Tmem139 (transmembrane protein 139) - Rat Genome Database

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Gene: Tmem139 (transmembrane protein 139) Mus musculus
Analyze
Symbol: Tmem139
Name: transmembrane protein 139
RGD ID: 1623859
MGI Page MGI
Description: Orthologous to human TMEM139 (transmembrane protein 139).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A930027H06Rik; RIKEN cDNA A930027H06 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,238,866 - 42,241,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,238,893 - 42,241,489 (+)EnsemblGRCm39 Ensembl
GRCm38642,261,932 - 42,264,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,261,959 - 42,264,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,211,969 - 42,214,554 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,191,566 - 42,194,160 (+)NCBIMGSCv36mm8
Celera642,206,268 - 42,208,853 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:20562862   PMID:38355793  


Genomics

Comparative Map Data
Tmem139
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,238,866 - 42,241,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,238,893 - 42,241,489 (+)EnsemblGRCm39 Ensembl
GRCm38642,261,932 - 42,264,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,261,959 - 42,264,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,211,969 - 42,214,554 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,191,566 - 42,194,160 (+)NCBIMGSCv36mm8
Celera642,206,268 - 42,208,853 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
TMEM139
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,284,899 - 143,288,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,279,957 - 143,288,048 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,981,992 - 142,985,142 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,692,185 - 142,695,263 (+)NCBINCBI36Build 36hg18NCBI36
Celera7137,818,928 - 137,822,006 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7137,319,401 - 137,322,503 (+)NCBIHuRef
CHM1_17142,918,927 - 142,922,028 (+)NCBICHM1_1
T2T-CHM13v2.07144,640,307 - 144,643,457 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,384,156 - 142,387,257 (+)NCBI
Tmem139
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,113,437 - 72,115,786 (+)NCBIGRCr8
mRatBN7.2471,147,072 - 71,149,151 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,146,724 - 71,167,399 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0471,648,705 - 71,651,861 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,650,575 - 71,651,438 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,451,731 - 136,454,222 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,026,809 - 70,028,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera466,076,637 - 66,079,793 (+)NCBICelera
Cytogenetic Map4q24NCBI
Tmem139
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494369,309 - 371,516 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955494369,309 - 371,526 (-)NCBIChiLan1.0ChiLan1.0
TMEM139
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,130,699 - 180,140,945 (+)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl7147,770,478 - 147,773,583 (+)Ensemblpanpan1.1panPan2
TMEM139
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,397,507 - 6,401,385 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,380,778 - 6,399,579 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,386,566 - 7,388,551 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,251,398 - 6,253,391 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,250,535 - 6,253,294 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,198,790 - 6,200,782 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,050,709 - 6,052,702 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,125,847 - 6,128,096 (-)NCBIUU_Cfam_GSD_1.0
Tmem139
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,164,385 - 12,167,869 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527736,085 - 739,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936527736,173 - 739,142 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM139
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,970,891 - 6,973,394 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,970,887 - 6,974,130 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,211,799 - 7,215,042 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM139
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,167,475 - 112,172,327 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,170,253 - 112,171,143 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660728,893,511 - 8,896,620 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem139
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,468,819 - 11,470,751 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480011,468,362 - 11,470,732 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:113
Interacting mature miRNAs:125
Transcripts:ENSMUST00000095987
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse

Markers in Region
UniSTS:493102  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38642,263,514 - 42,264,262UniSTSGRCm38
MGSCv37642,213,513 - 42,214,261UniSTSGRCm37
Celera642,207,812 - 42,208,560UniSTS
Cytogenetic Map6B2.1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000095987   ⟹   ENSMUSP00000100590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,238,904 - 42,241,489 (+)Ensembl
GRCm38.p6 Ensembl642,261,970 - 42,264,555 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238607
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,238,893 - 42,241,487 (+)Ensembl
GRCm38.p6 Ensembl642,261,959 - 42,264,553 (+)Ensembl
RefSeq Acc Id: NM_175408   ⟹   NP_780617
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,238,904 - 42,241,489 (+)NCBI
GRCm38642,261,970 - 42,264,555 (+)NCBI
MGSCv37642,211,969 - 42,214,554 (+)RGD
Celera642,206,268 - 42,208,853 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505326   ⟹   XP_006505389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,238,887 - 42,241,489 (+)NCBI
GRCm38642,261,953 - 42,264,555 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006505327   ⟹   XP_006505390
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,238,866 - 42,241,489 (+)NCBI
GRCm38642,261,932 - 42,264,555 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006505328   ⟹   XP_006505391
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,238,886 - 42,241,489 (+)NCBI
GRCm38642,261,952 - 42,264,555 (+)NCBI
Sequence:
RefSeq Acc Id: NP_780617   ⟸   NM_175408
- UniProtKB: E9PX92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505390   ⟸   XM_006505327
- Peptide Label: isoform X1
- UniProtKB: E9PX92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505391   ⟸   XM_006505328
- Peptide Label: isoform X1
- UniProtKB: E9PX92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505389   ⟸   XM_006505326
- Peptide Label: isoform X1
- UniProtKB: E9PX92 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000100590   ⟸   ENSMUST00000095987

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PX92-F1-model_v2 AlphaFold E9PX92 1-214 view protein structure

Promoters
RGD ID:6839050
Promoter ID:MM_KWN:45774
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:ENSMUST00000095987,   NM_175408,   OTTMUST00000057721,   OTTMUST00000057722,   OTTMUST00000057723,   OTTMUST00000057724,   OTTMUST00000057725,   OTTMUST00000057726
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36642,211,736 - 42,215,192 (+)MPROMDB
RGD ID:6889530
Promoter ID:EPDNEW_M8216
Type:initiation region
Name:Tmem139_1
Description:Mus musculus transmembrane protein 139 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38642,261,970 - 42,262,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924444 AgrOrtholog
Ensembl Genes ENSMUSG00000071506 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000095987 ENTREZGENE
  ENSMUST00000095987.4 UniProtKB/TrEMBL
InterPro TMEM139 UniProtKB/TrEMBL
KEGG Report mmu:109218 UniProtKB/TrEMBL
MGD MGI:1924444 ENTREZGENE
NCBI Gene Tmem139 ENTREZGENE
PANTHER PTHR36294 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 139 UniProtKB/TrEMBL
PhenoGen Tmem139 PhenoGen
UniProt E9PX92 ENTREZGENE, UniProtKB/TrEMBL
  Q8C6T0_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Tmem139  transmembrane protein 139  A930027H06Rik  RIKEN cDNA A930027H06 gene  Symbol and/or name change 5135510 APPROVED
2024-08-21 A930027H06Rik  RIKEN cDNA A930027H06 gene  Tmem139  transmembrane protein 139  Symbol and/or name change 5135510 APPROVED