PYCR1 (pyrroline-5-carboxylate reductase 1)

Gene: PYCR1 (pyrroline-5-carboxylate reductase 1) Chlorocebus sabaeus

Analyze

Symbol:

PYCR1

Name:

pyrroline-5-carboxylate reductase 1

RGD ID:

18375785

Description:

ENCODES a protein that exhibits identical protein binding (inferred); oxidoreductase activity (inferred); pyrroline-5-carboxylate reductase activity (inferred); INVOLVED IN cellular response to oxidative stress (inferred); L-proline biosynthetic process (inferred); negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (inferred); ASSOCIATED WITH Autosomal Recessive Cutis Laxa (ortholog); autosomal recessive cutis laxa type IIB (ortholog); autosomal recessive cutis laxa type IIIB (ortholog); FOUND IN mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pyrroline-5-carboxylate reductase 1, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,805,680 - 73,810,707 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,805,409 - 73,810,199 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	45,257,773 - 45,262,751 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Cutis Laxa (ISO)

autosomal recessive cutis laxa type IIB (ISO)

autosomal recessive cutis laxa type IIIB (ISO)

COVID-19 (ISO)

cutis laxa (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

microcephaly (ISO)

progeria (ISO)

Wiedemann-Rautenstrauch syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to oxidative stress (IEA)

L-proline biosynthetic process (IEA)

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (IEA)

proline biosynthetic process (IEA)

regulation of mitochondrial membrane potential (IEA)

Cellular Component

mitochondrion (IEA)

Molecular Function

identical protein binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

pyrroline-5-carboxylate reductase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PYCR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,805,680 - 73,810,707 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,805,409 - 73,810,199 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	45,257,773 - 45,262,751 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PYCR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,932,391 - 81,937,300 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	81,932,384 - 81,942,412 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	79,890,267 - 79,895,176 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,483,558 - 77,488,259 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	76,494,307 - 76,499,008 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,291,232 - 75,295,933 (-)	NCBI		HuRef
CHM1_1	17	79,976,471 - 79,981,172 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,799,550 - 82,804,459 (-)	NCBI		T2T-CHM13v2.0

Pycr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,527,591 - 120,534,602 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,526,538 - 120,534,595 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	120,638,998 - 120,643,748 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,635,712 - 120,643,769 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,497,026 - 120,504,984 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,455,514 - 120,459,794 (-)	NCBI		MGSCv36	mm8
Celera	11	132,371,062 - 132,379,022 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.37	NCBI

Pycr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,416,056 - 106,420,982 (-)	NCBI		GRCr8
mRatBN7.2	10	105,917,732 - 105,922,658 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,917,680 - 105,922,549 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	111,022,441 - 111,025,645 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,485,479 - 110,488,683 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,839,131 - 105,842,439 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,817,300 - 109,822,218 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,818,177 - 109,821,807 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,411,300 - 109,414,609 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	110,030,931 - 110,035,883 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	110,046,548 - 110,050,508 (-)	NCBI
Celera	10	104,462,087 - 104,465,395 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

Pycr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,231,863 - 1,236,550 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	1,231,874 - 1,236,550 (+)	NCBI	ChiLan1.0	ChiLan1.0

PYCR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,468,518 - 98,479,691 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,369,297 - 103,386,282 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,337,991 - 76,348,207 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	82,040,824 - 82,045,691 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,040,824 - 82,045,686 (-)	Ensembl	panpan1.1		panPan2

PYCR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	360,353 - 364,795 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	360,376 - 364,570 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	962,468 - 966,895 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	953,687 - 958,114 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	953,684 - 958,106 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	978,841 - 983,268 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,105,463 - 1,109,889 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,184,099 - 1,188,527 (+)	NCBI		UU_Cfam_GSD_1.0

