LDHB (lactate dehydrogenase B) - Rat Genome Database

Name: LDHB
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: LDHB (lactate dehydrogenase B) Chlorocebus sabaeus

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Symbol:

LDHB

Name:

lactate dehydrogenase B

RGD ID:

18510434

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); kinase binding (ortholog); L-lactate dehydrogenase activity (ortholog); INVOLVED IN lactate metabolic process (ortholog); NAD metabolic process (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Breast Neoplasms (ortholog); dilated cardiomyopathy 1O (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

L-lactate dehydrogenase B chain

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LDHB (lactate dehydrogenase B)	NCBI	Ortholog
Mus musculus (house mouse):	Ldhb (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ldhb (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ldhb (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LDHB (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LDHB (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ldhb (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LDHB (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ldhb (lactate dehydrogenase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	21,489,815 - 21,511,892 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	21,488,814 - 21,511,938 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	13,631,514 - 13,654,346 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

Breast Neoplasms (ISO)

dilated cardiomyopathy 1O (ISO)

ductal carcinoma in situ (ISO)

Experimental Liver Cirrhosis (ISO)

inherited metabolic disorder (ISO)

Lactate Dehydrogenase B Deficiency (ISO)

Neoplasm Invasiveness (ISO)

Prostatic Neoplasms (ISO)

renal cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carboxylic acid metabolic process (IEA)

lactate metabolic process (IEA,ISO)

NAD metabolic process (ISO)

pyruvate metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

membrane raft (IEA)

mitochondrial inner membrane (IEA)

oxidoreductase complex (IEA)

Molecular Function

identical protein binding (IEA,ISO)

kinase binding (ISO)

L-lactate dehydrogenase activity (IEA,ISO)

lactate dehydrogenase activity (ISO)

NAD binding (ISO)

oxidoreductase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

LDHB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	21,489,815 - 21,511,892 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	21,488,814 - 21,511,938 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	13,631,514 - 13,654,346 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LDHB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	21,635,342 - 21,657,842 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	21,635,342 - 21,757,857 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	21,788,276 - 21,810,776 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	21,679,543 - 21,702,043 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	21,679,544 - 21,702,042	NCBI
Celera	12	26,943,264 - 26,965,789 (-)	NCBI		Celera
Cytogenetic Map	12	p12.1	NCBI
HuRef	12	21,561,869 - 21,584,405 (-)	NCBI		HuRef
CHM1_1	12	21,753,523 - 21,776,056 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	21,513,920 - 21,536,444 (-)	NCBI		T2T-CHM13v2.0

Ldhb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	142,435,975 - 142,453,683 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	142,435,975 - 142,453,683 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	142,490,249 - 142,507,957 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	142,490,249 - 142,507,957 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	142,438,769 - 142,456,463 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	142,447,471 - 142,465,165 (-)	NCBI		MGSCv36	mm8
Celera	6	145,551,908 - 145,569,602 (-)	NCBI		Celera
Cytogenetic Map	6	G2	NCBI
cM Map	6	74.17	NCBI

Ldhb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	177,159,389 - 177,177,408 (-)	NCBI		GRCr8
mRatBN7.2	4	175,428,382 - 175,446,403 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	175,428,385 - 175,446,403 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	181,723,217 - 181,741,234 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	177,507,488 - 177,525,505 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	176,128,058 - 176,146,075 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	176,701,980 - 176,719,999 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	176,701,983 - 176,720,012 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	240,918,027 - 240,936,014 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	180,061,567 - 180,079,473 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	180,306,690 - 180,322,406 (-)	NCBI
Celera	4	163,963,498 - 163,981,517 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

Ldhb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	17,261,118 - 17,283,593 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	17,264,337 - 17,283,530 (-)	NCBI	ChiLan1.0	ChiLan1.0

LDHB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	75,145,106 - 75,167,533 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	75,141,504 - 75,163,931 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	64,640,994 - 64,663,418 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	67,245,012 - 67,267,487 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	67,245,130 - 67,267,487 (+)	Ensembl	panpan1.1		panPan2

LDHB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	25,470,666 - 25,493,114 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	25,470,665 - 25,492,920 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	20,864,321 - 20,886,793 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	25,693,648 - 25,716,172 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	25,693,609 - 25,716,160 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	25,492,290 - 25,514,750 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	25,515,724 - 25,538,195 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	21,035,083 - 21,057,566 (-)	NCBI		UU_Cfam_GSD_1.0

Ldhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	87,301,989 - 87,321,822 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936548	5,227,666 - 5,244,525 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936548	5,224,905 - 5,244,708 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LDHB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	51,810,932 - 51,831,218 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	55,086,895 - 55,106,892 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Ldhb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	17,049,296 - 17,069,553 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	17,046,640 - 17,065,910 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007967875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000005990 ⟹ ENSCSAP00000004204

