ALKAL1 (ALK and LTK ligand 1) - Rat Genome Database

Name: ALKAL1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ALKAL1 (ALK and LTK ligand 1) Pan paniscus

Analyze

Symbol:

ALKAL1

Name:

ALK and LTK ligand 1

RGD ID:

11735804

Description:

ENCODES a protein that exhibits cytokine activity (inferred); receptor signaling protein tyrosine kinase activator activity (inferred); receptor tyrosine kinase binding (inferred); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (inferred); positive regulation of ERK1 and ERK2 cascade (inferred); positive regulation of ERK5 cascade (inferred); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); schizophrenia (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

FAM150A; family with sequence similarity 150 member A

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ALKAL1 (ALK and LTK ligand 1)	NCBI	Ortholog
Mus musculus (house mouse):	Alkal1 (ALK and LTK ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Alkal1 (ALK and LTK ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ALKAL1 (ALK and LTK ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Alkal1 (ALK and LTK ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ALKAL1 (ALK and LTK ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ALKAL1 (ALK and LTK ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Alkal1 (ALK and LTK ligand 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	68,168,573 - 68,200,225 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	43,893,772 - 43,925,387 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	48,957,611 - 48,989,157 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	46,341,310 - 46,372,344 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	46,341,310 - 46,372,344 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

genetic disease (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of ERK5 cascade (IEA)

positive regulation of neuron projection development (IEA)

signal transduction (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA,ISO)

Molecular Function

cytokine activity (IEA)

protein binding (ISO)

receptor signaling protein tyrosine kinase activator activity (IEA)

receptor tyrosine kinase binding (IEA)

transmembrane receptor protein tyrosine kinase activator activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ALKAL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	68,168,573 - 68,200,225 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	43,893,772 - 43,925,387 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	48,957,611 - 48,989,157 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	46,341,310 - 46,372,344 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	46,341,310 - 46,372,344 (-)	Ensembl	panpan1.1		panPan2

ALKAL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	52,534,037 - 52,565,430 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	52,534,037 - 52,565,430 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	53,446,597 - 53,477,990 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	53,609,251 - 53,640,574 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	49,436,928 - 49,468,353 (-)	NCBI		Celera
Cytogenetic Map	8	q11.23	NCBI
HuRef	8	48,914,390 - 48,945,583 (-)	NCBI		HuRef
CHM1_1	8	53,498,972 - 53,530,389 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	52,910,076 - 52,941,473 (-)	NCBI		T2T-CHM13v2.0

Alkal1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	6,429,555 - 6,464,955 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	6,429,442 - 6,464,955 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	6,359,331 - 6,394,731 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	6,359,218 - 6,394,731 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	6,349,134 - 6,384,812 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	6,349,134 - 6,384,812 (+)	NCBI		MGSCv36	mm8
Celera	1	6,345,912 - 6,381,049 (+)	NCBI		Celera
Cytogenetic Map	1	A1	NCBI
cM Map	1	1.89	NCBI

Alkal1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	17,806,601 - 17,836,789 (-)	NCBI		GRCr8
mRatBN7.2	5	13,019,729 - 13,049,913 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	13,019,429 - 13,049,948 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	15,189,353 - 15,219,628 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	16,821,441 - 16,851,558 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	16,524,040 - 16,554,319 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	12,896,136 - 12,925,571 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	12,896,558 - 12,925,571 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	17,668,931 - 17,697,947 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	13,167,027 - 13,196,791 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	12,433,940 - 12,464,105 (-)	NCBI		Celera
Cytogenetic Map	5	q12	NCBI

ALKAL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	4,375,877 - 4,395,708 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	4,815,737 - 4,835,644 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	4,441,691 - 4,461,589 (-)	NCBI		ROS_Cfam_1.0

Alkal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	75,186,430 - 75,209,168 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936590	376,301 - 396,488 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936590	376,301 - 396,488 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ALKAL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	77,673,244 - 77,683,074 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	77,673,200 - 77,682,697 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ALKAL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	48,641,163 - 48,672,392 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	48,645,771 - 48,669,954 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	93,330,791 - 93,359,214 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alkal1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	2,914,937 - 2,941,798 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	2,915,115 - 2,941,401 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003823257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034966080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000057750 ⟹ ENSPPAP00000034865

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	8	46,341,310 - 46,372,344 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000057752 ⟹ ENSPPAP00000034867

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	8	46,341,465 - 46,372,139 (-)	Ensembl

RefSeq Acc Id:

XM_003823257 ⟹ XP_003823305

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	68,168,573 - 68,200,225 (-)	NCBI
NHGRI_mPanPan1	8	43,893,772 - 43,925,387 (-)	NCBI
Mhudiblu_PPA_v0	8	48,957,614 - 48,989,157 (-)	NCBI
PanPan1.1	8	46,341,310 - 46,372,344 (-)	NCBI