Pycr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	968,399 - 972,773 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,439,175 - 5,443,564 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,439,911 - 5,443,535 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PYCR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,060,570 - 1,064,805 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	1,060,028 - 1,064,808 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Pycr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,776,747 - 10,781,614 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,777,407 - 10,781,572 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	20		20
Low	16	20	40
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008013295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008013296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008013297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008013298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000000217 ⟹ ENSCSAP00000015836

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	73,805,409 - 73,810,199 (-)	Ensembl

RefSeq Acc Id:

XM_008013295 ⟹ XP_008011486

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	73,805,680 - 73,810,707 (-)	NCBI
Vero_WHO_p1.0	NW_023666077	45,257,784 - 45,262,751 (-)	NCBI

Sequence:

show sequence

AGCAAATTGTTTTCAACCCCGCCCCCGCGCGCGCACACACACACACACAAAGGAAAGAAAACGC
GGTGCAGCCGGGCTTCTCCAAACTCGATGACAGTAGAAGGGACTGATTCCCAGAGAGCACCGGC
CACGCGCCCAGGGCTGCCAGCTTGACGCGTCCGTGTCCGGGTGGCCCAAGACAAAGCCCTGCGT
GCAGGGCCCCCTTGGACCGCCCCCTCCGCCCGCGTCCTCGGACCCCACGTCTCATCCCGCAGAG
CCGGTGCCATCTGTGGGGGCTTTGGGCCGGGGGTCTCCCGACAGCATGAGCGTGGGCTTCATCG
GCGCTGGCCAGCTGGCTTTTGCCCTGGTCAAGGGCTTCACAGCAGCAGGCATCTTGGCTGCCCA
CAAGATAATGGCTAGCTCCCCAGACATGGACCTGGCCACGGTTTCTGCCCTCAGGAAGATGGGG
GTGAAGCTGACACCCCACAACAAGGAGGCGGTGCAGCACAGTGATGTGCTCTTCCTGGCTGTGA
AGCCACACATCATCCCCTTCATCCTGGATGAGATAGGCAACCACATTGAGGACAGGCACATCGT
GGTGTCCTGTGCGGCCGGCGTCACCATCGGCTCCATAGAGAAGAAGCTGTCAGCGTTTCGACCA
ACCCCCAGGGTCATCCGCTGCATGACCAACATCCCGGTCGTGGTCCGGGAGGGGGCCACCGTGT
ACGCCACAGGCACACACGCCCAGGTGGAGGACGGGAGGCTCCTGGAGCAGCTGCTGAGCAGCGT
GGGCTTCTGCACAGAGGTGGAAGAGGACCTGATCGATGCCGTCACGGGGCTCAGTGGCAGTGGC
CCCGCCTACGCGTTCACAGCCCTGGATGCCCTGGCTGATGGGGGCGTGAAGATGGGACTTCCAA
GGCGCCTGGCAGTCCGCCTCGGGGCCCAGGCCCTCCTGGGGGCTGCCAAGATGCTGCTGCACTC
AGAACAGCACCCAGGCCAGCTCAAGGACAACGTCAGCTCTCCTGGTGGGGCCACCATCCATGCC
TTGCACGTGCTGGAAAGTGGGGGCTTCCGCTCTCTGCTCATCAACGCTGTGGAGGCCTCCTGCA
TCCGCACACGGGAGCTGCAGTCCATGGCTGACCAGGAGCAGGTGTCACCAGCCGCCATCAAGAA
GACCATCCTGGACAAGGTGAAGCTGGAATCCCCTGCAGGGACCTCTCTGTCGCCTTCTGGCCAC
ACCAAGCTGCTCCCCCGCAGCCTGGCGCCAGTGGGCAAGGATTGACATGTCCTGCCTGACCACC
ACCCTGCCACCATCTTCTCTTCTCTCATCACTAGGGGGACTAGGGGGTCCCCGATAGTGGCCCA
CTGTCTGGCTCTGATCAGCGCAGGGGCCAGCCAGGGACATAGCCAGGGAGGGGCCACGTCACTT
CCCACTGGAAATCTCTGTGGTCTGCAAGTGTTTCCCAGCCCAGAACAGGGGCGGATTCCCCAAC
CTCAACCTCCTTTCTCCTCTGCTCCCAAACCATGTCAGGACCACCTTCCTCTAGCGCTCAGGAG
CCCGGAGGGTCTTCACCCACTCTTACTCCAGTGTCAGCTGGCATGGGCTCCTTCCTGAGTGCAA
AGGTCAAAGGCCCCCTCTGTGAAGGCTCAGCAGAGGTGGGATCCCACACCCCCTCCTGGCCCCT
CCCTGCCCTCCATTCAGGGAGAAACCTCTCCTTCCCGTGTGAGAAGGCCCGGAGGGTCCAGGCA
TCGCGAGTCCAGGGTGAAGGGCCACAGCCCCTCTTGGCTGCCAAGCACCCAGATCTCACGGACA
TTTGGGGAAAGGGCTCCTTGGGTTGCCGGTGAACTTCCTGTGGCCACCCCCTCCTGCTCCTGAC
CTCCCTGGCAGGGTGCTATCACTTCTGGCCCTTCCAGTTTTATAAATCGGTTTCCAGCCCCTAG
TGCCCTGACTTCTGTCTGCCAGATGAGGAGGGAGGCCCTGCCTGTCAGGGAGGGTGGTTACTGT
GGATGGAATAGTGGGGCCTTCAACTGATTAGACAAGGCCTGCCCACATCTTGGAGGGCATCTGC
CTTACTGATTAAAATGTCAATGTAAT

hide sequence

RefSeq Acc Id:

XM_008013296 ⟹ XP_008011487

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	73,805,680 - 73,810,203 (-)	NCBI
Vero_WHO_p1.0	NW_023666077	45,257,773 - 45,262,347 (-)	NCBI

Sequence:

show sequence

ACGGCCTGCGCACGTCTCATCCCGCAGAGCCGGTGCCATCTGTGGGGGCTTTGGGCCGGGGGTC
TCCCGACAGCATGAGCGTGGGCTTCATCGGCGCTGGCCAGCTGGCTTTTGCCCTGGTCAAGGGC
TTCACAGCAGCAGGCATCTTGGCTGCCCACAAGATAATGGCTAGCTCCCCAGACATGGACCTGG
CCACGGTTTCTGCCCTCAGGAAGATGGGGGTGAAGCTGACACCCCACAACAAGGAGGCGGTGCA
GCACAGTGATGTGCTCTTCCTGGCTGTGAAGCCACACATCATCCCCTTCATCCTGGATGAGATA
GGCAACCACATTGAGGACAGGCACATCGTGGTGTCCTGTGCGGCCGGCGTCACCATCGGCTCCA
TAGAGAAGAAGCTGTCAGCGTTTCGACCAACCCCCAGGGTCATCCGCTGCATGACCAACATCCC
GGTCGTGGTCCGGGAGGGGGCCACCGTGTACGCCACAGGCACACACGCCCAGGTGGAGGACGGG
AGGCTCCTGGAGCAGCTGCTGAGCAGCGTGGGCTTCTGCACAGAGGTGGAAGAGGACCTGATCG
ATGCCGTCACGGGGCTCAGTGGCAGTGGCCCCGCCTACGCGTTCACAGCCCTGGATGCCCTGGC
TGATGGGGGCGTGAAGATGGGACTTCCAAGGCGCCTGGCAGTCCGCCTCGGGGCCCAGGCCCTC
CTGGGGGCTGCCAAGATGCTGCTGCACTCAGAACAGCACCCAGGCCAGCTCAAGGACAACGTCA
GCTCTCCTGGTGGGGCCACCATCCATGCCTTGCACGTGCTGGAAAGTGGGGGCTTCCGCTCTCT
GCTCATCAACGCTGTGGAGGCCTCCTGCATCCGCACACGGGAGCTGCAGTCCATGGCTGACCAG
GAGCAGGTGTCACCAGCCGCCATCAAGAAGACCATCCTGGACAAGGTGAAGCTGGAATCCCCTG
CAGGGACCTCTCTGTCGCCTTCTGGCCACACCAAGCTGCTCCCCCGCAGCCTGGCGCCAGTGGG
CAAGGATTGACATGTCCTGCCTGACCACCACCCTGCCACCATCTTCTCTTCTCTCATCACTAGG
GGGACTAGGGGGTCCCCGATAGTGGCCCACTGTCTGGCTCTGATCAGCGCAGGGGCCAGCCAGG
GACATAGCCAGGGAGGGGCCACGTCACTTCCCACTGGAAATCTCTGTGGTCTGCAAGTGTTTCC
CAGCCCAGAACAGGGGCGGATTCCCCAACCTCAACCTCCTTTCTCCTCTGCTCCCAAACCATGT
CAGGACCACCTTCCTCTAGCGCTCAGGAGCCCGGAGGGTCTTCACCCACTCTTACTCCAGTGTC
AGCTGGCATGGGCTCCTTCCTGAGTGCAAAGGTCAAAGGCCCCCTCTGTGAAGGCTCAGCAGAG
GTGGGATCCCACACCCCCTCCTGGCCCCTCCCTGCCCTCCATTCAGGGAGAAACCTCTCCTTCC
CGTGTGAGAAGGCCCGGAGGGTCCAGGCATCGCGAGTCCAGGGTGAAGGGCCACAGCCCCTCTT
GGCTGCCAAGCACCCAGATCTCACGGACATTTGGGGAAAGGGCTCCTTGGGTTGCCGGTGAACT
TCCTGTGGCCACCCCCTCCTGCTCCTGACCTCCCTGGCAGGGTGCTATCACTTCTGGCCCTTCC
AGTTTTATAAATCGGTTTCCAGCCCCTAGTGCCCTGACTTCTGTCTGCCAGATGAGGAGGGAGG
CCCTGCCTGTCAGGGAGGGTGGTTACTGTGGATGGAATAGTGGGGCCTTCAACTGATTAGACAA
GGCCTGCCCACATCTTGGAGGGCATCTGCCTTACTGATTAAAATGTCAATGTAAT