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	11	21,488,814 - 21,511,938 (-)	Ensembl

RefSeq Acc Id:

XM_007967875 ⟹ XP_007966066

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	11	21,489,815 - 21,511,892 (-)	NCBI
Vero_WHO_p1.0	NW_023666069	13,631,514 - 13,654,346 (+)	NCBI

Sequence:

show sequence

TGGGGCCCCGCCCCGCCTTGCTGAGCCGGCGCCGGAGGAGACGCACGCAGTTCACATTGTCTTC
TCCGCACTGCTGTTACTGAGGTCTCCAGAGCCTTCTCCCTCCTGTGCAAAATGGCAACTCTTAA
GGAAAAACTCATTGCACCAGTTGCGGAAGAAGAGACAACAGTCCCAAACAATAAGATCACTGTA
GTGGGTGTTGGACAAGTTGGTATGGCGTGTGCTATCAGCATTCTGGGAAAGTCTCTGGCTGATG
AACTTGCTCTTGTGGATGTTTTGGAAGATAAGCTTAAAGGAGAAATGATGGATCTGCAGCATGG
GAGCTTATTTCTTCAGACGCCTAAAATTGTGGCAGATAAAGATTATTCTGTGACTGCCAATTCT
AAGATTGTAGTAGTAACTGCAGGAGTCCGTCAGCAAGAAGGGGAGAGTCGGCTCAATTTGGTGC
AGAGAAATGTTAATGTCTTCAAATTCATTATTCCTCAGATCGTCAAGTACAGTCCTGATTGCAT
CATAATTGTGGTTTCCAACCCAGTGGACATTCTTACGTATGTTACCTGGAAACTAAGTGGATTA
CCCAAACACCGCGTGATTGGAAGTGGATGTAATCTGGATTCTGCTAGATTTCGCTACCTTATGG
CTGAAAAACTTGGCATTCATCCCAGCAGCTGCCATGGGTGGATTTTGGGGGAACATGGCGACTC
AAGTGTGGCTGTATGGAGTGGCGTGAATGTGGCAGGTGTTTCTCTCCAAGAATTGAATCCAGAA
ATGGGAACGGACAATGATAGTGAAAATTGGAAGGAAGTGCATAAGATGGTGGTTGAAAGTGCCT
ATGAAGTCATCAAGCTAAAAGGATATACCAACTGGGCTATTGGATTAAGTGTGGCTGATCTTAT
TGAATCCATGTTGAAAAATCTATCCAGGATTCATCCCGTGTCAACAATGGTAAAGGGGATGTAT
GGCATCGAGAATGAAGTCTTCCTGAGCCTTCCGTGTATCCTCAATGCCCGAGGATTAACCAGCG
TTATCAACCAGAAGCTAAAGGATGATGAAGTTGCTCAGCTCAAGAAAAGTGCAGATACCCTGTG
GGACATCCAGAAGGACCTAAAAGACCTGTGACTACTGGGCTCTAGGCTATAGAAATTTAAAAAC
TACAATGTTATTAACTCTGAGCCTTTAGTTTTCATCTGTGTACATGAATCGCAGTTTGCTTTGA
CCTTCTTCAATATGTGAATTTGGGCTCATAGAATCAAAGCCTATGCTTGGTTTAATGCTTGCAA
TATGAGCTCTTGAACAAATAAAATTAACTATTGTAGTGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007966066	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004204
	ENSCSAP00000004204.1

RefSeq Acc Id:	XP_007966066 ⟸ XM_007967875
- UniProtKB:	A0A0D9R6G5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000004204 ⟸ ENSCSAT00000005990

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000007940	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000005990.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.110.10	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	L-lactate/malate_DH	UniProtKB/TrEMBL
	L-lactate_DH	UniProtKB/TrEMBL
	L-lactate_DH_AS	UniProtKB/TrEMBL
	Lactate/malate_DH_C	UniProtKB/TrEMBL
	Lactate/malate_DH_N	UniProtKB/TrEMBL
	Lactate_DH/Glyco_Ohase_4_C	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	csab:103218738	UniProtKB/TrEMBL
NCBI Gene	LDHB	ENTREZGENE
PANTHER	L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))	UniProtKB/TrEMBL
	L-LACTATE DEHYDROGENASE B CHAIN	UniProtKB/TrEMBL
Pfam	Ldh_1_C	UniProtKB/TrEMBL
	Ldh_1_N	UniProtKB/TrEMBL
PIRSF	Lac_mal_DH	UniProtKB/TrEMBL
PRINTS	LLDHDRGNASE	UniProtKB/TrEMBL
PROSITE	L_LDH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
	SSF56327	UniProtKB/TrEMBL
UniProt	A0A0D9R6G5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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