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Gene: Smim22 (small integral membrane protein 22) Mus musculus

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Symbol:

Smim22

Name:

small integral membrane protein 22

RGD ID:

1623569

MGI Page

MGI

Description:

Predicted to be involved in several processes, including lipid droplet formation; positive regulation of cell migration; and regulation of actin cytoskeleton organization. Is expressed in embryo; embryo endoderm; and node. Orthologous to human SMIM22 (small integral membrane protein 22).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

EG432995; Gm5480; uncharacterized protein LOC432995

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	4,825,152 - 4,826,173 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	4,825,152 - 4,826,173 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	5,007,288 - 5,008,309 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	5,007,288 - 5,008,309 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	5,007,396 - 5,008,402 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	4,922,615 - 4,923,627 (+)	NCBI		MGSCv36	mm8
Celera	16	5,638,677 - 5,639,683 (+)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	2.49	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim22	Mouse	epilepsy		ISO	RGD:7247217	8554872	ClinVar Annotator: match by term: Epilepsy	ClinVar	PMID:28492532
Smim22	Mouse	Idiopathic Generalized Epilepsy		ISO	RGD:7247217	8554872	ClinVar Annotator: match by term: Idiopathic generalized epilepsy	ClinVar	PMID:28492532
Smim22	Mouse	Kohlschutter-Tonz syndrome		ISO	RGD:7247217	8554872	ClinVar Annotator: match by term: Amelocerebrohypohidrotic syndrome	ClinVar	PMID:28492532
Smim22	Mouse	Rubinstein-Taybi syndrome		ISO	RGD:7247217	8554872	ClinVar Annotator: match by term: Rubinstein-Taybi syndrome	ClinVar	PMID:12114483\|PMID:17855048\|PMID:18688873\|PMID:19833603\|PMID:21302340\|PMID:22307725\|PMID:22664659\|PMID:23063576\|PMID:25805166\|PMID:27257017\|PMID:28492532
Smim22	Mouse	short-rib thoracic dysplasia 9 with or without polydactyly		ISO	RGD:7247217	8554872	ClinVar Annotator: match by term: Saldino-Mainzer syndrome	ClinVar	PMID:28492532

