 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,083,553 - 129,113,400 (+)EnsemblGRCm39 Ensembl
GRCm384129,189,734 - 129,219,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,189,760 - 129,219,607 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,867,039 - 128,896,851 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,692,255 - 128,721,911 (+)NCBIMGSCv36mm8
Celera4127,529,758 - 127,559,623 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.05NCBI
Yars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,820,163 - 146,848,377 (+)NCBIGRCr8
mRatBN7.25141,535,815 - 141,564,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,535,759 - 141,563,833 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,233,688 - 144,262,170 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,003,509 - 146,031,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,003,105 - 146,031,352 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,375,350 - 147,403,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,375,350 - 147,403,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,109,967 - 151,138,479 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,350,363 - 148,378,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,360,401 - 148,389,028 (+)NCBI
Celera5140,015,592 - 140,043,428 (+)NCBICelera
Cytogenetic Map5q36NCBI
Yars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,046,047 - 11,078,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,046,047 - 11,078,016 (-)NCBIChiLan1.0ChiLan1.0
YARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,004,825 - 194,044,614 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,126,810 - 193,166,838 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,068,202 - 32,108,664 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,232,163 - 33,295,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,232,905 - 33,294,558 (-)Ensemblpanpan1.1panPan2
YARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,535,402 - 68,566,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,535,447 - 68,565,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,115,258 - 65,146,054 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,100,498 - 69,131,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,100,535 - 69,132,060 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,912,002 - 65,942,953 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,934,433 - 66,965,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,926,368 - 67,957,551 (+)NCBIUU_Cfam_GSD_1.0
Yars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,867,056 - 49,896,532 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,691,842 - 15,721,953 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,691,838 - 15,721,308 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,088,544 - 89,119,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1689,088,122 - 89,118,837 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,115,016 - 83,145,732 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Yars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,898,646 - 15,933,400 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,898,648 - 15,933,386 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in YARS1
762 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20



Ensembl Acc Id: ENSCSAT00000017471   ⟹   ENSCSAP00000016951
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20100,052,535 - 100,095,980 (+)Ensembl
RefSeq Acc Id: XM_007979540   ⟹   XP_007977731
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120100,050,717 - 100,096,719 (+)NCBI
Vero_WHO_p1.0NW_02366603316,595,639 - 16,639,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037996484   ⟹   XP_037852412
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603316,595,637 - 16,639,571 (-)NCBI
RefSeq Acc Id: XM_037996487   ⟹   XP_037852415
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603316,595,637 - 16,632,884 (-)NCBI
Protein RefSeqs XP_007977731 (Get FASTA)   NCBI Sequence Viewer  
  XP_037852412 (Get FASTA)   NCBI Sequence Viewer  
  XP_037852415 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016951
  ENSCSAP00000016951.1
RefSeq Acc Id: XP_007977731   ⟸   XM_007979540
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S7W2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000016951   ⟸   ENSCSAT00000017471
RefSeq Acc Id: XP_037852412   ⟸   XM_037996484
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037852415   ⟸   XM_037996487
- Peptide Label: isoform X3



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000001062 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017471.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  3.40.50.620 UniProtKB/TrEMBL
  Tyrosyl-Transfer RNA Synthetase UniProtKB/TrEMBL
InterPro aa-tRNA-synth_Ic UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  tRNA-bd_dom UniProtKB/TrEMBL
  Tyr-tRNA-ligase UniProtKB/TrEMBL
  Tyrosine-tRNA_ligase_regulator UniProtKB/TrEMBL
KEGG Report csab:103225174 UniProtKB/TrEMBL
NCBI Gene YARS1 ENTREZGENE
PANTHER TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER UniProtKB/TrEMBL
  TYROSINE--TRNA LIGASE, CYTOPLASMIC UniProtKB/TrEMBL
Pfam tRNA-synt_1b UniProtKB/TrEMBL
  tRNA_bind UniProtKB/TrEMBL
PRINTS TRNASYNTHTYR UniProtKB/TrEMBL
PROSITE TRBD UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF50249 UniProtKB/TrEMBL
UniProt A0A0D9S7W2 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows