ALKAL1 (ALK and LTK ligand 1) - Rat Genome Database

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Gene: ALKAL1 (ALK and LTK ligand 1) Chlorocebus sabaeus
Analyze
Symbol: ALKAL1
Name: ALK and LTK ligand 1
RGD ID: 18428866
Description: ENCODES a protein that exhibits transmembrane receptor protein tyrosine kinase activator activity (ortholog); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); positive regulation of neuron projection development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); schizophrenia (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FAM150A; family with sequence similarity 150 member A; protein FAM150A
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1848,641,163 - 48,672,392 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl848,645,771 - 48,669,954 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603993,330,791 - 93,359,214 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ALKAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1848,641,163 - 48,672,392 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl848,645,771 - 48,669,954 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603993,330,791 - 93,359,214 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ALKAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38852,534,037 - 52,565,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl852,534,037 - 52,565,430 (-)EnsemblGRCh38hg38GRCh38
GRCh37853,446,597 - 53,477,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36853,609,251 - 53,640,574 (-)NCBINCBI36Build 36hg18NCBI36
Celera849,436,928 - 49,468,353 (-)NCBICelera
Cytogenetic Map8q11.23NCBI
HuRef848,914,390 - 48,945,583 (-)NCBIHuRef
CHM1_1853,498,972 - 53,530,389 (-)NCBICHM1_1
T2T-CHM13v2.0852,910,076 - 52,941,473 (-)NCBIT2T-CHM13v2.0
Alkal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3916,429,555 - 6,464,955 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl16,429,442 - 6,464,955 (+)EnsemblGRCm39 Ensembl
GRCm3816,359,331 - 6,394,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl16,359,218 - 6,394,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv3716,349,134 - 6,384,812 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3616,349,134 - 6,384,812 (+)NCBIMGSCv36mm8
Celera16,345,912 - 6,381,049 (+)NCBICelera
Cytogenetic Map1A1NCBI
cM Map11.89NCBI
Alkal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8517,806,601 - 17,836,789 (-)NCBIGRCr8
mRatBN7.2513,019,729 - 13,049,913 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl513,019,429 - 13,049,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx515,189,353 - 15,219,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0516,821,441 - 16,851,558 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0516,524,040 - 16,554,319 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0512,896,136 - 12,925,571 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl512,896,558 - 12,925,571 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0517,668,931 - 17,697,947 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4513,167,027 - 13,196,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera512,433,940 - 12,464,105 (-)NCBICelera
Cytogenetic Map5q12NCBI
ALKAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2768,168,573 - 68,200,225 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1843,893,772 - 43,925,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0848,957,611 - 48,989,157 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1846,341,310 - 46,372,344 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl846,341,310 - 46,372,344 (-)Ensemblpanpan1.1panPan2
ALKAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1294,375,877 - 4,395,708 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha294,815,737 - 4,835,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0294,441,691 - 4,461,589 (-)NCBIROS_Cfam_1.0
Alkal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530375,186,430 - 75,209,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936590376,301 - 396,488 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936590376,301 - 396,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALKAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl477,673,244 - 77,683,074 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1477,673,200 - 77,682,697 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Alkal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247352,914,937 - 2,941,798 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247352,915,115 - 2,941,401 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 14 5
Below cutoff 12 4 27

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012818   ⟹   ENSCSAP00000010839
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl848,645,771 - 48,669,954 (-)Ensembl
RefSeq Acc Id: XM_008000618   ⟹   XP_007998809
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1848,641,163 - 48,672,392 (-)NCBI
Vero_WHO_p1.0NW_02366603993,330,830 - 93,359,113 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038000507   ⟹   XP_037856435
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603993,330,814 - 93,357,130 (+)NCBI
RefSeq Acc Id: XM_038000508   ⟹   XP_037856436
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603993,330,791 - 93,359,214 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007998809 (Get FASTA)   NCBI Sequence Viewer  
  XP_037856435 (Get FASTA)   NCBI Sequence Viewer  
  XP_037856436 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010839.1
Reference Protein Sequences
RefSeq Acc Id: XP_007998809   ⟸   XM_008000618
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RQF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010839   ⟸   ENSCSAT00000012818
RefSeq Acc Id: XP_037856436   ⟸   XM_038000508
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RQF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037856435   ⟸   XM_038000507
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RQF0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014724 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012818.1 UniProtKB/TrEMBL
InterPro FAM150A/B UniProtKB/TrEMBL
KEGG Report csab:103236787 UniProtKB/TrEMBL
NCBI Gene ALKAL1 ENTREZGENE
PANTHER ALK AND LTK LIGAND 1 UniProtKB/TrEMBL
  PTHR28676 UniProtKB/TrEMBL
Pfam FAM150 UniProtKB/TrEMBL
UniProt A0A0D9RQF0 ENTREZGENE, UniProtKB/TrEMBL