WARS1 (tryptophanyl-tRNA synthetase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: WARS1 (tryptophanyl-tRNA synthetase 1) Chlorocebus sabaeus
Analyze
Symbol: WARS1
Name: tryptophanyl-tRNA synthetase 1
RGD ID: 18490210
Description: ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); kinase inhibitor activity (inferred); INVOLVED IN negative regulation of protein kinase activity (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 9 (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tryptophan--tRNA ligase, cytoplasmic; WARS
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,296,154 - 78,340,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,295,741 - 78,339,732 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,436,415 - 65,479,619 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,296,154 - 78,340,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,295,741 - 78,339,732 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,436,415 - 65,479,619 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
WARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,333,790 - 100,376,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,333,790 - 100,376,805 (-)EnsemblGRCh38hg38GRCh38
GRCh3714100,800,127 - 100,842,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,869,878 - 99,912,433 (-)NCBINCBI36Build 36hg18NCBI36
Build 341499,869,877 - 99,911,680NCBI
Celera1480,854,751 - 80,897,310 (-)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,981,470 - 81,024,059 (-)NCBIHuRef
CHM1_114100,737,895 - 100,780,446 (-)NCBICHM1_1
T2T-CHM13v2.01494,566,811 - 94,609,425 (-)NCBIT2T-CHM13v2.0
Wars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,825,956 - 108,860,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,825,956 - 108,860,100 (-)EnsemblGRCm39 Ensembl
GRCm3812108,860,030 - 108,894,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,860,030 - 108,894,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712110,098,240 - 110,132,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,307,841 - 109,341,004 (-)NCBIMGSCv36mm8
Celera12110,098,849 - 110,127,409 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.66NCBI
Wars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,540,463 - 133,571,645 (-)NCBIGRCr8
mRatBN7.26127,776,088 - 127,807,273 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,776,090 - 127,807,269 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,899,086 - 127,930,096 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,194,132 - 128,225,140 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,553,503 - 127,584,499 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,771,026 - 132,802,262 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,771,021 - 132,802,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,941,102 - 141,972,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,200,866 - 133,232,048 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16133,207,052 - 133,238,235 (-)NCBI
Celera6125,326,985 - 125,358,157 (-)NCBICelera
Cytogenetic Map6q32NCBI
Wars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543821,414,815 - 21,445,042 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543821,414,878 - 21,445,417 (-)NCBIChiLan1.0ChiLan1.0
WARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,485,389 - 101,526,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,701,881 - 100,742,894 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,954,852 - 80,996,316 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114100,268,845 - 100,310,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14100,268,845 - 100,310,662 (-)Ensemblpanpan1.1panPan2
WARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,610,105 - 68,644,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,610,090 - 68,643,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,128,827 - 68,162,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,893,954 - 68,928,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,893,953 - 68,928,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,555,815 - 68,590,006 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,621,956 - 68,656,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,019,419 - 69,053,607 (-)NCBIUU_Cfam_GSD_1.0
Wars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,065,559 - 6,097,465 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,984,872 - 4,016,911 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,985,002 - 4,016,870 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,212,981 - 121,238,113 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,212,981 - 121,238,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,677,569 - 128,702,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Wars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,782,733 - 3,817,852 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247343,777,866 - 3,815,369 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WARS1
703 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000008428   ⟹   ENSCSAP00000006574
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2478,295,741 - 78,339,732 (-)Ensembl
RefSeq Acc Id: XM_007987840   ⟹   XP_007986031
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12478,296,154 - 78,339,924 (-)NCBI
Vero_WHO_p1.0NW_02366605365,436,415 - 65,478,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007987841   ⟹   XP_007986032
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12478,296,154 - 78,340,633 (-)NCBI
Vero_WHO_p1.0NW_02366605365,437,092 - 65,479,566 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007987842   ⟹   XP_007986033
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12478,296,154 - 78,340,683 (-)NCBI
Vero_WHO_p1.0NW_02366605365,437,097 - 65,479,619 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037984508   ⟹   XP_037840436
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605365,437,092 - 65,479,358 (-)NCBI
RefSeq Acc Id: XM_037984509   ⟹   XP_037840437
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605365,437,092 - 65,479,028 (-)NCBI
RefSeq Acc Id: XM_037984510   ⟹   XP_037840438
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605365,437,092 - 65,479,360 (-)NCBI
RefSeq Acc Id: XP_007986033   ⟸   XM_007987842
- UniProtKB: A0A0D9RD85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986032   ⟸   XM_007987841
- UniProtKB: A0A0D9RD85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007986031   ⟸   XM_007987840
- UniProtKB: A0A0D9RD85 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000006574   ⟸   ENSCSAT00000008428
RefSeq Acc Id: XP_037840438   ⟸   XM_037984510
- UniProtKB: A0A0D9RD85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840436   ⟸   XM_037984508
- UniProtKB: A0A0D9RD85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840437   ⟸   XM_037984509
- UniProtKB: A0A0D9RD85 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008428.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.620 UniProtKB/TrEMBL
  S15/NS1, RNA-binding UniProtKB/TrEMBL
  Tyrosyl-Transfer RNA Synthetase UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  aa-tRNA-synth_Ic UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  S15_NS1_RNA-bd UniProtKB/TrEMBL
  Trp-tRNA-ligase UniProtKB/TrEMBL
  WHEP-TRS_dom UniProtKB/TrEMBL
KEGG Report csab:103229694 UniProtKB/TrEMBL
NCBI Gene WARS1 ENTREZGENE
PANTHER TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC UniProtKB/TrEMBL
  TRYPTOPHANYL-TRNA SYNTHETASE UniProtKB/TrEMBL
Pfam tRNA-synt_1b UniProtKB/TrEMBL
  WHEP-TRS UniProtKB/TrEMBL
PRINTS TRNASYNTHTRP UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
  WHEP_TRS_1 UniProtKB/TrEMBL
  WHEP_TRS_2 UniProtKB/TrEMBL
SMART WHEP-TRS UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF47060 UniProtKB/TrEMBL
UniProt A0A0D9RD85 ENTREZGENE, UniProtKB/TrEMBL