MTMR4 (myotubularin related protein 4) - Rat Genome Database

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Gene: MTMR4 (myotubularin related protein 4) Chlorocebus sabaeus
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Symbol: MTMR4
Name: myotubularin related protein 4
RGD ID: 18369298
Description: ENCODES a protein that exhibits molecular adaptor activity (ortholog); R-SMAD binding (ortholog); INVOLVED IN midbody abscission (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regulation of endocytic recycling (ortholog); ASSOCIATED WITH Fanconi anemia complementation group O (ortholog); hereditary breast ovarian cancer syndrome (ortholog); Joubert syndrome 1 (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myotubularin-related protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11634,889,637 - 34,918,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1634,890,764 - 34,918,263 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,704,030 - 5,732,484 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MTMR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11634,889,637 - 34,918,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1634,890,764 - 34,918,263 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,704,030 - 5,732,484 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MTMR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,489,537 - 58,519,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,489,529 - 58,517,905 (-)EnsemblGRCh38hg38GRCh38
GRCh371756,566,898 - 56,595,241 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,921,897 - 53,950,211 (-)NCBINCBI36Build 36hg18NCBI36
Build 341753,921,896 - 53,950,211NCBI
Celera1753,028,691 - 53,057,049 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,927,353 - 51,955,501 (-)NCBIHuRef
CHM1_11756,632,457 - 56,660,825 (-)NCBICHM1_1
T2T-CHM13v2.01759,357,413 - 59,386,918 (-)NCBIT2T-CHM13v2.0
Mtmr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,482,769 - 87,507,128 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,482,988 - 87,507,128 (+)EnsemblGRCm39 Ensembl
GRCm381187,591,954 - 87,616,302 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,592,162 - 87,616,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,405,719 - 87,429,798 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,408,412 - 87,432,491 (+)NCBIMGSCv36mm8
Celera1197,187,562 - 97,211,641 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.15NCBI
Mtmr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81072,890,665 - 72,913,598 (+)NCBIGRCr8
mRatBN7.21072,393,411 - 72,416,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,392,551 - 72,416,342 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,003,919 - 77,026,852 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,508,832 - 76,531,763 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01071,973,349 - 71,996,280 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,886,600 - 74,909,532 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,886,985 - 74,909,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,192,507 - 75,215,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,883,526 - 75,906,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11075,896,715 - 75,918,774 (+)NCBI
Celera1071,307,233 - 71,330,165 (+)NCBICelera
Cytogenetic Map10q26NCBI
Mtmr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,532,295 - 4,558,225 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,531,966 - 4,557,528 (+)NCBIChiLan1.0ChiLan1.0
MTMR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,660,136 - 74,690,715 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,471,440 - 79,502,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,564,455 - 52,592,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,418,229 - 57,446,539 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,418,229 - 57,446,545 (-)Ensemblpanpan1.1panPan2
MTMR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1933,110,983 - 33,136,843 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl933,112,143 - 33,136,684 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,346,134 - 32,372,514 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0933,917,037 - 33,943,425 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,917,038 - 33,942,605 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,703,682 - 32,730,052 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,987,246 - 33,013,417 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0933,079,196 - 33,105,587 (-)NCBIUU_Cfam_GSD_1.0
Mtmr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,436,863 - 32,463,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,611,517 - 4,638,511 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,611,350 - 4,638,181 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTMR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,745,236 - 34,771,167 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,745,232 - 34,771,315 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,044,693 - 36,069,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mtmr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871302,588 - 328,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871302,589 - 328,773 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000003807   ⟹   ENSCSAP00000002078
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1634,890,764 - 34,918,263 (+)Ensembl
RefSeq Acc Id: XM_008011293   ⟹   XP_008009484
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11634,889,637 - 34,918,101 (+)NCBI
Vero_WHO_p1.0NW_0236660775,704,030 - 5,732,484 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037993617   ⟹   XP_037849545
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660775,707,172 - 5,732,484 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008009484 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849545 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002078.1
RefSeq Acc Id: XP_008009484   ⟸   XM_008011293
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R0D9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000002078   ⟸   ENSCSAT00000003807
RefSeq Acc Id: XP_037849545   ⟸   XM_037993617
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R0D9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003807.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro MTMR4 UniProtKB/TrEMBL
  MTMR4_FYVE UniProtKB/TrEMBL
  MTMR4_PH-GRAM UniProtKB/TrEMBL
  Myotubularin-like_Pase_dom UniProtKB/TrEMBL
  Myotubularin_fam UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene MTMR4 ENTREZGENE
PANTHER PTHR10807 UniProtKB/TrEMBL
  PTHR10807:SF64 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  Myotub-related UniProtKB/TrEMBL
PROSITE PPASE_MYOTUBULARIN UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
SMART FYVE UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A0D9R0D9 ENTREZGENE, UniProtKB/TrEMBL