Sequence:

show sequence

TTAGGCTTCGGCACACTGAGGACCGAGTCCCAGTGCAGCTCCAGCCGACCCCCGGGACGTAGAC
AAGGGCAGGCGCGCGGTGAAGACTGCGGCCGGCCGCGTAGCCGCGCTGTGGTCCCGCTGGCCTT
CTCTTGGGCCGCGCACCCTCCGGACCTGCGTCGGGATCCTCCCCGAGTCTCCCGCTCTCTCCTC
CCGGCTTGCGAACATGCGGCCCCTTAAGCCCGGCGCCCCTTTGCCCGCACTCTTCCTGCTGGCG
CTGGCTTTGTCTCCGCACGGAGCCCACGGGAGGCCCCGGGGGCGCAGGGGAGCGCGCGTCACGG
ATAAGGAGCCCAAGCCGTTGCTTTTCCTCCCCGCGGCCGGGGCCGGCCGGACTCCCAGCGGCTC
CCAGAGCGCAGAAATATTCCCAAGAGACTCTAACTTAAAAGACAAATTCATAAAGCATTTCACA
GGGCCGGTCACATTTTCGCCAGAATGCAGCAAACATTTCCACCGACTCTATTACAATACCAGGG
AGTGCTCAACGCCAGCTTATTACAAAAGATGTGCTAGATTGTTAACAAGATTAGCAGTGAGTCC
ACTGTGCTCCCAGACCTAGCAAAACTACCCTACATTTCCTAAGAATGTACATCTAATTTGAAGA
AAAAGTGCCTCAAATCATGCAAAATGTAAAAAAAGATGAAATTTATATTTTTATGGATATTAAG
ATGAGTAAAATAAGAGACTTCCCAGAAATAACTGGTTAGCTGTTTCCTGTCATAGAATGGAGTC
TTTCTTGCTTTATCTTTTTGTGTATACAGTAATTTATAATTTTGTAAAATAGAGTTTGAATCGC
ATATTGAAAATTAGATATTAAAAATTGTGTGATTGTATTTTATTTTTACTAGATATATTATTTT
CTTTATATGGTTAACATTCTAATTAAACATTTAATTGTGTAAATTATATCTGTGAGTGCCAGTG
AGAAATAATGATTTTTTTGTATATGACTGTTAGTATATATTTGTCAAATCATCGTGTACCAAGT
TAAATTTTATAATTCTTATTTAATATTTAAATACATTTCTTTAGAACTTGTTGTCTTCACTTGC
ATTAATTTGAACTGTGAATTTTATTAAAGTTGAAATATGAAAAAGTGTGTTGTTTCCTTTGAAT
TAAGGATGTTTGTAATAGA

hide sequence

RefSeq Acc Id:

XM_034966080 ⟹ XP_034821971

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	68,168,671 - 68,200,225 (-)	NCBI
NHGRI_mPanPan1	8	43,893,926 - 43,925,387 (-)	NCBI
Mhudiblu_PPA_v0	8	48,957,611 - 48,989,157 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003823305	(Get FASTA)	NCBI Sequence Viewer
	XP_034821971	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000034865
	ENSPPAP00000034865.1
	ENSPPAP00000034867.1

RefSeq Acc Id:	XP_003823305 ⟸ XM_003823257
- UniProtKB:	A0A2R9C248 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPLKPGAPLPALFLLALALSPHGAHGRPRGRRGARVTDKEPKPLLFLPAAGAGRTPSGSQSAE IFPRDSNLKDKFIKHFTGPVTFSPECSKHFHRLYYNTRECSTPAYYKRCARLLTRLAVSPLCSQ T hide sequence

RefSeq Acc Id:	XP_034821971 ⟸ XM_034966080
- UniProtKB:	A0A2R9C248 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000034865 ⟸ ENSPPAT00000057750

RefSeq Acc Id:

ENSPPAP00000034867 ⟸ ENSPPAT00000057752

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000040265	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000057750.1	UniProtKB/TrEMBL
	ENSPPAT00000057752.1	UniProtKB/TrEMBL
InterPro	FAM150A/B	UniProtKB/TrEMBL
KEGG Report	pps:100975135	UniProtKB/TrEMBL
NCBI Gene	FAM150A	ENTREZGENE
PANTHER	ALK AND LTK LIGAND 1	UniProtKB/TrEMBL
	PTHR28676	UniProtKB/TrEMBL
Pfam	FAM150	UniProtKB/TrEMBL
UniProt	A0A2R9BYW4_PANPA	UniProtKB/TrEMBL
	A0A2R9C248	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-02-07	ALKAL1	ALK and LTK ligand 1	FAM150A	family with sequence similarity 150 member A	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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