hide sequence

RefSeq Acc Id:

XM_008013297 ⟹ XP_008011488

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	73,805,680 - 73,810,157 (-)	NCBI
Vero_WHO_p1.0	NW_023666077	45,257,784 - 45,262,254 (-)	NCBI

Sequence:

show sequence

TGGGCGGCGGCTGTCGGGTGGGGCGCGAAGTCTCATCCCGCAGAGCCGGTGCCATCTGTGGGGG
CTTTGGGCCGGGGGTCTCCCGACAGCATGAGCGTGGGCTTCATCGGCGCTGGCCAGCTGGCTTT
TGCCCTGGTCAAGGGCTTCACAGCAGCAGGCATCTTGGCTGCCCACAAGATAATGGCTAGCTCC
CCAGACATGGACCTGGCCACGGTTTCTGCCCTCAGGAAGATGGGGGTGAAGCTGACACCCCACA
ACAAGGAGGCGGTGCAGCACAGTGATGTGCTCTTCCTGGCTGTGAAGCCACACATCATCCCCTT
CATCCTGGATGAGATAGGCAACCACATTGAGGACAGGCACATCGTGGTGTCCTGTGCGGCCGGC
GTCACCATCGGCTCCATAGAGAAGAAGCTGTCAGCGTTTCGACCAACCCCCAGGGTCATCCGCT
GCATGACCAACATCCCGGTCGTGGTCCGGGAGGGGGCCACCGTGTACGCCACAGGCACACACGC
CCAGGTGGAGGACGGGAGGCTCCTGGAGCAGCTGCTGAGCAGCGTGGGCTTCTGCACAGAGGTG
GAAGAGGACCTGATCGATGCCGTCACGGGGCTCAGTGGCAGTGGCCCCGCCTACGCGTTCACAG
CCCTGGATGCCCTGGCTGATGGGGGCGTGAAGATGGGACTTCCAAGGCGCCTGGCAGTCCGCCT
CGGGGCCCAGGCCCTCCTGGGGGCTGCCAAGATGCTGCTGCACTCAGAACAGCACCCAGGCCAG
CTCAAGGACAACGTCAGCTCTCCTGGTGGGGCCACCATCCATGCCTTGCACGTGCTGGAAAGTG
GGGGCTTCCGCTCTCTGCTCATCAACGCTGTGGAGGCCTCCTGCATCCGCACACGGGAGCTGCA
GTCCATGGCTGACCAGGAGCAGGTGTCACCAGCCGCCATCAAGAAGACCATCCTGGACAAGGTG
AAGCTGGAATCCCCTGCAGGGACCTCTCTGTCGCCTTCTGGCCACACCAAGCTGCTCCCCCGCA
GCCTGGCGCCAGTGGGCAAGGATTGACATGTCCTGCCTGACCACCACCCTGCCACCATCTTCTC
TTCTCTCATCACTAGGGGGACTAGGGGGTCCCCGATAGTGGCCCACTGTCTGGCTCTGATCAGC
GCAGGGGCCAGCCAGGGACATAGCCAGGGAGGGGCCACGTCACTTCCCACTGGAAATCTCTGTG
GTCTGCAAGTGTTTCCCAGCCCAGAACAGGGGCGGATTCCCCAACCTCAACCTCCTTTCTCCTC
TGCTCCCAAACCATGTCAGGACCACCTTCCTCTAGCGCTCAGGAGCCCGGAGGGTCTTCACCCA
CTCTTACTCCAGTGTCAGCTGGCATGGGCTCCTTCCTGAGTGCAAAGGTCAAAGGCCCCCTCTG
TGAAGGCTCAGCAGAGGTGGGATCCCACACCCCCTCCTGGCCCCTCCCTGCCCTCCATTCAGGG
AGAAACCTCTCCTTCCCGTGTGAGAAGGCCCGGAGGGTCCAGGCATCGCGAGTCCAGGGTGAAG
GGCCACAGCCCCTCTTGGCTGCCAAGCACCCAGATCTCACGGACATTTGGGGAAAGGGCTCCTT