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim22	Mouse	(+)-schisandrin B	multiple interactions	ISO	RGD:1563547	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMIM22 mRNA]	CTD	PMID:31150632
Smim22	Mouse	(1->4)-beta-D-glucan	multiple interactions	EXP		6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMIM22 mRNA	CTD	PMID:36331819
Smim22	Mouse	1-naphthyl isothiocyanate	increases expression	ISO	RGD:1563547	6480464	1-Naphthylisothiocyanate results in increased expression of SMIM22 mRNA	CTD	PMID:30723492
Smim22	Mouse	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1563547	6480464	Tetrachlorodibenzodioxin results in increased expression of SMIM22 mRNA	CTD	PMID:32109520
Smim22	Mouse	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1563547	6480464	Tetrachlorodibenzodioxin results in decreased expression of SMIM22 mRNA	CTD	PMID:33387578
Smim22	Mouse	2,3,7,8-Tetrachlorodibenzofuran	increases expression	ISO	RGD:1563547	6480464	2,3,7,8-tetrachlorodibenzofuran results in increased expression of SMIM22 mRNA	CTD	PMID:32109520
Smim22	Mouse	2,4-dibromophenyl 2,4,5-tribromophenyl ether	affects expression	EXP		6480464	2,2',4,4',5-brominated diphenyl ether affects the expression of SMIM22 mRNA	CTD	PMID:38648751
Smim22	Mouse	4-hydroxyphenyl retinamide	increases expression	EXP		6480464	Fenretinide results in increased expression of SMIM22 mRNA	CTD	PMID:28973697
Smim22	Mouse	acetamide	increases expression	ISO	RGD:1563547	6480464	acetamide results in increased expression of SMIM22 mRNA	CTD	PMID:31881176
Smim22	Mouse	all-trans-retinoic acid	decreases expression	ISO	RGD:7247217	6480464	Tretinoin results in decreased expression of SMIM22 mRNA	CTD	PMID:23724009
Smim22	Mouse	alpha-Zearalanol	multiple interactions	ISO	RGD:1563547	6480464	[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SMIM22 mRNA	CTD	PMID:35163327
Smim22	Mouse	arsenite(3-)	multiple interactions	ISO	RGD:7247217	6480464	arsenite promotes the reaction [G3BP1 protein binds to SMIM22 mRNA]	CTD	PMID:32406909
Smim22	Mouse	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of SMIM22 mRNA	CTD	PMID:32417428
Smim22	Mouse	bisphenol A	affects expression	ISO	RGD:1563547	6480464	bisphenol A affects the expression of SMIM22 mRNA	CTD	PMID:25181051
Smim22	Mouse	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of SMIM22 mRNA	CTD	PMID:32156529
Smim22	Mouse	bisphenol A	decreases expression	ISO	RGD:1563547	6480464	bisphenol A results in decreased expression of SMIM22 mRNA	CTD	PMID:30816183\|PMID:32145629\|PMID:32528016
Smim22	Mouse	cadmium dichloride	increases methylation	ISO	RGD:1563547	6480464	Cadmium Chloride results in increased methylation of SMIM22 promoter	CTD	PMID:22457795
Smim22	Mouse	cisplatin	multiple interactions	ISO	RGD:7247217	6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of SMIM22 mRNA	CTD	PMID:27392435
Smim22	Mouse	cisplatin	decreases expression	ISO	RGD:7247217	6480464	Cisplatin results in decreased expression of SMIM22 mRNA	CTD	PMID:27392435
Smim22	Mouse	cobalt dichloride	decreases expression	ISO	RGD:1563547	6480464	cobaltous chloride results in decreased expression of SMIM22 mRNA	CTD	PMID:24386269
Smim22	Mouse	Cuprizon	increases expression	ISO	RGD:1563547	6480464	Cuprizone results in increased expression of SMIM22 mRNA	CTD	PMID:26577399
Smim22	Mouse	dichloroacetic acid	decreases expression	EXP		6480464	Dichloroacetic Acid results in decreased expression of SMIM22 mRNA	CTD	PMID:28962523
Smim22	Mouse	diuron	increases expression	ISO	RGD:1563547	6480464	Diuron results in increased expression of SMIM22 mRNA	CTD	PMID:21551480
Smim22	Mouse	gentamycin	decreases expression	ISO	RGD:1563547	6480464	Gentamicins results in decreased expression of SMIM22 mRNA	CTD	PMID:33387578
Smim22	Mouse	glycidol	increases expression	ISO	RGD:1563547	6480464	glycidol results in increased expression of SMIM22 mRNA	CTD	PMID:24395379
Smim22	Mouse	inulin	multiple interactions	EXP		6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SMIM22 mRNA	CTD	PMID:36331819
Smim22	Mouse	N(4)-hydroxycytidine	decreases expression	EXP		6480464	N(4)-hydroxycytidine results in decreased expression of SMIM22 mRNA	CTD	PMID:37748715
Smim22	Mouse	N-nitrosodiethylamine	increases expression	EXP		6480464	Diethylnitrosamine results in increased expression of SMIM22 mRNA	CTD	PMID:24535843
Smim22	Mouse	paracetamol	decreases expression	ISO	RGD:1563547	6480464	Acetaminophen results in decreased expression of SMIM22 mRNA	CTD	PMID:33387578
Smim22	Mouse	perfluorooctane-1-sulfonic acid	multiple interactions	EXP		6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMIM22 mRNA; [perfluorooctane sulfonic more ...	CTD	PMID:36331819
Smim22	Mouse	perfluorooctanoic acid	multiple interactions	ISO	RGD:1563547	6480464	[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SMIM22 mRNA	CTD	PMID:35163327
Smim22	Mouse	permethrin	increases expression	ISO	RGD:7247217	6480464	Permethrin results in increased expression of SMIM22 mRNA	CTD	PMID:37047231
Smim22	Mouse	silicon dioxide	affects expression	ISO	RGD:7247217	6480464	Silicon Dioxide analog affects the expression of SMIM22 mRNA	CTD	PMID:25895662
Smim22	Mouse	sodium arsenite	decreases expression	EXP		6480464	sodium arsenite results in decreased expression of SMIM22 mRNA	CTD	PMID:37682722
Smim22	Mouse	tetrachloromethane	decreases expression	ISO	RGD:1563547	6480464	Carbon Tetrachloride results in decreased expression of SMIM22 mRNA	CTD	PMID:31150632
Smim22	Mouse	tetrachloromethane	multiple interactions	ISO	RGD:1563547	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMIM22 mRNA]	CTD	PMID:31150632
Smim22	Mouse	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of SMIM22 mRNA	CTD	PMID:31919559
Smim22	Mouse	thioacetamide	decreases expression	ISO	RGD:1563547	6480464	Thioacetamide results in decreased expression of SMIM22 mRNA	CTD	PMID:34492290
Smim22	Mouse	trichloroethene	decreases expression	ISO	RGD:1563547	6480464	Trichloroethylene results in decreased expression of SMIM22 mRNA	CTD	PMID:33387578

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim22	Mouse	lipid droplet formation	involved_in	ISO	UniProtKB:K7EJ46	2290270		GO_Central	GO_REF:0000119
Smim22	Mouse	positive regulation of cell migration	involved_in	ISO	UniProtKB:K7EJ46	2290270		GO_Central	GO_REF:0000119
Smim22	Mouse	regulation of actin cytoskeleton organization	involved_in	ISO	UniProtKB:K7EJ46	2290270		GO_Central	GO_REF:0000119
Smim22	Mouse	regulation of cell cycle	involved_in	ISO	UniProtKB:K7EJ46	2290270		GO_Central	GO_REF:0000119
Smim22	Mouse	regulation of cell population proliferation	involved_in	ISO	UniProtKB:K7EJ46	2290270		GO_Central	GO_REF:0000119
Smim22	Mouse	regulation of cell population proliferation	involved_in	IBA	PANTHER:PTN002864020\|UniProtKB:K7EJ46	2290270		GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim22	Mouse	cellular_component	is_active_in	ND		2290270		MGI	GO_REF:0000015

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smim22	Mouse	molecular_function	enables	ND		2290270		MGI	GO_REF:0000015
Smim22	Mouse	protein binding	enables	ISO	UniProtKB:P27824\|UniProtKB:P39656\|UniProtKB:Q14534	9068941	PMID:29765154	UniProt	PMID:29765154

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:14610273	PMID:16141072	PMID:21873635	PMID:22008794

Smim22
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	4,825,152 - 4,826,173 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	4,825,152 - 4,826,173 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	5,007,288 - 5,008,309 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	5,007,288 - 5,008,309 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	5,007,396 - 5,008,402 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	4,922,615 - 4,923,627 (+)	NCBI		MGSCv36	mm8
Celera	16	5,638,677 - 5,639,683 (+)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	2.49	NCBI

SMIM22
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	4,788,397 - 4,796,491 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	4,788,397 - 4,796,491 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	4,838,398 - 4,846,492 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	4,785,445 - 4,786,283 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	5,047,168 - 5,055,052 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	4,804,628 - 4,812,690 (+)	NCBI		HuRef
CHM1_1	16	4,839,242 - 4,847,338 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	4,817,885 - 4,825,973 (+)	NCBI		T2T-CHM13v2.0

Smim22
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	11,079,019 - 11,080,804 (-)	NCBI		GRCr8
mRatBN7.2	10	10,572,146 - 10,574,339 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	10	15,280,550 - 15,281,731 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	14,769,369 - 14,770,550 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	10,438,679 - 10,439,860 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	10,766,208 - 10,768,044 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	10,766,208 - 10,767,389 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	9,533,221 - 9,535,017 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	10,688,460 - 10,689,937 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	9,536,341 - 9,537,575 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Smim22
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	12,700,461 - 12,701,283 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	12,700,461 - 12,701,283 (-)	NCBI	ChiLan1.0	ChiLan1.0

SMIM22
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	5,323,401 - 5,324,979 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	9,113,553 - 9,115,131 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	3,719,356 - 3,720,380 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	4,884,964 - 4,885,870 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	4,884,977 - 4,885,869 (+)	Ensembl	panpan1.1		panPan2

SMIM22
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	36,624,080 - 36,625,631 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	36,624,992 - 36,625,505 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	38,016,333 - 38,022,481 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	36,827,053 - 36,833,200 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	36,827,965 - 36,828,478 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	36,621,097 - 36,627,183 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	36,513,993 - 36,520,072 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	36,916,208 - 36,922,354 (-)	NCBI		UU_Cfam_GSD_1.0

Smim22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	106,909,199 - 106,910,406 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	4,755,222 - 4,755,817 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936530	4,754,946 - 4,755,830 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMIM22
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	37,599,576 - 37,601,086 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	37,599,574 - 37,601,316 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	38,670,635 - 38,672,152 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SMIM22
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	4,465,215 - 4,466,550 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	4,465,603 - 4,466,738 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	26,192,962 - 26,194,293 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smim22
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	2,648,641 - 2,649,427 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	2,645,488 - 2,649,428 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Smim22
32 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	1584
Count of miRNA genes:	440
Interacting mature miRNAs:	513
Transcripts:	ENSMUST00000178155, ENSMUST00000183381, ENSMUST00000183477, ENSMUST00000183631, ENSMUST00000183821, ENSMUST00000184256, ENSMUST00000184439, ENSMUST00000185147
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301970	Heal11_m	wound healing/regeneration 11 (mouse)			Not determined		16	1	24263853	Mouse
4141468	Nhdlq10_m	non-HDL QTL 10 (mouse)			Not determined		16	1	24263853	Mouse
1301559	Bbaa19_m	B.burgdorferi-associated arthritis 19 (mouse)			Not determined		16	1	30066977	Mouse
38501069	Tip4_m	tuberculosis immunophenotype 4, IFN-g level (mouse)					16	4317864	44520363	Mouse
1302106	Rapop1_m	radiation-induced apoptosis 1 (mouse)			Not determined		16	3780779	15731053	Mouse
26884432	Zlq7_m	zygomatic length QTL 7, 10 week (mouse)					16	3817864	64620363	Mouse
1300632	Loca2_m	locomotor activity 2 (mouse)			Not determined		16	1	22500574	Mouse
27226768	Tibl9_m	tibia length 9, 5 week (mouse)					16	3317864	51420363	Mouse
1301443	Mopkd2_m	modifier of polycystic kidney disease progression 2 (mouse)			Not determined		16	4646314	38646414	Mouse
1301575	Tanidd3_m	tally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)			Not determined		16	1	22897739	Mouse
27095908	Scvln7_m	sacral vertebrae length 2, 5 week (mouse)					16	3317864	39820362	Mouse
4141060	Pbwg19_m	postnatal body weight growth 19 (mouse)			Not determined		16	1	20780888	Mouse
1301384	Dice1_m	determination of interleukin 4 commitment 1 (mouse)			Not determined		16	1	28434358	Mouse
10043879	Adip25_m	adiposity 25 (mouse)			Not determined		16	1	22520318	Mouse
27226785	Feml12_m	femur length 12, 5 week (mouse)					16	3317864	64620363	Mouse
10402497	Lmr23_m	leishmaniasis resistance 23 (mouse)			Not determined		16	1	29674200	Mouse
10412289	Ppsl_m	plasma P-selectin levels (mouse)			Not determined		16	1	30814572	Mouse

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_001253796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001253797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001253802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001253803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_045595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_045596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC163723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW985536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BB610432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC047216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ043101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ237462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ320043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000178155 ⟹ ENSMUSP00000137083

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,201 - 4,826,173 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,337 - 5,008,309 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000183381

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,216 - 4,826,173 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,352 - 5,008,309 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000183477

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,223 - 4,826,173 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,359 - 5,008,309 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000183631

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,632 - 4,826,173 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,768 - 5,008,309 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000183821

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,180 - 4,825,906 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,316 - 5,008,042 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000184256

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,216 - 4,826,170 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,352 - 5,008,306 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000184439 ⟹ ENSMUSP00000139370

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,152 - 4,826,170 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,288 - 5,008,306 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000185147 ⟹ ENSMUSP00000139067

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	16	4,825,216 - 4,826,173 (+)	Ensembl
GRCm38.p6 Ensembl	16	5,007,352 - 5,008,309 (+)	Ensembl

RefSeq Acc Id:

NM_001253796 ⟹ NP_001240725

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	4,825,180 - 4,826,173 (+)	NCBI
GRCm38	16	5,007,316 - 5,008,309 (+)	NCBI
Celera	16	5,638,662 - 5,639,683 (+)	ENTREZGENE
cM Map	16		ENTREZGENE

Sequence:

show sequence

AGGAAGCAGTGTGAGTTCCTAGGACCTACCTGGCCTGGGGGGGAAGGGGTGCCACTAGAGGCAGGTGGGGGCACTGGAATCAGCTTTGCTGGGGAGAGAGGAGGTGGCTGAGATGGGGCTTTCTGATG
AGGAGCTGAGGCAGGAGCTGCAGGCCACTGCAGAGGAAGTACTGGGGAGGCTGAGGAGCCGGCAGCTCTTCCAGTCGGAATGGGACGTCGCTGCCTTTGTGGTCTTTCTCACATTTGTGGGCACTGTG
CTGTTGTTGCTGTTGCTGGTCTTTGTCCATTGCTGCTGTTGTTGCTGCTGCAACACCTCCCCCAGGCCCCGGAAGGTGAGCCCCGGGAAGGAAAAGCGCAATGGTGTGGATAACTTGGCCCTGGAACC
TTAATGCTAACTTGCCCTTGGCATGGGTCCTGCTGGATGACAGTAACAGAGCCAATGTTTGCCAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001253797 ⟹ NP_001240726

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	4,825,180 - 4,826,173 (+)	NCBI
GRCm38	16	5,007,316 - 5,008,309 (+)	NCBI
Celera	16	5,638,662 - 5,639,683 (+)	ENTREZGENE
cM Map	16		ENTREZGENE

Sequence:

show sequence

AGGAAGCAGTGTGAGTTCCTAGGACCTACCTGGCCTGGGGGGGAAGGGGTGCCACTAGAGGCAGGTGGGGGCACTGGAATCAGCTTTGCTGGGGAGAGAGGAGGTGGCTGAGATGGGGCTTTCTGATG
AGGAGCTGAGGCAGGAGCTGCAGGCCACTGCAGAGGAAGTACTGGGGAGGCTGAGGAGCCGGCAGCTCTTCCAGTCGGAATGGGACGTCGCTGCCTTTGTGGTCTTTCTCACATTTGTGGGCACTGTG
CTGTTGTTGCTGTTGCTGGTCTTTGTCCATTGCTGCTGTTGTTGCTGCTGCAACACCTCCCCCAGGCCCCGGAAGGAAAAGCGCAATGGTGTGGATAACTTGGCCCTGGAACCTTAATGCTAACTTGC
CCTTGGCATGGGTCCTGCTGGATGACAGTAACAGAGCCAATGTTTGCCAAA

hide sequence

RefSeq Acc Id:

NM_001253802 ⟹ NP_001240731

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	4,825,152 - 4,826,173 (+)	NCBI
GRCm38	16	5,007,288 - 5,008,309 (+)	NCBI
Celera	16	5,638,662 - 5,639,683 (+)	ENTREZGENE
cM Map	16		ENTREZGENE

Sequence:

show sequence

AGGTGGTGCGGATCCTGGATCCGGAAGCAGGAAGCAGTGTGGCTGAGATGGGGCTTTCTGATGA
GGAGCTGAGGCAGGAGCTGCAGGCCACTGCAGAGGAAGTACTGGGGAGGCTGAGGAGCCGGCAGCTCTTCCAGTCGGAATGGGACGTCGCTGCCTTTGTGGTCTTTCTCACATTTGTGGGCACTGTGC
TGTTGTTGCTGTTGCTGGTCTTTGTCCATTGCTGCTGTTGTTGCTGCTGCAACACCTCCCCCAGGCCCCGGAAGGTGAGCCCCGGGAAGGAAAAGCGCAATGGTGTGGATAACTTGGCCCTGGAACCT
TAATGCTAACTTGCCCTTGGCATGGGTCCTGCTGGATGACAGTAACAGAGCCAATGTTTGCCAAA

hide sequence

RefSeq Acc Id:

NM_001253803 ⟹ NP_001240732

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	4,825,152 - 4,826,173 (+)	NCBI
GRCm38	16	5,007,288 - 5,008,309 (+)	NCBI
Celera	16	5,638,662 - 5,639,683 (+)	ENTREZGENE
cM Map	16		ENTREZGENE

Sequence:

show sequence

AGGTGGTGCGGATCCTGGATCCGGAAGCAGGAAGCAGTGTGGCTGAGATGGGGCTTTCTGATGAGGAGCTGAGGCAGGAGCTGCAGGCCACTGCAGAGGAAGTACTGGGGAGGCTGAGGAGCCGGCAG
CTCTTCCAGTCGGAATGGGACGTCGCTGCCTTTGTGGTCTTTCTCACATTTGTGGGCACTGTGCTGTTGTTGCTGTTGCTGGTCTTTGTCCATTGCTGCTGTTGTTGCTGCTGCAACACCTCCCCCAG
GCCCCGGAAGGAAAAGCGCAATGGTGTGGATAACTTGGCCCTGGAACCTTAATGCTAACTTGCCCTTGGCATGGGTCCTGCTGGATGACAGTAACAGAGCCAATGTTTGCCAAA

hide sequence

RefSeq Acc Id:

NR_045595

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	4,825,180 - 4,826,173 (+)	NCBI
GRCm38	16	5,007,316 - 5,008,309 (+)	NCBI
Celera	16	5,638,662 - 5,639,683 (+)	ENTREZGENE
cM Map	16		ENTREZGENE

Sequence:

show sequence

AGGAAGCAGTGTGAGTTCCTAGGACCTACCTGGCCTGGGGGGGAAGGGGTGCCACTAGAGGCAGGTGGGGGCACTGGAATCAGCTTTGCTGGGGAGAGAGGAGCTGAGGCAGGAGCTGCAGGCCACTG
CAGAGGAAGTACTGGGGAGGCTGAGGAGCCGGCAGCTCTTCCAGTCGGAATGGGACGTCGCTGCCTTTGTGGTCTTTCTCACATTTGTGGGCACTGTGCTGTTGTTGCTGTTGCTGGTCTTTGTCCAT
TGCTGCTGTTGTTGCTGCTGCAACACCTCCCCCAGGCCCCGGAAGGTGAGCCCCGGGAAGGAAAAGCGCAATGGTGTGGATAACTTGGCCCTGGAACCTTAATGCTAACTTGCCCTTGGCATGGGTCC
TGCTGGATGACAGTAACAGAGCCAATGTTTGCCAAA

hide sequence

RefSeq Acc Id:

NR_045596

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	16	4,825,180 - 4,826,173 (+)	NCBI
GRCm38	16	5,007,316 - 5,008,309 (+)	NCBI
Celera	16	5,638,662 - 5,639,683 (+)	ENTREZGENE
cM Map	16		ENTREZGENE

Sequence:

show sequence

AGGAAGCAGTGTGAGTTCCTAGGACCTACCTGGCCTGGGGGGGAAGGGGTGCCACTAGAGGCAG
GTGGGGGCACTGGAATCAGCTTTGCTGGGGAGAGAGGAGGCACTGTGCTGTTGTTGCTGTTGCTGGTCTTTGTCCATTGCTGCTGTTGTTGCTGCTGCAACACCTCCCCCAGGCCCCGGAAGGTGAGC
CCCGGGAAGGAAAAGCGCAATGGTGTGGATAACTTGGCCCTGGAACCTTAATGCTAACTTGCCCTTGGCATGGGTCCTGCTGGATGACAGTAACAGAGCCAATGTTTGCCAAA

hide sequence


Protein RefSeqs	NP_001240725	(Get FASTA)	NCBI Sequence Viewer
	NP_001240726	(Get FASTA)	NCBI Sequence Viewer
	NP_001240731	(Get FASTA)	NCBI Sequence Viewer
	NP_001240732	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDK97269	(Get FASTA)	NCBI Sequence Viewer
	EDK97270	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000137083
	ENSMUSP00000137083.2
	ENSMUSP00000139067
	ENSMUSP00000139067.2
	ENSMUSP00000139370
	ENSMUSP00000139370.2

RefSeq Acc Id:	NP_001240731 ⟸ NM_001253802
- Peptide Label:	isoform 1
- UniProtKB:	J3QP37 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLSDEELRQELQATAEEVLGRLRSRQLFQSEWDVAAFVVFLTFVGTVLLLLLLVFVHCCCCCCCNTSPRPRKVSPGKEKRNGVDNLALEP hide sequence

RefSeq Acc Id:	NP_001240732 ⟸ NM_001253803
- Peptide Label:	isoform 2
- UniProtKB:	V9GXA9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLSDEELRQELQATAEEVLGRLRSRQLFQSEWDVAAFVVFLTFVGTVLLLLLLVFVHCCCCCCCNTSPRPRKEKRNGVDNLALEP hide sequence

RefSeq Acc Id:	NP_001240725 ⟸ NM_001253796
- Peptide Label:	isoform 1
- UniProtKB:	J3QP37 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLSDEELRQELQATAEEVLGRLRSRQLFQSEWDVAAFVVFLTFVGTVLLLLLLVFVHCCCCCCCNTSPRPRKVSPGKEKRNGVDNLALEP hide sequence

RefSeq Acc Id:	NP_001240726 ⟸ NM_001253797
- Peptide Label:	isoform 2
- UniProtKB:	V9GXA9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLSDEELRQELQATAEEVLGRLRSRQLFQSEWDVAAFVVFLTFVGTVLLLLLLVFVHCCCCCCCNTSPRPRKEKRNGVDNLALEP hide sequence

Ensembl Acc Id:

ENSMUSP00000139370 ⟸ ENSMUST00000184439

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-J3QP37-F1-model_v2	AlphaFold	J3QP37	1-91	view protein structure

RGD ID:

6827082

Promoter ID:

MM_KWN:20010

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney

Transcripts:

BC047216_GM5480

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	16	5,007,051 - 5,007,551 (+)	MPROMDB

RGD ID:

8685366

Promoter ID:

EPDNEW_M20713

Type:

initiation region

Name:

Smim22_1

Description:

Mus musculus small integral membrane protein 22 , transcriptvariant 6, non-coding RNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	16	5,007,323 - 5,007,383	EPDNEW

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000096215	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000178155	ENTREZGENE
	ENSMUST00000178155.9	UniProtKB/TrEMBL
	ENSMUST00000183381	ENTREZGENE
	ENSMUST00000184256	ENTREZGENE
	ENSMUST00000184439	ENTREZGENE
	ENSMUST00000184439.8	UniProtKB/TrEMBL
	ENSMUST00000185147	ENTREZGENE
	ENSMUST00000185147.8	UniProtKB/TrEMBL
InterPro	DUF4713	UniProtKB/TrEMBL
	SIM_Modulators	UniProtKB/TrEMBL
KEGG Report	mmu:432995	UniProtKB/TrEMBL
MGD	MGI:3643379	ENTREZGENE
NCBI Gene	432995	ENTREZGENE
PANTHER	CLCA DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	SMALL INTEGRAL MEMBRANE PROTEIN 22	UniProtKB/TrEMBL
Pfam	DUF4713	UniProtKB/TrEMBL
PhenoGen	Smim22	PhenoGen
UniProt	J3QP37	ENTREZGENE, UniProtKB/TrEMBL
	V9GXA9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-06	Smim22	small integral membrane protein 22	Gm5480	predicted gene 5480	Symbol and/or name change	5135510	APPROVED
2011-12-13	Gm5480	predicted gene 5480	EG432995	predicted gene, EG432995	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar