SPOP (speckle type BTB/POZ protein) - Rat Genome Database

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Gene: SPOP (speckle type BTB/POZ protein) Chlorocebus sabaeus
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Symbol: SPOP
Name: speckle type BTB/POZ protein
RGD ID: 18447692
Description: ENCODES a protein that exhibits identical protein binding (ortholog); molecular function inhibitor activity (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN glucose homeostasis (ortholog); intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (ortholog); negative regulation of DNA-binding transcription factor activity (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); Ductal Carcinoma (ortholog); Endometrial Neoplasms (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nuclear speck (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103243644; speckle-type POZ protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,990,554 - 70,073,241 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607741,098,933 - 41,182,120 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SPOP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,990,554 - 70,073,241 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607741,098,933 - 41,182,120 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SPOP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,598,884 - 49,678,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,598,884 - 49,678,163 (-)EnsemblGRCh38hg38GRCh38
GRCh371747,676,246 - 47,755,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,031,245 - 45,110,524 (-)NCBINCBI36Build 36hg18NCBI36
Build 341745,031,246 - 45,110,524NCBI
Celera1744,131,243 - 44,210,519 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,041,208 - 43,120,660 (-)NCBIHuRef
CHM1_11747,741,302 - 47,820,599 (-)NCBICHM1_1
T2T-CHM13v2.01750,462,011 - 50,541,274 (-)NCBIT2T-CHM13v2.0
Spop
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,304,909 - 95,384,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,304,906 - 95,384,232 (+)EnsemblGRCm39 Ensembl
GRCm381195,414,083 - 95,493,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,414,080 - 95,493,406 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,275,397 - 95,354,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,230,204 - 95,309,103 (+)NCBIMGSCv36mm8
Celera11105,038,004 - 105,132,151 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Spop
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,854,890 - 80,935,781 (+)NCBIGRCr8
mRatBN7.21080,358,121 - 80,438,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,358,124 - 80,483,955 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,306,751 - 85,387,911 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,804,797 - 84,885,956 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,196,824 - 80,277,774 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,231,187 - 83,311,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,231,238 - 83,311,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,040,592 - 83,121,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,099,990 - 84,185,130 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,102,831 - 84,199,894 (+)NCBI
Celera1079,129,126 - 79,210,141 (+)NCBICelera
Cytogenetic Map10q26NCBI
Spop
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,897,592 - 11,970,269 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,897,642 - 11,970,269 (+)NCBIChiLan1.0ChiLan1.0
SPOP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,784,045 - 65,863,127 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,590,547 - 70,669,645 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,685,913 - 43,765,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,417,634 - 48,495,725 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,417,634 - 48,440,623 (-)Ensemblpanpan1.1panPan2
SPOP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,685,723 - 25,752,953 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,686,439 - 25,752,900 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,143,931 - 25,211,377 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,480,666 - 26,548,198 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,480,865 - 26,548,177 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,248,665 - 25,316,107 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,507,666 - 25,575,090 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,636,940 - 25,704,391 (-)NCBIUU_Cfam_GSD_1.0
Spop
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,105,808 - 25,180,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,894,406 - 11,970,155 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,894,449 - 11,969,730 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPOP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,792,630 - 25,860,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,792,621 - 25,860,630 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,770,383 - 25,777,618 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Spop
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247955,698,131 - 5,769,209 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_008013065   ⟹   XP_008011256
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11669,990,554 - 70,073,241 (-)NCBI
Vero_WHO_p1.0NW_02366607741,098,933 - 41,182,006 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008013067   ⟹   XP_008011258
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11669,990,554 - 70,073,214 (-)NCBI
Vero_WHO_p1.0NW_02366607741,099,327 - 41,182,120 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008013068   ⟹   XP_008011259
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11669,990,554 - 70,073,241 (-)NCBI
Vero_WHO_p1.0NW_02366607741,099,326 - 41,182,072 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037993497   ⟹   XP_037849425
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607741,099,327 - 41,130,684 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008011256 (Get FASTA)   NCBI Sequence Viewer  
  XP_008011258 (Get FASTA)   NCBI Sequence Viewer  
  XP_008011259 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849425 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_008011256   ⟸   XM_008013065
RefSeq Acc Id: XP_008011259   ⟸   XM_008013068
RefSeq Acc Id: XP_008011258   ⟸   XM_008013067
RefSeq Acc Id: XP_037849425   ⟸   XM_037993497


Additional Information

Database Acc Id Source(s)
NCBI Gene SPOP ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 SPOP  speckle type BTB/POZ protein  LOC103243644  speckle type BTB/POZ protein  Symbol and/or name change 5135510 APPROVED
2020-12-08 LOC103243644  speckle type BTB/POZ protein  SPOP  speckle type BTB/POZ protein  Symbol and/or name change 5135510 APPROVED