GGGTTGCCGGTGAACTTCCTGTGGCCACCCCCTCCTGCTCCTGACCTCCCTGGCAGGGTGCTAT
CACTTCTGGCCCTTCCAGTTTTATAAATCGGTTTCCAGCCCCTAGTGCCCTGACTTCTGTCTGC
CAGATGAGGAGGGAGGCCCTGCCTGTCAGGGAGGGTGGTTACTGTGGATGGAATAGTGGGGCCT
TCAACTGATTAGACAAGGCCTGCCCACATCTTGGAGGGCATCTGCCTTACTGATTAAAATGTCA
ATGTAAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_008011486	(Get FASTA)	NCBI Sequence Viewer
	XP_008011487	(Get FASTA)	NCBI Sequence Viewer
	XP_008011488	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015836.1

RefSeq Acc Id:	XP_008011486 ⟸ XM_008013295
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9S4P7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008011487 ⟸ XM_008013296
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9S4P7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008011488 ⟸ XM_008013297
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9S4P7 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000015836 ⟸ ENSCSAT00000000217

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002197	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000000217.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
	ProC C-terminal domain-like	UniProtKB/TrEMBL
InterPro	6-PGluconate_DH-like_C_sf	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	P5C_Rdtase_cat_N	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
	Pyrroline-COOH_reductase	UniProtKB/TrEMBL
KEGG Report	csab:103243742	UniProtKB/TrEMBL
NCBI Gene	PYCR1	ENTREZGENE
PANTHER	PTHR11645	UniProtKB/TrEMBL
	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	F420_oxidored	UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/TrEMBL
PIRSF	Pyrrol-5-carb_rd	UniProtKB/TrEMBL
PROSITE	P5CR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48179	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A0D9S4P7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM